Citation: Zhenhua Tang, Jiamin Liu, Yihong Fu, Weinan Hu, Zhenchao Wang, Guiping Ouyang. Progress in Antitumor Activity of 3-Substituted Indole Derivatives[J]. Chemistry, ;2021, 84(1): 47-52. shu

Progress in Antitumor Activity of 3-Substituted Indole Derivatives

Zhenhua Tang ¹ ,
Jiamin Liu ¹ ,
Yihong Fu ¹ ,
Weinan Hu ¹ ,
Zhenchao Wang ^{1, 2,,} ,
Guiping Ouyang ^{1, 2, 3,,}

1.
School of Pharmacy, Guizhou University, Guiyang, 550025
2.
State Key Laboratory of Functions and Application of Medicinal Plants, Guizhou Medicinal University, Guiyang, 550014
3.
Guizhou Engineering Laboratory for Synthetic Drugs, Guiyang, 550025

Corresponding author: Zhenchao Wang, wzc.4884@163.com Guiping Ouyang, oygp710@163.com
Received Date: 28 June 2020
Accepted Date: 2 September 2020

Indole is a compound widely found in nature, having a variety of biological activities like antitumor, antioxidant and antibacterial. The introduction of different substituents at the 3-position on the indole ring for structural modification and transformation has always been a drug research hotspot. In this article the related literature in recent years were summarized, and the antitumor activities of 3-substitution indole derivatives with the different heterocycle substituents such as pyrazoles and pyrazolines, diazoles and triazoles, cyclization with 2-position were reviewed in order to provide a theoretical basis for the development of highly active antitumor drugs.
- 3-substitution indole,
- Heterocycle,
- Antitumor activity
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