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Citation: Cheng Yufei, Gao Wenchao, Liu Qiang, Chang Honghong, Zhang Jiandong, Wei Wenlong. Syntheses of 2-Aryl-3-sulfenyl-4(1H)-quinolinones Using Electrophilic Sulfur Reagents[J]. Chemistry, ;2018, 81(12): 1121-1126. shu

Syntheses of 2-Aryl-3-sulfenyl-4(1H)-quinolinones Using Electrophilic Sulfur Reagents

College of Chemistry and Chemical Engineering, Taiyuan University of Technology, Taiyuan 030024

Received Date: 27 June 2018
Accepted Date: 30 August 2018

Figures(1)

The syntheses of 2-aryl-3-sulfenyl-2, 3-dihydroquinolin-4(1H)-ones are realized using (E)-1-(2-tosylaminophenyl)-3-arylprop-2-en-1-ones (1) and N-sulfanylsuccinimides as substrates through electrophilic cyclization. With BF₃·Et₂O (20(mol)%) as the catalyst and 1, 2-dichloroethane as the solvent, the reaction can be performed well at 60℃ and give the desired 2-aryl-3-sulfenyl-4(1H)-quinolinones in a yield of 60%~92%. Compounds 3a-3l have not been reported in the literature, and their structures are confirmed by ¹H NMR, ¹³C NMR and HR-MS.
- N-Sulfanylsuccinimides,
- 2-Aryl-3-sulfenyl-4(1H)-quinolinones,
- Electrophilic cyclization,
- Sulfide syntheses
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