Citation: He Sheng ZHANG, Chuan Fu ZHONG, Xiao Ping BAO. Studies of the Total Synthesis of Epothilone B and D:A Facile Synthesis of C7-C14 and C15-C21 Fragments[J]. Chinese Chemical Letters, ;2003, 14(2): 115-117. shu

Studies of the Total Synthesis of Epothilone B and D:A Facile Synthesis of C7-C14 and C15-C21 Fragments

Department of Chemistry, Hubei University, Wuhan 430062

Received Date: 1 April 2002

Fund Project: Ministry of EducationNalural Science Foundation and Education Commission of Hubei Province for financial support.We are grateful to the National Natural Science Foundation of China (No.20214)

A mild and highly efficient synthesis of C7-C14 and C15-C21 fragments of epothilone B and D is described in which racemic C7-C14 fragment is prepared from nerol through four steps, and C15-C21 fragment is obtained from 1, 3-dichloroacetone, thioacetamide and propionaldehyde.
- Epothilone B and D,
- anticancer drugs,
- nerol,
- synthesis
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