{"研究专题":[{"abstractInfo":"烯烃的不对称氢官能团化是一个重要的研究方向.从简单的烯烃原料出发，通过该方法可以高效构建手性分子.多取代烯烃的不对称氢官能团化仍然是一个挑战.一方面，烯烃有两个反应位点，反应的区域选择性需要进行有效的控制.另一方面，如果反应生成了多个手性中心，则涉及到非对映选择性的控制.此外，还需要控制反应的对映选择性.因此，此类研究的关键在于如何发展有效的催化体系，以同时实现区域选择性、非对映选择性及对映选择性的高效控制.针对这一问题，我们采用配位辅助策略，利用底物中的配位基团及烯烃与金属中心形成双位点配位模式，从而有效控制烯烃转化的区域选择性及立体选择性.以烯烃不对称炔氢化作为模型转化，以研究多取代烯烃催化不对称转化中的选择性控制.","abstractInfoCn":"烯烃的不对称氢官能团化是一个重要的研究方向.从简单的烯烃原料出发，通过该方法可以高效构建手性分子.多取代烯烃的不对称氢官能团化仍然是一个挑战.一方面，烯烃有两个反应位点，反应的区域选择性需要进行有效的控制.另一方面，如果反应生成了多个手性中心，则涉及到非对映选择性的控制.此外，还需要控制反应的对映选择性.因此，此类研究的关键在于如何发展有效的催化体系，以同时实现区域选择性、非对映选择性及对映选择性的高效控制.针对这一问题，我们采用配位辅助策略，利用底物中的配位基团及烯烃与金属中心形成双位点配位模式，从而有效控制烯烃转化的区域选择性及立体选择性.以烯烃不对称炔氢化作为模型转化，以研究多取代烯烃催化不对称转化中的选择性控制.","abstractInfoEn":"Catalytic asymmetric hydrofunctionalization of alkene is an important research field, which enables efficient construction of chiral molecules from readily available starting materials. Asymmetric hydrofunctionalization of multiple substituted alkenes represents a significant challenge to organic chemists because this process involves the simutaneous control of regio-, diastereo-, and enantio-selectivities. The key to solve this challenge is to identify novel catalyst systems to exert powerful regio- and stereo-control. Recently, by taking advantage of substrate-directed strategy, we have developed a number of alkene functionalization methods with excellent regio-, diastereo-, and enantio-selectivities. In particular, we focus on catalytic asymmetric hydroalkynylation of alkenes as a model transformation to analyze the factors that control the selectivity.","articleNo":"","authorCnList":["张雯雯"," 王紫璇"," 白小燕"," 李必杰"],"authorEnList":["Zhang Wenwen"," Wang Zixuan"," Bai Xiaoyan"," Li Bijie"],"authorList":["张雯雯"," 王紫璇"," 白小燕"," 李必杰"],"authors":"张雯雯, 王紫璇, 白小燕, 李必杰","authorsCn":"张雯雯, 王紫璇, 白小燕, 李必杰","authorsEn":"Zhang Wenwen, Wang Zixuan, Bai Xiaoyan, Li Bijie","categoryName":"研究专题","categoryNameCn":"研究专题","categoryNameEn":"Reviews","citation":"张雯雯, 王紫璇, 白小燕, 李必杰. 基于配位辅助的烯烃催化不对称炔氢化. 有机化学, 2020, 40(5): 1087-1095. doi: 10.6023/cjoc202002017.","citationCn":"张雯雯, 王紫璇, 白小燕, 李必杰. 基于配位辅助的烯烃催化不对称炔氢化. 有机化学, 2020, 40(5): 1087-1095. doi: 10.6023/cjoc202002017.","citationEn":"张雯雯, 王紫璇, 白小燕, 李必杰. Substrate-Directed Catalytic Asymmetric Hydroalkynylation of Alkenes. Chinese Journal of Organic Chemistry, 2020, 40(5): 1087-1095. doi: 10.6023/cjoc202002017.","doi":"10.6023/cjoc202002017","figContent":"yjhx-40-5-1087-1.jpg$$yjhx-40-5-1087-2.jpg$$yjhx-40-5-1087-3.jpg$$yjhx-40-5-1087-4.jpg$$yjhx-40-5-1087-5.jpg$$yjhx-40-5-1087-6.jpg$$yjhx-40-5-1087-7.jpg$$yjhx-40-5-1087-8.jpg$$yjhx-40-5-1087-9.jpg$$yjhx-40-5-1087-10.jpg$$yjhx-40-5-1087-11.jpg$$yjhx-40-5-1087-12.jpg$$yjhx-40-5-1087-13.jpg","figList":["yjhx-40-5-1087-1.jpg","yjhx-40-5-1087-2.jpg","yjhx-40-5-1087-3.jpg","yjhx-40-5-1087-4.jpg","yjhx-40-5-1087-5.jpg","yjhx-40-5-1087-6.jpg","yjhx-40-5-1087-7.jpg","yjhx-40-5-1087-8.jpg","yjhx-40-5-1087-9.jpg","yjhx-40-5-1087-10.jpg","yjhx-40-5-1087-11.jpg","yjhx-40-5-1087-12.jpg","yjhx-40-5-1087-13.jpg"],"firstFig":"yjhx-40-5-1087-1.jpg","fpage":"1087","highCitedState":"","htmlCount":785,"htmlFile":"","id":"f47e488d-544b-4b1f-938f-66e1618ee6fc","issnPpub":"0253-2786","issue":"5","journalPublishId":"yjhx","journalReferenceCodeType":0,"journalTitleCn":"有机化学","journalTitleEn":"Chinese Journal of Organic Chemistry","keyword":"烯烃转化, 不对称催化, 选择性, 配位辅助, 过渡金属催化","keywordCn":"烯烃转化, 不对称催化, 选择性, 配位辅助, 过渡金属催化","keywordCnList":["烯烃转化"," 不对称催化"," 选择性"," 配位辅助"," 过渡金属催化"],"keywordEn":"alkene functionalization, asymmetric catalysis, selectivity, substrate-directed strategy, transition metal catalysis","keywordEnList":["alkene functionalization"," asymmetric catalysis"," selectivity"," substrate-directed strategy"," transition metal catalysis"],"keywordList":["烯烃转化"," 不对称催化"," 选择性"," 配位辅助"," 过渡金属催化"],"language":"zh","latestInfo":"","latestState":"","latestStateEn":"","lpage":"1095","oldUrl":"http://sioc-journal.cn/Jwk_yjhx/CN/volumn/home.shtml","pdfDownCount":48,"pdfSize":603.6,"pubDate":"2020-05-01","recommendState":"","releaseState":"1","secCount":0,"title":"基于配位辅助的烯烃催化不对称炔氢化","titleCn":"基于配位辅助的烯烃催化不对称炔氢化","titleEn":"Substrate-Directed Catalytic Asymmetric Hydroalkynylation of Alkenes","viewCount":2817,"volume":"40","year":2020}],"综述与进展":[{"abstractInfo":"过渡金属络合物催化的均相不对称氢化反应是合成手性化合物的重要方法之一，目前主要集中于钌、铑、铱和钯等贵重过渡金属催化体系，这些贵重过渡金属催化体系面临着地球储量有限、价格昂贵和重金属污染环境等问题，因而发展地球储量丰富、价格低廉、无毒或低毒且对环境友好的铁、钴、镍和铜的均相不对称氢化反应催化体系符合现代化学可持续发展的要求和趋势.简要综述了近些年来廉价金属镍催化的均相不对称氢化反应研究领域的新进展，基于前手性不饱和化合物双键的不同类型，即碳-氧双键（C=O）、碳-碳双键（C=C）以及碳-氮双键（C=N）等，依次介绍它们的研究现状，目前已经取得了突破和可观的研究成果，系统地分析了镍催化体系中催化氢化不同类型底物的优势与不足，并展望了未来的研究方向.","abstractInfoCn":"过渡金属络合物催化的均相不对称氢化反应是合成手性化合物的重要方法之一，目前主要集中于钌、铑、铱和钯等贵重过渡金属催化体系，这些贵重过渡金属催化体系面临着地球储量有限、价格昂贵和重金属污染环境等问题，因而发展地球储量丰富、价格低廉、无毒或低毒且对环境友好的铁、钴、镍和铜的均相不对称氢化反应催化体系符合现代化学可持续发展的要求和趋势.简要综述了近些年来廉价金属镍催化的均相不对称氢化反应研究领域的新进展，基于前手性不饱和化合物双键的不同类型，即碳-氧双键（C=O）、碳-碳双键（C=C）以及碳-氮双键（C=N）等，依次介绍它们的研究现状，目前已经取得了突破和可观的研究成果，系统地分析了镍催化体系中催化氢化不同类型底物的优势与不足，并展望了未来的研究方向.","abstractInfoEn":"Transition metal complexes-catalyzed homogeneous asymmetric hydrogenation is an important method for the synthesis of chiral compounds. At present, it is mainly focused on precious transition metal catalytic systems, such as ruthenium, rhodium, iridium and palladium. However, they are suffered from the difficulties of limited resource, high cost and environmental contamination. Therefore, it is important and necessary to develop catalytic systems based on cheap, non-toxic or low toxic, environmentally friendly and earth-abundant iron, cobalt, nickel, copper transition metal, which are in accordance with the requirements and research trend of the sustainable development of modern chemistry. The recent progress of nickel-catalyzed homogeneous asymmetric hydrogenation of prochiral unsaturated compounds containing carbon oxygen double bond (C=O), carbon carbon double bond (C=C) and carbon nitrogen double bond (C=N) is reviewed, and some breakthroughs and considerable research results achieved are introduced. In addition, the advantages and disadvantages of different types of substrates in nickel catalyst system are analyzed, and the future research direction is prospected.","articleNo":"","authorCnList":["刘元华"," 董秀琴"," 张绪穆"],"authorEnList":["Liu Yuanhua"," Dong Xiu-Qin"," Zhang Xumu"],"authorList":["刘元华"," 董秀琴"," 张绪穆"],"authors":"刘元华, 董秀琴, 张绪穆","authorsCn":"刘元华, 董秀琴, 张绪穆","authorsEn":"Liu Yuanhua, Dong Xiu-Qin, Zhang Xumu","categoryName":"综述与进展","categoryNameCn":"综述与进展","categoryNameEn":"Reviews","citation":"刘元华, 董秀琴, 张绪穆. 镍催化均相不对称氢化反应研究进展. 有机化学, 2020, 40(5): 1096-1104. doi: 10.6023/cjoc201912025.","citationCn":"刘元华, 董秀琴, 张绪穆. 镍催化均相不对称氢化反应研究进展. 有机化学, 2020, 40(5): 1096-1104. doi: 10.6023/cjoc201912025.","citationEn":"刘元华, 董秀琴, 张绪穆. Recent Advances of Nickel-Catalyzed Homogeneous Asymmetric Hydrogenation. Chinese Journal of Organic Chemistry, 2020, 40(5): 1096-1104. doi: 10.6023/cjoc201912025.","doi":"10.6023/cjoc201912025","figContent":"yjhx-40-5-1096-S1.jpg$$yjhx-40-5-1096-S2.jpg$$yjhx-40-5-1096-S3.jpg$$yjhx-40-5-1096-S4.jpg$$yjhx-40-5-1096-S5.jpg$$yjhx-40-5-1096-S6.jpg$$yjhx-40-5-1096-S7.jpg$$yjhx-40-5-1096-S8.jpg$$yjhx-40-5-1096-S9.jpg$$yjhx-40-5-1096-S10.jpg$$yjhx-40-5-1096-S11.jpg$$yjhx-40-5-1096-S12.jpg$$yjhx-40-5-1096-S13.jpg$$yjhx-40-5-1096-S14.jpg$$yjhx-40-5-1096-S15.jpg$$yjhx-40-5-1096-S16.jpg$$yjhx-40-5-1096-S17.jpg$$yjhx-40-5-1096-S18.jpg$$yjhx-40-5-1096-S19.jpg$$yjhx-40-5-1096-S20.jpg$$yjhx-40-5-1096-S21.jpg","figList":["yjhx-40-5-1096-S1.jpg","yjhx-40-5-1096-S2.jpg","yjhx-40-5-1096-S3.jpg","yjhx-40-5-1096-S4.jpg","yjhx-40-5-1096-S5.jpg","yjhx-40-5-1096-S6.jpg","yjhx-40-5-1096-S7.jpg","yjhx-40-5-1096-S8.jpg","yjhx-40-5-1096-S9.jpg","yjhx-40-5-1096-S10.jpg","yjhx-40-5-1096-S11.jpg","yjhx-40-5-1096-S12.jpg","yjhx-40-5-1096-S13.jpg","yjhx-40-5-1096-S14.jpg","yjhx-40-5-1096-S15.jpg","yjhx-40-5-1096-S16.jpg","yjhx-40-5-1096-S17.jpg","yjhx-40-5-1096-S18.jpg","yjhx-40-5-1096-S19.jpg","yjhx-40-5-1096-S20.jpg","yjhx-40-5-1096-S21.jpg"],"firstFig":"yjhx-40-5-1096-S1.jpg","fpage":"1096","highCitedState":"","htmlCount":724,"htmlFile":"","id":"dc6e60e5-9301-4af2-99ca-a7a5bbb561d0","issnPpub":"0253-2786","issue":"5","journalPublishId":"yjhx","journalReferenceCodeType":0,"journalTitleCn":"有机化学","journalTitleEn":"Chinese Journal of Organic Chemistry","keyword":"不对称氢化, 镍催化, 手性双膦配体, 手性化合物, 立体选择性","keywordCn":"不对称氢化, 镍催化, 手性双膦配体, 手性化合物, 立体选择性","keywordCnList":["不对称氢化"," 镍催化"," 手性双膦配体"," 手性化合物"," 立体选择性"],"keywordEn":"asymmetric hydrogenation, nickel catalysis, chiral diphosphine ligand, chiral compounds, stereoselectivity","keywordEnList":["asymmetric hydrogenation"," nickel catalysis"," chiral diphosphine ligand"," chiral compounds"," stereoselectivity"],"keywordList":["不对称氢化"," 镍催化"," 手性双膦配体"," 手性化合物"," 立体选择性"],"language":"zh","latestInfo":"","latestState":"","latestStateEn":"","lpage":"1104","oldUrl":"http://sioc-journal.cn/Jwk_yjhx/CN/volumn/home.shtml","pdfDownCount":71,"pdfSize":624.03,"pubDate":"2020-05-01","recommendState":"","releaseState":"1","secCount":0,"title":"镍催化均相不对称氢化反应研究进展","titleCn":"镍催化均相不对称氢化反应研究进展","titleEn":"Recent Advances of Nickel-Catalyzed Homogeneous Asymmetric Hydrogenation","viewCount":2597,"volume":"40","year":2020},{"abstractInfo":"二氟甲基在活性分子中可以起到氢键供体、生物电子等排体、亲脂性调节等作用，在药物和农药分子的设计中被广泛使用.3，4-二取代-3-（二氟甲基）吡唑骨架的发现及应用是该领域的一个突出代表，研究表明含有这类骨架的分子能够抑制琥珀酸脱氢酶（SDHIs），具有作为杀菌剂的潜力，目前市场上已有近十种农药分子含有3，4-二取代-3-（二氟甲基）吡唑结构单元，年销售额高达十几亿美元.按照所用含氟砌块的不同种类，对近二十年来3，4-二取代-3-（二氟甲基）吡唑类化合物的合成方法进行总结和展望.","abstractInfoCn":"二氟甲基在活性分子中可以起到氢键供体、生物电子等排体、亲脂性调节等作用，在药物和农药分子的设计中被广泛使用.3，4-二取代-3-（二氟甲基）吡唑骨架的发现及应用是该领域的一个突出代表，研究表明含有这类骨架的分子能够抑制琥珀酸脱氢酶（SDHIs），具有作为杀菌剂的潜力，目前市场上已有近十种农药分子含有3，4-二取代-3-（二氟甲基）吡唑结构单元，年销售额高达十几亿美元.按照所用含氟砌块的不同种类，对近二十年来3，4-二取代-3-（二氟甲基）吡唑类化合物的合成方法进行总结和展望.","abstractInfoEn":"The CHF2<\/sub> moiety has been widely utilized in the design of pharmaceuticals and agrochemicals, because this group can act as hydrogen-bonding donor to improve the binding selectivity of biologically active compounds, as a bioisostere to substitute for methyl, methoxy, hydroxy, amino and thiol groups, and as a lipophilic regulator to improve the liposolubility of the active compounds. For example, 3-difluoromethylpyrazole scaffolds are present in many organic compounds that exhibit important biological activities. In this content, there are nearly ten kinds of pesticide molecules on the market that contain 3, 4-disubstituted-3-(difluoromethyl)pyrazole units, with annual sales of up to one billion dollars. In this review, the methods of construction of 3, 4-disubstituted 3-difluoromethylpyrazoles will been briefly summarized that have been reported so far. Four different strategies including using fluorinated reagents as substrates, difluoroacetic acid and its derivatives as fluorine building blocks, difluorodiazonium and others as fluorine building blocks will be introduced.","articleNo":"","authorCnList":["曾俊良"," 许志红"," 马军安"],"authorEnList":["Zeng Junliang"," Xu Zhihong"," Ma Junan"],"authorList":["曾俊良"," 许志红"," 马军安"],"authors":"曾俊良, 许志红, 马军安","authorsCn":"曾俊良, 许志红, 马军安","authorsEn":"Zeng Junliang, Xu Zhihong, Ma Junan","categoryName":"综述与进展","categoryNameCn":"综述与进展","categoryNameEn":"Reviews","citation":"曾俊良, 许志红, 马军安. 3, 4-二取代-3-(二氟甲基)吡唑类化合物的构建. 有机化学, 2020, 40(5): 1105-1116. doi: 10.6023/cjoc201912024.","citationCn":"曾俊良, 许志红, 马军安. 3, 4-二取代-3-(二氟甲基)吡唑类化合物的构建. 有机化学, 2020, 40(5): 1105-1116. doi: 10.6023/cjoc201912024.","citationEn":"曾俊良, 许志红, 马军安. Construction of 3, 4-Disubstituted-3-(difluoromethyl)pyrazoles. 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The photocatalytic and electrocatalytic thiocyanation reactions have been widely concerned in organic chemistry due to the advantages of green, efficiency and safety. In this review, the cross-coupling/thiocyanation reactions based on the photocatalytic and electrocatalytic are described, which is expected to be helpful in exploring the green synthesis of thiocyanates compounds.","articleNo":"","authorCnList":["张龙菲"," 牛聪"," 杨晓婷"," 秦宏云"," 杨建静"," 文江伟"," 王桦"],"authorEnList":["Zhang Longfei"," Niu Cong"," Yang Xiaoting"," Qin Hongyun"," Yang Jianjing"," Wen Jiangwei"," Wang Hua"],"authorList":["张龙菲"," 牛聪"," 杨晓婷"," 秦宏云"," 杨建静"," 文江伟"," 王桦"],"authors":"张龙菲, 牛聪, 杨晓婷, 秦宏云, 杨建静, 文江伟, 王桦","authorsCn":"张龙菲, 牛聪, 杨晓婷, 秦宏云, 杨建静, 文江伟, 王桦","authorsEn":"Zhang Longfei, Niu Cong, Yang Xiaoting, Qin Hongyun, Yang Jianjing, Wen Jiangwei, Wang Hua","categoryName":"综述与进展","categoryNameCn":"综述与进展","categoryNameEn":"Reviews","citation":"张龙菲, 牛聪, 杨晓婷, 秦宏云, 杨建静, 文江伟, 王桦. 光、电催化硫氰基化反应研究进展. 有机化学, 2020, 40(5): 1117-1128. doi: 10.6023/cjoc201912011.","citationCn":"张龙菲, 牛聪, 杨晓婷, 秦宏云, 杨建静, 文江伟, 王桦. 光、电催化硫氰基化反应研究进展. 有机化学, 2020, 40(5): 1117-1128. doi: 10.6023/cjoc201912011.","citationEn":"张龙菲, 牛聪, 杨晓婷, 秦宏云, 杨建静, 文江伟, 王桦. Recent Advances on the Photocatalytic and Electrocatalytic Thiocyanation Reactions. Chinese Journal of Organic Chemistry, 2020, 40(5): 1117-1128. doi: 10.6023/cjoc201912011.","doi":"10.6023/cjoc201912011","figContent":"yjhx-40-5-1117-S1.jpg$$yjhx-40-5-1117-S2.jpg$$yjhx-40-5-1117-S3.jpg$$yjhx-40-5-1117-S4.jpg$$yjhx-40-5-1117-S5.jpg$$yjhx-40-5-1117-S6.jpg$$yjhx-40-5-1117-S7.jpg$$yjhx-40-5-1117-S8.jpg$$yjhx-40-5-1117-S9.jpg$$yjhx-40-5-1117-S10.jpg$$yjhx-40-5-1117-S11.jpg$$yjhx-40-5-1117-S12.jpg$$yjhx-40-5-1117-S13.jpg$$yjhx-40-5-1117-S14.jpg$$yjhx-40-5-1117-S15.jpg$$yjhx-40-5-1117-S16.jpg$$yjhx-40-5-1117-S17.jpg$$yjhx-40-5-1117-S18.jpg$$yjhx-40-5-1117-S19.jpg$$yjhx-40-5-1117-S20.jpg$$yjhx-40-5-1117-S21.jpg$$yjhx-40-5-1117-S22.jpg$$yjhx-40-5-1117-S23.jpg$$yjhx-40-5-1117-S24.jpg$$yjhx-40-5-1117-S25.jpg$$yjhx-40-5-1117-S26.jpg$$yjhx-40-5-1117-S27.jpg$$yjhx-40-5-1117-S28.jpg$$yjhx-40-5-1117-S29.jpg$$yjhx-40-5-1117-S30.jpg$$yjhx-40-5-1117-S31.jpg$$yjhx-40-5-1117-S32.jpg$$yjhx-40-5-1117-S33.jpg$$yjhx-40-5-1117-S34.jpg","figList":["yjhx-40-5-1117-S1.jpg","yjhx-40-5-1117-S2.jpg","yjhx-40-5-1117-S3.jpg","yjhx-40-5-1117-S4.jpg","yjhx-40-5-1117-S5.jpg","yjhx-40-5-1117-S6.jpg","yjhx-40-5-1117-S7.jpg","yjhx-40-5-1117-S8.jpg","yjhx-40-5-1117-S9.jpg","yjhx-40-5-1117-S10.jpg","yjhx-40-5-1117-S11.jpg","yjhx-40-5-1117-S12.jpg","yjhx-40-5-1117-S13.jpg","yjhx-40-5-1117-S14.jpg","yjhx-40-5-1117-S15.jpg","yjhx-40-5-1117-S16.jpg","yjhx-40-5-1117-S17.jpg","yjhx-40-5-1117-S18.jpg","yjhx-40-5-1117-S19.jpg","yjhx-40-5-1117-S20.jpg","yjhx-40-5-1117-S21.jpg","yjhx-40-5-1117-S22.jpg","yjhx-40-5-1117-S23.jpg","yjhx-40-5-1117-S24.jpg","yjhx-40-5-1117-S25.jpg","yjhx-40-5-1117-S26.jpg","yjhx-40-5-1117-S27.jpg","yjhx-40-5-1117-S28.jpg","yjhx-40-5-1117-S29.jpg","yjhx-40-5-1117-S30.jpg","yjhx-40-5-1117-S31.jpg","yjhx-40-5-1117-S32.jpg","yjhx-40-5-1117-S33.jpg","yjhx-40-5-1117-S34.jpg"],"firstFig":"yjhx-40-5-1117-S1.jpg","fpage":"1117","highCitedState":"","htmlCount":823,"htmlFile":"","id":"892b40b2-fcef-4504-9086-59232f20214f","issnPpub":"0253-2786","issue":"5","journalPublishId":"yjhx","journalReferenceCodeType":0,"journalTitleCn":"有机化学","journalTitleEn":"Chinese Journal of Organic Chemistry","keyword":"硫氰化, 光催化, 电催化","keywordCn":"硫氰化, 光催化, 电催化","keywordCnList":["硫氰化"," 光催化"," 电催化"],"keywordEn":"thiocyanation, photocatalytic, electrocatalytic","keywordEnList":["thiocyanation"," photocatalytic"," electrocatalytic"],"keywordList":["硫氰化"," 光催化"," 电催化"],"language":"zh","latestInfo":"","latestState":"","latestStateEn":"","lpage":"1128","oldUrl":"http://sioc-journal.cn/Jwk_yjhx/CN/volumn/home.shtml","pdfDownCount":51,"pdfSize":819.32,"pubDate":"2020-05-01","recommendState":"","releaseState":"1","secCount":0,"title":"光、电催化硫氰基化反应研究进展","titleCn":"光、电催化硫氰基化反应研究进展","titleEn":"Recent Advances on the Photocatalytic and Electrocatalytic Thiocyanation Reactions","viewCount":2945,"volume":"40","year":2020},{"abstractInfo":"具有光学活性的1，3-氨基醇既是有机化学中重要的合成砌块，也是众多生物活性分子的核心结构，因此不对称合成1，3-氨基醇一直是合成领域的一个热点.从aldol缩合或azo<\/i>-aldol缩合合成，过渡金属催化C—H键活化、氨化合成，氮杂环的开环-加成合成，[3+2]偶极环加成反应等方面综述了近年来所发展的1，3-氨基醇的合成方法及进展.","abstractInfoCn":"具有光学活性的1，3-氨基醇既是有机化学中重要的合成砌块，也是众多生物活性分子的核心结构，因此不对称合成1，3-氨基醇一直是合成领域的一个热点.