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Citation: Ji Lingbo, Wang Dingzhong, Chai Guobi, Cui Kai, Ma Ji, Xi Hui, Hu Youchi, Zong Yongli, Fan Wu, Liu Junhui. Tansition-Metal-Free Syntheses of Indeno[1, 2-b]-indol-10(5H)-one Derivatives[J]. Chemistry, ;2018, 81(12): 1127-1131. shu

Tansition-Metal-Free Syntheses of Indeno[1, 2-b]-indol-10(5H)-one Derivatives

Zhengzhou Tabacco Research Institute of CNTC, Zhengzhou 450001

Corresponding author: Fan Wu, fanwu2015@126.com Liu Junhui, ljhpku@outlook.com
Received Date: 7 May 2018
Accepted Date: 31 August 2018

Figures(1)

A convenient method for the preparation of indenoindolones from 3-(2-bromobenzoyl)-indoles without the aid of transition-metal catalysis has been developed. 2-Zincioindole reagents, prepared in-situ from 3-(2-bromobenzoyl)-indoles, n-BuLi and ZnI₂, were found to undergo intramolecular addition-cyclizing reactions with aryl bromides in the presence of LiI in a mixed solvent consisting of toluene and THF(2:1). Various substituted indeno[1, 2-b]indol-10(5H)-ones can be obtained in good yields. The effects of reaction parameters such as solvent, zinc halide and additive on the yield were investigated.
- Lithium iodide 2-zincioindole,
- addition-cyclizing,
- aryl bromides,
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