Citation: Wei LU, Guang Rong ZHENG, Jing Shan SHEN, Jun Chao CAI. Synthesis of the (3R, 9S, 10S)-Diastereoisomer of Panaxytriol,a Potent Antitumor Polyacetylene from Panax ginseng[J]. Chinese Chemical Letters, ;1999, 10(3): 201-204. shu

Synthesis of the (3R, 9S, 10S)-Diastereoisomer of Panaxytriol,a Potent Antitumor Polyacetylene from Panax ginseng

Shanghai Institute of Materia Medica Chinese Academy of Sciences, Shanghai 200031

Received Date: 31 August 1998

Fund Project: We thank the State Key Laboratory of Drug Research for financial support.

(3R, 9S.lOS)-Heptadec-l-ene-4,6-diyne-3.9.10-triol 2.a diastereoisomer of panaxytriol 1 was synthesized using L-(+)-diethyl tartrate 5 as a chiral template.through the Cadiot-Chodkiczwicz coupling of the terminal acetylene 3 with bromoacetylene 4.
- Diastereoisomer,
- panaxytriol,
- Cadiot-Chodkiczwicz coupling
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