从aldol缩合或azo<\/i>-aldol缩合合成，过渡金属催化C—H键活化、氨化合成，氮杂环的开环-加成合成，[3+2]偶极环加成反应等方面综述了近年来所发展的1，3-氨基醇的合成方法及进展.","abstractInfoEn":"Optically pure 1, 3-amino alcohol is not only the important synthon in organic synthesis, but also the core structure of numerous bioactive molecule. As a result, the formation of 1, 3-amino alcohols occupies a hot resarch topic in asymmetric synthesis. This review symmarizes several types of frequently-used methods and progress on synthesizing 1, 3-amino alcohols:aldol or azo-<\/i>aldol condensation synthesis, transition metal catalyzed C-H activation and amination synthesis, ring-opening and addition of azocyclic compounds, and[3+2] dipolar-cycloaddition reaction etc<\/i>.","articleNo":"","authorCnList":["王伟"," 胡燚"," 林睿褀"," 吴恒"," 童启"," 汪连生"," 肖祖峰"," 朱磊"],"authorEnList":["Wang Wei"," Hu Yi"," Lin Ruiqi"," Wu Heng"," Tong Qi"," Wang Liansheng"," Xiao Zufeng"," Zhu Lei"],"authorList":["王伟"," 胡燚"," 林睿褀"," 吴恒"," 童启"," 汪连生"," 肖祖峰"," 朱磊"],"authors":"王伟, 胡燚, 林睿褀, 吴恒, 童启, 汪连生, 肖祖峰, 朱磊","authorsCn":"王伟, 胡燚, 林睿褀, 吴恒, 童启, 汪连生, 肖祖峰, 朱磊","authorsEn":"Wang Wei, Hu Yi, Lin Ruiqi, Wu Heng, Tong Qi, Wang Liansheng, Xiao Zufeng, Zhu Lei","categoryName":"综述与进展","categoryNameCn":"综述与进展","categoryNameEn":"Reviews","citation":"王伟, 胡燚, 林睿褀, 吴恒, 童启, 汪连生, 肖祖峰, 朱磊. 1, 3-氨基醇的合成研究进展. 有机化学, 2020, 40(5): 1129-1149. doi: 10.6023/cjoc201911011.","citationCn":"王伟, 胡燚, 林睿褀, 吴恒, 童启, 汪连生, 肖祖峰, 朱磊. 1, 3-氨基醇的合成研究进展. 有机化学, 2020, 40(5): 1129-1149. doi: 10.6023/cjoc201911011.","citationEn":"王伟, 胡燚, 林睿褀, 吴恒, 童启, 汪连生, 肖祖峰, 朱磊. Progress on the Synthesis of 1, 3-Amino Alcohol. Chinese Journal of Organic Chemistry, 2020, 40(5): 1129-1149. doi: 10.6023/cjoc201911011.","doi":"10.6023/cjoc201911011","figContent":"yjhx-40-5-1129-S1.jpg$$yjhx-40-5-1129-S2.jpg$$yjhx-40-5-1129-S3.jpg$$yjhx-40-5-1129-S4.jpg$$yjhx-40-5-1129-S5.jpg$$yjhx-40-5-1129-S6.jpg$$yjhx-40-5-1129-S7.jpg$$yjhx-40-5-1129-S8.jpg$$yjhx-40-5-1129-S9.jpg$$yjhx-40-5-1129-S10.jpg$$yjhx-40-5-1129-S11.jpg$$yjhx-40-5-1129-S12.jpg$$yjhx-40-5-1129-S13.jpg$$yjhx-40-5-1129-S14.jpg$$yjhx-40-5-1129-S15.jpg$$yjhx-40-5-1129-S16.jpg$$yjhx-40-5-1129-S17.jpg$$yjhx-40-5-1129-S18.jpg$$yjhx-40-5-1129-S19.jpg$$yjhx-40-5-1129-S20.jpg$$yjhx-40-5-1129-S21.jpg$$yjhx-40-5-1129-S22.jpg$$yjhx-40-5-1129-S23.jpg$$yjhx-40-5-1129-S24.jpg","figList":["yjhx-40-5-1129-S1.jpg","yjhx-40-5-1129-S2.jpg","yjhx-40-5-1129-S3.jpg","yjhx-40-5-1129-S4.jpg","yjhx-40-5-1129-S5.jpg","yjhx-40-5-1129-S6.jpg","yjhx-40-5-1129-S7.jpg","yjhx-40-5-1129-S8.jpg","yjhx-40-5-1129-S9.jpg","yjhx-40-5-1129-S10.jpg","yjhx-40-5-1129-S11.jpg","yjhx-40-5-1129-S12.jpg","yjhx-40-5-1129-S13.jpg","yjhx-40-5-1129-S14.jpg","yjhx-40-5-1129-S15.jpg","yjhx-40-5-1129-S16.jpg","yjhx-40-5-1129-S17.jpg","yjhx-40-5-1129-S18.jpg","yjhx-40-5-1129-S19.jpg","yjhx-40-5-1129-S20.jpg","yjhx-40-5-1129-S21.jpg","yjhx-40-5-1129-S22.jpg","yjhx-40-5-1129-S23.jpg","yjhx-40-5-1129-S24.jpg"],"firstFig":"yjhx-40-5-1129-S1.jpg","fpage":"1129","highCitedState":"","htmlCount":627,"htmlFile":"","id":"0f1fc75b-10b2-4067-8d63-5ab2e711a2f1","issnPpub":"0253-2786","issue":"5","journalPublishId":"yjhx","journalReferenceCodeType":0,"journalTitleCn":"有机化学","journalTitleEn":"Chinese Journal of Organic Chemistry","keyword":"1, 3-氨基醇, 不对称合成, 催化剂","keywordCn":"1, 3-氨基醇, 不对称合成, 催化剂","keywordCnList":["1"," 3-氨基醇"," 不对称合成"," 催化剂"],"keywordEn":"1, 3-amino alcohol, asymmetric synthesis, catalyst","keywordEnList":["1"," 3-amino alcohol"," asymmetric synthesis"," catalyst"],"keywordList":["1"," 3-氨基醇"," 不对称合成"," 催化剂"],"language":"zh","latestInfo":"","latestState":"","latestStateEn":"","lpage":"1149","oldUrl":"http://sioc-journal.cn/Jwk_yjhx/CN/volumn/home.shtml","pdfDownCount":33,"pdfSize":1060.68,"pubDate":"2020-05-01","recommendState":"","releaseState":"1","secCount":0,"title":"1, 3-氨基醇的合成研究进展","titleCn":"1, 3-氨基醇的合成研究进展","titleEn":"Progress on the Synthesis of 1, 3-Amino Alcohol","viewCount":2500,"volume":"40","year":2020},{"abstractInfo":"由于具有较强的环张力，环丙烷能够与多种不饱和化合物发生[3+2]扩环反应构建五元碳环或五元杂环骨架结构.这些五元环化合物是许多药物、天然产物和生物活性分子的核心结构，同时也是一类重要的有机反应中间体，在医药、农业、化工、有机合成等领域具有十分广泛的用途.近年来，许多化学研究者以环丙烷作为三碳合成子，构建了结构复杂的五元碳环和五元杂环结构，促进了环丙烷领域的快速发展.对近十年来烯烃、醛酮、腈等含有不饱和键的化合物与环丙烷发生的[3+2]扩环反应进行了综述，并对该领域的发展方向进行了展望.","abstractInfoCn":"由于具有较强的环张力，环丙烷能够与多种不饱和化合物发生[3+2]扩环反应构建五元碳环或五元杂环骨架结构.这些五元环化合物是许多药物、天然产物和生物活性分子的核心结构，同时也是一类重要的有机反应中间体，在医药、农业、化工、有机合成等领域具有十分广泛的用途.近年来，许多化学研究者以环丙烷作为三碳合成子，构建了结构复杂的五元碳环和五元杂环结构，促进了环丙烷领域的快速发展.对近十年来烯烃、醛酮、腈等含有不饱和键的化合物与环丙烷发生的[3+2]扩环反应进行了综述，并对该领域的发展方向进行了展望.","abstractInfoEn":"Due to its high ring strain, cyclopropanes can react with a variety of unsaturated compounds to construct five- membered carbo- and hetero-cycles through[3+2] ring-expansion reaction. These five-membered compounds are key skeletons of many drugs, natural products and bioactive molecules, and are also an important class of organic intermediates which have wide applications in medicine, agriculture, chemical engineering, organic synthesis and other related areas. Recently, more and more chemists have constructed a lot of complex five-membered carbo- and hetero-cycles by using cyclopropane as a three-carbon synthon, which has promoted the rapid development of focus area. This review summarizes the most recent [3+2] ring-expansion reaction of cyclopropanes with compounds containing unsaturated bonds such as olefins, aldehydes, ketones and nitriles in the past decade. Moreover, the prospects of future development are also discussed.","articleNo":"","authorCnList":["刘文竹"," 豆立娟"," 母伟花"],"authorEnList":["Liu Wenzhu"," Dou Lijuan"," Mu Weihua"],"authorList":["刘文竹"," 豆立娟"," 母伟花"],"authors":"刘文竹, 豆立娟, 母伟花","authorsCn":"刘文竹, 豆立娟, 母伟花","authorsEn":"Liu Wenzhu, Dou Lijuan, Mu Weihua","categoryName":"综述与进展","categoryNameCn":"综述与进展","categoryNameEn":"Reviews","citation":"刘文竹, 豆立娟, 母伟花. 环丙烷与不饱和化合物发生[3+2]扩环反应的研究进展. 有机化学, 2020, 40(5): 1150-1176. doi: 10.6023/cjoc201910019.","citationCn":"刘文竹, 豆立娟, 母伟花. 环丙烷与不饱和化合物发生[3+2]扩环反应的研究进展. 有机化学, 2020, 40(5): 1150-1176. doi: 10.6023/cjoc201910019.","citationEn":"刘文竹, 豆立娟, 母伟花. Recent Progress on[3+<\/b>2] Ring-Expansion Reaction of Cyclopropane with Unsaturated Compounds. Chinese Journal of Organic Chemistry, 2020, 40(5): 1150-1176. doi: 10.6023/cjoc201910019.","doi":"10.6023/cjoc201910019","figContent":"yjhx-40-5-1150-S1.jpg$$yjhx-40-5-1150-S2.jpg$$yjhx-40-5-1150-S3.jpg$$yjhx-40-5-1150-S4.jpg$$yjhx-40-5-1150-S5.jpg$$yjhx-40-5-1150-S6.jpg$$yjhx-40-5-1150-S7.jpg$$yjhx-40-5-1150-S8.jpg$$yjhx-40-5-1150-S9.jpg$$yjhx-40-5-1150-S10.jpg$$yjhx-40-5-1150-S11.jpg$$yjhx-40-5-1150-S12.jpg$$yjhx-40-5-1150-S13.jpg$$yjhx-40-5-1150-S14.jpg$$yjhx-40-5-1150-S15.jpg$$yjhx-40-5-1150-S16.jpg$$yjhx-40-5-1150-S17.jpg$$yjhx-40-5-1150-S18.jpg$$yjhx-40-5-1150-S19.jpg$$yjhx-40-5-1150-S20.jpg$$yjhx-40-5-1150-S21.jpg$$yjhx-40-5-1150-S22.jpg$$yjhx-40-5-1150-S23.jpg$$yjhx-40-5-1150-S24.jpg$$yjhx-40-5-1150-S25.jpg$$yjhx-40-5-1150-S26.jpg$$yjhx-40-5-1150-S27.jpg$$yjhx-40-5-1150-S28.jpg$$yjhx-40-5-1150-S29.jpg$$yjhx-40-5-1150-S30.jpg$$yjhx-40-5-1150-S31.jpg$$yjhx-40-5-1150-S32.jpg$$yjhx-40-5-1150-S33.jpg$$yjhx-40-5-1150-S34.jpg$$yjhx-40-5-1150-S35.jpg$$yjhx-40-5-1150-S36.jpg$$yjhx-40-5-1150-S37.jpg$$yjhx-40-5-1150-S38.jpg$$yjhx-40-5-1150-S39.jpg$$yjhx-40-5-1150-S40.jpg$$yjhx-40-5-1150-S41.jpg$$yjhx-40-5-1150-S42.jpg$$yjhx-40-5-1150-S43.jpg$$y","figList":["yjhx-40-5-1150-S1.jpg","yjhx-40-5-1150-S2.jpg","yjhx-40-5-1150-S3.jpg","yjhx-40-5-1150-S4.jpg","yjhx-40-5-1150-S5.jpg","yjhx-40-5-1150-S6.jpg","yjhx-40-5-1150-S7.jpg","yjhx-40-5-1150-S8.jpg","yjhx-40-5-1150-S9.jpg","yjhx-40-5-1150-S10.jpg","yjhx-40-5-1150-S11.jpg","yjhx-40-5-1150-S12.jpg","yjhx-40-5-1150-S13.jpg","yjhx-40-5-1150-S14.jpg","yjhx-40-5-1150-S15.jpg","yjhx-40-5-1150-S16.jpg","yjhx-40-5-1150-S17.jpg","yjhx-40-5-1150-S18.jpg","yjhx-40-5-1150-S19.jpg","yjhx-40-5-1150-S20.jpg","yjhx-40-5-1150-S21.jpg","yjhx-40-5-1150-S22.jpg","yjhx-40-5-1150-S23.jpg","yjhx-40-5-1150-S24.jpg","yjhx-40-5-1150-S25.jpg","yjhx-40-5-1150-S26.jpg","yjhx-40-5-1150-S27.jpg","yjhx-40-5-1150-S28.jpg","yjhx-40-5-1150-S29.jpg","yjhx-40-5-1150-S30.jpg","yjhx-40-5-1150-S31.jpg","yjhx-40-5-1150-S32.jpg","yjhx-40-5-1150-S33.jpg","yjhx-40-5-1150-S34.jpg","yjhx-40-5-1150-S35.jpg","yjhx-40-5-1150-S36.jpg","yjhx-40-5-1150-S37.jpg","yjhx-40-5-1150-S38.jpg","yjhx-40-5-1150-S39.jpg","yjhx-40-5-1150-S40.jpg","yjhx-40-5-1150-S41.jpg","yjhx-40-5-1150-S42.jpg","yjhx-40-5-1150-S43.jpg","y"],"firstFig":"yjhx-40-5-1150-S1.jpg","fpage":"1150","highCitedState":"","htmlCount":782,"htmlFile":"","id":"39c3d57b-f7cc-4f91-b454-d9bc8cf44d39","issnPpub":"0253-2786","issue":"5","journalPublishId":"yjhx","journalReferenceCodeType":0,"journalTitleCn":"有机化学","journalTitleEn":"Chinese Journal of Organic Chemistry","keyword":"环丙烷, 不饱和键, [3+2]扩环反应, 五元环","keywordCn":"环丙烷, 不饱和键, [3+2]扩环反应, 五元环","keywordCnList":["环丙烷"," 不饱和键"," [3+2]扩环反应"," 五元环"],"keywordEn":"cyclopropane, unsaturated bond, [3+2]ring-expansion reaction, five-membered ring","keywordEnList":["cyclopropane"," unsaturated bond"," [3+2]ring-expansion reaction"," five-membered ring"],"keywordList":["环丙烷"," 不饱和键"," [3+2]扩环反应"," 五元环"],"language":"zh","latestInfo":"","latestState":"","latestStateEn":"","lpage":"1176","oldUrl":"http://sioc-journal.cn/Jwk_yjhx/CN/volumn/home.shtml","pdfDownCount":48,"pdfSize":1287.86,"pubDate":"2020-05-01","recommendState":"","releaseState":"1","secCount":0,"title":"环丙烷与不饱和化合物发生[3+2]扩环反应的研究进展","titleCn":"环丙烷与不饱和化合物发生[3+2]扩环反应的研究进展","titleEn":"Recent Progress on[3+<\/b>2] Ring-Expansion Reaction of Cyclopropane with Unsaturated Compounds","viewCount":3448,"volume":"40","year":2020},{"abstractInfo":"钴元素含量丰富，相较于贵金属而言具有价格低和毒性低的优点，已被应用于众多催化反应中，表现出良好的催化性能，是近年来有机金属催化领域重要的研究热点之一.总结了钴催化剂应用于烯烃、炔烃和羰基化合物等不饱和化合物硅氢加成反应的研究进展，分析了钴配合物在催化反应过程中存在的不足和原因，并对其作为催化剂的应用前景进行了展望.","abstractInfoCn":"钴元素含量丰富，相较于贵金属而言具有价格低和毒性低的优点，已被应用于众多催化反应中，表现出良好的催化性能，是近年来有机金属催化领域重要的研究热点之一.总结了钴催化剂应用于烯烃、炔烃和羰基化合物等不饱和化合物硅氢加成反应的研究进展，分析了钴配合物在催化反应过程中存在的不足和原因，并对其作为催化剂的应用前景进行了展望.","abstractInfoEn":"Cobalt is abound in the earth and has advantages of low cost and low toxicity. Cobalt complexes have been widely applied as catalysts in numerous catalytic organic reactions, in which the complexes show excellent catalytic performance and have been recognized as a very important research field. The recent progress in the application of cobalt complexes in the catalytic hydrosilylation of alkenes, alkynes, carbonyl compounds and other unsaturated double bond is summarized. Furthermore, the deficiencies of the catalysts have been discussed. At last, the future development and prospects of these complexes as catalysts are also proposed.","articleNo":"","authorCnList":["代自男"," 余泽浩"," 白赢"," 厉嘉云"," 彭家建"],"authorEnList":["Dai Zinan"," Yu Zehao"," Bai Ying"," Li Jiayun"," Peng Jiajian"],"authorList":["代自男"," 余泽浩"," 白赢"," 厉嘉云"," 彭家建"],"authors":"代自男, 余泽浩, 白赢, 厉嘉云, 彭家建","authorsCn":"代自男, 余泽浩, 白赢, 厉嘉云, 彭家建","authorsEn":"Dai Zinan, Yu Zehao, Bai Ying, Li Jiayun, Peng Jiajian","categoryName":"综述与进展","categoryNameCn":"综述与进展","categoryNameEn":"Reviews","citation":"代自男, 余泽浩, 白赢, 厉嘉云, 彭家建. 钴配合物催化硅氢加成反应研究进展. 有机化学, 2020, 40(5): 1177-1187. doi: 10.6023/cjoc201910012.","citationCn":"代自男, 余泽浩, 白赢, 厉嘉云, 彭家建. 钴配合物催化硅氢加成反应研究进展. 有机化学, 2020, 40(5): 1177-1187. doi: 10.6023/cjoc201910012.","citationEn":"代自男, 余泽浩, 白赢, 厉嘉云, 彭家建. Progress in Catalysis of Hydrosilylation by Cobalt Complexes. Chinese Journal of Organic Chemistry, 2020, 40(5): 1177-1187. doi: 10.6023/cjoc201910012.","doi":"10.6023/cjoc201910012","figContent":"yjhx-40-5-1177-S1.jpg$$yjhx-40-5-1177-S2.jpg$$yjhx-40-5-1177-S3.jpg$$yjhx-40-5-1177-S4.jpg","figList":["yjhx-40-5-1177-S1.jpg","yjhx-40-5-1177-S2.jpg","yjhx-40-5-1177-S3.jpg","yjhx-40-5-1177-S4.jpg"],"firstFig":"yjhx-40-5-1177-S1.jpg","fpage":"1177","highCitedState":"","htmlCount":533,"htmlFile":"","id":"620d9c74-8cd8-489d-9561-aace605ae934","issnPpub":"0253-2786","issue":"5","journalPublishId":"yjhx","journalReferenceCodeType":0,"journalTitleCn":"有机化学","journalTitleEn":"Chinese Journal of Organic Chemistry","keyword":"钴配合物, 催化, 硅氢加成","keywordCn":"钴配合物, 催化, 硅氢加成","keywordCnList":["钴配合物"," 催化"," 硅氢加成"],"keywordEn":"cobalt complex, catalysis, hydrosilylation","keywordEnList":["cobalt complex"," catalysis"," hydrosilylation"],"keywordList":["钴配合物"," 催化"," 硅氢加成"],"language":"zh","latestInfo":"","latestState":"","latestStateEn":"","lpage":"1187","oldUrl":"http://sioc-journal.cn/Jwk_yjhx/CN/volumn/home.shtml","pdfDownCount":22,"pdfSize":733.77,"pubDate":"2020-05-01","recommendState":"","releaseState":"1","secCount":0,"title":"钴配合物催化硅氢加成反应研究进展","titleCn":"钴配合物催化硅氢加成反应研究进展","titleEn":"Progress in Catalysis of Hydrosilylation by Cobalt Complexes","viewCount":2549,"volume":"40","year":2020},{"abstractInfo":"N<\/i>-芳基磺酰胺骨架广泛存在于具有生物活性的分子中，在医药领域有十分重要的应用.因此研究N<\/i>-芳基磺酰胺类化合物的合成方法受到了人们的广泛关注.近年来过渡金属催化的卤代芳烃、芳基硼酸和CAr<\/sub>—H键的磺酰胺化反应得到了快速发展，为N<\/i>-芳基磺酰胺类化合物的合成提供了高效、绿色的方法.按照芳基源、过渡金属催化剂、配体和磺酰胺化试剂进行分类，综述了过渡金属催化的芳环磺酰胺化反应的最新研究进展，并对此类反应的研究方向进行了展望.","abstractInfoCn":"N<\/i>-芳基磺酰胺骨架广泛存在于具有生物活性的分子中，在医药领域有十分重要的应用.因此研究N<\/i>-芳基磺酰胺类化合物的合成方法受到了人们的广泛关注.近年来过渡金属催化的卤代芳烃、芳基硼酸和CAr<\/sub>—H键的磺酰胺化反应得到了快速发展，为N<\/i>-芳基磺酰胺类化合物的合成提供了高效、绿色的方法.按照芳基源、过渡金属催化剂、配体和磺酰胺化试剂进行分类，综述了过渡金属催化的芳环磺酰胺化反应的最新研究进展，并对此类反应的研究方向进行了展望.","abstractInfoEn":"The N<\/i>-arylsulfonamide group is an important moiety in medicinal chemistry because of its presence in many useful molecules with potential bioactivities. As a result, the development of synthetic routes to N<\/i>-arylsulfonamides has been actively investigated. In recent years, the transition metal-catalyzed sulfonamidations of aryl halides, arylboronic acids and CAr<\/sub>-H bonds have extensively investigated, providing more efficient and environmentally friendly procedures for the synthesis of N<\/i>-arylsulfonamides. The recent progress in the transition metal-catalyzed sulfonamidation reactions is reviewed. The aromatic substrates, transition metal-catalysts, ligands, sulfonamidating reagents, mechanisms of the sulfonamidation reactions are mainly discussed. Finally, the future development of them is also prospected.","articleNo":"","authorCnList":["欧阳班来"," 郑燕霞"," 夏克坚"," 徐小玲"," 王艺"],"authorEnList":["Ouyang Banlai"," Zheng Yanxia"," Xia Kejian"," Xu Xiaoling"," Wang Yi"],"authorList":["欧阳班来"," 郑燕霞"," 夏克坚"," 徐小玲"," 王艺"],"authors":"欧阳班来, 郑燕霞, 夏克坚, 徐小玲, 王艺","authorsCn":"欧阳班来, 郑燕霞, 夏克坚, 徐小玲, 王艺","authorsEn":"Ouyang Banlai, Zheng Yanxia, Xia Kejian, Xu Xiaoling, Wang Yi","categoryName":"综述与进展","categoryNameCn":"综述与进展","categoryNameEn":"Reviews","citation":"欧阳班来, 郑燕霞, 夏克坚, 徐小玲, 王艺. 过渡金属催化的芳环磺酰胺化反应研究进展. 有机化学, 2020, 40(5): 1188-1205. doi: 10.6023/cjoc201910002.","citationCn":"欧阳班来, 郑燕霞, 夏克坚, 徐小玲, 王艺. 过渡金属催化的芳环磺酰胺化反应研究进展. 