Citation: WANG Zhuting, ZHANG Peiming, SUN Shumen. SYNTHESIS AND CHARACTERIZATION OF POLYMER DERIVATIVES OF cis-PLATINUM COMPLEXES[J]. Chinese Journal of Polymer Science, ;1986, 4(4): 359-369. shu

SYNTHESIS AND CHARACTERIZATION OF POLYMER DERIVATIVES OF cis-PLATINUM COMPLEXES

Received Date: 11 April 1986

Cis-platinum complexes used as antitumor drugs were attached onto preformed polymers toreduce the toxicity. Either alternating copolymer of styrene and maleic anhydride (CPSMA) orpolyacrylic acid (PAA) is readily dissolved in alkaline solution. The cis-platinum complexes areeasily converted into water soluble species when treated by silver nitrate in water. The expectedproducts could be obtained when the two aqueous solutions were brought together. The productswere characterized by elementary analysis, IR and XPS.The polymer derivatives could exchange Jigands with nucleophilic groups in biological environment and also exhibit antineoplastic activity.
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