Citation: Duan Bingya, Wang Tianyuan, Sun Yingfei. Research Progress in Computer Aided Metalloprotein Design and Engineering[J]. Chemistry, ;2019, 82(3): 221-230. shu

Research Progress in Computer Aided Metalloprotein Design and Engineering

1.
School of Electronic, Electrical and Communication Engineering, University of Chinese Academy of Sciences, Beijing 101408
2.
XtalPi Co. Ltd., Beijing 100190

Corresponding author: Wang Tianyuan, tianyuan.wang@xtalpi.com Sun Yingfei, yfsun@ucas.ac.cn
Received Date: 15 October 2018
Accepted Date: 20 November 2018

Figures(10)

Metalloproteins are proteins containing metal ions, they play important roles in biology system due to their special catalytic activity. A lot of study has been done to elucidate their structural and functional mechanism. Based on the active site mimic of existing metalloprotein, artificially designed metalloproteins with specific structure and function can be achieved through computer aided protein design method. In this paper, research progress in computer aided metalloprotein design and engineering was reviewed. The general principle for introducing metal ion binding site and protein activity enhancement was summarized. We also presented current problems and challenges in this field, along with future directions and probable breakthrough point.
- Metalloprotein,
- Computer aided protein design,
- Enzyme de novo design,
- Genetic code expansion
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沈阳化工大学材料科学与工程学院沈阳 110142