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Citation: Su Changhui, Liu Xia, Ding Zhiyuan, Cui Kai, Ma Jiejie. Synthesis of Amine Polyethylene Glycol-1, 2-distearoyl-glycero-3-phosphoethanolamine[J]. Chemistry, ;2019, 82(2): 183-186. shu

Synthesis of Amine Polyethylene Glycol-1, 2-distearoyl-glycero-3-phosphoethanolamine

Su Changhui ^1, ,
Liu Xia ² ,
Ding Zhiyuan ¹ ,
Cui Kai ¹ ,
Ma Jiejie ¹

1.
School of Chemistry and Life Science, Nanjing University Jinling College, Nanjing 210089
2.
College of Environment Science and ecology, Jiangsu Open University, Nanjing 210036

Received Date: 15 August 2018
Accepted Date: 9 October 2018

Figures(1)

DSPE was synthesized by reactions with glycerol-1, 2-distearate, phosphorusoxychloride and 2-aminoethanol as raw materials. N₃-PEG2000 was achieved by an efficient two step process from readily available PEG2000. Subsequently, N₃-PEG2000-DSPE was obtained by linking DSPE to N₃-PEG2000 via CDI. Finally, catalytic hydrogenation of the azido group yielded the target compound NH₂-PEG2000-DSPE, which was characterized by IR, ¹H NMR, and MS.
- Polyethylene glycol,
- Liposomes,
- Phospholipid,
- Synthesis
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