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Citation: Yu Xiang, Chen Yafang, Qin Yan, Yan Jing. Syntheses and Antifungal Activities of 5-Arylidene-2, 3-diaryl-thiazolidin-4-one Derivatives[J]. Chemistry, ;2019, 82(1): 68-73. shu

Syntheses and Antifungal Activities of 5-Arylidene-2, 3-diaryl-thiazolidin-4-one Derivatives

Yu Xiang ^1,2,, ,
Chen Yafang ¹ ,
Qin Yan ¹ ,
Yan Jing ¹

1.
College of Pharmacy, Guizhou University of Chinese Medicine, Guiyang 550025
2.
Guizhou Key Laboratory of Miao Medicine, Guizhou University of Chinese Medicine, Guiyang 550025

Corresponding author: Yu Xiang, yuxiangjx@126.com
Received Date: 28 July 2018
Accepted Date: 1 September 2018

Figures(1)

A series of 5-arylidene-2, 3-diaryl-thiazolidin-4-one derivatives (4a~4r) were synthesized from 2, 3-diphenyl-thiazolidin-4-one via microwave irradiation, and evaluated in vitro at the concentration of 100μg/mL against seven phytopathogenic fungi, namely Fusarium graminearum, Alternaria alternata, Fusarium oxysporium f. sp. vasinfectum, Pyricularia oryzae, Valsa mali, Alternaria solani and Alternaria brassicae. All the prepared compounds were characterized for structural confirmation by melting point, ¹H NMR, and MS. The activity results indicated that 4g and 4n exhibit potential antifungal activities against the phytopathogenic fungi.
- 5-Arylidene-2, 3-diary-lthiazolidin-4-one,
- Microwave irradiation,
- Antifungal activity
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