Citation: Bing Hao LUO, Hui Ping GUAN, Quan Fu WANG, Chang Ming HU. Synthesis of 2-Fluoroalkylated Tetrahydrofuran Derivatives from Ethyl α-Fluoroalkylacetates[J]. Chinese Chemical Letters, ;1997, 8(7): 583-586. shu

Synthesis of 2-Fluoroalkylated Tetrahydrofuran Derivatives from Ethyl α-Fluoroalkylacetates

354.
Fenglin Road, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai 200032

Received Date: 14 March 1997

Fund Project: We thank the National Natural Science Foundation of China (No. 29632003) for financial support.

Ethyl α-(2-alkenyl)-α-perfluoroacylacetates (4) are synthesized from the reaction of ethyl α-perfluoroalkylacetates with allylic alcohols in the presence of the mixed base of triethylamine and sodium dicarbonate.lodoenoletherification of the compounds 4 afforded 2-fluoroalkylated tetrahvdrofuran derivatives 5 under the improved conditions.The possible reaction pathways are suggested.
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