有机化学, 2020, 40(5): 1188-1205. doi: 10.6023/cjoc201910002.","citationEn":"欧阳班来, 郑燕霞, 夏克坚, 徐小玲, 王艺. Recent Progress in Transition Metal Catalyzed Sulfonamidation of Aromatic Compounds. Chinese Journal of Organic Chemistry, 2020, 40(5): 1188-1205. doi: 10.6023/cjoc201910002.","doi":"10.6023/cjoc201910002","figContent":"yjhx-40-5-1188-S1.jpg$$yjhx-40-5-1188-S2.jpg$$yjhx-40-5-1188-S3.jpg$$yjhx-40-5-1188-S4.jpg$$yjhx-40-5-1188-S5.jpg$$yjhx-40-5-1188-S6.jpg$$yjhx-40-5-1188-S7.jpg$$yjhx-40-5-1188-S8.jpg$$yjhx-40-5-1188-S9.jpg$$yjhx-40-5-1188-S10.jpg$$yjhx-40-5-1188-S11.jpg$$yjhx-40-5-1188-S12.jpg$$yjhx-40-5-1188-S13.jpg$$yjhx-40-5-1188-S14.jpg$$yjhx-40-5-1188-S15.jpg$$yjhx-40-5-1188-S16.jpg$$yjhx-40-5-1188-S17.jpg$$yjhx-40-5-1188-S18.jpg$$yjhx-40-5-1188-S19.jpg$$yjhx-40-5-1188-S20.jpg$$yjhx-40-5-1188-S21.jpg$$yjhx-40-5-1188-S22.jpg$$yjhx-40-5-1188-S23.jpg$$yjhx-40-5-1188-S24.jpg$$yjhx-40-5-1188-S25.jpg$$yjhx-40-5-1188-S26.jpg$$yjhx-40-5-1188-S27.jpg$$yjhx-40-5-1188-S28.jpg$$yjhx-40-5-1188-S29.jpg$$yjhx-40-5-1188-S30.jpg$$yjhx-40-5-1188-S31.jpg$$yjhx-40-5-1188-S32.jpg$$yjhx-40-5-1188-S33.jpg$$yjhx-40-5-1188-S34.jpg$$yjhx-40-5-1188-S35.jpg$$yjhx-40-5-1188-S36.jpg$$yjhx-40-5-1188-S37.jpg$$yjhx-40-5-1188-S38.jpg$$yjhx-40-5-1188-S39.jpg$$yjhx-40-5-1188-S40.jpg$$yjhx-40-5-1188-S41.jpg$$yjhx-40-5-1188-S42.jpg$$yjhx-40-5-1188-S43.jpg$$y","figList":["yjhx-40-5-1188-S1.jpg","yjhx-40-5-1188-S2.jpg","yjhx-40-5-1188-S3.jpg","yjhx-40-5-1188-S4.jpg","yjhx-40-5-1188-S5.jpg","yjhx-40-5-1188-S6.jpg","yjhx-40-5-1188-S7.jpg","yjhx-40-5-1188-S8.jpg","yjhx-40-5-1188-S9.jpg","yjhx-40-5-1188-S10.jpg","yjhx-40-5-1188-S11.jpg","yjhx-40-5-1188-S12.jpg","yjhx-40-5-1188-S13.jpg","yjhx-40-5-1188-S14.jpg","yjhx-40-5-1188-S15.jpg","yjhx-40-5-1188-S16.jpg","yjhx-40-5-1188-S17.jpg","yjhx-40-5-1188-S18.jpg","yjhx-40-5-1188-S19.jpg","yjhx-40-5-1188-S20.jpg","yjhx-40-5-1188-S21.jpg","yjhx-40-5-1188-S22.jpg","yjhx-40-5-1188-S23.jpg","yjhx-40-5-1188-S24.jpg","yjhx-40-5-1188-S25.jpg","yjhx-40-5-1188-S26.jpg","yjhx-40-5-1188-S27.jpg","yjhx-40-5-1188-S28.jpg","yjhx-40-5-1188-S29.jpg","yjhx-40-5-1188-S30.jpg","yjhx-40-5-1188-S31.jpg","yjhx-40-5-1188-S32.jpg","yjhx-40-5-1188-S33.jpg","yjhx-40-5-1188-S34.jpg","yjhx-40-5-1188-S35.jpg","yjhx-40-5-1188-S36.jpg","yjhx-40-5-1188-S37.jpg","yjhx-40-5-1188-S38.jpg","yjhx-40-5-1188-S39.jpg","yjhx-40-5-1188-S40.jpg","yjhx-40-5-1188-S41.jpg","yjhx-40-5-1188-S42.jpg","yjhx-40-5-1188-S43.jpg","y"],"firstFig":"yjhx-40-5-1188-S1.jpg","fpage":"1188","highCitedState":"","htmlCount":361,"htmlFile":"","id":"3fd073cb-88ca-4be5-9eb9-3865c2fb7daa","issnPpub":"0253-2786","issue":"5","journalPublishId":"yjhx","journalReferenceCodeType":0,"journalTitleCn":"有机化学","journalTitleEn":"Chinese Journal of Organic Chemistry","keyword":"N<\/i>-芳基磺酰胺, 磺酰胺化, 过渡金属催化, C—N键构建, C—H键活化","keywordCn":"N<\/i>-芳基磺酰胺, 磺酰胺化, 过渡金属催化, C—N键构建, C—H键活化","keywordCnList":["N<\/i>-芳基磺酰胺"," 磺酰胺化"," 过渡金属催化"," C—N键构建"," C—H键活化"],"keywordEn":"N<\/i>-arylsulfonamides, sulfonamidation, transition metal-catalyzed, C-N bond construction, C-H bond activation","keywordEnList":["N<\/i>-arylsulfonamides"," sulfonamidation"," transition metal-catalyzed"," C-N bond construction"," C-H bond activation"],"keywordList":["N<\/i>-芳基磺酰胺"," 磺酰胺化"," 过渡金属催化"," C—N键构建"," C—H键活化"],"language":"zh","latestInfo":"","latestState":"","latestStateEn":"","lpage":"1205","oldUrl":"http://sioc-journal.cn/Jwk_yjhx/CN/volumn/home.shtml","pdfDownCount":15,"pdfSize":1039.39,"pubDate":"2020-05-01","recommendState":"","releaseState":"1","secCount":0,"title":"过渡金属催化的芳环磺酰胺化反应研究进展","titleCn":"过渡金属催化的芳环磺酰胺化反应研究进展","titleEn":"Recent Progress in Transition Metal Catalyzed Sulfonamidation of Aromatic Compounds","viewCount":2047,"volume":"40","year":2020},{"abstractInfo":"次氯酸（HClO）和次氯酸钠（NaClO）广泛存在于生命体和环境中，并与生命体的健康或疾病密切相关.近年来，为揭示HClO对生物体的作用及作用机制，已经设计出许多HClO比色荧光探针，这些次氯酸比色荧光探针由于具有灵敏、快速、高选择性、可视化和实时监测等优点而被用于环境或生物体中HClO或ClO-<\/sup>的检测.根据探针对HClO识别机制的不同，将HClO比色荧光探针分为五大类，总结评价近五年来次氯酸比色荧光探针的设计、特征及实际应用.","abstractInfoCn":"次氯酸（HClO）和次氯酸钠（NaClO）广泛存在于生命体和环境中，并与生命体的健康或疾病密切相关.近年来，为揭示HClO对生物体的作用及作用机制，已经设计出许多HClO比色荧光探针，这些次氯酸比色荧光探针由于具有灵敏、快速、高选择性、可视化和实时监测等优点而被用于环境或生物体中HClO或ClO-<\/sup>的检测.根据探针对HClO识别机制的不同，将HClO比色荧光探针分为五大类，总结评价近五年来次氯酸比色荧光探针的设计、特征及实际应用.","abstractInfoEn":"Hypochlorous acid (HClO) and sodium hypochlorite (NaClO) exist widely in living organisms and environment and is closely related to the health or disease of living organisms. In recent years, in order to reveal the effect and mechanism of HClO on living organisms, many HClO colorimetric and fluorimetric probes have been designed and applied to the detection HClO or ClO-<\/sup> in environment or living organisms due to their sensitivity, rapidity, high selectivity and real-time monitoring. According to the different recognition mechanism of probes for HClO, HCO colorimetric fluorescent probes are divided into five categories. The design, characteristics and practical application of hypochlorite colorimetric fluorescent probes in the past five years are summarized and evaluated.","articleNo":"","authorCnList":["余青"," 陈晓丽"," 刘华"," 张奇龙"],"authorEnList":["Yu Qing"," Chen Xiaoli"," Liu Hua"," Zhang Qilong"],"authorList":["余青"," 陈晓丽"," 刘华"," 张奇龙"],"authors":"余青, 陈晓丽, 刘华, 张奇龙","authorsCn":"余青, 陈晓丽, 刘华, 张奇龙","authorsEn":"Yu Qing, Chen Xiaoli, Liu Hua, Zhang Qilong","categoryName":"综述与进展","categoryNameCn":"综述与进展","categoryNameEn":"Reviews","citation":"余青, 陈晓丽, 刘华, 张奇龙. 次氯酸比色荧光探针的研究进展. 有机化学, 2020, 40(5): 1206-1231. doi: 10.6023/cjoc201911004.","citationCn":"余青, 陈晓丽, 刘华, 张奇龙. 次氯酸比色荧光探针的研究进展. 有机化学, 2020, 40(5): 1206-1231. doi: 10.6023/cjoc201911004.","citationEn":"余青, 陈晓丽, 刘华, 张奇龙. Recent Progress in Colorimetric and Fluorimetric Probes for the Detection of Hypochlorous Acid. Chinese Journal of Organic Chemistry, 2020, 40(5): 1206-1231. doi: 10.6023/cjoc201911004.","doi":"10.6023/cjoc201911004","figContent":"yjhx-40-5-1206-S1.jpg$$yjhx-40-5-1206-1.jpg$$yjhx-40-5-1206-S2.jpg$$yjhx-40-5-1206-S3.jpg$$yjhx-40-5-1206-S4.jpg$$yjhx-40-5-1206-S5.jpg$$yjhx-40-5-1206-S6.jpg$$yjhx-40-5-1206-S7.jpg$$yjhx-40-5-1206-S8.jpg$$yjhx-40-5-1206-S9.jpg$$yjhx-40-5-1206-S10.jpg$$yjhx-40-5-1206-S11.jpg$$yjhx-40-5-1206-S12.jpg$$yjhx-40-5-1206-S13.jpg$$yjhx-40-5-1206-S14.jpg$$yjhx-40-5-1206-S15.jpg$$yjhx-40-5-1206-S16.jpg$$yjhx-40-5-1206-S17.jpg$$yjhx-40-5-1206-S18.jpg$$yjhx-40-5-1206-S19.jpg$$yjhx-40-5-1206-S20.jpg$$yjhx-40-5-1206-S21.jpg$$yjhx-40-5-1206-S22.jpg$$yjhx-40-5-1206-S23.jpg$$yjhx-40-5-1206-S24.jpg$$yjhx-40-5-1206-S25.jpg$$yjhx-40-5-1206-S26.jpg","figList":["yjhx-40-5-1206-S1.jpg","yjhx-40-5-1206-1.jpg","yjhx-40-5-1206-S2.jpg","yjhx-40-5-1206-S3.jpg","yjhx-40-5-1206-S4.jpg","yjhx-40-5-1206-S5.jpg","yjhx-40-5-1206-S6.jpg","yjhx-40-5-1206-S7.jpg","yjhx-40-5-1206-S8.jpg","yjhx-40-5-1206-S9.jpg","yjhx-40-5-1206-S10.jpg","yjhx-40-5-1206-S11.jpg","yjhx-40-5-1206-S12.jpg","yjhx-40-5-1206-S13.jpg","yjhx-40-5-1206-S14.jpg","yjhx-40-5-1206-S15.jpg","yjhx-40-5-1206-S16.jpg","yjhx-40-5-1206-S17.jpg","yjhx-40-5-1206-S18.jpg","yjhx-40-5-1206-S19.jpg","yjhx-40-5-1206-S20.jpg","yjhx-40-5-1206-S21.jpg","yjhx-40-5-1206-S22.jpg","yjhx-40-5-1206-S23.jpg","yjhx-40-5-1206-S24.jpg","yjhx-40-5-1206-S25.jpg","yjhx-40-5-1206-S26.jpg"],"firstFig":"yjhx-40-5-1206-S1.jpg","fpage":"1206","highCitedState":"","htmlCount":726,"htmlFile":"","id":"1878074f-679d-411d-bb75-d1a08275005d","issnPpub":"0253-2786","issue":"5","journalPublishId":"yjhx","journalReferenceCodeType":0,"journalTitleCn":"有机化学","journalTitleEn":"Chinese Journal of Organic Chemistry","keyword":"次氯酸, 荧光比色探针, 识别机制, 应用","keywordCn":"次氯酸, 荧光比色探针, 识别机制, 应用","keywordCnList":["次氯酸"," 荧光比色探针"," 识别机制"," 应用"],"keywordEn":"hypochlorous acid, colorimetric and fluorimetric probe, recognition mechanism, application","keywordEnList":["hypochlorous acid"," colorimetric and fluorimetric probe"," recognition mechanism"," application"],"keywordList":["次氯酸"," 荧光比色探针"," 识别机制"," 应用"],"language":"zh","latestInfo":"","latestState":"","latestStateEn":"","lpage":"1231","oldUrl":"http://sioc-journal.cn/Jwk_yjhx/CN/volumn/home.shtml","pdfDownCount":37,"pdfSize":2473.75,"pubDate":"2020-05-25","recommendState":"","releaseState":"1","secCount":0,"title":"次氯酸比色荧光探针的研究进展","titleCn":"次氯酸比色荧光探针的研究进展","titleEn":"Recent Progress in Colorimetric and Fluorimetric Probes for the Detection of Hypochlorous Acid","viewCount":3467,"volume":"40","year":2020}],"研究论文":[{"abstractInfo":"设计并合成了一种基于3，4，5-三羟基苯甲酰肼和4-甲基-7-羟基-8-醛基香豆素的简单传感器FQ<\/b>，该传感器在水性介质中对氰化物具有“开启”的荧光响应.传感器FQ<\/b>的羟基和酚羟基是识别基团，香豆素起信号报告的作用.传感器FQ<\/b>上的吸电子基团（羟基）阻止了与香豆素基团之间的分子内电荷转移.当添加氰根时，可通过两步去质子化作用去掉酰肼上的质子和羟基上的质子，从而苯基和香豆素基团之间的分子内电荷转移（ICT）可以正常进行.通过1<\/sup>HNMR滴定和量化计算（DFT）证实了逐步去质子化的机理.此外，传感器FQ<\/b>对氰根的荧光响应的检测极限相对较低（9.92×10-8<\/sup>mol·L-1<\/sup>）.值得注意的是，传感器FQ<\/b>已成功用于检测食品样品中的氰化物阴离子，而且制备了基于FQ<\/b>的检测试纸，该试纸可以方便快捷地检测水中的氰根.","abstractInfoCn":"设计并合成了一种基于3，4，5-三羟基苯甲酰肼和4-甲基-7-羟基-8-醛基香豆素的简单传感器FQ<\/b>，该传感器在水性介质中对氰化物具有“开启”的荧光响应.传感器FQ<\/b>的羟基和酚羟基是识别基团，香豆素起信号报告的作用.传感器FQ<\/b>上的吸电子基团（羟基）阻止了与香豆素基团之间的分子内电荷转移.当添加氰根时，可通过两步去质子化作用去掉酰肼上的质子和羟基上的质子，从而苯基和香豆素基团之间的分子内电荷转移（ICT）可以正常进行.通过1<\/sup>H NMR滴定和量化计算（DFT）证实了逐步去质子化的机理.此外，传感器FQ<\/b>对氰根的荧光响应的检测极限相对较低（9.92×10-8<\/sup> mol·L-1<\/sup>）.值得注意的是，传感器FQ<\/b>已成功用于检测食品样品中的氰化物阴离子，而且制备了基于FQ<\/b>的检测试纸，该试纸可以方便快捷地检测水中的氰根.","abstractInfoEn":"Based on 3, 4, 5-trihydroxybenzohydrazide and 4-methyl-7-hydroxy-8-aldehyde coumarin, a simple sensor FQ<\/b> was designed and synthesized, which showed the \"turn-on\" fluorescence response to cyanide in an aqueous medium. The hydrazide, hydroxyl and phenolic hydroxyl groups on FQ<\/b> were receptor unit, and coumarin plays a role in signal reporting. The electron withdrawing group (hydroxyl group) of FQ<\/b> prevented its intramolecular charge transfer with coumarin group. When CN-<\/sup> was added, the protons of hydrazide and hydroxyl group were removed by protonation in two-step, so that intramolecular charge transfer (ICT) between phenyl group and coumarin group could be carried out. The mechanism of step-by-step deprotonation was confirmed by 1<\/sup>H NMR titration and DFT calculation. Furthermore, compared to the reported literature, FQ<\/b> had a lower detection line for CN-<\/sup> fluorescence detection (9.92×10-8<\/sup> mol·L-1<\/sup>). Notably sensor FQ<\/b> has been successfully used to detect cyanide anions in food samples. The prepared FQ<\/b>-containing test strip could be used colorimetric device for CN-<\/sup> detection.","articleNo":"","authorCnList":["付青青"," 胡京汉"," 姚瑛"," 殷志远"," 贵铠"," 龙辰"," 倪朋伟"],"authorEnList":["Fu Qingqing"," Hu Jinghan"," Yao Ying"," Yin Zhiyuan"," Gui Kui"," Long Chen"," Ni Pengwei"],"authorList":["付青青"," 胡京汉"," 姚瑛"," 殷志远"," 贵铠"," 龙辰"," 倪朋伟"],"authors":"付青青, 胡京汉, 姚瑛, 殷志远, 贵铠, 龙辰, 倪朋伟","authorsCn":"付青青, 胡京汉, 姚瑛, 殷志远, 贵铠, 龙辰, 倪朋伟","authorsEn":"Fu Qingqing, Hu Jinghan, Yao Ying, Yin Zhiyuan, Gui Kui, Long Chen, Ni Pengwei","categoryName":"研究论文","categoryNameCn":"研究论文","categoryNameEn":"Articles","citation":"付青青, 胡京汉, 姚瑛, 殷志远, 贵铠, 龙辰, 倪朋伟. 基于香豆素衍生物在水溶液中检测CN-<\/sup>的高灵敏性双通道化学传感器及其在食品样品中的应用. 有机化学, 2020, 40(5): 1232-1238. doi: 10.6023/cjoc201909037.","citationCn":"付青青, 胡京汉, 姚瑛, 殷志远, 贵铠, 龙辰, 倪朋伟. 基于香豆素衍生物在水溶液中检测CN-<\/sup>的高灵敏性双通道化学传感器及其在食品样品中的应用. 有机化学, 2020, 40(5): 1232-1238. doi: 10.6023/cjoc201909037.","citationEn":"付青青, 胡京汉, 姚瑛, 殷志远, 贵铠, 龙辰, 倪朋伟. Novel High Sensitivity Dual-Channel Chemosensor for Detecting CN-<\/sup> Based on Coumarin Derivative in Aqueous Media and Its Application in Food Samples. Chinese Journal of Organic Chemistry, 2020, 40(5): 1232-1238. doi: 10.6023/cjoc201909037.","doi":"10.6023/cjoc201909037","figContent":"yjhx-40-5-1232-S1.jpg$$yjhx-40-5-1232-1.jpg$$yjhx-40-5-1232-2.jpg$$yjhx-40-5-1232-3.jpg$$yjhx-40-5-1232-4.jpg$$yjhx-40-5-1232-5.jpg$$yjhx-40-5-1232-6.jpg$$yjhx-40-5-1232-7.jpg$$yjhx-40-5-1232-S2.jpg$$yjhx-40-5-1232-8.jpg","figList":["yjhx-40-5-1232-S1.jpg","yjhx-40-5-1232-1.jpg","yjhx-40-5-1232-2.jpg","yjhx-40-5-1232-3.jpg","yjhx-40-5-1232-4.jpg","yjhx-40-5-1232-5.jpg","yjhx-40-5-1232-6.jpg","yjhx-40-5-1232-7.jpg","yjhx-40-5-1232-S2.jpg","yjhx-40-5-1232-8.jpg"],"firstFig":"yjhx-40-5-1232-S1.jpg","fpage":"1232","highCitedState":"","htmlCount":217,"htmlFile":"","id":"df5c0f0c-5321-43b4-9f86-7d0609bbd92d","issnPpub":"0253-2786","issue":"5","journalPublishId":"yjhx","journalReferenceCodeType":0,"journalTitleCn":"有机化学","journalTitleEn":"Chinese Journal of Organic Chemistry","keyword":"CN-<\/sup>, 比色, 分步去质子, 试纸条, DFT","keywordCn":"CN-<\/sup>, 比色, 分步去质子, 试纸条, DFT","keywordCnList":["CN-<\/sup>"," 比色"," 分步去质子"," 试纸条"," DFT"],"keywordEn":"CN-<\/sup>, colorimetric, deprotonation, test strip, DFT","keywordEnList":["CN-<\/sup>"," colorimetric"," deprotonation"," test strip"," DFT"],"keywordList":["CN-<\/sup>"," 比色"," 分步去质子"," 试纸条"," DFT"],"language":"zh","latestInfo":"","latestState":"","latestStateEn":"","lpage":"1238","oldUrl":"http://sioc-journal.cn/Jwk_yjhx/CN/volumn/home.shtml","pdfDownCount":14,"pdfSize":2172.2,"pubDate":"2020-05-25","recommendState":"","releaseState":"1","secCount":0,"title":"基于香豆素衍生物在水溶液中检测CN-<\/sup>的高灵敏性双通道化学传感器及其在食品样品中的应用","titleCn":"基于香豆素衍生物在水溶液中检测CN-<\/sup>的高灵敏性双通道化学传感器及其在食品样品中的应用","titleEn":"Novel High Sensitivity Dual-Channel Chemosensor for Detecting CN-<\/sup> Based on Coumarin Derivative in Aqueous Media and Its Application in Food Samples","viewCount":1444,"volume":"40","year":2020},{"abstractInfo":"生命体内小分子硫醇，如半胱氨酸（Cys）、同型半胱氨酸（Hcy）和谷胱甘肽（GSH），在多种生理和病理过程中发挥重要作用.以氟硼二吡咯（BODIPY）为荧光团，硝基烯烃为识别基团，经三步简单有机合成，构建了一个打开型硫醇荧光探针.密度泛函理论计算结果表明，硝基通过光诱导电子转移（PET）机制淬灭BODIPY荧光.光谱测试结果表明，探针与硫醇发生迈克尔加成反应，响应迅速，选择性好，灵敏度高，对GSH的检测极限低至11×10-9<\/sup>mol/L.荧光共聚焦成像结果表明，探针可用于HeLa细胞和斑马鱼内源生物硫醇荧光成像研究.","abstractInfoCn":"生命体内小分子硫醇，如半胱氨酸（Cys）、同型半胱氨酸（Hcy）和谷胱甘肽（GSH），在多种生理和病理过程中发挥重要作用.以氟硼二吡咯（BODIPY）为荧光团，硝基烯烃为识别基团，经三步简单有机合成，构建了一个打开型硫醇荧光探针.密度泛函理论计算结果表明，硝基通过光诱导电子转移（PET）机制淬灭BODIPY荧光.光谱测试结果表明，探针与硫醇发生迈克尔加成反应，响应迅速，选择性好，灵敏度高，对GSH的检测极限低至11×10-9<\/sup> mol/L.荧光共聚焦成像结果表明，探针可用于HeLa细胞和斑马鱼内源生物硫醇荧光成像研究.","abstractInfoEn":"Intracellular small-molecule thiols, such as cysteine (Cys), homocysteine (Hcy) and glutathione (GSH), play pivotal roles in several physiological and pathological processes. A bodipy-nitroolefin-conjugated fluorescent probe based on photoinduced electron transfer (PET) mechanism was designed and successfully constructed. The probe selectively responds to biothiols by Michael addition reaction of the sulfhydryl group to the double bond activated by Nitroolefin moiety and gives an off-on fluorescent response. The fluorescence detection limit for GSH was calculated to be 11×10-9<\/sup> mol/L. The results of fluorescence confocal imaging indicated that the probe has appreciable cell permeability and can serve as a fluorescent probe for detecting biothiols in living cells and zebrafish.","articleNo":"","authorCnList":["郭振波"," 郑雪阳"," 李雪艳"," 贾清菲"," 张平竹"," 魏超"," 李小六"],"authorEnList":["Guo Zhenbo"," Zheng Xueyang"," Li Xueyan"," Jia Qingfei"," Zhang Pingzhu"," Wei Chao"," Li Xiaoliu"],"authorList":["郭振波"," 郑雪阳"," 李雪艳"," 贾清菲"," 张平竹"," 魏超"," 李小六"],"authors":"郭振波, 郑雪阳, 李雪艳, 贾清菲, 张平竹, 魏超, 李小六","authorsCn":"郭振波, 郑雪阳, 李雪艳, 贾清菲, 张平竹, 魏超, 李小六","authorsEn":"Guo Zhenbo, Zheng Xueyang, Li Xueyan, Jia Qingfei, Zhang Pingzhu, Wei Chao, Li Xiaoliu","categoryName":"研究论文","categoryNameCn":"研究论文","categoryNameEn":"Articles","citation":"郭振波, 郑雪阳, 李雪艳, 贾清菲, 张平竹, 魏超, 李小六. 一种基于硝基烯烃的硫醇荧光探针的合成及生物成像研究. 有机化学, 2020, 40(5): 1239-1245. doi: 10.6023/cjoc201911015.","citationCn":"郭振波, 郑雪阳, 李雪艳, 贾清菲, 张平竹, 魏超, 李小六. 一种基于硝基烯烃的硫醇荧光探针的合成及生物成像研究. 有机化学, 2020, 40(5): 1239-1245. doi: 10.6023/cjoc201911015.","citationEn":"郭振波, 郑雪阳, 李雪艳, 贾清菲, 张平竹, 魏超, 李小六. A Nitroolefin Based Thiol Fluorescent Probe: Synthesis and Application in Bioimaging. Chinese Journal of Organic Chemistry, 2020, 40(5): 1239-1245. doi: 10.6023/cjoc201911015.","doi":"10.6023/cjoc201911015","figContent":"yjhx-40-5-1239-1.jpg$$yjhx-40-5-1239-S1.jpg$$yjhx-40-5-1239-2.jpg$$yjhx-40-5-1239-3.jpg$$yjhx-40-5-1239-4.jpg$$yjhx-40-5-1239-5.jpg$$yjhx-40-5-1239-S2.jpg$$yjhx-40-5-1239-6.jpg$$yjhx-40-5-1239-7.jpg","figList":["yjhx-40-5-1239-1.jpg","yjhx-40-5-1239-S1.jpg","yjhx-40-5-1239-2.jpg","yjhx-40-5-1239-3.jpg","yjhx-40-5-1239-4.jpg","yjhx-40-5-1239-5.jpg","yjhx-40-5-1239-S2.jpg","yjhx-40-5-1239-6.jpg","yjhx-40-5-1239-7.jpg"],"firstFig":"yjhx-40-5-1239-1.jpg","fpage":"1239","highCitedState":"","htmlCount":380,"htmlFile":"","id":"0c9b527e-d298-4914-9ea7-f44c70f49e78","issnPpub":"0253-2786","issue":"5","journalPublishId":"yjhx","journalReferenceCodeType":0,"journalTitleCn":"有机化学","journalTitleEn":"Chinese Journal of Organic Chemistry","keyword":"硫醇, 硝基烯烃, 荧光探针, 生物成像","keywordCn":"硫醇, 硝基烯烃, 荧光探针, 生物成像","keywordCnList":["硫醇"," 硝基烯烃"," 荧光探针"," 生物成像"],"keywordEn":"thiol, nitroolefin, fluorescent probe, bioimaging","keywordEnList":["thiol"," nitroolefin"," fluorescent probe"," bioimaging"],"keywordList":["硫醇"," 硝基烯烃"," 荧光探针"," 生物成像"],"language":"zh","latestInfo":"","latestState":"","latestStateEn":"","lpage":"1245","oldUrl":"http://sioc-journal.cn/Jwk_yjhx/CN/volumn/home.shtml","pdfDownCount":17,"pdfSize":2968.33,"pubDate":"2020-05-25","recommendState":"","releaseState":"1","secCount":0,"title":"一种基于硝基烯烃的硫醇荧光探针的合成及生物成像研究","titleCn":"一种基于硝基烯烃的硫醇荧光探针的合成及生物成像研究","titleEn":"A Nitroolefin Based Thiol Fluorescent Probe: Synthesis and Application in Bioimaging","viewCount":1799,"volume":"40","year":2020},{"abstractInfo":"通过克脑文盖尔缩合反应合成了一种近红外I区的氟硼二吡咯荧光染料（QBOP-lys），QBOP-lys染料是由喹啉-氟硼二吡咯与两个对吗啉苯乙烯结构共轭连接而成，是一种D-A构型的染料，该染料的结构通过了核磁共振以及高分辨质谱表征.在DMSO溶液中，QBOP-lys最大吸收波长为698nm（摩尔消光系数为5.9×104<\/sup>L·mol-1<\/sup>·cm-1<\/sup>），最大发射波长位于770nm，Stokes位移达到73nm，荧光量子产率为0.18.此外，QBOP-lys还被制备成水溶性的二氧化硅荧光纳米粒子（QBOP-lys/SiO2<\/sub>），在纯水溶液中最大发射波长位于726nm，荧光量子产率达到了0.33，使得QBOP-lys无论是在有机溶剂或者是纯水溶剂中都具有非常好的近红外荧光发射特性.另一方面，QBOP-lys还被用于SGC-7901细胞内的溶酶体成像，染料QBOP-lys与溶酶体商业绿色染料Lyso-TrackerGreen的共定位系数高达0.9.此外，染料QBOP-lys在SGC-7901细胞内孵育48h之后，依然能保持很好的荧光成像效果，可被用于长期的溶酶体追踪成像.染料QBOP-lys的体外实验与细胞实验证明，QBOP-lys是一种非常有应用前景的近红外BODIPY染料.","abstractInfoCn":"通过克脑文盖尔缩合反应合成了一种近红外I区的氟硼二吡咯荧光染料（QBOP-lys），QBOP-lys染料是由喹啉-氟硼二吡咯与两个对吗啉苯乙烯结构共轭连接而成，是一种D-A构型的染料，该染料的结构通过了核磁共振以及高分辨质谱表征.在DMSO溶液中，QBOP-lys最大吸收波长为698 nm（摩尔消光系数为5.9×104<\/sup> L·mol-1<\/sup>·cm-1<\/sup>），最大发射波长位于770 nm，Stokes位移达到73 nm，荧光量子产率为0.18.