Advanced Search

Citation: Liu Wandong, Zhu Panhu, Li Jiaming, Wang Xianna, Tong Pingping. Design, Synthesis, and Anti-Platelet Aggregation Activities Evaluation of Oxiracetam Derivatives[J]. Chemistry, ;2019, 82(3): 275-279. shu

Design, Synthesis, and Anti-Platelet Aggregation Activities Evaluation of Oxiracetam Derivatives

  • 1.

    College of Pharmacy, Anhui University of Chinese Medicine, Hefei 230038

  • 2.

    Department of Medicinal Chemistry, Anhui Academy of Chinese Medicine, Hefei 230038

  • Corresponding author: Li Jiaming, lijiaming2017@sina.com
  • Received Date: 6 September 2018
    Accepted Date: 12 November 2018

Figures(2)

  • Herein, seven novel oxiracetam derivatives were designed and synthesized upon employing pharmacophore-combination strategy. Among them, compounds 4a~4f were attained via structurally combining oxiracetam with cinnamylic acid fragment, while compounds 4g were attained via combining oxiracetam with indobufen through ester functionality. All the target compounds were biologically evaluated for the inhibitory activities of platelet aggregation induced by arachidonic acid (AA) and adenosine diphoshate (ADP) via Bron method. The results of in vitro anti-platelet aggregation activities showed that the compounds had certain anti-platelet aggregation activities, and the anti-platelet aggregation activity of compound 4f was consistent with that of the positive control indobuprofen.
  • 加载中
    1. [1]

      W Wang, B Jiang, H Sun et al. Circulation, 2017, 135(8):759~771. 

    2. [2]

      A Taruya, A Hatada, Y Nishimura et al. J. Cardiol. Cases, 2014, 10(1):1~3. 

    3. [3]

       

    4. [4]

       

    5. [5]

       

    6. [6]

       

    7. [7]

       

    8. [8]

       

    9. [9]

       

    10. [10]

      Z H Jiang, J R Wang, M Li et al. J. Nat. Prod., 2005, 68(3):397~399. 

    11. [11]

       

    12. [12]

       

  • 加载中
    1. [1]

      Huirong BAO , Jun YANG , Xiaomiao FENG . Preparation and electrochemical properties of NiCoP/polypyrrole/carbon cloth by electrodeposition. Chinese Journal of Inorganic Chemistry, 2025, 41(6): 1083-1093. doi: 10.11862/CJIC.20250008

    2. [2]

      Yuena Yu ,  Fang Fang . Microwave-Assisted Synthesis of Safinamide Methanesulfonate. University Chemistry, 2024, 39(11): 210-216. doi: 10.3866/PKU.DXHX202401076

    3. [3]

      Jia-He Li ,  Yu-Ze Liu ,  Jia-Hui Ma ,  Qing-Xiao Tong ,  Jian-Ji Zhong ,  Jing-Xin Jian . 洛芬碱衍生物的合成、化学发光与重金属离子检测. University Chemistry, 2025, 40(6): 230-237. doi: 10.12461/PKU.DXHX202407080

    4. [4]

      Junjie TANG , Yunting ZHANG , Zhengjiang LIU , Jiani WU . Preparation of CeO2 by starch template method for photo-Fenton degradation of methyl orange. Chinese Journal of Inorganic Chemistry, 2025, 41(8): 1617-1631. doi: 10.11862/CJIC.20240420

    5. [5]

      Xiaomei Ning ,  Liang Zhan ,  Xiaosong Zhou ,  Jin Luo ,  Xunfu Zhou ,  Cuifen Luo . Preparation and Electro-Oxidation Performance of PtBi Supported on Carbon Cloth: A Recommended Comprehensive Chemical Experiment. University Chemistry, 2024, 39(11): 217-224. doi: 10.3866/PKU.DXHX202401085

    6. [6]

      Wuxin Bai , Qianqian Zhou , Zhenjie Lu , Ye Song , Yongsheng Fu . Co-Ni Bimetallic Zeolitic Imidazolate Frameworks Supported on Carbon Cloth as Free-Standing Electrode for Highly Efficient Oxygen Evolution. Acta Physico-Chimica Sinica, 2024, 40(3): 2305041-0. doi: 10.3866/PKU.WHXB202305041

    7. [7]

      Yujia LI , Tianyu WANG , Fuxue WANG , Chongchen WANG . Direct Z-scheme MIL-100(Fe)/BiOBr heterojunctions: Construction and photo-Fenton degradation for sulfamethoxazole. Chinese Journal of Inorganic Chemistry, 2024, 40(3): 481-495. doi: 10.11862/CJIC.20230314

    8. [8]

      Xinyu ZENG , Guhua TANG , Jianming OUYANG . Inhibitory effect of Desmodium styracifolium polysaccharides with different content of carboxyl groups on the growth, aggregation and cell adhesion of calcium oxalate crystals. Chinese Journal of Inorganic Chemistry, 2024, 40(8): 1563-1576. doi: 10.11862/CJIC.20230374

    9. [9]

      Yanyang Li ,  Zongpei Zhang ,  Kai Li ,  Shuangquan Zang . Ideological and Political Design for the Comprehensive Experiment of the Synthesis and Aggregation-Induced Emission (AIE) Performance Study of Salicylaldehyde Schiff-Base. University Chemistry, 2024, 39(2): 105-109. doi: 10.3866/PKU.DXHX202307020

Get Citation
PDF
XML
Metrics
  • PDF Downloads(7)
  • Abstract views(458)
  • HTML views(69)

通讯作者: 陈斌, bchen63@163.com
  • 1. 

    沈阳化工大学材料科学与工程学院 沈阳 110142

  1. 本站搜索
  2. 百度学术搜索
  3. 万方数据库搜索
  4. CNKI搜索
Address：Zhongguancun North First Street 2,100190 Beijing, PR China Tel: +86-010-82449177-888
Powered By info@rhhz.net

/

DownLoad:  Full-Size Img  PowerPoint
Return