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Citation: Yan Jinhua, Zhang Xiuxin, Yang Yuxin, Zhong Qidi. Syntheses of 3-Cyano-1, 4-dihydropyridine Derivatives[J]. Chemistry, ;2020, 83(8): 735-740. shu

Syntheses of 3-Cyano-1, 4-dihydropyridine Derivatives

College of Pharmacy, North China University of Science and Technology, Tangshan, 063200

Corresponding author: Zhong Qidi, qidizhong@hotmail.com
Received Date: 22 March 2020
Accepted Date: 11 May 2020

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1, 4-dihydropyridine compounds have a variety of biological activities and are widely used in the treatment of various cardiovascular and cerebrovascular diseases. The intermediate salts were synthesized from 3-cyanopyridine and benzyl bromide containing different substituents under the condition of reflux for 15 hours. Potassium borohydride (KBH₄) was used for the reduction of the intermediate salts in an ice-water bath, 15 relatively novel 1, 4-dihydrogen pyridine derivatives (a~o) were synthesized with the yield of 85%~90%. Their structures were characterized by ¹H NMR, ¹³C NMR and MS. The method has the characteristics of low cost, environmently friendly, easy operation and high yield.
- 1, 4-Dihydropyridine,
- Synthesis,
- Potassium borohydride,
- 3-Cyanopyridine
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