此外，QBOP-lys还被制备成水溶性的二氧化硅荧光纳米粒子（QBOP-lys/SiO2<\/sub>），在纯水溶液中最大发射波长位于726 nm，荧光量子产率达到了0.33，使得QBOP-lys无论是在有机溶剂或者是纯水溶剂中都具有非常好的近红外荧光发射特性.另一方面，QBOP-lys还被用于SGC-7901细胞内的溶酶体成像，染料QBOP-lys与溶酶体商业绿色染料Lyso-Tracker Green的共定位系数高达0.9.此外，染料QBOP-lys在SGC-7901细胞内孵育48 h之后，依然能保持很好的荧光成像效果，可被用于长期的溶酶体追踪成像.染料QBOP-lys的体外实验与细胞实验证明，QBOP-lys是一种非常有应用前景的近红外BODIPY染料.","abstractInfoEn":"A near-infrared region (NIR) fluoroborodipyrrole fluorescent dye (QBOP-lys) was synthesized through Knoevenagel condensation reaction. The D-A configuration of the QBOP-lys dyes was conjugated by two p<\/i>-morpholine styrene with one 8-hydroxyquino BODIPY structure. This QBOP-lys dye has been characterized by NMR and high resolution mass spectrometry. In dimethyl sulfoxide (DMSO) solution, the maximum absorption wavelength of QBOP-lys was at 698 nm and its molar extinction coefficient was 5.9×104<\/sup> L·mol-1<\/sup>·cm-1<\/sup>, the maximum emission wavelength was at 770 nm and its stokes shift was 73 nm. Besides that, QBOP-lys has been prepared as water-soluble nano-silica fluorescent nanoparticles (QBOP-lys/SiO2<\/sub>). The maximum emission wavelength of QBOP-lys/SiO2<\/sub> was 726 nm in pure aqueous solution and the fluorescence quantum of QBOP-lys/SiO2<\/sub> was 0.33, which made QBOP-lys have good near-infrared fluorescence emission characteristics in organic solvents or pure water. On the other hand, QBOP-lys was also used for lysosomal imaging in SGC-7901 cells, the colocalization coefficient of dye QBOP-lys with Lyso-Tracker Green, a commercial lysosomal green dye, was up to 0.9. Besides that, after QBOP-lys incubate with cells SGC-7901 for 48 h, it could still maintain good fluorescence imaging performance which could be used for long-term tracking imaging. The spectroscopy experiments and cell experiments both proved that dye QBOP-lys was a very promising NIR dye in future application.","articleNo":"","authorCnList":["王凌锋"," 钱鹰"],"authorEnList":["Wang Lingfeng"," Qian Ying"],"authorList":["王凌锋"," 钱鹰"],"authors":"王凌锋, 钱鹰","authorsCn":"王凌锋, 钱鹰","authorsEn":"Wang Lingfeng, Qian Ying","categoryName":"研究论文","categoryNameCn":"研究论文","categoryNameEn":"Articles","citation":"王凌锋, 钱鹰. 近红外I区喹啉-氟硼二吡咯荧光染料的合成及其在溶酶体内的荧光成像. 有机化学, 2020, 40(5): 1246-1250. doi: 10.6023/cjoc201911022.","citationCn":"王凌锋, 钱鹰. 近红外I区喹啉-氟硼二吡咯荧光染料的合成及其在溶酶体内的荧光成像. 有机化学, 2020, 40(5): 1246-1250. doi: 10.6023/cjoc201911022.","citationEn":"王凌锋, 钱鹰. Near-Infrared Quinoline-Fluoroborodipyrrole Dye: Synthesis and Lysosomal Fluorescence Imaging. Chinese Journal of Organic Chemistry, 2020, 40(5): 1246-1250. doi: 10.6023/cjoc201911022.","doi":"10.6023/cjoc201911022","figContent":"yjhx-40-5-1246-S1.jpg$$yjhx-40-5-1246-1.jpg$$yjhx-40-5-1246-S2.jpg$$yjhx-40-5-1246-2.jpg$$yjhx-40-5-1246-3.jpg","figList":["yjhx-40-5-1246-S1.jpg","yjhx-40-5-1246-1.jpg","yjhx-40-5-1246-S2.jpg","yjhx-40-5-1246-2.jpg","yjhx-40-5-1246-3.jpg"],"firstFig":"yjhx-40-5-1246-S1.jpg","fpage":"1246","highCitedState":"","htmlCount":385,"htmlFile":"","id":"1bb802bd-78df-4d10-bd85-6aa4c8278358","issnPpub":"0253-2786","issue":"5","journalPublishId":"yjhx","journalReferenceCodeType":0,"journalTitleCn":"有机化学","journalTitleEn":"Chinese Journal of Organic Chemistry","keyword":"D-A型喹啉-氟硼二吡咯, 荧光纳米粒子, 克脑文盖尔缩合反应, 近红外I区荧光成像","keywordCn":"D-A型喹啉-氟硼二吡咯, 荧光纳米粒子, 克脑文盖尔缩合反应, 近红外I区荧光成像","keywordCnList":["D-A型喹啉-氟硼二吡咯"," 荧光纳米粒子"," 克脑文盖尔缩合反应"," 近红外I区荧光成像"],"keywordEn":"D-A type quinoline-fluoroboron dipyrrole, fluorescent nanoparticles, Knoevenagel condensation reaction, NIR fluorescence imaging","keywordEnList":["D-A type quinoline-fluoroboron dipyrrole"," fluorescent nanoparticles"," Knoevenagel condensation reaction"," NIR fluorescence imaging"],"keywordList":["D-A型喹啉-氟硼二吡咯"," 荧光纳米粒子"," 克脑文盖尔缩合反应"," 近红外I区荧光成像"],"language":"zh","latestInfo":"","latestState":"","latestStateEn":"","lpage":"1250","oldUrl":"http://sioc-journal.cn/Jwk_yjhx/CN/volumn/home.shtml","pdfDownCount":21,"pdfSize":1222.9,"pubDate":"2020-05-25","recommendState":"","releaseState":"1","secCount":0,"title":"近红外I区喹啉-氟硼二吡咯荧光染料的合成及其在溶酶体内的荧光成像","titleCn":"近红外I区喹啉-氟硼二吡咯荧光染料的合成及其在溶酶体内的荧光成像","titleEn":"Near-Infrared Quinoline-Fluoroborodipyrrole Dye: Synthesis and Lysosomal Fluorescence Imaging","viewCount":2004,"volume":"40","year":2020},{"abstractInfo":"以7-羟基四氢喹喔啉-6-甲醛为基础，设计合成了一种新型酰腙类荧光探针L<\/b>，探针在DMSO/Tris（V<\/i>：V<\/i>=7：3）溶液中能够高选择性识别Al3+<\/sup>.向该探针中加入Al3+<\/sup>后由无荧光变为紫红色荧光，最大发射波长为640nm，达到近红外范围，并且具有较大的斯托克斯位移（170nm），检测限为0.521μmol/L，pH适用范围为5~9.此外，探针L<\/b>可在实际水样中对Al3+<\/sup>进行检测，还可在MCF-7细胞中对Al3+<\/sup>进行荧光成像.","abstractInfoCn":"以7-羟基四氢喹喔啉-6-甲醛为基础，设计合成了一种新型酰腙类荧光探针L<\/b>，探针在DMSO/Tris（V<\/i>：V<\/i>=7：3）溶液中能够高选择性识别Al3+<\/sup>.向该探针中加入Al3+<\/sup>后由无荧光变为紫红色荧光，最大发射波长为640 nm，达到近红外范围，并且具有较大的斯托克斯位移（170 nm），检测限为0.521 μmol/L，pH适用范围为5~9.此外，探针L<\/b>可在实际水样中对Al3+<\/sup>进行检测，还可在MCF-7细胞中对Al3+<\/sup>进行荧光成像.","abstractInfoEn":"A novel acylhydrazone derivative (i.e.<\/i> fluorescence probe L<\/b>) was designed and synthesized based on 7-hydroxy- tetrahydroquinoxaline-6-formaldehyde. Probe L<\/b> can recognize for Al3+<\/sup> with highly selectivity in DMSO/Tris (V<\/i>:V<\/i>=7:3) solution. When Al3+<\/sup> is added into the solution of L<\/b>, the fluorescence color of solution changes from non-fluorescence to purple red fluorescence, and the maximum emission wavelength of L<\/b> is 640 nm within range of the near-infrared. Probe L<\/b> possesses a large Stokes shift (170 nm) and the detection limit of L<\/b> is 0.521 μmol/L. In addition, L<\/b> can detect Al3+<\/sup> in the real water samples and imaging for Al3+<\/sup> in MCF-7 cells.","articleNo":"","authorCnList":["钟克利"," 周璐璐"," 邓隆隆"," 汤立军"," 高雪"," 刘秀英"," 燕小梅"],"authorEnList":["Zhong Keli"," Zhou Lulu"," Deng Longlong"," Tang Lijun"," Gao Xue"," Liu Xiuying"," Yan Xiaomei"],"authorList":["钟克利"," 周璐璐"," 邓隆隆"," 汤立军"," 高雪"," 刘秀英"," 燕小梅"],"authors":"钟克利, 周璐璐, 邓隆隆, 汤立军, 高雪, 刘秀英, 燕小梅","authorsCn":"钟克利, 周璐璐, 邓隆隆, 汤立军, 高雪, 刘秀英, 燕小梅","authorsEn":"Zhong Keli, Zhou Lulu, Deng Longlong, Tang Lijun, Gao Xue, Liu Xiuying, Yan Xiaomei","categoryName":"研究论文","categoryNameCn":"研究论文","categoryNameEn":"Articles","citation":"钟克利, 周璐璐, 邓隆隆, 汤立军, 高雪, 刘秀英, 燕小梅. 新型7-羟基四氢喹喔啉-6-甲醛酰腙衍生物的合成及其对Al3+<\/sup>的识别. 有机化学, 2020, 40(5): 1251-1256. doi: 10.6023/cjoc201912026.","citationCn":"钟克利, 周璐璐, 邓隆隆, 汤立军, 高雪, 刘秀英, 燕小梅. 新型7-羟基四氢喹喔啉-6-甲醛酰腙衍生物的合成及其对Al3+<\/sup>的识别. 有机化学, 2020, 40(5): 1251-1256. doi: 10.6023/cjoc201912026.","citationEn":"钟克利, 周璐璐, 邓隆隆, 汤立军, 高雪, 刘秀英, 燕小梅. Synthesis of Novel 7-Hydroxytetrahydroquinoxaline-6-formaldehyde Acylhydrazone Derivative and Its Recognition for Al3+<\/sup>. Chinese Journal of Organic Chemistry, 2020, 40(5): 1251-1256. doi: 10.6023/cjoc201912026.","doi":"10.6023/cjoc201912026","figContent":"yjhx-40-5-1251-1.jpg$$yjhx-40-5-1251-2.jpg$$yjhx-40-5-1251-3.jpg$$yjhx-40-5-1251-4.jpg$$yjhx-40-5-1251-5.jpg$$yjhx-40-5-1251-6.jpg$$yjhx-40-5-1251-7.jpg$$yjhx-40-5-1251-8.jpg","figList":["yjhx-40-5-1251-1.jpg","yjhx-40-5-1251-2.jpg","yjhx-40-5-1251-3.jpg","yjhx-40-5-1251-4.jpg","yjhx-40-5-1251-5.jpg","yjhx-40-5-1251-6.jpg","yjhx-40-5-1251-7.jpg","yjhx-40-5-1251-8.jpg"],"firstFig":"yjhx-40-5-1251-1.jpg","fpage":"1251","highCitedState":"","htmlCount":242,"htmlFile":"","id":"dc64b558-9621-4bb3-8415-92f24a6b1b95","issnPpub":"0253-2786","issue":"5","journalPublishId":"yjhx","journalReferenceCodeType":0,"journalTitleCn":"有机化学","journalTitleEn":"Chinese Journal of Organic Chemistry","keyword":"7-羟基四氢喹喔啉-6-甲醛, 荧光探针, Al3+<\/sup>, 识别, 细胞成像","keywordCn":"7-羟基四氢喹喔啉-6-甲醛, 荧光探针, Al3+<\/sup>, 识别, 细胞成像","keywordCnList":["7-羟基四氢喹喔啉-6-甲醛"," 荧光探针"," Al3+<\/sup>"," 识别"," 细胞成像"],"keywordEn":"7-hydroxytetrahydroquinoxaline-6-formaldehyde, fluorescent probe, Al3+<\/sup>, recognition, cell imaging","keywordEnList":["7-hydroxytetrahydroquinoxaline-6-formaldehyde"," fluorescent probe"," Al3+<\/sup>"," recognition"," cell imaging"],"keywordList":["7-羟基四氢喹喔啉-6-甲醛"," 荧光探针"," Al3+<\/sup>"," 识别"," 细胞成像"],"language":"zh","latestInfo":"","latestState":"","latestStateEn":"","lpage":"1256","oldUrl":"http://sioc-journal.cn/Jwk_yjhx/CN/volumn/home.shtml","pdfDownCount":9,"pdfSize":2698.13,"pubDate":"2020-05-25","recommendState":"","releaseState":"1","secCount":0,"title":"新型7-羟基四氢喹喔啉-6-甲醛酰腙衍生物的合成及其对Al3+<\/sup>的识别","titleCn":"新型7-羟基四氢喹喔啉-6-甲醛酰腙衍生物的合成及其对Al3+<\/sup>的识别","titleEn":"Synthesis of Novel 7-Hydroxytetrahydroquinoxaline-6-formaldehyde Acylhydrazone Derivative and Its Recognition for Al3+<\/sup>","viewCount":1577,"volume":"40","year":2020},{"abstractInfo":"硫酸有效地催化炔丙醇和一系列碳和氧亲核试剂的直接亲核取代反应以形成碳-碳键和碳-氧键.反应可以在未除水溶剂中和空气条件下进行并获得良好的产率.室温下大多数底物的反应能在1min内完成.","abstractInfoCn":"硫酸有效地催化炔丙醇和一系列碳和氧亲核试剂的直接亲核取代反应以形成碳-碳键和碳-氧键.反应可以在未除水溶剂中和空气条件下进行并获得良好的产率.室温下大多数底物的反应能在1 min内完成.","abstractInfoEn":"Sulfuric acid efficiently catalyzes the direct substitution of the hydroxyl group of propargylic alcohols with a variety of C- and O-based nucleophiles to aid C-C and C-O bond formation. The reactions can be performed in an undried solvent under air atmosphere to obtain the desired products in good yields. In most cases, the reaction proceeds to completion in 1 min at room temperature.","articleNo":"","authorCnList":["张顺吉"," 刘会丽"],"authorEnList":["Zhang Shunji"," Liu Huili"],"authorList":["张顺吉"," 刘会丽"],"authors":"张顺吉, 刘会丽","authorsCn":"张顺吉, 刘会丽","authorsEn":"Zhang Shunji, Liu Huili","categoryName":"研究论文","categoryNameCn":"研究论文","categoryNameEn":"Articles","citation":"张顺吉, 刘会丽. 硫酸催化的炔丙醇快速亲核取代反应. 有机化学, 2020, 40(5): 1257-1265. doi: 10.6023/cjoc201911036.","citationCn":"张顺吉, 刘会丽. 硫酸催化的炔丙醇快速亲核取代反应. 有机化学, 2020, 40(5): 1257-1265. doi: 10.6023/cjoc201911036.","citationEn":"张顺吉, 刘会丽. Sulfuric Acid Catalyzed Rapid Nucleophilic Substitution of Propargyl Alcohols. Chinese Journal of Organic Chemistry, 2020, 40(5): 1257-1265. doi: 10.6023/cjoc201911036.","doi":"10.6023/cjoc201911036","figContent":"yjhx-40-5-1257-S1.jpg","figList":["yjhx-40-5-1257-S1.jpg"],"firstFig":"yjhx-40-5-1257-S1.jpg","fpage":"1257","highCitedState":"","htmlCount":238,"htmlFile":"","id":"1a04125f-6293-4f99-aa33-37940ba0f5fb","issnPpub":"0253-2786","issue":"5","journalPublishId":"yjhx","journalReferenceCodeType":0,"journalTitleCn":"有机化学","journalTitleEn":"Chinese Journal of Organic Chemistry","keyword":"硫酸, 催化, 炔丙醇, 亲核取代","keywordCn":"硫酸, 催化, 炔丙醇, 亲核取代","keywordCnList":["硫酸"," 催化"," 炔丙醇"," 亲核取代"],"keywordEn":"sulfuric acid, catalyzed, propargyl alcohols, nucleophilic substitution","keywordEnList":["sulfuric acid"," catalyzed"," propargyl alcohols"," nucleophilic substitution"],"keywordList":["硫酸"," 催化"," 炔丙醇"," 亲核取代"],"language":"zh","latestInfo":"","latestState":"","latestStateEn":"","lpage":"1265","oldUrl":"http://sioc-journal.cn/Jwk_yjhx/CN/volumn/home.shtml","pdfDownCount":13,"pdfSize":492.83,"pubDate":"2020-05-25","recommendState":"","releaseState":"1","secCount":0,"title":"硫酸催化的炔丙醇快速亲核取代反应","titleCn":"硫酸催化的炔丙醇快速亲核取代反应","titleEn":"Sulfuric Acid Catalyzed Rapid Nucleophilic Substitution of Propargyl Alcohols","viewCount":1108,"volume":"40","year":2020},{"abstractInfo":"以朝格尔碱衍生物（5，12-二甲基-3，10-二苯基-双-1H<\/i>-吡唑[b<\/i>，f<\/i>][4<\/xref>,5<\/xref>]<\/sup>-1，5-二氮杂双环[3.3.1]-2，6-辛二烯，1<\/b>）为催化剂，以取代的α<\/i>-溴代苯乙酮、芳香醛、丙二腈和硫脲为原料四组分一锅法合成了一系列噻唑并[3，2-a<\/i>]嘧啶衍生物.通过1<\/sup>HNMR和化学实验探讨了该反应的机理.体外药理活性实验结果表明，多个产物对人肝癌细胞（HepG2）、人非小细胞肺癌细胞（247）和人非小细胞肺癌细胞（A549）中的一个或多个细胞株具有较高抑制活性，七个产物对耐甲氧西林金黄色葡萄球菌具有抑菌活性.这些结果表明该类化合物在新药开发中具有巨大潜力.","abstractInfoCn":"以朝格尔碱衍生物（5，12-二甲基-3，10-二苯基-双-1H<\/i>-吡唑[b<\/i>，f<\/i>][4<\/xref>, 5<\/xref>]<\/sup>-1，5-二氮杂双环[3.3.1]-2，6-辛二烯，1<\/b>）为催化剂，以取代的α<\/i>-溴代苯乙酮、芳香醛、丙二腈和硫脲为原料四组分一锅法合成了一系列噻唑并[3，2-a<\/i>]嘧啶衍生物.通过1<\/sup>H NMR和化学实验探讨了该反应的机理.体外药理活性实验结果表明，多个产物对人肝癌细胞（HepG2）、人非小细胞肺癌细胞（247）和人非小细胞肺癌细胞（A549）中的一个或多个细胞株具有较高抑制活性，七个产物对耐甲氧西林金黄色葡萄球菌具有抑菌活性.这些结果表明该类化合物在新药开发中具有巨大潜力.","abstractInfoEn":"A series of thiazolo[3, 2-a<\/i>]pyrimidine derivatives were synthesized from the reaction of α<\/i>-bromoacetophenone, aromatic aldehyde, malononitrile and thiourea which was catalyzed by Tröger's base derivative 5, 12-dimethyl-3, 10-diphenyl- bis-1H<\/i>-pyrazol[b<\/i>, f<\/i>] [4<\/xref>, 5<\/xref>]<\/sup>-1, 5- diazadicyclo[3.3.1]-2, 6-octadiene (1<\/b>). The reaction mechanism was discussed by the 1<\/sup>H NMR analysis and chemical experiments. The pharmacological activity results of the products indicated that most of products showed high inhibitory on one or more cancer cells in human hepatocarcinoma cell (HepG2), human non-small cell lung cancer cell (247) and human non-small cell lung cancer cell (A549) in vitro<\/i>. And seven products have antibacterial activity against the methicillin-resistant Staphylococcus aureus<\/i>. These results showed the great potential of these compounds in drug development.","articleNo":"","authorCnList":["任璇璇"," 苑睿"," 陈雯"," 周杭"," 叶菲"," 师雪荧"," 胡娟"," 张鹏"," 周生亮"," 宛瑜"," 吴翚"],"authorEnList":["Ren Xuanxuan"," Yuan Rui"," Chen Wen"," Zhou Hang"," Ye Fei"," Shi Xueying"," Hu Juan"," Zhang Peng"," Zhou Shengliang"," Wan Yu"," Wu Hui"],"authorList":["任璇璇"," 苑睿"," 陈雯"," 周杭"," 叶菲"," 师雪荧"," 胡娟"," 张鹏"," 周生亮"," 宛瑜"," 吴翚"],"authors":"任璇璇, 苑睿, 陈雯, 周杭, 叶菲, 师雪荧, 胡娟, 张鹏, 周生亮, 宛瑜, 吴翚","authorsCn":"任璇璇, 苑睿, 陈雯, 周杭, 叶菲, 师雪荧, 胡娟, 张鹏, 周生亮, 宛瑜, 吴翚","authorsEn":"Ren Xuanxuan, Yuan Rui, Chen Wen, Zhou Hang, Ye Fei, Shi Xueying, Hu Juan, Zhang Peng, Zhou Shengliang, Wan Yu, Wu Hui","categoryName":"研究论文","categoryNameCn":"研究论文","categoryNameEn":"Articles","citation":"任璇璇, 苑睿, 陈雯, 周杭, 叶菲, 师雪荧, 胡娟, 张鹏, 周生亮, 宛瑜, 吴翚. 多取代-5-氨基-3, 7-二苯基-7H<\/i>-噻唑并[3, 2-a<\/i>]嘧啶-6-腈衍生物的合成及生物活性. 有机化学, 2020, 40(5): 1266-1274. doi: 10.6023/cjoc201908007.","citationCn":"任璇璇, 苑睿, 陈雯, 周杭, 叶菲, 师雪荧, 胡娟, 张鹏, 周生亮, 宛瑜, 吴翚. 多取代-5-氨基-3, 7-二苯基-7H<\/i>-噻唑并[3, 2-a<\/i>]嘧啶-6-腈衍生物的合成及生物活性. 有机化学, 2020, 40(5): 1266-1274. doi: 10.6023/cjoc201908007.","citationEn":"任璇璇, 苑睿, 陈雯, 周杭, 叶菲, 师雪荧, 胡娟, 张鹏, 周生亮, 宛瑜, 吴翚. Synthesis and Biological Evaluation of Polysubstituted 5-Amino-3, 7-diphenyl-7H<\/i>-thiazolo[3, 2-a<\/i>]pyrimidine-6-carbonitriles. Chinese Journal of Organic Chemistry, 2020, 40(5): 1266-1274. doi: 10.6023/cjoc201908007.","doi":"10.6023/cjoc201908007","figContent":"yjhx-40-5-1266-1.jpg$$yjhx-40-5-1266-S1.jpg$$yjhx-40-5-1266-2.jpg$$yjhx-40-5-1266-S2.jpg","figList":["yjhx-40-5-1266-1.jpg","yjhx-40-5-1266-S1.jpg","yjhx-40-5-1266-2.jpg","yjhx-40-5-1266-S2.jpg"],"firstFig":"yjhx-40-5-1266-1.jpg","fpage":"1266","highCitedState":"","htmlCount":158,"htmlFile":"","id":"973275db-6a39-4260-bde1-6c70a2b197dc","issnPpub":"0253-2786","issue":"5","journalPublishId":"yjhx","journalReferenceCodeType":0,"journalTitleCn":"有机化学","journalTitleEn":"Chinese Journal of Organic Chemistry","keyword":"Tröger碱衍生物, 催化, 噻唑并[3, 2-a<\/i>]嘧啶衍生物, 抗肿瘤, 抑菌","keywordCn":"Tröger碱衍生物, 催化, 噻唑并[3, 2-a<\/i>]嘧啶衍生物, 抗肿瘤, 抑菌","keywordCnList":["Tröger碱衍生物"," 催化"," 噻唑并[3"," 2-a<\/i>]嘧啶衍生物"," 抗肿瘤"," 抑菌"],"keywordEn":"Tröger's base derivative, catalysis, thiazolo[3, 2-a<\/i>]pyrimidine derivative, anti-tumor, anti-bacterial","keywordEnList":["Tröger's base derivative"," catalysis"," thiazolo[3"," 2-a<\/i>]pyrimidine derivative"," anti-tumor"," anti-bacterial"],"keywordList":["Tröger碱衍生物"," 催化"," 噻唑并[3"," 2-a<\/i>]嘧啶衍生物"," 抗肿瘤"," 抑菌"],"language":"zh","latestInfo":"","latestState":"","latestStateEn":"","lpage":"1274","oldUrl":"http://sioc-journal.cn/Jwk_yjhx/CN/volumn/home.shtml","pdfDownCount":8,"pdfSize":1227.87,"pubDate":"2020-05-25","recommendState":"","releaseState":"1","secCount":0,"title":"多取代-5-氨基-3, 7-二苯基-7H<\/i>-噻唑并[3, 2-a<\/i>]嘧啶-6-腈衍生物的合成及生物活性","titleCn":"多取代-5-氨基-3, 7-二苯基-7H<\/i>-噻唑并[3, 2-a<\/i>]嘧啶-6-腈衍生物的合成及生物活性","titleEn":"Synthesis and Biological Evaluation of Polysubstituted 5-Amino-3, 7-diphenyl-7H<\/i>-thiazolo[3, 2-a<\/i>]pyrimidine-6-carbonitriles","viewCount":1339,"volume":"40","year":2020},{"abstractInfo":"首次从软珊瑚共附生曲霉属真菌Aspergillus<\/i>sp.EGF15-0-3中分离得到可逆性胆碱酯酶抑制剂环戊烷倍半萜类化合物柳珊瑚酸（1<\/b>）及其类似物2-脱氧-2β<\/i>-羟基柳珊瑚酸（2<\/b>），并确定其结构.根据单菌株多次级代谢产物（OSMAC）策略和富营养化培养，在23种不同的培养基中首次应用全球天然产物分子网络（GNPS）检测1<\/b>和2<\/b>是否存在，并选出1<\/b>和2<\/b>的最佳培养基组成.结果表明，除马铃薯葡萄糖肉汤（PDB）培养基外，1<\/b>还存在其他6种培养基中，2<\/b>的含量在液体和大米培养基中不同，其中GPY+CaCO3<\/sub>培养基为1<\/b>和2<\/b>的最佳培养基.首次证实软珊瑚共附生曲霉属真菌EGF15-0-3是1<\/b>和2<\/b>的可能微生物来源，同时也验证了海洋无脊椎动物产生新颖的具有生物活性的次级代谢产物通常来自内生、附生、共生或环境微生物的假说.","abstractInfoCn":"首次从软珊瑚共附生曲霉属真菌Aspergillus<\/i> sp.EGF15-0-3中分离得到可逆性胆碱酯酶抑制剂环戊烷倍半萜类化合物柳珊瑚酸（1<\/b>）及其类似物2-脱氧-2β<\/i>-羟基柳珊瑚酸（2<\/b>），并确定其结构.