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Citation: Liu Jie, Tu Changchun, Zhang Maolin, Hou Shikuan, Wang Enbo. Activity of Vanadium-substituted Heteropolytungstate to Antipseudorabies Virus[J]. Chinese Journal of Applied Chemistry, ;1998, 15(4): 41-44. shu

Activity of Vanadium-substituted Heteropolytungstate to Antipseudorabies Virus

1.
Deprtment of Chemistry, Northeast Normal University, Changchun 130024;
2.
The Military Veterinary Institute, University of Agriculure and Animal Sciences, Changchun 130024

Received Date: 27 October 1997
Revised Date: 30 March 1998

Some vanadium-substituted hetropolytungstates were synthesized. Their toxicity to the cells of RK and activity to antipseudorabies virus at nontoxic concentrations were tested by cell-culture methods. The results showed that some of the compounds had high anti-PRV activity at nontoxic concentration. Among them three had high antivirus and selective activity with median effective concentration 3.2~5.0 mg/L and cell median toxicity concentration 400~420 mg/L. At concentration of the compounds 12.5 mg/L the inhibition to PRV was more than 70%~80%, while virus TCID₅₀ values descended four log. The relation between the structure and activity has been discussed briefly.
- vanadium-substituted heteropolytungstate,
- antivirus activity,
- pseudorabies virus,
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