Citation: Jiang Ming, Gai Shuangshuang, Lan Junfeng, Wen Sheng, Jiang Caiyun, Qin Yiming. Cu (Ⅱ) and Ni (Ⅱ) Complexes: Synthesis, Antitumor Effects and Cell Cycle Arrest[J]. Chemistry, ;2020, 83(3): 253-257. shu

Cu (Ⅱ) and Ni (Ⅱ) Complexes: Synthesis, Antitumor Effects and Cell Cycle Arrest

Jiang Ming ^1,2 ,
Gai Shuangshuang ¹ ,
Lan Junfeng ¹ ,
Wen Sheng ¹ ,
Jiang Caiyun ^1,, ,
Qin Yiming ^1,2,,

1.
School of Food and Biochemical Engineering, Guangxi Science&Technology Normal University
2.
Key Laboratory for Research and Development of Characteristic Yao, Guangxi Science&Technology Normal University, Laibin, Guangxi, 545004

Corresponding author: Jiang Caiyun, jiangcaiyun2013@163.com Qin Yiming, qinyiming@163.com
Received Date: 20 November 2019
Accepted Date: 20 December 2019

Figures(4)

Two metal complexes, named C1 and C2, were synthesized by reaction of Schiff base synthesized from 2-amino-5-chlorophenol and 2-quinoline formaldehyde with nickel chloride and copper chloride respectively. Their structures were characterized by single crystal X-ray diffraction. The inhibitory activities of complexes C1 and C2 on the proliferation of different human hepatoma cell lines and normal hepatoma cell lines HL-7702 were tested by MTT method. The results showed that the inhibitory activities of C1 and C2 on human hepatoma cell lines are better than that of cisplatin, C1 and C2 are less toxic to normal hepatoma cell lines HL-7702 than cisplatin. Through the experiments of reactive oxygen species and cell cycle, it can be concluded that the anti-tumor mechanism of complexes C1 and C2 is the oxidative damage of tumor cells caused by the production of living oxygen and the arrest of cell cycle in G0/G1 phase.
- Metal complexes,
- Human hepatoma cell line,
- Cell cycle,
- Reactive oxygen species
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