根据单菌株多次级代谢产物（OSMAC）策略和富营养化培养，在23种不同的培养基中首次应用全球天然产物分子网络（GNPS）检测1<\/b>和2<\/b>是否存在，并选出1<\/b>和2<\/b>的最佳培养基组成.结果表明，除马铃薯葡萄糖肉汤（PDB）培养基外，1<\/b>还存在其他6种培养基中，2<\/b>的含量在液体和大米培养基中不同，其中GPY+CaCO3<\/sub>培养基为1<\/b>和2<\/b>的最佳培养基.首次证实软珊瑚共附生曲霉属真菌EGF15-0-3是1<\/b>和2<\/b>的可能微生物来源，同时也验证了海洋无脊椎动物产生新颖的具有生物活性的次级代谢产物通常来自内生、附生、共生或环境微生物的假说.","abstractInfoEn":"Subergorgic acid (1<\/b>), a cyclopentapentalane sesquiterpenoid and potential reversible cholinesterase inhibitor, and its analogue 2-deoxy-2β<\/i>-hydroxysubergorgic acid (2<\/b>) were first isolated from soft coral-<\/i>associated symbiotic and epiphytic fungus Aspergillus<\/i> sp. EGF15-0-3. Their structures were established by NMR and HRESIMS spectroscopic data. According to the strategy of one strain many compounds (OSMAC) and eutrophic culture, Global Natural Products Molecular Networking (GNPS) was applied to detect the presence of compounds 1<\/b> and 2<\/b> in 23 different media for optimal medium compositions. As a result, compound 1<\/b> was found in 6 different media besides potato dextrose broth (PDB) medium, the contents of 2<\/b> were different in the solid and liquid media, and the best medium for compounds 1<\/b> and 2<\/b> was GPY+CaCO3<\/sub>. It was demonstrated that the soft coral-associated symbiotic and epiphytic fungus Aspergillus<\/i> sp. EGF15-0-3 was the microbiological producer of compounds 1<\/b> and 2<\/b>. This work provided strong evidence to support the hypothesis that novel and bioactive secondary metabolites produced by marine invertebrates often come from endogenetic, epiphytic, symbiotic or environmental microorganisms.","articleNo":"","authorCnList":["冯婵"," 韦霞"," 胡金姗"," 王思玉"," 刘炳新"," 谢珍玉"," 荣莉"," 李小翚"," 张翠仙"],"authorEnList":["Feng Chan"," Wei Xia"," Hu Jinshan"," Wang Siyu"," Liu Bingxin"," Xie Zhenyu"," Rong Li"," Li Xiaohui"," Zhang Cuixian"],"authorList":["冯婵"," 韦霞"," 胡金姗"," 王思玉"," 刘炳新"," 谢珍玉"," 荣莉"," 李小翚"," 张翠仙"],"authors":"冯婵, 韦霞, 胡金姗, 王思玉, 刘炳新, 谢珍玉, 荣莉, 李小翚, 张翠仙","authorsCn":"冯婵, 韦霞, 胡金姗, 王思玉, 刘炳新, 谢珍玉, 荣莉, 李小翚, 张翠仙","authorsEn":"Feng Chan, Wei Xia, Hu Jinshan, Wang Siyu, Liu Bingxin, Xie Zhenyu, Rong Li, Li Xiaohui, Zhang Cuixian","categoryName":"研究论文","categoryNameCn":"研究论文","categoryNameEn":"Articles","citation":"冯婵, 韦霞, 胡金姗, 王思玉, 刘炳新, 谢珍玉, 荣莉, 李小翚, 张翠仙. 软珊瑚共附生真菌Aspergillus<\/i> sp.EGF15-0-3的柳珊瑚酸类代谢产物研究. 有机化学, 2020, 40(5): 1275-1280. doi: 10.6023/cjoc201911040.","citationCn":"冯婵, 韦霞, 胡金姗, 王思玉, 刘炳新, 谢珍玉, 荣莉, 李小翚, 张翠仙. 软珊瑚共附生真菌Aspergillus<\/i> sp.EGF15-0-3的柳珊瑚酸类代谢产物研究. 有机化学, 2020, 40(5): 1275-1280. doi: 10.6023/cjoc201911040.","citationEn":"冯婵, 韦霞, 胡金姗, 王思玉, 刘炳新, 谢珍玉, 荣莉, 李小翚, 张翠仙. Researches on the Subergane-Type Sesquiterpenes from the Soft Coral-Derived Fungus Aspergillus<\/i> sp. EGF15-0-3. Chinese Journal of Organic Chemistry, 2020, 40(5): 1275-1280. doi: 10.6023/cjoc201911040.","doi":"10.6023/cjoc201911040","figContent":"yjhx-40-5-1275-1.jpg$$yjhx-40-5-1275-2.jpg$$yjhx-40-5-1275-3.jpg","figList":["yjhx-40-5-1275-1.jpg","yjhx-40-5-1275-2.jpg","yjhx-40-5-1275-3.jpg"],"firstFig":"yjhx-40-5-1275-1.jpg","fpage":"1275","highCitedState":"","htmlCount":222,"htmlFile":"","id":"fb8581c2-b214-453c-bbc9-3fb4f2d4afb3","issnPpub":"0253-2786","issue":"5","journalPublishId":"yjhx","journalReferenceCodeType":0,"journalTitleCn":"有机化学","journalTitleEn":"Chinese Journal of Organic Chemistry","keyword":"软珊瑚附生真菌, 曲霉属真菌Aspergillus<\/i> sp.EGF15-0-3, 柳珊瑚酸, GNPS","keywordCn":"软珊瑚附生真菌, 曲霉属真菌Aspergillus<\/i> sp.EGF15-0-3, 柳珊瑚酸, GNPS","keywordCnList":["软珊瑚附生真菌"," 曲霉属真菌Aspergillus<\/i> sp.EGF15-0-3"," 柳珊瑚酸"," GNPS"],"keywordEn":"soft coral-<\/i>associated symbiotic and epiphytic fungus, Aspergillus<\/i> sp.EGF15-0-3, subergorgic acid, GNPS","keywordEnList":["soft coral-<\/i>associated symbiotic and epiphytic fungus"," Aspergillus<\/i> sp.EGF15-0-3"," subergorgic acid"," GNPS"],"keywordList":["软珊瑚附生真菌"," 曲霉属真菌Aspergillus<\/i> sp.EGF15-0-3"," 柳珊瑚酸"," GNPS"],"language":"zh","latestInfo":"","latestState":"","latestStateEn":"","lpage":"1280","oldUrl":"http://sioc-journal.cn/Jwk_yjhx/CN/volumn/home.shtml","pdfDownCount":14,"pdfSize":6963.25,"pubDate":"2020-05-25","recommendState":"","releaseState":"1","secCount":0,"title":"软珊瑚共附生真菌Aspergillus<\/i> sp.EGF15-0-3的柳珊瑚酸类代谢产物研究","titleCn":"软珊瑚共附生真菌Aspergillus<\/i> sp.EGF15-0-3的柳珊瑚酸类代谢产物研究","titleEn":"Researches on the Subergane-Type Sesquiterpenes from the Soft Coral-Derived Fungus Aspergillus<\/i> sp. EGF15-0-3","viewCount":1528,"volume":"40","year":2020},{"abstractInfo":"研究了1-苯甲酰基-3，4-二氢异喹啉生物碱的一条新的合成路线.以3，4-二甲氧基苯甲醛为起始原料，通过6步反应，以50%的总收率首次全合成得到生物碱Nelumstemine；另外，以香兰醛为起始原料，通过9步反应，以35%的总收率首次全合成得到生物碱Longifolonine.上述全合成的关键步骤为，可见光照射下1-苄基-3，4-二氢异喹啉在室温下被空气氧化为1-苯甲酰基-3，4-二氢异喹啉的反应，并对此温和的光化学反应进行了详细研究.","abstractInfoCn":"研究了1-苯甲酰基-3，4-二氢异喹啉生物碱的一条新的合成路线.以3，4-二甲氧基苯甲醛为起始原料，通过6步反应，以50%的总收率首次全合成得到生物碱Nelumstemine；另外，以香兰醛为起始原料，通过9步反应，以35%的总收率首次全合成得到生物碱Longifolonine.上述全合成的关键步骤为，可见光照射下1-苄基-3，4-二氢异喹啉在室温下被空气氧化为1-苯甲酰基-3，4-二氢异喹啉的反应，并对此温和的光化学反应进行了详细研究.","abstractInfoEn":"A novel synthetic route for the total syntheses of 1-benzoyl-3, 4-dihydroisoquinoline alkaloids was developed. Nelumstemine was synthesized for the first time via 6 steps in 50% overall yield starting from 3, 4-dimethoxybenzaldehyde, and longifolonine was also synthesized for the first time via 9 steps in 35% overall yield starting from vanillin. The key step of these total syntheses is photo-oxidation of 1-benzyl-3, 4-dihydroisoquinolines to 1-benzoyl-3, 4-dihydroisoquinolines by air under visible-light irradiation at room temperature. The unique mild photo-oxidation of 1-benzyl-3, 4-dihydro-isoquinolines has been studied in detail.","articleNo":"","authorCnList":["黄永康"," 解文静"," 罗永强"," 范琪琦"," 朱星亮"," 刘世领"," 施小新"],"authorEnList":["Huang Yongkang"," Xie Wenjing"," Luo Yongqiang"," Fan Qiqi"," Zhu Xingliang"," Liu Shiling"," Shi Xiaoxin"],"authorList":["黄永康"," 解文静"," 罗永强"," 范琪琦"," 朱星亮"," 刘世领"," 施小新"],"authors":"黄永康, 解文静, 罗永强, 范琪琦, 朱星亮, 刘世领, 施小新","authorsCn":"黄永康, 解文静, 罗永强, 范琪琦, 朱星亮, 刘世领, 施小新","authorsEn":"Huang Yongkang, Xie Wenjing, Luo Yongqiang, Fan Qiqi, Zhu Xingliang, Liu Shiling, Shi Xiaoxin","categoryName":"研究论文","categoryNameCn":"研究论文","categoryNameEn":"Articles","citation":"黄永康, 解文静, 罗永强, 范琪琦, 朱星亮, 刘世领, 施小新. 基于光氧化反应的1-苯甲酰基-3, 4-二氢异喹啉类生物碱Nelumstemine和Longifolonine的首次全合成. 有机化学, 2020, 40(5): 1281-1289. doi: 10.6023/cjoc201912002.","citationCn":"黄永康, 解文静, 罗永强, 范琪琦, 朱星亮, 刘世领, 施小新. 基于光氧化反应的1-苯甲酰基-3, 4-二氢异喹啉类生物碱Nelumstemine和Longifolonine的首次全合成. 有机化学, 2020, 40(5): 1281-1289. doi: 10.6023/cjoc201912002.","citationEn":"黄永康, 解文静, 罗永强, 范琪琦, 朱星亮, 刘世领, 施小新. First Total Syntheses of 1-Benzoyl-3, 4-dihydroisoquinoline Alkaloids Nelumstemine and Longifolonine Based on the Photo-oxidation. Chinese Journal of Organic Chemistry, 2020, 40(5): 1281-1289. doi: 10.6023/cjoc201912002.","doi":"10.6023/cjoc201912002","figContent":"yjhx-40-5-1281-1.jpg$$yjhx-40-5-1281-S1.jpg$$yjhx-40-5-1281-S2.jpg$$yjhx-40-5-1281-S3.jpg$$yjhx-40-5-1281-S4.jpg","figList":["yjhx-40-5-1281-1.jpg","yjhx-40-5-1281-S1.jpg","yjhx-40-5-1281-S2.jpg","yjhx-40-5-1281-S3.jpg","yjhx-40-5-1281-S4.jpg"],"firstFig":"yjhx-40-5-1281-1.jpg","fpage":"1281","highCitedState":"","htmlCount":289,"htmlFile":"","id":"df1425bd-76c2-4924-a62a-a97167780a7a","issnPpub":"0253-2786","issue":"5","journalPublishId":"yjhx","journalReferenceCodeType":0,"journalTitleCn":"有机化学","journalTitleEn":"Chinese Journal of Organic Chemistry","keyword":"苯甲酰基二氢异喹啉生物碱, 光氧化, Nelumstemine, Longifolonine","keywordCn":"苯甲酰基二氢异喹啉生物碱, 光氧化, Nelumstemine, Longifolonine","keywordCnList":["苯甲酰基二氢异喹啉生物碱"," 光氧化"," Nelumstemine"," Longifolonine"],"keywordEn":"benzoyl dihydroisoquinoline alkaloids, photo-oxygenation, nelumstemine, longifolonine","keywordEnList":["benzoyl dihydroisoquinoline alkaloids"," photo-oxygenation"," nelumstemine"," longifolonine"],"keywordList":["苯甲酰基二氢异喹啉生物碱"," 光氧化"," Nelumstemine"," Longifolonine"],"language":"zh","latestInfo":"","latestState":"","latestStateEn":"","lpage":"1289","oldUrl":"http://sioc-journal.cn/Jwk_yjhx/CN/volumn/home.shtml","pdfDownCount":9,"pdfSize":550.91,"pubDate":"2020-05-25","recommendState":"","releaseState":"1","secCount":0,"title":"基于光氧化反应的1-苯甲酰基-3, 4-二氢异喹啉类生物碱Nelumstemine和Longifolonine的首次全合成","titleCn":"基于光氧化反应的1-苯甲酰基-3, 4-二氢异喹啉类生物碱Nelumstemine和Longifolonine的首次全合成","titleEn":"First Total Syntheses of 1-Benzoyl-3, 4-dihydroisoquinoline Alkaloids Nelumstemine and Longifolonine Based on the Photo-oxidation","viewCount":1811,"volume":"40","year":2020},{"abstractInfo":"以丙炔酸、仲胺、烷基醛和甲醛为试剂，在过渡金属铜催化下高效地构建了一系列非对称1，4-二氨基-2-丁炔化合物.该多组分一锅二步方法历经A3<\/sup>-脱羧偶联生成关键中间体炔丙胺，随后该中间体加成到原位形成的亚胺离子上，最终以中等到优异的产率得到交叉偶联产物.该策略成功地将脂肪族仲胺引入到反应体系中，具有底物胺兼容性较好的特点.","abstractInfoCn":"以丙炔酸、仲胺、烷基醛和甲醛为试剂，在过渡金属铜催化下高效地构建了一系列非对称1，4-二氨基-2-丁炔化合物.该多组分一锅二步方法历经A3<\/sup>-脱羧偶联生成关键中间体炔丙胺，随后该中间体加成到原位形成的亚胺离子上，最终以中等到优异的产率得到交叉偶联产物.该策略成功地将脂肪族仲胺引入到反应体系中，具有底物胺兼容性较好的特点.","abstractInfoEn":"A highly selective and efficient copper-catalyzed sequential approach for the one-pot two-step synthesis of unsymmetrical 1, 4-diamino-2-butynes from propiolic acid, secondary alkylamine, aldehyde and formaldehyde solution has been developed. The process of this reaction was involved in the generation of key intermediate propargylamines which were obtained via decarboxylative A3<\/sup>-coupling reaction. After that, the intermediate propargylamines would react with in situ<\/i> formed iminium ions to give the cross-coupling target products in moderate to excellent yields under microwave irradiation.","articleNo":"","authorCnList":["刘博瑜"," 徐仙君"," 黄立梁"," 冯煌迪"],"authorEnList":["Liu Boyu"," Xu Xianjun"," Huang Liliang"," Feng Huangdi"],"authorList":["刘博瑜"," 徐仙君"," 黄立梁"," 冯煌迪"],"authors":"刘博瑜, 徐仙君, 黄立梁, 冯煌迪","authorsCn":"刘博瑜, 徐仙君, 黄立梁, 冯煌迪","authorsEn":"Liu Boyu, Xu Xianjun, Huang Liliang, Feng Huangdi","categoryName":"研究论文","categoryNameCn":"研究论文","categoryNameEn":"Articles","citation":"刘博瑜, 徐仙君, 黄立梁, 冯煌迪. 铜(I)催化丙炔酸、仲胺、醛和甲醛一锅法交叉偶联构建非对称1, 4-二氨基丁炔. 有机化学, 2020, 40(5): 1290-1296. doi: 10.6023/cjoc201911020.","citationCn":"刘博瑜, 徐仙君, 黄立梁, 冯煌迪. 铜(I)催化丙炔酸、仲胺、醛和甲醛一锅法交叉偶联构建非对称1, 4-二氨基丁炔. 有机化学, 2020, 40(5): 1290-1296. doi: 10.6023/cjoc201911020.","citationEn":"刘博瑜, 徐仙君, 黄立梁, 冯煌迪. One-Pot Synthesis of Unsymmetrical 1, 4-Diaminobutynes by Cu(I)-Catalyzed Cross-Coupling of Propiolic Acid, Secondary Amine, Aldehydes and Formaldehyde. Chinese Journal of Organic Chemistry, 2020, 40(5): 1290-1296. doi: 10.6023/cjoc201911020.","doi":"10.6023/cjoc201911020","figContent":"yjhx-40-5-1290-S1.jpg$$yjhx-40-5-1290-S2.jpg$$yjhx-40-5-1290-S3.jpg","figList":["yjhx-40-5-1290-S1.jpg","yjhx-40-5-1290-S2.jpg","yjhx-40-5-1290-S3.jpg"],"firstFig":"yjhx-40-5-1290-S1.jpg","fpage":"1290","highCitedState":"","htmlCount":243,"htmlFile":"","id":"a3bebcea-a1a6-470b-8329-abba33afc95e","issnPpub":"0253-2786","issue":"5","journalPublishId":"yjhx","journalReferenceCodeType":0,"journalTitleCn":"有机化学","journalTitleEn":"Chinese Journal of Organic Chemistry","keyword":"非对称二氨基丁炔, 脱羧偶联, A3<\/sup>-偶联, 交叉偶联, 铜催化","keywordCn":"非对称二氨基丁炔, 脱羧偶联, A3<\/sup>-偶联, 交叉偶联, 铜催化","keywordCnList":["非对称二氨基丁炔"," 脱羧偶联"," A3<\/sup>-偶联"," 交叉偶联"," 铜催化"],"keywordEn":"unsymmetrical diaminobutynes, decarboxylative coupling, A3<\/sup>-coupling, cross-coupling, copper-catalyzed","keywordEnList":["unsymmetrical diaminobutynes"," decarboxylative coupling"," A3<\/sup>-coupling"," cross-coupling"," copper-catalyzed"],"keywordList":["非对称二氨基丁炔"," 脱羧偶联"," A3<\/sup>-偶联"," 交叉偶联"," 铜催化"],"language":"zh","latestInfo":"","latestState":"","latestStateEn":"","lpage":"1296","oldUrl":"http://sioc-journal.cn/Jwk_yjhx/CN/volumn/home.shtml","pdfDownCount":9,"pdfSize":506.04,"pubDate":"2020-05-25","recommendState":"","releaseState":"1","secCount":0,"title":"铜(I)催化丙炔酸、仲胺、醛和甲醛一锅法交叉偶联构建非对称1, 4-二氨基丁炔","titleCn":"铜(I)催化丙炔酸、仲胺、醛和甲醛一锅法交叉偶联构建非对称1, 4-二氨基丁炔","titleEn":"One-Pot Synthesis of Unsymmetrical 1, 4-Diaminobutynes by Cu(I)-Catalyzed Cross-Coupling of Propiolic Acid, Secondary Amine, Aldehydes and Formaldehyde","viewCount":1632,"volume":"40","year":2020},{"abstractInfo":"4-烷基汉斯酯是一种很好的烷基自由基储存体.研究了4-烷基汉斯酯和Baylis-Hillman加成物在光催化氧化还原条件下制备多取代的α<\/i>，β<\/i>-不饱和羧酸酯.该反应条件温和，无需额外添加剂，偶联产物收率中等到良好.","abstractInfoCn":"4-烷基汉斯酯是一种很好的烷基自由基储存体.研究了4-烷基汉斯酯和Baylis-Hillman加成物在光催化氧化还原条件下制备多取代的α<\/i>，β<\/i>-不饱和羧酸酯.该反应条件温和，无需额外添加剂，偶联产物收率中等到良好.","abstractInfoEn":"4-Alkyl Hasntzch esters are good alkyl radical storage. The preparation of multisubstituted α<\/i>, β<\/i>-unsaturated carboxylic acid esters under photocatalytic redox conditions by 4-alkyl Hantzsch esters and Baylis-Hillman adducts was investigated. The reaction conditions are mild and no additional additives are required. The coupling products were obtained in moderate to good yields.","articleNo":"","authorCnList":["陈跃峰"," 赵赫"," 程冬萍"," 李小年"," 许孝良"],"authorEnList":["Chen Yuefeng"," Zhao He"," Cheng Dongping"," Li Xiaonian"," Xu Xiaoliang"],"authorList":["陈跃峰"," 赵赫"," 程冬萍"," 李小年"," 许孝良"],"authors":"陈跃峰, 赵赫, 程冬萍, 李小年, 许孝良","authorsCn":"陈跃峰, 赵赫, 程冬萍, 李小年, 许孝良","authorsEn":"Chen Yuefeng, Zhao He, Cheng Dongping, Li Xiaonian, Xu Xiaoliang","categoryName":"研究论文","categoryNameCn":"研究论文","categoryNameEn":"Articles","citation":"陈跃峰, 赵赫, 程冬萍, 李小年, 许孝良. 可见光催化的汉斯酯和Baylis-Hillman加成物的偶联反应研究. 有机化学, 2020, 40(5): 1297-1304. doi: 10.6023/cjoc201911024.","citationCn":"陈跃峰, 赵赫, 程冬萍, 李小年, 许孝良. 可见光催化的汉斯酯和Baylis-Hillman加成物的偶联反应研究. 有机化学, 2020, 40(5): 1297-1304. doi: 10.6023/cjoc201911024.","citationEn":"陈跃峰, 赵赫, 程冬萍, 李小年, 许孝良. Coupling of Hantzsch Esters with Baylis-Hillman Derivatives via Visible-Light Photoredox Catalysis. Chinese Journal of Organic Chemistry, 2020, 40(5): 1297-1304. doi: 10.6023/cjoc201911024.","doi":"10.6023/cjoc201911024","figContent":"yjhx-40-5-1297-S1.jpg$$yjhx-40-5-1297-S2.jpg$$yjhx-40-5-1297-S3.jpg","figList":["yjhx-40-5-1297-S1.jpg","yjhx-40-5-1297-S2.jpg","yjhx-40-5-1297-S3.jpg"],"firstFig":"yjhx-40-5-1297-S1.jpg","fpage":"1297","highCitedState":"","htmlCount":615,"htmlFile":"","id":"33547e9a-619a-4d71-a692-7f900870cc53","issnPpub":"0253-2786","issue":"5","journalPublishId":"yjhx","journalReferenceCodeType":0,"journalTitleCn":"有机化学","journalTitleEn":"Chinese Journal of Organic Chemistry","keyword":"可见光催化, 自由基加成, Baylis-Hillman加成物, 4-烷基汉斯酯","keywordCn":"可见光催化, 自由基加成, Baylis-Hillman加成物, 4-烷基汉斯酯","keywordCnList":["可见光催化"," 自由基加成"," Baylis-Hillman加成物"," 4-烷基汉斯酯"],"keywordEn":"visible light photocatalysis, radical addition, Baylis-Hillman adducts, 4-alkyl Hantzsch esters","keywordEnList":["visible light photocatalysis"," radical addition"," Baylis-Hillman adducts"," 4-alkyl Hantzsch esters"],"keywordList":["可见光催化"," 自由基加成"," Baylis-Hillman加成物"," 4-烷基汉斯酯"],"language":"zh","latestInfo":"","latestState":"","latestStateEn":"","lpage":"1304","oldUrl":"http://sioc-journal.cn/Jwk_yjhx/CN/volumn/home.shtml","pdfDownCount":27,"pdfSize":533.3,"pubDate":"2020-05-25","recommendState":"","releaseState":"1","secCount":0,"title":"可见光催化的汉斯酯和Baylis-Hillman加成物的偶联反应研究","titleCn":"可见光催化的汉斯酯和Baylis-Hillman加成物的偶联反应研究","titleEn":"Coupling of Hantzsch Esters with Baylis-Hillman Derivatives via Visible-Light Photoredox Catalysis","viewCount":2172,"volume":"40","year":2020},{"abstractInfo":"根据密度泛函理论，对分别以丙烯醛、丙醛、巴豆醛、正丁醛和异丁醛为共还原剂时，丙烯环氧化过程中可能存在的反应路径的能垒进行了理论计算，通过分析对比确定了最优反应路径为过氧酰基与丙烯进行自由基加成，然后分解为酯基自由基和环氧丙烷.此外得到了醛类的自氧化过程以及反应过程中的脱羧反应对环氧化反应有着一定影响的结论，与实验数据进行对比，二者结果比较相符.对共还原剂醛类的筛选具有一定的指导作用.","abstractInfoCn":"根据密度泛函理论，对分别以丙烯醛、丙醛、巴豆醛、正丁醛和异丁醛为共还原剂时，丙烯环氧化过程中可能存在的反应路径的能垒进行了理论计算，通过分析对比确定了最优反应路径为过氧酰基与丙烯进行自由基加成，然后分解为酯基自由基和环氧丙烷.此外得到了醛类的自氧化过程以及反应过程中的脱羧反应对环氧化反应有着一定影响的结论，与实验数据进行对比，二者结果比较相符.对共还原剂醛类的筛选具有一定的指导作用.","abstractInfoEn":"On the basis of density functional theory, theoretical calculation is conducted to obtain the free energy barriers of the reaction path, which may exist in the process of propylene epoxidation with co-reductant acrolein, propanal, crotonaldehyde, N<\/i>-butyl aldehyde and isobutyl aldehyde respectively. And the optimal reaction path was determined to be free radical addition of peroxy acyl and propylene through analysis and comparison. In addition, the conclusion that auto-oxidation process of aldehydes and the decarboxylation in the reaction process have a certain influence on the epoxidation reaction can be conducted, and the results are in good consistent with the experimental data. It has a certain guiding effect on the choosing of co-reducing aldehydes.","articleNo":"","authorCnList":["祁连山"," 王涛"," 魏永梅"," 田恒水"],"authorEnList":["Qi Lianshan"," Wang Tao"," Wei Yongmei"," Tian Hengshui"],"authorList":["祁连山"," 王涛"," 魏永梅"," 田恒水"],"authors":"祁连山, 王涛, 魏永梅, 田恒水","authorsCn":"祁连山, 王涛, 魏永梅, 田恒水","authorsEn":"Qi Lianshan, Wang Tao, Wei Yongmei, Tian Hengshui","categoryName":"研究论文","categoryNameCn":"研究论文","categoryNameEn":"Articles","citation":"祁连山, 王涛, 魏永梅, 田恒水. 