Citation: Jiadong Hu, Wen Wen, Le Chen, Xiaowu Fang. Synthesis of 2-Hydroxy-3, 4, 6-trimethoxychalcone[J]. Chemistry, ;2021, 84(3): 279-283. shu

Synthesis of 2-Hydroxy-3, 4, 6-trimethoxychalcone

Jiadong Hu ^{1, 2,,} ,
Wen Wen ¹ ,
Le Chen ² ,
Xiaowu Fang ²

1.
School of Medicinal and Chemical Engineering, Yangling Vocational & Technical College, Yangling, 712100
2.
College of Chemistry & Pharmacy, Northwest A&F University, Yangling, 712100

Corresponding author: Jiadong Hu, hujiadong@aliyun.com
Received Date: 4 July 2020
Accepted Date: 12 October 2020

Figures(3)

A convenient 10-grams-scale synthesis of 2-hydroxy-3, 4, 6-trimethoxychalcone (1) is described. The total yield of 2-hydroxy-3, 4, 6-trimethoxybenzaldehyde (7) was increased from 22% reported in the literature to 68% after the optimization of methylation and formylation. 7 was furnished in 85% yield at 80℃ from 7 via the Wittig reaction in acetonitrile.
- 2-Hydroxy-3, 4, 6-trimethoxychalcone,
- 2-Hydroxy-6-trimethoxybenzaldehyde,
- Methylation,
- Formylation,
- Wittig reaction
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