Citation: Bin Liu, Xiaona Xu, Zhoujing Zhu, Hongjuan Tong, Yanmin Zhang, Wenqiang Tang. Synthesis, Crystal Structure and Antitumor Activity of N-(2, 6-Dichloro-4-(1, 2, 4-oxadiazol-3-yl)phenyl)-2-methoxynicotinamide[J]. Chemistry, ;2021, 84(4): 383-387, 399. shu

Synthesis, Crystal Structure and Antitumor Activity of N-(2, 6-Dichloro-4-(1, 2, 4-oxadiazol-3-yl)phenyl)-2-methoxynicotinamide

Bin Liu ^{1, 2,,} ,
Xiaona Xu ³ ,
Zhoujing Zhu ^{1, 2} ,
Hongjuan Tong ^{1, 2} ,
Yanmin Zhang ^{1, 2} ,
Wenqiang Tang ^{1, 2}

1.
School of Pharmacy, Shaanxi Institute of International Trade&Commerce, Xianyang, 712046
2.
Collaborative Innovation Center of Green Manufacturing Technology for Traditional Chinese Medicine in Shaanxi Province, Xianyang, 712046
3.
School of Pharmaceutical&Chemical Engineering, Xianyang Vocational Technical College, Xianyang, 712000

Corresponding author: Bin Liu, lb125lb@163.com
Received Date: 15 August 2020
Accepted Date: 10 November 2020

Figures(4)

A novel 1, 2, 4-oxadiazol derivative N-(2, 6-dichloro-4-(1, 2, 4-oxadiazol-3-yl) phenyl)-2-methoxynicotinamide (C₁₅H₁₀Cl₂N₄O₃) was synthesized, and the structure was characterized by ¹H NMR, ¹³C NMR, HRMS and single-crystal X-ray diffraction. The crystal belongs to the triclinic system, space group P1 with a=7.1291 (9), b=8.4352 (10), c=14.0021 (18) Å, α=73.834 (3)°, β=77.407 (3)°, γ=70.019 (3)°, M_r=366.18, V=752.97 (16) Å³, Z=2, D_c=1.611 g/cm³, μ(MoKα)=0.454 mm^-1, F(000)=372.0, and R_int=0.023. The preliminary biological results suggested that the titled compound has obvious inhibitory effect on LoVo, A549, SK-BR-3, and HeLa cell lines, especially the inhibitory activity on HeLa cells was comparable to the positive drug 5-fluorouracil (5-FU).
- Nicotinamide derivatives,
- 1, 2, 4-Oxadiazol,
- Crystal structure,
- Antitumor activity
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沈阳化工大学材料科学与工程学院沈阳 110142