共还原剂醛类对金属卟啉催化丙烯环氧化的作用研究. 有机化学, 2020, 40(5): 1305-1309. doi: 10.6023/cjoc201910028.","citationCn":"祁连山, 王涛, 魏永梅, 田恒水. 共还原剂醛类对金属卟啉催化丙烯环氧化的作用研究. 有机化学, 2020, 40(5): 1305-1309. doi: 10.6023/cjoc201910028.","citationEn":"祁连山, 王涛, 魏永梅, 田恒水. Study on the Effect of Co-reductant Aldehydes on Epoxidation of Propylene Catalyzed by Metalloporphyrins. Chinese Journal of Organic Chemistry, 2020, 40(5): 1305-1309. doi: 10.6023/cjoc201910028.","doi":"10.6023/cjoc201910028","figContent":"yjhx-40-5-1305-S1.jpg$$yjhx-40-5-1305-1.jpg$$yjhx-40-5-1305-2.jpg$$yjhx-40-5-1305-S2.jpg$$yjhx-40-5-1305-3.jpg$$yjhx-40-5-1305-4.jpg$$yjhx-40-5-1305-5.jpg","figList":["yjhx-40-5-1305-S1.jpg","yjhx-40-5-1305-1.jpg","yjhx-40-5-1305-2.jpg","yjhx-40-5-1305-S2.jpg","yjhx-40-5-1305-3.jpg","yjhx-40-5-1305-4.jpg","yjhx-40-5-1305-5.jpg"],"firstFig":"yjhx-40-5-1305-S1.jpg","fpage":"1305","highCitedState":"","htmlCount":335,"htmlFile":"","id":"a595d142-2d4b-4844-a509-efb37b84f68e","issnPpub":"0253-2786","issue":"5","journalPublishId":"yjhx","journalReferenceCodeType":0,"journalTitleCn":"有机化学","journalTitleEn":"Chinese Journal of Organic Chemistry","keyword":"理论计算, 丙烯环氧化, 共还原剂","keywordCn":"理论计算, 丙烯环氧化, 共还原剂","keywordCnList":["理论计算"," 丙烯环氧化"," 共还原剂"],"keywordEn":"theoretical calculation, propylene epoxidation, co-reductant","keywordEnList":["theoretical calculation"," propylene epoxidation"," co-reductant"],"keywordList":["理论计算"," 丙烯环氧化"," 共还原剂"],"language":"zh","latestInfo":"","latestState":"","latestStateEn":"","lpage":"1309","oldUrl":"http://sioc-journal.cn/Jwk_yjhx/CN/volumn/home.shtml","pdfDownCount":19,"pdfSize":1672.92,"pubDate":"2020-05-25","recommendState":"","releaseState":"1","secCount":0,"title":"共还原剂醛类对金属卟啉催化丙烯环氧化的作用研究","titleCn":"共还原剂醛类对金属卟啉催化丙烯环氧化的作用研究","titleEn":"Study on the Effect of Co-reductant Aldehydes on Epoxidation of Propylene Catalyzed by Metalloporphyrins","viewCount":1713,"volume":"40","year":2020},{"abstractInfo":"N<\/i>-氟代二苯磺酰亚胺（NFSI）的胺化反应已成为制备胺类化合物的重要方法，但利用它制备N<\/i>-烯基磺酰亚胺的方法不多.在磷酸氢二钠存在下，碳酸银和1，10-菲啰啉衍生物共同催化NFSI与丙炔酸酯或丙炔酰胺发生氢胺化反应，高选择性地生成顺式N<\/i>-烯基二苯磺酰亚胺类化合物，产率为35%~71%.","abstractInfoCn":"N<\/i>-氟代二苯磺酰亚胺（NFSI）的胺化反应已成为制备胺类化合物的重要方法，但利用它制备N<\/i>-烯基磺酰亚胺的方法不多.在磷酸氢二钠存在下，碳酸银和1，10-菲啰啉衍生物共同催化NFSI与丙炔酸酯或丙炔酰胺发生氢胺化反应，高选择性地生成顺式N<\/i>-烯基二苯磺酰亚胺类化合物，产率为35%~71%.","abstractInfoEn":"Amination using N<\/i>-fluorobenzenesulfonimide (NFSI) as nitrogen source has become an important route to prepare amines. However, there are few methods to prepare N<\/i>-vinyl sulfonimides using NFSI as nitrogen source. In the presence of Na2<\/sub>HPO4<\/sub>, the hydroamination of propiolates or propiolamides with N<\/i>-fluorobenzenesulfonimide (NFSI) was realized, where Ag2<\/sub>CO3<\/sub> and 1, 10-phenanthroline derivatives were added as catalysts. It leads to N<\/i>-vinyldibenzenesulfonimides in high selectivity of Z<\/i> isomers in the yields of 35%~71%.","articleNo":"","authorCnList":["任海平"," 田再文"," 李柯"," 张万轩"],"authorEnList":["Ren Haiping"," Tian Zaiwen"," Li Ke"," Zhang Wanxuan"],"authorList":["任海平"," 田再文"," 李柯"," 张万轩"],"authors":"任海平, 田再文, 李柯, 张万轩","authorsCn":"任海平, 田再文, 李柯, 张万轩","authorsEn":"Ren Haiping, Tian Zaiwen, Li Ke, Zhang Wanxuan","categoryName":"研究论文","categoryNameCn":"研究论文","categoryNameEn":"Articles","citation":"任海平, 田再文, 李柯, 张万轩. 碳酸银催化N<\/i>-氟代二苯磺酰亚胺与丙炔酸衍生物的氢胺化反应. 有机化学, 2020, 40(5): 1310-1315. doi: 10.6023/cjoc201912001.","citationCn":"任海平, 田再文, 李柯, 张万轩. 碳酸银催化N<\/i>-氟代二苯磺酰亚胺与丙炔酸衍生物的氢胺化反应. 有机化学, 2020, 40(5): 1310-1315. doi: 10.6023/cjoc201912001.","citationEn":"任海平, 田再文, 李柯, 张万轩. Hydroamination of Propiolic Derivatives with N<\/i>-Fluorobenzene-sulfonimide Catalyzed by Silver Carbonate. Chinese Journal of Organic Chemistry, 2020, 40(5): 1310-1315. doi: 10.6023/cjoc201912001.","doi":"10.6023/cjoc201912001","figContent":"yjhx-40-5-1310-S1.jpg","figList":["yjhx-40-5-1310-S1.jpg"],"firstFig":"yjhx-40-5-1310-S1.jpg","fpage":"1310","highCitedState":"","htmlCount":332,"htmlFile":"","id":"e019668f-5222-4a0e-b042-fff9518ec126","issnPpub":"0253-2786","issue":"5","journalPublishId":"yjhx","journalReferenceCodeType":0,"journalTitleCn":"有机化学","journalTitleEn":"Chinese Journal of Organic Chemistry","keyword":"碳酸银, N<\/i>-氟代二苯磺酰亚胺, N<\/i>-烯基二苯磺酰亚胺, 丙炔酸酯, 丙炔酰胺","keywordCn":"碳酸银, N<\/i>-氟代二苯磺酰亚胺, N<\/i>-烯基二苯磺酰亚胺, 丙炔酸酯, 丙炔酰胺","keywordCnList":["碳酸银"," N<\/i>-氟代二苯磺酰亚胺"," N<\/i>-烯基二苯磺酰亚胺"," 丙炔酸酯"," 丙炔酰胺"],"keywordEn":"silver carbonate, N<\/i>-fluorobenzenesulfonimide, N<\/i>-vinyldibenzenesulfonimide, propiolate, propiolamide","keywordEnList":["silver carbonate"," N<\/i>-fluorobenzenesulfonimide"," N<\/i>-vinyldibenzenesulfonimide"," propiolate"," propiolamide"],"keywordList":["碳酸银"," N<\/i>-氟代二苯磺酰亚胺"," N<\/i>-烯基二苯磺酰亚胺"," 丙炔酸酯"," 丙炔酰胺"],"language":"zh","latestInfo":"","latestState":"","latestStateEn":"","lpage":"1315","oldUrl":"http://sioc-journal.cn/Jwk_yjhx/CN/volumn/home.shtml","pdfDownCount":7,"pdfSize":457.37,"pubDate":"2020-05-25","recommendState":"","releaseState":"1","secCount":0,"title":"碳酸银催化N<\/i>-氟代二苯磺酰亚胺与丙炔酸衍生物的氢胺化反应","titleCn":"碳酸银催化N<\/i>-氟代二苯磺酰亚胺与丙炔酸衍生物的氢胺化反应","titleEn":"Hydroamination of Propiolic Derivatives with N<\/i>-Fluorobenzene-sulfonimide Catalyzed by Silver Carbonate","viewCount":1699,"volume":"40","year":2020},{"abstractInfo":"以DOT1L（Disruptoroftelomericsilencing1-like）抑制剂（8<\/b>）为母体结构，对其核心骨架三氮唑并噻二唑两端的取代基进行结构修饰，设计合成了两个系列的三氮唑并噻二唑类结构衍生物，并测试了化合物在浓度为50μmol/L时的DOT1L酶抑制活性.结果表明，所测化合物均表现出一定的酶抑制活性，其中N<\/i>，N<\/i>-二甲基-4-（6-甲基-[1,2,4]三唑并[3，4-b<\/i>][1,3,4]噻二唑-3-基）苯胺（14b<\/b>）和（R<\/i>）-{1-{{3-[4-（二甲基氨基）苯基]-[1,2,4]三唑并[3，4-b<\/i>][1,3,4]噻二唑-6-基叔丁基}甲基}哌啶-3-基}氨基甲酸叔丁酯（16a<\/b>）具有显著的DOT1L抑制活性，IC50<\/sub>值分别为7.37和7.84μmol/L，与阳性对照化合物8<\/b>的酶抑制活性相当.构效分析表明，当苯基连三氮唑并噻二唑部分占据S<\/i>-腺苷-L<\/i>-甲硫氨酸（SAM）结合位点时，R1<\/sup>为4-N<\/i>，N<\/i>-二甲基、分子尾部R2<\/sup>基团为疏水基团，适宜于分子与酶的结合，且其体积对活性影响较小.","abstractInfoCn":"以DOT1L（Disruptor of telomeric silencing 1-like）抑制剂（8<\/b>）为母体结构，对其核心骨架三氮唑并噻二唑两端的取代基进行结构修饰，设计合成了两个系列的三氮唑并噻二唑类结构衍生物，并测试了化合物在浓度为50 μmol/L时的DOT1L酶抑制活性.结果表明，所测化合物均表现出一定的酶抑制活性，其中N<\/i>，N<\/i>-二甲基-4-（6-甲基-[1, 2, 4]三唑并[3，4-b<\/i>][1, 3, 4]噻二唑-3-基）苯胺（14b<\/b>）和（R<\/i>）-{1-{{3-[4-（二甲基氨基）苯基]-[1, 2, 4]三唑并[3，4-b<\/i>][1, 3, 4]噻二唑-6-基叔丁基}甲基}哌啶-3-基}氨基甲酸叔丁酯（16a<\/b>）具有显著的DOT1L抑制活性，IC50<\/sub>值分别为7.37和7.84 μmol/L，与阳性对照化合物8<\/b>的酶抑制活性相当.构效分析表明，当苯基连三氮唑并噻二唑部分占据S<\/i>-腺苷-L<\/i>-甲硫氨酸（SAM）结合位点时，R1<\/sup>为4-N<\/i>，N<\/i>-二甲基、分子尾部R2<\/sup>基团为疏水基团，适宜于分子与酶的结合，且其体积对活性影响较小.","abstractInfoEn":"A series of novel derivatives containing triazolo-thiadiazole moiety have been synthesized by structural modifications on a lead disruptor of telomeric silencing 1-like (DOT1L) inhibitor 8<\/b>. All the compounds have been evaluated for their DOT1L inhibitory activities at the concentration of 50 μmol/L. The results showed that the tested compounds showed certain DOT1L inhibitory activities. Among them, N<\/i>, N<\/i>-dimethyl-4-(6-methyl-[1, 2, 4]triazolo[3, 4-b<\/i>] [1, 3, 4]thiadiazol-3-yl)aniline (14b<\/b>) and (R<\/i>)-tert<\/i>-butyl (1-((3-(4-(dimethylamino)phenyl)-[1, 2, 4]triazolo[3, 4-b] [1, 3, 4]thiadiazol-6-yl)methyl)-piperidin-3-yl)carba- mate (16a<\/b>) were the best ones with IC50<\/sub> values of 7.37 and 7.84 μmol/L, respectively, near that of the positive control 8<\/b>. The structure-activity analysis showed that when the triazolo-thiadiazole moiety occupied the binding-site of S<\/i>-adenosylmethionine (SAM) in DOT1L and R1<\/sup> group was 4-N<\/i>, N<\/i>-dimethyl, the hydrophobic substituents as the tailed R2<\/sup> groups would be accommodated into the DOT1L binding site, and the sizes of the substituents seemed no effects on their DOT1L inhibitory activities of the compounds.","articleNo":"","authorCnList":["徐晓明"," 郭思岐"," 张静"," 陈彦韬"," 康亚青"," 刘娜"," 刘俊芳"," 罗成"," 陈示洁"," 陈华"],"authorEnList":["Xu Xiaoming"," Guo Siqi"," Zhang Jing"," Chen Yantao"," Kang Yaqing"," Liu Na"," Liu Junfang"," Luo Cheng"," Chen Shijie"," Chen Hua"],"authorList":["徐晓明"," 郭思岐"," 张静"," 陈彦韬"," 康亚青"," 刘娜"," 刘俊芳"," 罗成"," 陈示洁"," 陈华"],"authors":"徐晓明, 郭思岐, 张静, 陈彦韬, 康亚青, 刘娜, 刘俊芳, 罗成, 陈示洁, 陈华","authorsCn":"徐晓明, 郭思岐, 张静, 陈彦韬, 康亚青, 刘娜, 刘俊芳, 罗成, 陈示洁, 陈华","authorsEn":"Xu Xiaoming, Guo Siqi, Zhang Jing, Chen Yantao, Kang Yaqing, Liu Na, Liu Junfang, Luo Cheng, Chen Shijie, Chen Hua","categoryName":"研究论文","categoryNameCn":"研究论文","categoryNameEn":"Articles","citation":"徐晓明, 郭思岐, 张静, 陈彦韬, 康亚青, 刘娜, 刘俊芳, 罗成, 陈示洁, 陈华. 三氮唑并噻二唑类DOT1L抑制剂的结构修饰及活性. 有机化学, 2020, 40(5): 1345-1354. doi: 10.6023/cjoc201911012.","citationCn":"徐晓明, 郭思岐, 张静, 陈彦韬, 康亚青, 刘娜, 刘俊芳, 罗成, 陈示洁, 陈华. 三氮唑并噻二唑类DOT1L抑制剂的结构修饰及活性. 有机化学, 2020, 40(5): 1345-1354. doi: 10.6023/cjoc201911012.","citationEn":"徐晓明, 郭思岐, 张静, 陈彦韬, 康亚青, 刘娜, 刘俊芳, 罗成, 陈示洁, 陈华. Structural Modifications of the Triazolo-thiadiazole Derivatives as DOT1L Inhibitors and Their Activities. Chinese Journal of Organic Chemistry, 2020, 40(5): 1345-1354. doi: 10.6023/cjoc201911012.","doi":"10.6023/cjoc201911012","figContent":"yjhx-40-5-1345-1.jpg$$yjhx-40-5-1345-2.jpg$$yjhx-40-5-1345-S1.jpg$$yjhx-40-5-1345-S2.jpg$$yjhx-40-5-1345-S3.jpg$$yjhx-40-5-1345-3.jpg","figList":["yjhx-40-5-1345-1.jpg","yjhx-40-5-1345-2.jpg","yjhx-40-5-1345-S1.jpg","yjhx-40-5-1345-S2.jpg","yjhx-40-5-1345-S3.jpg","yjhx-40-5-1345-3.jpg"],"firstFig":"yjhx-40-5-1345-1.jpg","fpage":"1345","highCitedState":"","htmlCount":229,"htmlFile":"","id":"729b29b1-f2d8-4360-ac79-7b6103c0cf56","issnPpub":"0253-2786","issue":"5","journalPublishId":"yjhx","journalReferenceCodeType":0,"journalTitleCn":"有机化学","journalTitleEn":"Chinese Journal of Organic Chemistry","keyword":"DOT1L抑制剂, 三氮唑并噻二唑, 结构改造, 疏水基团, 构效关系","keywordCn":"DOT1L抑制剂, 三氮唑并噻二唑, 结构改造, 疏水基团, 构效关系","keywordCnList":["DOT1L抑制剂"," 三氮唑并噻二唑"," 结构改造"," 疏水基团"," 构效关系"],"keywordEn":"DOT1L inhibitor, ttriazolo-thiadiazole, structural modification, hydrophobic substituent, structure-activity analysis","keywordEnList":["DOT1L inhibitor"," ttriazolo-thiadiazole"," structural modification"," hydrophobic substituent"," structure-activity analysis"],"keywordList":["DOT1L抑制剂"," 三氮唑并噻二唑"," 结构改造"," 疏水基团"," 构效关系"],"language":"zh","latestInfo":"","latestState":"","latestStateEn":"","lpage":"1354","oldUrl":"http://sioc-journal.cn/Jwk_yjhx/CN/volumn/home.shtml","pdfDownCount":14,"pdfSize":713.38,"pubDate":"2020-05-25","recommendState":"","releaseState":"1","secCount":0,"title":"三氮唑并噻二唑类DOT1L抑制剂的结构修饰及活性","titleCn":"三氮唑并噻二唑类DOT1L抑制剂的结构修饰及活性","titleEn":"Structural Modifications of the Triazolo-thiadiazole Derivatives as DOT1L Inhibitors and Their Activities","viewCount":1557,"volume":"40","year":2020}],"Articles":[{"abstractInfo":"Inthispaper,coppernanoparticles(CuNPs)weresynthesizedfromcoppersulfatebyhydrothermalmethodusinghydrazinehydrateasreducingagent.Theobtainedcatalystwascharacterizedbytransmissionelectronmicroscope(TEM)andX-raydiffraction(XRD),andsuccessfullyusedasheterogeneouscatalysttopromotethethree-componentcouplingreactionofphenylacetylene,amineandaldehydeinsolvent-free.UnderCuNPs(10mol%),110℃andreactiontime10h,thecatalystexhibitsexcellentcatalyticactivitywith88%yield.Itisworthnotingthatthecatalystsystemcanmaintainhighcatalyticactivitywithonlyaslightdecreaseafter4cycles(allisolatedyields>84%).Apropargylaminesyntheticmethodbythree-componentcouplingreactionwasprovidedpossessingtheadvantagesofsimplepost-treatmentprocedure,solvent-free,extensivesubstraterangeandgoodreusabilityofcatalyst.","abstractInfoCn":"以硫酸铜为原料，水合肼为还原剂，采用水热法合成了铜纳米粒子.用透射电子显微镜（TEM）和X射线衍射（XRD）对所得催化剂进行了表征，继而成功地将其用作非均相催化剂，促进了苯乙炔、胺和醛在无溶剂条件下的三组分偶联反应.在Cu NPs（10 mol%）、110℃、10 h反应条件下，催化剂表现出良好的催化活性，产率达88%.值得注意的是，经过4次循环使用后，催化剂体系的催化活性仅略有下降（分离产率>84%）.本研究结果提供了一种三组分偶联反应合成丙炔胺的方法，该方法具有后处理简单、无溶剂、底物范围广、催化剂可重复使用等优点.","abstractInfoEn":"In this paper, copper nanoparticles (Cu NPs) were synthesized from copper sulfate by hydrothermal method using hydrazine hydrate as reducing agent. The obtained catalyst was characterized by transmission electron microscope (TEM) and X-ray diffraction (XRD), and successfully used as heterogeneous catalyst to promote the three-component coupling reaction of phenylacetylene, amine and aldehyde in solvent-free. Under Cu NPs (10 mol%), 110℃ and reaction time 10 h, the catalyst exhibits excellent catalytic activity with 88% yield. It is worth noting that the catalyst system can maintain high catalytic activity with only a slight decrease after 4 cycles (all isolated yields >84%). A propargylamine synthetic method by three-component coupling reaction was provided possessing the advantages of simple post-treatment procedure, solvent-free, extensive substrate range and good reusability of catalyst.","articleNo":"","authorCnList":["史大鹏"," 段中余"],"authorEnList":["Shi Dapeng"," Duan Zhongyu"],"authorList":["Shi Dapeng"," Duan Zhongyu"],"authors":"Shi Dapeng, Duan Zhongyu","authorsCn":"史大鹏, 段中余","authorsEn":"Shi Dapeng, Duan Zhongyu","categoryName":"Articles","categoryNameCn":"研究论文","categoryNameEn":"Articles","citation":"Shi Dapeng, Duan Zhongyu. Propargylamine Synthesis via Three-Component Coupling Reaction Catalyzed by Recyclable Cu Nanoparticles under Solvent-Free Conditions. Chinese Journal of Organic Chemistry, 2020, 40(5): 1316-1322. doi: 10.6023/cjoc201912003.","citationCn":"Shi Dapeng, Duan Zhongyu. 可回收铜纳米颗粒在无溶剂下催化三组分偶联反应合成炔丙基胺. 有机化学, 2020, 40(5): 1316-1322. doi: 10.6023/cjoc201912003.","citationEn":"Shi Dapeng, Duan Zhongyu. Propargylamine Synthesis via Three-Component Coupling Reaction Catalyzed by Recyclable Cu Nanoparticles under Solvent-Free Conditions. Chinese Journal of Organic Chemistry, 2020, 40(5): 1316-1322. doi: 10.6023/cjoc201912003.","doi":"10.6023/cjoc201912003","figContent":"yjhx-40-5-1316-S1.jpg$$yjhx-40-5-1316-1.jpg$$yjhx-40-5-1316-2.jpg$$yjhx-40-5-1316-3.jpg$$yjhx-40-5-1316-S2.jpg","figList":["yjhx-40-5-1316-S1.jpg","yjhx-40-5-1316-1.jpg","yjhx-40-5-1316-2.jpg","yjhx-40-5-1316-3.jpg","yjhx-40-5-1316-S2.jpg"],"firstFig":"yjhx-40-5-1316-S1.jpg","fpage":"1316","highCitedState":"","htmlCount":183,"htmlFile":"","id":"e89ef16c-6134-4573-a654-787d406ed1a5","issnPpub":"0253-2786","issue":"5","journalPublishId":"yjhx","journalReferenceCodeType":0,"journalTitleCn":"有机化学","journalTitleEn":"Chinese Journal of Organic Chemistry","keyword":"copper nanoparticles, propargylamine, three-component coupling, solvent-free, recyclability","keywordCn":"铜纳米粒子, 炔丙基胺, 三组分偶联, 无溶剂, 可回收性","keywordCnList":["铜纳米粒子"," 炔丙基胺"," 三组分偶联"," 无溶剂"," 可回收性"],"keywordEn":"copper nanoparticles, propargylamine, three-component coupling, solvent-free, recyclability","keywordEnList":["copper nanoparticles"," propargylamine"," three-component coupling"," solvent-free"," recyclability"],"keywordList":["copper nanoparticles"," propargylamine"," three-component coupling"," solvent-free"," recyclability"],"language":"en","latestInfo":"","latestState":"","latestStateEn":"","lpage":"1322","oldUrl":"http://sioc-journal.cn/Jwk_yjhx/CN/volumn/home.shtml","pdfDownCount":16,"pdfSize":1777.09,"pubDate":"2020-05-25","recommendState":"","releaseState":"1","secCount":0,"title":"Propargylamine Synthesis via Three-Component Coupling Reaction Catalyzed by Recyclable Cu Nanoparticles under Solvent-Free Conditions","titleCn":"可回收铜纳米颗粒在无溶剂下催化三组分偶联反应合成炔丙基胺","titleEn":"Propargylamine Synthesis via Three-Component Coupling Reaction Catalyzed by Recyclable Cu Nanoparticles under Solvent-Free Conditions","viewCount":1411,"volume":"40","year":2020},{"abstractInfo":"Agreenandefficientnucleophilicadditionreactionoftrifluoromethylketonewithpyrazolonewasdevelopedunder\"onwater\"conditions,affordingpyrazolonesubstitutedtertiarytrifluoromethylalcoholsinhighyields.Theadvantagesofbeingcatalyst-free,columnchromatography-free,environmentallybenignandeasyworkupmakeitapromisingmethodforpreparationofavarietyofpyrazolonesubstitutedtertiarytrifluoromethylalcohols.","abstractInfoCn":"基于水相条件下发展了一种绿色高效的吡唑啉酮与三氟甲基酮的亲核加成的方法，且以高收率获得吡唑啉酮取代的叔三氟甲基醇类化合物.