Citation: Gai Shuangshuang, Jiang Ming. Biological Properties of Cu(Ⅱ) Complex with Human Serum Albumin[J]. Chemistry, ;2018, 81(3): 253-257. shu

Biological Properties of Cu(Ⅱ) Complex with Human Serum Albumin

Gai Shuangshuang ,
Jiang Ming ^,

Guangxi Science & Technology Normal University, College of Teacher Education, Liuzhou 545004

Corresponding author: Jiang Ming, jiangbiochem@163.com
Received Date: 18 November 2017
Accepted Date: 3 January 2018

Figures(8)

Copper (Ⅱ) complexes are likely to become the next generation of anti-tumor drugs. Schiff base was synthesized from 2-amino-5-chlorophenol and 2-quinolinecarbaldehyde, which was used as ligand to further complex with Cu (Ⅱ) to form complex 1. In vitro anti-tumor tests of complex 1 and HSA-1 complex on different tumor cells were carried out. The results indicated that HSA can improve the anti-tumor activity of complex 1 and reduce the toxicity to normal cells. Mitochondrial membrane potential assays revealed that copper(Ⅱ) complex induced apoptosis might mediate via the mitochondrial pathway.
- Copper(Ⅱ) complexes,
- Cell apoptosis,
- Mitochondrial membrane potential
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