Citation: Zeng Zao, Shu Qunwei, Li Jinhai. Synthesis and Properties of Dehydronorcantharidin Imide-Salicylaldehyde[J]. Chemistry, ;2018, 81(1): 83-87. shu

Synthesis and Properties of Dehydronorcantharidin Imide-Salicylaldehyde

Zeng Zao ^1,2, ,
Shu Qunwei ¹ ,
Li Jinhai ¹

1.
Center of Natural Products, Guizhou University of Engineering Science, Bijie 551700
2.
Guizhou Key Laboratory of Applied Chemistry, Bijie 551700

Received Date: 31 May 2017
Accepted Date: 12 September 2017

Figures(5)

In this work, dehydronorcantharidin imide-salicylaldehyde was synthesized from furan, maleic anhydride and hydrazine hydrate, and the structure of synthesized compound was confirmed by NMR, MS and elemental analysis. The bacteriostatic activity of the product and the interaction with bovine serum albumin (BSA) were tested. The results showed that the compound has good antibacterial activity against E.coli and S.aureus. The quenching mechanism of titled compound to BSA is static quenching. Moreover, at 293, 303 and 310 K, the quenching constants are 3.39×10⁴ L/mol, 3.29×10⁴ L/mol, and 3.13×10⁴ L/mol, respectively. The interaction of the compound to BSA is mainly driven by hydrophobic force. Meanwhile, the binding distance is 2.688 nm, and the number of binding sites is 1.049 (303K).
- Dehydronorcantharidin,
- Salicylaldehyde,
- Synthesis,
- Bacteriostatic activity,
- Fluorescence properties
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