Citation: Hong Xia LIU, Shu Sheng ZHANG, Jian Chen ZHANG, Xiao YANG, Ling Bo QU, Yu Fen ZHAO. ESI/MS of N-(O, O-Diisopropyl) Phosphoryl Aromatic Amino Acids and their Stability Investigation Using HPLC/UV/ESI/MS[J]. Chinese Chemical Letters, ;2005, 16(5): 643-646. shu

ESI/MS of N-(O, O-Diisopropyl) Phosphoryl Aromatic Amino Acids and their Stability Investigation Using HPLC/UV/ESI/MS

1.
Chemistry Department, Key Laboratory of Chemical Biology and Organic Chemistry of Henan, Zhengzhou University, Zhengzhou 450052;
2.
The Key Laboratory for Bioorganic Phosphorus Chemistry, Tsinghua University, Beijing 10084

Received Date: 9 May 2004

Fund Project: The authors would like to thank for the supporting of Henan Outstanding Youth Grant (04120001200) and Henan Outstanding People Innovation Grant (0421002300).

The full scan ESI/MS and ESI/MS² of N-(O, O-diisopropyl) phosphoryl aromatic amino acids (DIPPAAAs), N-(O, O-diisopropyl) phosphoryl phenylalanine, N-(O, O-diisopropyl)phosphoryl tryptophan and N-(O, O-diisopropyl) phosphoryl tyrosine, were obtained. The specific ions for them were found. Their stability in the LC mobile phase was investigated using developed HPLC/UV/ESI/MS and the results demonstrated that the DIPPAAAs were stable in the mobile phase (5 mmol/L NH₄Ac-MeCN (80:20,v/v, pH7.5) within 48 h.
- ESI/MS,
- HPLC,
- diisopropyl phosphorylation,
- amino acid
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