Citation: Wang Miao, Huang Lin, Su Yan, Xu Yinghong, Huang Lingyue, Zhou Xiaoqun, Li Fangyao. Syntheses and Cytotoxicity Evaluation of Novel Paeonol-Thiazoles Derivatives[J]. Chemistry, ;2019, 82(7): 630-635. shu

Syntheses and Cytotoxicity Evaluation of Novel Paeonol-Thiazoles Derivatives

Wang Miao ¹ ,
Huang Lin ¹ ,
Su Yan ¹ ,
Xu Yinghong ¹ ,
Huang Lingyue ¹ ,
Zhou Xiaoqun ² ,
Li Fangyao ^1,,

1.
College of Pharmacy, Guilin Medical University, Guilin 541004
2.
College of Humanities and Management, Guilin Medical University, Guilin 541004

Corresponding author: Li Fangyao, lifangyao2006@163.com
Received Date: 31 January 2019
Accepted Date: 18 February 2019

Figures(1)

Fifteen novel paeonol thiazole derivatives were synthesized using paeonol as starting material and their structures were confirmed by IR, ¹H NMR, ¹³C NMR and MS. All of them were evaluated for their cytotoxicity against three human cancer cell lines (MGC-803, LOVO and T-24) in vitro by standard MTT assay. The results presented that some of the target compounds exhibit significant cytotoxic activity, such as compounds 4b, 4e, 4f, 4h, 4l exhibite better antitumor activity than the positive reference cisplatin against MGC-803. In particular, compound 4b shows the most potent antitumor activities with IC₅₀ values of 11.39±4.46 μg/mL, 2.06±1.27 μg/mL and 6.03±0.86 μg/mL against MGC-803, LOVO and T-24 tumor cell lines, respectively. It suggestes that compound 4b might be the candidate for further investigation.
- Paeonol,
- Thiazole,
- Synthesis,
- Cytotoxicity
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