Citation: Qingqing Zhou, Wengui Duan, Luzhi Liu, Yan Huang. Construction and Antitumor Activity of Supramolecular Nano Drug Delivery System Based on Amphiphilic Pillar[5]arene[J]. Chemistry, ;2021, 84(5): 460-466. shu

Construction and Antitumor Activity of Supramolecular Nano Drug Delivery System Based on Amphiphilic Pillar[5]arene

Qingqing Zhou ¹ ,
Wengui Duan ¹ ,
Luzhi Liu ^1,, ,
Yan Huang ^2,,

1.
School of Chemistry and Chemical Engineering, Guangxi University, Nanning, 530004
2.
Guangxi Key Laboratory of Tradtitional Chinese Medicine Quality Standards, Guangxi Institute of Chinese Traditional Medical & Pharmaceutical Science, Nanning, 530022

Corresponding author: Luzhi Liu, llzh068@163.com Yan Huang, hy2002-2006@163.com
Received Date: 31 October 2020
Accepted Date: 7 December 2020

Figures(7)

A novel alanine substituted water-soluble pillar[5]arene DAP5 was synthesized, which could be used as building block to construct a supramolecular nano drug loading carrier SDBS⊂DAP5 through host-guest interaction with sodium dodecylbenzene sulfonate (SDBS). This carrier can efficiently encapsulate DOX with an entrapment efficiency of 62.6%. And its nano drug delivery system DOX⊂SDBS⊂DAP5 not only had good pH response performance and could continuously release the drug in a simulated weak acid tumor microenvironment, but also had low toxicity to normal liver cells (LO2) (IC₅₀ >10μmol/L). More importantly, DOX⊂SDBS⊂DAP5 exhibited stronger proliferation inhibition activity and shorter medication time over free drug for four tested cancer cells (Hela, HepG2, MGC-803 and T24). Especially for HepG2, after 24 hours of incubation with drug, IC₅₀ of DOX⊂SDBS⊂DAP5 was 0.77 μmol/L, about 22% of that of DOX (3.43 μmol/L). These results provide important reference information for improving the efficacy and reducing the side effects of supramolecular drug delivery system in the future cancer treatment.
- Pilar[5]arene,
- Host-guest interaction,
- Nano drug delivery system,
- Antitumor activity
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