该方法具有的无催化剂、无色谱柱分离、环境友好以及易于后处理的优点使其在制备各种吡唑啉酮取代的叔三氟甲基醇类化合物中很有应用前景.","abstractInfoEn":"A green and efficient nucleophilic addition reaction of trifluoromethyl ketone with pyrazolone was developed under \"on water\" conditions, affording pyrazolone substituted tertiary trifluoromethyl alcohols in high yields. The advantages of being catalyst-free, column chromatography-free, environmentally benign and easy workup make it a promising method for preparation of a variety of pyrazolone substituted tertiary trifluoromethyl alcohols.","articleNo":"","authorCnList":["罗亮"," 曹晓梅"," 赖国伟"," 刘金香"," 罗海清"," 路东亮"," 张勇"],"authorEnList":["Luo Liang"," Cao Xiaomei"," Lai Guowei"," Liu Jinxiang"," Luo Haiqing"," Lu Dongliang"," Zhang Yong"],"authorList":["Luo Liang"," Cao Xiaomei"," Lai Guowei"," Liu Jinxiang"," Luo Haiqing"," Lu Dongliang"," Zhang Yong"],"authors":"Luo Liang, Cao Xiaomei, Lai Guowei, Liu Jinxiang, Luo Haiqing, Lu Dongliang, Zhang Yong","authorsCn":"罗亮, 曹晓梅, 赖国伟, 刘金香, 罗海清, 路东亮, 张勇","authorsEn":"Luo Liang, Cao Xiaomei, Lai Guowei, Liu Jinxiang, Luo Haiqing, Lu Dongliang, Zhang Yong","categoryName":"Articles","categoryNameCn":"研究论文","categoryNameEn":"Articles","citation":"Luo Liang, Cao Xiaomei, Lai Guowei, Liu Jinxiang, Luo Haiqing, Lu Dongliang, Zhang Yong. \"On Water\" Nucleophilic Addition of Pyrazolones to Trifluoromethyl Ketones. Chinese Journal of Organic Chemistry, 2020, 40(5): 1323-1330. doi: 10.6023/cjoc201910038.","citationCn":"Luo Liang, Cao Xiaomei, Lai Guowei, Liu Jinxiang, Luo Haiqing, Lu Dongliang, Zhang Yong. “水上”吡唑啉酮与三氟甲基酮的亲核加成. 有机化学, 2020, 40(5): 1323-1330. doi: 10.6023/cjoc201910038.","citationEn":"Luo Liang, Cao Xiaomei, Lai Guowei, Liu Jinxiang, Luo Haiqing, Lu Dongliang, Zhang Yong. \"On Water\" Nucleophilic Addition of Pyrazolones to Trifluoromethyl Ketones. Chinese Journal of Organic Chemistry, 2020, 40(5): 1323-1330. doi: 10.6023/cjoc201910038.","doi":"10.6023/cjoc201910038","figContent":"yjhx-40-5-1323-S1.jpg$$yjhx-40-5-1323-1.jpg","figList":["yjhx-40-5-1323-S1.jpg","yjhx-40-5-1323-1.jpg"],"firstFig":"yjhx-40-5-1323-S1.jpg","fpage":"1323","highCitedState":"","htmlCount":143,"htmlFile":"","id":"1b41c0b6-e3a0-408b-a343-663f1bf19861","issnPpub":"0253-2786","issue":"5","journalPublishId":"yjhx","journalReferenceCodeType":0,"journalTitleCn":"有机化学","journalTitleEn":"Chinese Journal of Organic Chemistry","keyword":"\"on water\" reaction, nucleophilic addition, pyrazolone, trifluoromethyl ketone","keywordCn":"“水上”反应, 亲核加成, 吡唑啉酮, 三氟甲基酮","keywordCnList":["“水上”反应"," 亲核加成"," 吡唑啉酮"," 三氟甲基酮"],"keywordEn":"\"on water\" reaction, nucleophilic addition, pyrazolone, trifluoromethyl ketone","keywordEnList":["\"on water\" reaction"," nucleophilic addition"," pyrazolone"," trifluoromethyl ketone"],"keywordList":["\"on water\" reaction"," nucleophilic addition"," pyrazolone"," trifluoromethyl ketone"],"language":"en","latestInfo":"","latestState":"","latestStateEn":"","lpage":"1330","oldUrl":"http://sioc-journal.cn/Jwk_yjhx/CN/volumn/home.shtml","pdfDownCount":8,"pdfSize":482.42,"pubDate":"2020-05-25","recommendState":"","releaseState":"1","secCount":0,"title":"\"On Water\" Nucleophilic Addition of Pyrazolones to Trifluoromethyl Ketones","titleCn":"“水上”吡唑啉酮与三氟甲基酮的亲核加成","titleEn":"\"On Water\" Nucleophilic Addition of Pyrazolones to Trifluoromethyl Ketones","viewCount":1078,"volume":"40","year":2020},{"abstractInfo":"Inthispaper,aconvenientmethodformulti-componentone-potsynthesisofN<\/i>,O<\/i>-acetalcompoundswasdeveloped,usingaromaticaldehyde,ureaandalcoholasmaterials,alcoholalsoassolventandD<\/i>-prolineascatalyst.AseriesofN<\/i>,O<\/i>-acetalcompoundsweresynthesizedingoodyieldsafterreactingfor30hatroomtemperature.","abstractInfoCn":"以芳香醛、脲和醇为原料，过量的醇为溶剂，D<\/i>-脯氨酸为催化剂，开发了一种简单的多组分一锅法合成N<\/i>，O<\/i>-缩醛化合物的方法.在室温下反应30 h后，以良好的收率合成了一系列N<\/i>，O<\/i>-缩醛化合物.","abstractInfoEn":"In this paper, a convenient method for multi-component one-pot synthesis of N<\/i>, O<\/i>-acetal compounds was developed, using aromatic aldehyde, urea and alcohol as materials, alcohol also as solvent and D<\/i>-proline as catalyst. A series of N<\/i>, O<\/i>-acetal compounds were synthesized in good yields after reacting for 30 h at room temperature.","articleNo":"","authorCnList":["兰金"," 谢宗波"," 杨江楠"," 孟佳"," 刘一帅"," 乐长高"],"authorEnList":["Lan Jin"," Xie Zongbo"," Yang Jiangnan"," Meng Jia"," Liu Yishuai"," Le Zhanggao"],"authorList":["Lan Jin"," Xie Zongbo"," Yang Jiangnan"," Meng Jia"," Liu Yishuai"," Le Zhanggao"],"authors":"Lan Jin, Xie Zongbo, Yang Jiangnan, Meng Jia, Liu Yishuai, Le Zhanggao","authorsCn":"兰金, 谢宗波, 杨江楠, 孟佳, 刘一帅, 乐长高","authorsEn":"Lan Jin, Xie Zongbo, Yang Jiangnan, Meng Jia, Liu Yishuai, Le Zhanggao","categoryName":"Articles","categoryNameCn":"研究论文","categoryNameEn":"Articles","citation":"Lan Jin, Xie Zongbo, Yang Jiangnan, Meng Jia, Liu Yishuai, Le Zhanggao. One-Pot Multi-component Synthesis of N<\/i>, O<\/i>-Acetal Compounds Catalyzed by D<\/i>-Proline at Room Temperature. Chinese Journal of Organic Chemistry, 2020, 40(5): 1331-1336. doi: 10.6023/cjoc201911010.","citationCn":"Lan Jin, Xie Zongbo, Yang Jiangnan, Meng Jia, Liu Yishuai, Le Zhanggao. 室温条件下“一锅多组分”脯氨酸催化合成N, O<\/i>-缩醛化合物. 有机化学, 2020, 40(5): 1331-1336. doi: 10.6023/cjoc201911010.","citationEn":"Lan Jin, Xie Zongbo, Yang Jiangnan, Meng Jia, Liu Yishuai, Le Zhanggao. One-Pot Multi-component Synthesis of N<\/i>, O<\/i>-Acetal Compounds Catalyzed by D<\/i>-Proline at Room Temperature. Chinese Journal of Organic Chemistry, 2020, 40(5): 1331-1336. doi: 10.6023/cjoc201911010.","doi":"10.6023/cjoc201911010","figContent":"yjhx-40-5-1331-1.jpg$$yjhx-40-5-1331-S1.jpg$$yjhx-40-5-1331-S2.jpg$$yjhx-40-5-1331-S3.jpg","figList":["yjhx-40-5-1331-1.jpg","yjhx-40-5-1331-S1.jpg","yjhx-40-5-1331-S2.jpg","yjhx-40-5-1331-S3.jpg"],"firstFig":"yjhx-40-5-1331-1.jpg","fpage":"1331","highCitedState":"","htmlCount":172,"htmlFile":"","id":"026a4f4e-d14e-48b3-b43c-bb23c69c2d5d","issnPpub":"0253-2786","issue":"5","journalPublishId":"yjhx","journalReferenceCodeType":0,"journalTitleCn":"有机化学","journalTitleEn":"Chinese Journal of Organic Chemistry","keyword":"D<\/i>-proline, N<\/i>, O<\/i>-acetal compounds, one-pot synthesis, room temperature","keywordCn":"D<\/i>-脯氨酸, N<\/i>, O<\/i>-缩醛化合物, 一锅法合成, 室温","keywordCnList":["D<\/i>-脯氨酸"," N<\/i>"," O<\/i>-缩醛化合物"," 一锅法合成"," 室温"],"keywordEn":"D<\/i>-proline, N<\/i>, O<\/i>-acetal compounds, one-pot synthesis, room temperature","keywordEnList":["D<\/i>-proline"," N<\/i>"," O<\/i>-acetal compounds"," one-pot synthesis"," room temperature"],"keywordList":["D<\/i>-proline"," N<\/i>"," O<\/i>-acetal compounds"," one-pot synthesis"," room temperature"],"language":"en","latestInfo":"","latestState":"","latestStateEn":"","lpage":"1336","oldUrl":"http://sioc-journal.cn/Jwk_yjhx/CN/volumn/home.shtml","pdfDownCount":9,"pdfSize":450.88,"pubDate":"2020-05-25","recommendState":"","releaseState":"1","secCount":0,"title":"One-Pot Multi-component Synthesis of N<\/i>, O<\/i>-Acetal Compounds Catalyzed by D<\/i>-Proline at Room Temperature","titleCn":"室温条件下“一锅多组分”脯氨酸催化合成N, O<\/i>-缩醛化合物","titleEn":"One-Pot Multi-component Synthesis of N<\/i>, O<\/i>-Acetal Compounds Catalyzed by D<\/i>-Proline at Room Temperature","viewCount":1129,"volume":"40","year":2020},{"abstractInfo":"Thecyclizationreactionbetween2-(arylvinyl)anilineandacetophenoneinpresenceofiodinewasreported,whichofferedanefficientandcosteffectivestrategytogenerate2-acylquinolinederivativesundermildandmetal-freeconditions.","abstractInfoCn":"报道了碘存在下2-（芳基乙烯基）苯胺和苯乙酮通过环化反应得到2-酰基喹啉的合成方法，该法反应条件温和、无需金属催化剂的存在，底物适用范围广，产率良好或适中，为多样化2-酰基喹啉衍生物的合成提供了一种有效途径.","abstractInfoEn":"The cyclization reaction between 2-(arylvinyl)aniline and acetophenone in presence of iodine was reported, which offered an efficient and cost effective strategy to generate 2-acylquinoline derivatives under mild and metal-free conditions.","articleNo":"","authorCnList":["杜兴鹏"," 张玺"," 候飞"," 刘小军"," 王喜存"," 权正军"],"authorEnList":["Du Xingpeng"," Zhang Xi"," Hou Fei"," Liu Xiaojun"," Wang Xicun"," Quan Zhengjun"],"authorList":["Du Xingpeng"," Zhang Xi"," Hou Fei"," Liu Xiaojun"," Wang Xicun"," Quan Zhengjun"],"authors":"Du Xingpeng, Zhang Xi, Hou Fei, Liu Xiaojun, Wang Xicun, Quan Zhengjun","authorsCn":"杜兴鹏, 张玺, 候飞, 刘小军, 王喜存, 权正军","authorsEn":"Du Xingpeng, Zhang Xi, Hou Fei, Liu Xiaojun, Wang Xicun, Quan Zhengjun","categoryName":"Articles","categoryNameCn":"研究论文","categoryNameEn":"Articles","citation":"Du Xingpeng, Zhang Xi, Hou Fei, Liu Xiaojun, Wang Xicun, Quan Zhengjun. Iodine-Mediated Synthesis of 2-Acylquinoline from Acetophenone and 2-(Arylvinyl)aniline. Chinese Journal of Organic Chemistry, 2020, 40(5): 1337-1344. doi: 10.6023/cjoc201911029.","citationCn":"Du Xingpeng, Zhang Xi, Hou Fei, Liu Xiaojun, Wang Xicun, Quan Zhengjun. 碘促进苯乙酮与2-(芳基乙烯基)苯胺反应合成2-酰基喹啉. 有机化学, 2020, 40(5): 1337-1344. doi: 10.6023/cjoc201911029.","citationEn":"Du Xingpeng, Zhang Xi, Hou Fei, Liu Xiaojun, Wang Xicun, Quan Zhengjun. Iodine-Mediated Synthesis of 2-Acylquinoline from Acetophenone and 2-(Arylvinyl)aniline. Chinese Journal of Organic Chemistry, 2020, 40(5): 1337-1344. doi: 10.6023/cjoc201911029.","doi":"10.6023/cjoc201911029","figContent":"yjhx-40-5-1337-S1.jpg$$yjhx-40-5-1337-S2.jpg","figList":["yjhx-40-5-1337-S1.jpg","yjhx-40-5-1337-S2.jpg"],"firstFig":"yjhx-40-5-1337-S1.jpg","fpage":"1337","highCitedState":"","htmlCount":138,"htmlFile":"","id":"ab725db7-dbcd-417b-bab0-4868325ae554","issnPpub":"0253-2786","issue":"5","journalPublishId":"yjhx","journalReferenceCodeType":0,"journalTitleCn":"有机化学","journalTitleEn":"Chinese Journal of Organic Chemistry","keyword":"2-(arylvinyl) aniline, acetophenone, 2-acylquinoline, metal-free","keywordCn":"2-(芳基乙烯基)苯胺, 苯乙酮, 2-酰基喹啉, 碘催化","keywordCnList":["2-(芳基乙烯基)苯胺"," 苯乙酮"," 2-酰基喹啉"," 碘催化"],"keywordEn":"2-(arylvinyl) aniline, acetophenone, 2-acylquinoline, metal-free","keywordEnList":["2-(arylvinyl) aniline"," acetophenone"," 2-acylquinoline"," metal-free"],"keywordList":["2-(arylvinyl) aniline"," acetophenone"," 2-acylquinoline"," metal-free"],"language":"en","latestInfo":"","latestState":"","latestStateEn":"","lpage":"1344","oldUrl":"http://sioc-journal.cn/Jwk_yjhx/CN/volumn/home.shtml","pdfDownCount":15,"pdfSize":463.91,"pubDate":"2020-05-25","recommendState":"","releaseState":"1","secCount":0,"title":"Iodine-Mediated Synthesis of 2-Acylquinoline from Acetophenone and 2-(Arylvinyl)aniline","titleCn":"碘促进苯乙酮与2-(芳基乙烯基)苯胺反应合成2-酰基喹啉","titleEn":"Iodine-Mediated Synthesis of 2-Acylquinoline from Acetophenone and 2-(Arylvinyl)aniline","viewCount":1062,"volume":"40","year":2020}],"研究简报":[{"abstractInfo":"报道了一种在醋酸锰（Ⅲ）作用下，3-（2-萘基）-1-取代酰基硫脲自身发生环化反应，高效合成萘并[2，1-d<\/i>]噻唑类化合物的新方法.该方法具有操作简便、原子利用率高、对环境友好以及试剂价廉易得等优点.","abstractInfoCn":"报道了一种在醋酸锰（Ⅲ）作用下，3-（2-萘基）-1-取代酰基硫脲自身发生环化反应，高效合成萘并[2，1-d<\/i>]噻唑类化合物的新方法.该方法具有操作简便、原子利用率高、对环境友好以及试剂价廉易得等优点.","abstractInfoEn":"A new and efficient approach has been developed to synthesize 2-substituted acylamino naphtho[2, 1-d<\/i>]thiazole compounds through the reaction between 3-(2-naphthyl)-1-substituted acylthiourea and manganese(Ⅲ) acetate under ambient air. This reaction has the advantage of simple operation, high atom economy, environmentally friendly, and cheap reagents.","articleNo":"","authorCnList":["刘天宝"," 彭娜"," 王攀攀"," 彭艳芬"," 桂美芳"," 章敏"],"authorEnList":["Liu Tianbao"," Peng Na"," Wang Panpan"," Peng Yanfen"," Gui Meifang"," Zhang Min"],"authorList":["刘天宝"," 彭娜"," 王攀攀"," 彭艳芬"," 桂美芳"," 章敏"],"authors":"刘天宝, 彭娜, 王攀攀, 彭艳芬, 桂美芳, 章敏","authorsCn":"刘天宝, 彭娜, 王攀攀, 彭艳芬, 桂美芳, 章敏","authorsEn":"Liu Tianbao, Peng Na, Wang Panpan, Peng Yanfen, Gui Meifang, Zhang Min","categoryName":"研究简报","categoryNameCn":"研究简报","categoryNameEn":"Notes","citation":"刘天宝, 彭娜, 王攀攀, 彭艳芬, 桂美芳, 章敏. 一种新的萘并[2, 1-d<\/i>]噻唑类化合物的合成方法. 有机化学, 2020, 40(5): 1355-1360. doi: 10.6023/cjoc202001005.","citationCn":"刘天宝, 彭娜, 王攀攀, 彭艳芬, 桂美芳, 章敏. 一种新的萘并[2, 1-d<\/i>]噻唑类化合物的合成方法. 有机化学, 2020, 40(5): 1355-1360. doi: 10.6023/cjoc202001005.","citationEn":"刘天宝, 彭娜, 王攀攀, 彭艳芬, 桂美芳, 章敏. A New Method for Synthesis of Naphtho[2, 1-d<\/i>]thiazole Derivatives. Chinese Journal of Organic Chemistry, 2020, 40(5): 1355-1360. doi: 10.6023/cjoc202001005.","doi":"10.6023/cjoc202001005","figContent":"yjhx-40-5-1355-S1.jpg$$yjhx-40-5-1355-S2.jpg$$yjhx-40-5-1355-S3.jpg","figList":["yjhx-40-5-1355-S1.jpg","yjhx-40-5-1355-S2.jpg","yjhx-40-5-1355-S3.jpg"],"firstFig":"yjhx-40-5-1355-S1.jpg","fpage":"1355","highCitedState":"","htmlCount":273,"htmlFile":"","id":"895503c3-06bb-4c3c-8b9d-3fd1629bd2ca","issnPpub":"0253-2786","issue":"5","journalPublishId":"yjhx","journalReferenceCodeType":0,"journalTitleCn":"有机化学","journalTitleEn":"Chinese Journal of Organic Chemistry","keyword":"萘并[2, 1-d<\/i>]噻唑, 硫脲, 醋酸锰","keywordCn":"萘并[2, 1-d<\/i>]噻唑, 硫脲, 醋酸锰","keywordCnList":["萘并[2"," 1-d<\/i>]噻唑"," 硫脲"," 醋酸锰"],"keywordEn":"naphtho[2, 1-d<\/i>]thiazole, thiourea, manganese","keywordEnList":["naphtho[2"," 1-d<\/i>]thiazole"," thiourea"," manganese"],"keywordList":["萘并[2"," 1-d<\/i>]噻唑"," 硫脲"," 醋酸锰"],"language":"zh","latestInfo":"","latestState":"","latestStateEn":"","lpage":"1360","oldUrl":"http://sioc-journal.cn/Jwk_yjhx/CN/volumn/home.shtml","pdfDownCount":18,"pdfSize":510.67,"pubDate":"2020-05-25","recommendState":"","releaseState":"1","secCount":0,"title":"一种新的萘并[2, 1-d<\/i>]噻唑类化合物的合成方法","titleCn":"一种新的萘并[2, 1-d<\/i>]噻唑类化合物的合成方法","titleEn":"A New Method for Synthesis of Naphtho[2, 1-d<\/i>]thiazole Derivatives","viewCount":1664,"volume":"40","year":2020},{"abstractInfo":"由于d8<\/sup>和d10<\/sup>过渡金属具有配位不饱和性，其独特的电子结构以及易形成金属-金属键使其表现出特殊的光物理化学特性.而发光小分子的光学性质可通过主客体相互作用进行调控.为进一步探索主客体作用对d8<\/sup>和d10<\/sup>过渡金属配合物光学性质的影响，选择了葫芦[n<\/i>]脲（CB[n<\/i>]，n<\/i>=5~8，10）大环主体家族中具有最大空腔的成员葫芦[10<\/xref>]<\/sup>脲（CB[10]）作为主体，通过紫外、荧光、核磁和质谱等表征手段，研究了这类水溶性平面型过渡金属配合物进入主体空腔后的光物理性质的变化.研究表明，CB[10]的空腔可容纳多个Pt(Ⅱ)配合物分子，通过增强客体分子间的π-π相互作用，拉近了金属原子之间的距离，从而使其在水相中表现出金属-金属相互作用的特性.Ir(Ⅲ)配合物与CB[10]识别后，表现出激基缔合物的光谱特征.此外，水相中具有较强金属-金属相互作用的Rh(Ⅰ)配合物在进入CB[10]空腔后，其金属-金属相互作用被破坏，可归因于1：1主客体配合物的形成.此研究将主客体化学引入到d8<\/sup>和d10<\/sup>金属的光物理特性调控中，将进一步拓展过渡金属配合物在更广领域的研究应用.","abstractInfoCn":"由于d8<\/sup>和d10<\/sup>过渡金属具有配位不饱和性，其独特的电子结构以及易形成金属-金属键使其表现出特殊的光物理化学特性.而发光小分子的光学性质可通过主客体相互作用进行调控.为进一步探索主客体作用对d8<\/sup>和d10<\/sup>过渡金属配合物光学性质的影响，选择了葫芦[n<\/i>]脲（CB[n<\/i>]，n<\/i>=5~8，10）大环主体家族中具有最大空腔的成员葫芦[10<\/xref>]<\/sup>脲（CB[10]）作为主体，通过紫外、荧光、核磁和质谱等表征手段，研究了这类水溶性平面型过渡金属配合物进入主体空腔后的光物理性质的变化.研究表明，CB[10]的空腔可容纳多个Pt(Ⅱ)配合物分子，通过增强客体分子间的π-π相互作用，拉近了金属原子之间的距离，从而使其在水相中表现出金属-金属相互作用的特性.Ir(Ⅲ)配合物与CB[10]识别后，表现出激基缔合物的光谱特征.此外，水相中具有较强金属-金属相互作用的Rh(Ⅰ)配合物在进入CB[10]空腔后，其金属-金属相互作用被破坏，可归因于1：1主客体配合物的形成.此研究将主客体化学引入到d8<\/sup>和d10<\/sup>金属的光物理特性调控中，将进一步拓展过渡金属配合物在更广领域的研究应用.","abstractInfoEn":"Due to the coordination-unsaturation feature of d8<\/sup> and d10<\/sup> transition metals, their unique electronic structures and easy formation of metal-metal bonds make them exhibit special photophysical and photochemical properties. The optical properties of luminescent molecules can be regulated through host-guest interactions. In order to further explore the effect of host-guest interaction on the optical properties of d8<\/sup> and d10<\/sup> transition metal complexes, the member with the largest cavity in the macrocyclic family of cucurbit[n<\/i>]uril (CB[n<\/i>], n<\/i>=5~8, 10)-CB[10] was selected as host. The changes in photophysical properties of such water-soluble planar transition metal complexes after entering the host cavity were studied by means of UV/Vis, fluorescence, 1<\/sup>H NMR and mass spectra. The results show that the cavity of CB[10] can accommodate multiple Pt(Ⅱ) complex molecules. By enhancing the π-π interaction between guest molecules in the cavity of CB[10], the distance between metal atoms was shortened, leading the formation of metal-metal interactions in the water phase. Encapsulation of Ir(Ⅲ)complex in CB[10] causes the formation of excimer. In addition, strong metal-metal interactions between Rh(Ⅰ) complex molecules were weakened after the guest went into CB[10], which should be attributed to the formation of 1:1 host-guest complex. The introduction of host-guest chemistry in regulating photophysical properties of d8<\/sup> and d10<\/sup> metal complexes would further expand the application of transition metal complexes in a wider range of fields.","articleNo":"","authorCnList":["胡智雄"," 孙冬冬"," 韩勰"," 刘思敏"],"authorEnList":["Hu Zhixiong"," Sun Dongdong"," Han Xie"," Liu Simin"],"authorList":["胡智雄"," 孙冬冬"," 韩勰"," 刘思敏"],"authors":"胡智雄, 孙冬冬, 韩勰, 刘思敏","authorsCn":"胡智雄, 孙冬冬, 韩勰, 刘思敏","authorsEn":"Hu Zhixiong, Sun Dongdong, Han Xie, Liu Simin","categoryName":"研究简报","categoryNameCn":"研究简报","categoryNameEn":"Notes","citation":"胡智雄, 孙冬冬, 韩勰, 刘思敏. 