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Citation: Yu ZHAO, Yuan Ling KU, Shoei Sheng LEE. Preparation of AChE Inhibitors From Jujubogenin[J]. Chinese Chemical Letters, ;2000, 11(8): 671-674. shu

Preparation of AChE Inhibitors From Jujubogenin

a Laboratory of Phytochemistry, Kunnming Institute of Botany, Chinese Academy of Sciences, Kunming 650204;
b School of Pharmacy, College of Medicine, National Taiwan University, Taipei 10018

Received Date: 24 January 2000

A dammarane derivative dihydrojujubogenin-2-en-1-one, which possesses a skeleton and pharmacophore partially similar to those of Territrem B, a potent AChE inhibitor, was synthesized via three different paths. The anti-AChE activity of this compound and related analogue was measured.
- Alzheimer disease (AD),
- acetylcholinesterase (AChE) inhibitor,
- pharmaceutical chemistry,
- jujubogenin,
- Territrem B analogues
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