Citation: . SYNTHETIC STUDIES ON BLOOD COMPATIBLE BIOMATERIALS 13:A NOVEL SEGMENTED POLYURETHANE CONTAINING PHOSPHORYLCHOLINE STRUCTURE:SYNTHESIS,CHARACTERIZATION AND BLOOD COMPATIBILITY EVALUATION*[J]. Chinese Journal of Polymer Science, ;2003, 21(1): 45-50. shu

SYNTHETIC STUDIES ON BLOOD COMPATIBLE BIOMATERIALS 13:A NOVEL SEGMENTED POLYURETHANE CONTAINING PHOSPHORYLCHOLINE STRUCTURE:SYNTHESIS,CHARACTERIZATION AND BLOOD COMPATIBILITY EVALUATION*

Received Date: 5 February 2002
Revised Date: 10 May 2002

A new phosphorylcholine, (6-hydroxy) hexyl-2-(trimethylammonio) ethyl phosphate (HTEP), was synthesized andcharasterized. Segmented polyurethane (SPU) containing phosphorylcholine structure was synthesized based ondiphenylmethane diisocyanate (MDI), soft segment polytetramethylene glycol (PTMG) and HTEP, with 1,4-butanediol (BD)as a chain extender. The existence of phosphorylcholine structure on the surface of SPU was revealed by attenuated totalreflectance Fourier transform infrard spectroscopy(ATR-FTIR),X-ray photoelectron spectroscopy(XPS) and water contact angle measurements.The blood compatibilities of the polymers were evaluated by hemolytic testing and a platelet-rich plasma(PRP) adhesion experiment,which was viewed by scanning electron microscopy (SEM) with polyurethane as a reference.The novel segmented polyurethane containing phosphorylcholine structure showed improved blood compatibility.
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