Citation: Yi Yang Dong, Xue Qin REN, Ai Jin HUANG, Yi Liang SUN, Zeng Pei SUN. Chiral Separation of Esmolol and Terazosin by Cyclodextrinmodified Capillary Zone Electrophoresis[J]. Chinese Chemical Letters, ;1998, 9(6): 565-568. shu

Chiral Separation of Esmolol and Terazosin by Cyclodextrinmodified Capillary Zone Electrophoresis

1.
Department of Chendstry, Peking University, Beijing 10087;
2.
National Institute for the Control of Pharmaceutical and Biological Products, Beijing 100050

Received Date: 31 January 1998

Fund Project: The financial support jointly provided by the Doctoral Program Foundation of the State Commission of Education and National Science Foundation of China are gratefully acknowledged.

Cyclodextrin-modified CZE was applied to the chiral separation of two basic drugs, i.e., esmolol and terazosin. Selector screening and concentration optimization experiments were performed. Resolution 3.1 for esmolol, 1.2 for terazosin were achieved when using 60 mmol/L γ-CD and 60 mmol/L DM-β-CD, respectively, in 50 mmol/L pH 2.5 sodium phosphate buffer.
- Capillary zone electrophoresis,
- Chiral separation,
- Cyclodextrin,
- Esmolol,
- Terazosin
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