Citation: Wei LI, Wen YUAN, Wei Jun JIN, Chuan DONG. Study on the Interaction of Mitomycin C with ct-DNA by Pd-Porphin Room Temperature Phosphorescence Probe[J]. Chinese Chemical Letters, ;2001, 12(12): 1089-1092. shu

Study on the Interaction of Mitomycin C with ct-DNA by Pd-Porphin Room Temperature Phosphorescence Probe

Wei LI ^1,2, ,
Wen YUAN ¹ ,
Wei Jun JIN ¹ ,
Chuan DONG ¹

1.
Department of Chemistry, Shanxi University, Taiyuan 030006;
2.
Department of Environment Science, Shanxi University, Taiyuan 030006

Received Date: 16 April 2001

Fund Project: This work was financially supported by the National Natural Science Foundation of China (No.29875016), Natural Science Foundation of Shanxi Province (No.991010), and the Ministry of State Education Foundation.

Anticancer drug Mitomycin C (MMC) quenches remarkably phosphorescence and reduces lifetime of phosphorescence probe, Pd-meso-tetrakis-(4-trimethylaminophenyl) porphin (Pd-TAPP), in the presence of calf thymus DNA. These results may be attributed to the site competition of MMC with the probe and electron transfer between MMC and probe. MMC also increases polarization degree of the probe by covalent drug-DNA or DNA-drug-DNA crosslinking.
- Phosphorescence probe,
- mitomycin C,
- ct-DNA
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