平面型d8<\/sup>和d10<\/sup>过渡金属配合物与葫芦[10]脲的识别研究. 有机化学, 2020, 40(5): 1361-1366. doi: 10.6023/cjoc201912014.","citationCn":"胡智雄, 孙冬冬, 韩勰, 刘思敏. 平面型d8<\/sup>和d10<\/sup>过渡金属配合物与葫芦[10]脲的识别研究. 有机化学, 2020, 40(5): 1361-1366. doi: 10.6023/cjoc201912014.","citationEn":"胡智雄, 孙冬冬, 韩勰, 刘思敏. Molecular Recognition of Cucurbit[10]uril toward Planar d8<\/sup> and d10<\/sup> Transition Metal Complexes. Chinese Journal of Organic Chemistry, 2020, 40(5): 1361-1366. doi: 10.6023/cjoc201912014.","doi":"10.6023/cjoc201912014","figContent":"yjhx-40-5-1361-1.jpg$$yjhx-40-5-1361-2.jpg$$yjhx-40-5-1361-S1.jpg$$yjhx-40-5-1361-3.jpg$$yjhx-40-5-1361-4.jpg$$yjhx-40-5-1361-5.jpg$$yjhx-40-5-1361-6.jpg$$yjhx-40-5-1361-7.jpg$$yjhx-40-5-1361-8.jpg$$yjhx-40-5-1361-9.jpg$$yjhx-40-5-1361-10.jpg$$yjhx-40-5-1361-11.jpg$$yjhx-40-5-1361-12.jpg","figList":["yjhx-40-5-1361-1.jpg","yjhx-40-5-1361-2.jpg","yjhx-40-5-1361-S1.jpg","yjhx-40-5-1361-3.jpg","yjhx-40-5-1361-4.jpg","yjhx-40-5-1361-5.jpg","yjhx-40-5-1361-6.jpg","yjhx-40-5-1361-7.jpg","yjhx-40-5-1361-8.jpg","yjhx-40-5-1361-9.jpg","yjhx-40-5-1361-10.jpg","yjhx-40-5-1361-11.jpg","yjhx-40-5-1361-12.jpg"],"firstFig":"yjhx-40-5-1361-1.jpg","fpage":"1361","highCitedState":"","htmlCount":237,"htmlFile":"","id":"c99a5c6d-47c9-42eb-8dc3-d68e901443b0","issnPpub":"0253-2786","issue":"5","journalPublishId":"yjhx","journalReferenceCodeType":0,"journalTitleCn":"有机化学","journalTitleEn":"Chinese Journal of Organic Chemistry","keyword":"过渡金属配合物, 主客体作用, 葫芦[n<\/i>]脲, 包合物, 金属-金属相互作用","keywordCn":"过渡金属配合物, 主客体作用, 葫芦[n<\/i>]脲, 包合物, 金属-金属相互作用","keywordCnList":["过渡金属配合物"," 主客体作用"," 葫芦[n<\/i>]脲"," 包合物"," 金属-金属相互作用"],"keywordEn":"transition metal complex, host-guest interaction, cucurbit[n<\/i>]uril, inclusion complex, metal-metal interaction","keywordEnList":["transition metal complex"," host-guest interaction"," cucurbit[n<\/i>]uril"," inclusion complex"," metal-metal interaction"],"keywordList":["过渡金属配合物"," 主客体作用"," 葫芦[n<\/i>]脲"," 包合物"," 金属-金属相互作用"],"language":"zh","latestInfo":"","latestState":"","latestStateEn":"","lpage":"1366","oldUrl":"http://sioc-journal.cn/Jwk_yjhx/CN/volumn/home.shtml","pdfDownCount":7,"pdfSize":2721.53,"pubDate":"2020-05-25","recommendState":"","releaseState":"1","secCount":0,"title":"平面型d8<\/sup>和d10<\/sup>过渡金属配合物与葫芦[10]脲的识别研究","titleCn":"平面型d8<\/sup>和d10<\/sup>过渡金属配合物与葫芦[10]脲的识别研究","titleEn":"Molecular Recognition of Cucurbit[10]uril toward Planar d8<\/sup> and d10<\/sup> Transition Metal Complexes","viewCount":1427,"volume":"40","year":2020},{"abstractInfo":"卤代有机物给环境带来了严重的污染，有机卤代物的脱卤氢化不仅可以将卤代有机物转化为其它化学品，同时也可以降低其在环境领域的污染.以Pd/C为催化剂，以三乙胺作为碱、还原剂和氢源，报道了一种钯催化邻位三唑取代卤苯脱卤氢化反应.该方法具有反应体系简单、产物收率高和催化剂可回收等特点.","abstractInfoCn":"卤代有机物给环境带来了严重的污染，有机卤代物的脱卤氢化不仅可以将卤代有机物转化为其它化学品，同时也可以降低其在环境领域的污染.以Pd/C为催化剂，以三乙胺作为碱、还原剂和氢源，报道了一种钯催化邻位三唑取代卤苯脱卤氢化反应.该方法具有反应体系简单、产物收率高和催化剂可回收等特点.","abstractInfoEn":"The hydrodehalogenation of halogenated organic compounds which have brought serious pollution to the environment can not only transform them into other usefull chemicals, but also reduce their pollution in the field of environment. A Pd-catalyzed hydrodehalogenation of o<\/i>-triazole aryl halides is introduced, taking Pd/C as catalyst and Et3<\/sub>N as base, reductant and hydrogen source. This strategy is highlighted by appealing features such as simple reaction condition, recyclable catalyst, and good yield etc<\/i>.","articleNo":"","authorCnList":["邱会华"," 林白银"," 周鹏"," 张建涛"," 刘卫兵"],"authorEnList":["Qiu Huihua"," Lin Baiyin"," Zhou Peng"," Zhang Jiantao"," Liu Weibing"],"authorList":["邱会华"," 林白银"," 周鹏"," 张建涛"," 刘卫兵"],"authors":"邱会华, 林白银, 周鹏, 张建涛, 刘卫兵","authorsCn":"邱会华, 林白银, 周鹏, 张建涛, 刘卫兵","authorsEn":"Qiu Huihua, Lin Baiyin, Zhou Peng, Zhang Jiantao, Liu Weibing","categoryName":"研究简报","categoryNameCn":"研究简报","categoryNameEn":"Notes","citation":"邱会华, 林白银, 周鹏, 张建涛, 刘卫兵. 钯碳/三乙胺体系中邻位三唑取代芳基卤化物的脱卤氢化反应研究. 有机化学, 2020, 40(5): 1372-1377. doi: 10.6023/cjoc201912010.","citationCn":"邱会华, 林白银, 周鹏, 张建涛, 刘卫兵. 钯碳/三乙胺体系中邻位三唑取代芳基卤化物的脱卤氢化反应研究. 有机化学, 2020, 40(5): 1372-1377. doi: 10.6023/cjoc201912010.","citationEn":"邱会华, 林白银, 周鹏, 张建涛, 刘卫兵. Researches on the Hydrodehalogenation of o<\/i>-Triazole Aryl Halides in the System of Pd/C and Et3<\/sub>N. Chinese Journal of Organic Chemistry, 2020, 40(5): 1372-1377. doi: 10.6023/cjoc201912010.","doi":"10.6023/cjoc201912010","figContent":"yjhx-40-5-1372-S1.jpg$$yjhx-40-5-1372-S2.jpg$$yjhx-40-5-1372-S3.jpg$$yjhx-40-5-1372-S4.jpg$$yjhx-40-5-1372-S5.jpg","figList":["yjhx-40-5-1372-S1.jpg","yjhx-40-5-1372-S2.jpg","yjhx-40-5-1372-S3.jpg","yjhx-40-5-1372-S4.jpg","yjhx-40-5-1372-S5.jpg"],"firstFig":"yjhx-40-5-1372-S1.jpg","fpage":"1372","highCitedState":"","htmlCount":621,"htmlFile":"","id":"f56e5b0c-d0eb-4620-8d50-fcdec3a38d4c","issnPpub":"0253-2786","issue":"5","journalPublishId":"yjhx","journalReferenceCodeType":0,"journalTitleCn":"有机化学","journalTitleEn":"Chinese Journal of Organic Chemistry","keyword":"芳基卤化物, 脱卤氢化, 钯催化, 三唑, 三乙胺","keywordCn":"芳基卤化物, 脱卤氢化, 钯催化, 三唑, 三乙胺","keywordCnList":["芳基卤化物"," 脱卤氢化"," 钯催化"," 三唑"," 三乙胺"],"keywordEn":"aryl halides, hydrodehalogenation, Pd catalyzed, triazole, triethylamine","keywordEnList":["aryl halides"," hydrodehalogenation"," Pd catalyzed"," triazole"," triethylamine"],"keywordList":["芳基卤化物"," 脱卤氢化"," 钯催化"," 三唑"," 三乙胺"],"language":"zh","latestInfo":"","latestState":"","latestStateEn":"","lpage":"1377","oldUrl":"http://sioc-journal.cn/Jwk_yjhx/CN/volumn/home.shtml","pdfDownCount":33,"pdfSize":460.69,"pubDate":"2020-05-01","recommendState":"","releaseState":"1","secCount":0,"title":"钯碳/三乙胺体系中邻位三唑取代芳基卤化物的脱卤氢化反应研究","titleCn":"钯碳/三乙胺体系中邻位三唑取代芳基卤化物的脱卤氢化反应研究","titleEn":"Researches on the Hydrodehalogenation of o<\/i>-Triazole Aryl Halides in the System of Pd/C and Et3<\/sub>N","viewCount":2411,"volume":"40","year":2020},{"abstractInfo":"3-硒氰酸吲哚衍生物由于良好的生物活性，在药物研究方面具有潜在的应用价值.目前，关于3-硒氰酸吲哚的制备方法存在一定的不足，如反应条件苛刻、产率较低、底物适用性较差等.采用微波促进I2<\/sub>催化吲哚与硒氰酸钾的反应，制备了一系列3-硒氰酸吲哚衍生物.与已有方法相比，本方法具有反应速率快、产率高、原子经济性好等优点，为3-硒氰酸吲哚衍生物的制备提供高效的路径.","abstractInfoCn":"3-硒氰酸吲哚衍生物由于良好的生物活性，在药物研究方面具有潜在的应用价值.目前，关于3-硒氰酸吲哚的制备方法存在一定的不足，如反应条件苛刻、产率较低、底物适用性较差等.采用微波促进I2<\/sub>催化吲哚与硒氰酸钾的反应，制备了一系列3-硒氰酸吲哚衍生物.与已有方法相比，本方法具有反应速率快、产率高、原子经济性好等优点，为3-硒氰酸吲哚衍生物的制备提供高效的路径.","abstractInfoEn":"3-Selenocyanateindole derivatives have potential application in drug research due to their good biological activity. Until now, many methods for the synthesis of 3-selenocyanateindoles have been reported. However, drawbacks still exist, such as harsh reaction conditions, low yields and poor functional groups tolerance. A series of 3-selenocyanateindoles have been synthesized via the microwave-assisted 3-selenocyanation of indole derivatives by using 25 mol% iodine as catalyst, affording the corresponding products in good yields. Compared with the previous methods, this protocol has the advantages of rapid reaction, high yields and good atomic economy, providing an efficient route to 3-selenocyanateindole derivatives.","articleNo":"","authorCnList":["吴燕"," 田仙芝"," 张海玲"," 陈睿"," 曹团武"],"authorEnList":["Wu Yan"," Tian Xianzhi"," Zhang Hailing"," Chen Rui"," Cao Tuanwu"],"authorList":["吴燕"," 田仙芝"," 张海玲"," 陈睿"," 曹团武"],"authors":"吴燕, 田仙芝, 张海玲, 陈睿, 曹团武","authorsCn":"吴燕, 田仙芝, 张海玲, 陈睿, 曹团武","authorsEn":"Wu Yan, Tian Xianzhi, Zhang Hailing, Chen Rui, Cao Tuanwu","categoryName":"研究简报","categoryNameCn":"研究简报","categoryNameEn":"Notes","citation":"吴燕, 田仙芝, 张海玲, 陈睿, 曹团武. 微波促进I2<\/sub>催化吲哚3-硒氰酸化制备3-硒氰酸吲哚衍生物. 有机化学, 2020, 40(5): 1384-1387. doi: 10.6023/cjoc201910003.","citationCn":"吴燕, 田仙芝, 张海玲, 陈睿, 曹团武. 微波促进I2<\/sub>催化吲哚3-硒氰酸化制备3-硒氰酸吲哚衍生物. 有机化学, 2020, 40(5): 1384-1387. doi: 10.6023/cjoc201910003.","citationEn":"吴燕, 田仙芝, 张海玲, 陈睿, 曹团武. Microwave-Assisted Iodine-Catalyzed 3-Selenocyanation of Indole for the Synthesis of 3-Selenocyanateindole Derivatives. Chinese Journal of Organic Chemistry, 2020, 40(5): 1384-1387. doi: 10.6023/cjoc201910003.","doi":"10.6023/cjoc201910003","figContent":"yjhx-40-5-1384-1.jpg$$yjhx-40-5-1384-2.jpg","figList":["yjhx-40-5-1384-1.jpg","yjhx-40-5-1384-2.jpg"],"firstFig":"yjhx-40-5-1384-1.jpg","fpage":"1384","highCitedState":"","htmlCount":125,"htmlFile":"","id":"7998d5a7-d9d4-499c-b4fe-884fd8bb1f9e","issnPpub":"0253-2786","issue":"5","journalPublishId":"yjhx","journalReferenceCodeType":0,"journalTitleCn":"有机化学","journalTitleEn":"Chinese Journal of Organic Chemistry","keyword":"微波辅助反应, 碘催化硒氰酸化, 3-硒氰酸吲哚, 吲哚衍生物, 硒氰酸钾","keywordCn":"微波辅助反应, 碘催化硒氰酸化, 3-硒氰酸吲哚, 吲哚衍生物, 硒氰酸钾","keywordCnList":["微波辅助反应"," 碘催化硒氰酸化"," 3-硒氰酸吲哚"," 吲哚衍生物"," 硒氰酸钾"],"keywordEn":"microwave-assisted reaction, iodine-catalyzed selenocyanation, 3-selenocyanate iodines, iodine derivatives, potassium selenocyanate","keywordEnList":["microwave-assisted reaction"," iodine-catalyzed selenocyanation"," 3-selenocyanate iodines"," iodine derivatives"," potassium selenocyanate"],"keywordList":["微波辅助反应"," 碘催化硒氰酸化"," 3-硒氰酸吲哚"," 吲哚衍生物"," 硒氰酸钾"],"language":"zh","latestInfo":"","latestState":"","latestStateEn":"","lpage":"1387","oldUrl":"http://sioc-journal.cn/Jwk_yjhx/CN/volumn/home.shtml","pdfDownCount":6,"pdfSize":505.56,"pubDate":"2020-05-01","recommendState":"","releaseState":"1","secCount":0,"title":"微波促进I2<\/sub>催化吲哚3-硒氰酸化制备3-硒氰酸吲哚衍生物","titleCn":"微波促进I2<\/sub>催化吲哚3-硒氰酸化制备3-硒氰酸吲哚衍生物","titleEn":"Microwave-Assisted Iodine-Catalyzed 3-Selenocyanation of Indole for the Synthesis of 3-Selenocyanateindole Derivatives","viewCount":1172,"volume":"40","year":2020},{"abstractInfo":"1，1-二氯烯烃结构存在于许多天然产物中，同时也是一类重要的合成中间体，广泛应用于炔烃、卤代炔烃以及芳烃化合物的合成.报道了一个新的1，1-二氯烯烃化试剂：二氯甲基（2-吡啶基）砜.以叔丁醇钾作为碱，二氯甲基（2-吡啶基）砜与芳香醛顺利反应，以良好的产率制备得到了1，1-二氯烯烃化合物.该方法实验操作简便、试剂易得且纯化方便.","abstractInfoCn":"1，1-二氯烯烃结构存在于许多天然产物中，同时也是一类重要的合成中间体，广泛应用于炔烃、卤代炔烃以及芳烃化合物的合成.报道了一个新的1，1-二氯烯烃化试剂：二氯甲基（2-吡啶基）砜.以叔丁醇钾作为碱，二氯甲基（2-吡啶基）砜与芳香醛顺利反应，以良好的产率制备得到了1，1-二氯烯烃化合物.该方法实验操作简便、试剂易得且纯化方便.","abstractInfoEn":"The 1, 1-dichloroalkene structural unit is found in many natural products. 1, 1-Dichloroalkenes are important intermediates, which have been widely used in the synthesis of alkynes, halogenated acetylenes and aromatic compounds. In this paper, a new dichloroolefinating reagent, dichloromethyl 2-pyridyl sulfone, was reported. 1, 1-Dichloroalkenes can be conveniently obtained from the reaction of dichloromethyl 2-pyridyl sulfone with aromatic aldehydes using t<\/i>-BuOK as base. This method has the advantage of operational simplicity, usage of easily available reagents and easy purification, which may find applications in organic synthesis.","articleNo":"","authorCnList":["任新锋"," 宋小平"," 马影超"," 李亚"],"authorEnList":["Ren Xinfeng"," Song Xiaoping"," Ma Yingchao"," Li Ya"],"authorList":["任新锋"," 宋小平"," 马影超"," 李亚"],"authors":"任新锋, 宋小平, 马影超, 李亚","authorsCn":"任新锋, 宋小平, 马影超, 李亚","authorsEn":"Ren Xinfeng, Song Xiaoping, Ma Yingchao, Li Ya","categoryName":"研究简报","categoryNameCn":"研究简报","categoryNameEn":"Notes","citation":"任新锋, 宋小平, 马影超, 李亚. 一种1, 1-二氯烯烃化合物的新合成方法. 有机化学, 2020, 40(5): 1388-1393. doi: 10.6023/cjoc201910030.","citationCn":"任新锋, 宋小平, 马影超, 李亚. 一种1, 1-二氯烯烃化合物的新合成方法. 有机化学, 2020, 40(5): 1388-1393. doi: 10.6023/cjoc201910030.","citationEn":"任新锋, 宋小平, 马影超, 李亚. Method for the Synthesis of 1, 1-Dichloroalkenes. Chinese Journal of Organic Chemistry, 2020, 40(5): 1388-1393. doi: 10.6023/cjoc201910030.","doi":"10.6023/cjoc201910030","figContent":"yjhx-40-5-1388-1.jpg$$yjhx-40-5-1388-S1.jpg$$yjhx-40-5-1388-S3.jpg","figList":["yjhx-40-5-1388-1.jpg","yjhx-40-5-1388-S1.jpg","yjhx-40-5-1388-S3.jpg"],"firstFig":"yjhx-40-5-1388-1.jpg","fpage":"1388","highCitedState":"","htmlCount":220,"htmlFile":"","id":"e3d7bab4-a5ac-4fb8-9791-91526b92b2e0","issnPpub":"0253-2786","issue":"5","journalPublishId":"yjhx","journalReferenceCodeType":0,"journalTitleCn":"有机化学","journalTitleEn":"Chinese Journal of Organic Chemistry","keyword":"二氯甲基砜, 1, 1-二氯烯烃, 芳香醛","keywordCn":"二氯甲基砜, 1, 1-二氯烯烃, 芳香醛","keywordCnList":["二氯甲基砜"," 1"," 1-二氯烯烃"," 芳香醛"],"keywordEn":"dichloromethyl sulfone, 1, 1-dichloroalkenes, aromatic aldehydes","keywordEnList":["dichloromethyl sulfone"," 1"," 1-dichloroalkenes"," aromatic aldehydes"],"keywordList":["二氯甲基砜"," 1"," 1-二氯烯烃"," 芳香醛"],"language":"zh","latestInfo":"","latestState":"","latestStateEn":"","lpage":"1393","oldUrl":"http://sioc-journal.cn/Jwk_yjhx/CN/volumn/home.shtml","pdfDownCount":10,"pdfSize":433.79,"pubDate":"2020-05-01","recommendState":"","releaseState":"1","secCount":0,"title":"一种1, 1-二氯烯烃化合物的新合成方法","titleCn":"一种1, 1-二氯烯烃化合物的新合成方法","titleEn":"Method for the Synthesis of 1, 1-Dichloroalkenes","viewCount":1360,"volume":"40","year":2020}],"Notes":[{"abstractInfo":"Onenewcompound,namedhypoxoneA(1<\/b>),togetherwithtwonewnaturalproducts4,8-dimethoxy-1-naphthol(2<\/b>)and1'-hydroxy-4',8,8'-trimethoxy[2,2']binaphthalenyl-1,4-dione(3<\/b>),andfourteenknownderivatives4<\/b>~17<\/b>wereisolatedfromthebrothextractofthemarinefungusHypoxylonrubiginosum<\/i>FS521,whichwasisolatedfromadeep-seasedimentsample.Theirstructureswereelucidatedbyinterpretationofspectroscopicanalysisandcomparisonwithpreviouslypublisheddatafortheknownones.Moreover,compounds1<\/b>~4<\/b>wereevaluatedfortheirinvitro<\/i>cytotoxicactivitiesagainstSF-268,MCF-7,HepG-2,andA549tumorcelllines,andcompound3<\/b>exhibitedpotentcytotoxicactivitywithIC50<\/sub>valuesof1.85,3.21,2.53,and5.09mmol·L-1<\/sup>,respectively.","abstractInfoCn":"从海洋真菌赤褐炭团菌（Hypoxylon rubiginosum<\/i>）FS521中分离纯化得到17个聚酮类化合物，分别鉴定为4-乙酰氧基-8-甲氧基-3，4-二氢萘-1（2H<\/i>）-酮（1<\/b>）、4，8-二甲氧基-1-萘酚（2<\/b>）、1'-羟基-4'，8，8'-三甲氧基[2，2']联萘-1，4-二酮（3<\/b>）、3，6-dimethyl-atromentin（4<\/b>）、4-羟基-8-甲氧基-3，4-二氢萘-1（2H<\/i>）-酮（5<\/b>）、regiolone（6<\/b>）、methylsclerone（7<\/b>）、5-methylmellein（8<\/b>）、3，5-二甲基-8-甲氧基-3，4-二羟基异香豆素（9<\/b>）、9-甲氧基萘（10<\/b>）、1，8-二甲氧基萘（11<\/b>）、8-甲氧基-1-萘醇（12<\/b>）、7-甲氧基-3-甲基异苯并呋喃（13<\/b>）、3-甲基-4-羟基苯乙酸（14<\/b>）、nodulisporipyrone A（15<\/b>）、nodulisporipyrone B（16<\/b>）、3，4-二甲氧基-乙酰苯乙醇（17<\/b>）.其中化合物1<\/b>为新化合物，化合物2<\/b>和3<\/b>为新天然产物，新化合物的结构通过HRESIMS，1D NMR和2D NMR等光谱技术确定.此外，对分离所得的化合物1<\/b>~4<\/b>进行了体外细胞毒活性测试，结果表明化合物3<\/b>对SF-268、MCF-7、HepG-2、A549有较强的细胞毒活性，其IC50<\/sub>值分别为1.85、3.21、2.53、5.09 mmol·L-1<\/sup>.","abstractInfoEn":"One new compound, named hypoxone A (1<\/b>), together with two new natural products 4, 8-dimethoxy-1-naphthol (2<\/b>) and 1'-hydroxy-4', 8, 8'-trimethoxy[2, 2']binaphthalenyl-1, 4-dione (3<\/b>), and fourteen known derivatives 4<\/b>~17<\/b> were isolated from the broth extract of the marine fungus Hypoxylon rubiginosum<\/i> FS521, which was isolated from a deep-sea sediment sample. Their structures were elucidated by interpretation of spectroscopic analysis and comparison with previously published data for the known ones. Moreover, compounds 1<\/b>~4<\/b> were evaluated for their in vitro<\/i> cytotoxic activities against SF-268, MCF-7, HepG-2, and A549 tumor cell lines, and compound 3<\/b> exhibited potent cytotoxic activity with IC50<\/sub> values of 1.85, 3.21, 2.53, and 5.09 mmol·L-1<\/sup>, respectively.","articleNo":"","authorCnList":["张捷"," 陈玉婵"," 刘昭明"," 郭波红"," 高晓霞"," 刘洪新"," 章卫民"],"authorEnList":["Zhang Jie"," Chen Yuchan"," Liu Zhaoming"," Guo Bohong"," Gao Xiaoxia"," Liu Hongxin"," Zhang Weimin"],"authorList":["Zhang Jie"," Chen Yuchan"," Liu Zhaoming"," Guo Bohong"," Gao Xiaoxia"," Liu Hongxin"," Zhang Weimin"],"authors":"Zhang Jie, Chen Yuchan, Liu Zhaoming, Guo Bohong, Gao Xiaoxia, Liu Hongxin, Zhang Weimin","authorsCn":"张捷, 陈玉婵, 刘昭明, 郭波红, 高晓霞, 刘洪新, 章卫民","authorsEn":"Zhang Jie, Chen Yuchan, Liu Zhaoming, Guo Bohong, Gao Xiaoxia, Liu Hongxin, Zhang Weimin","categoryName":"Notes","categoryNameCn":"研究简报","categoryNameEn":"Notes","citation":"Zhang Jie, Chen Yuchan, Liu Zhaoming, Guo Bohong, Gao Xiaoxia, Liu Hongxin, Zhang Weimin. Cytotoxic Secondary Metabolites from a Sea-Derived Fungal Strain of Hypoxylon rubiginosum<\/i> FS521. Chinese Journal of Organic Chemistry, 2020, 40(5): 1367-1371. doi: 10.6023/cjoc201912012.","citationCn":"Zhang Jie, Chen Yuchan, Liu Zhaoming, Guo Bohong, Gao Xiaoxia, Liu Hongxin, Zhang Weimin. 海洋真菌赤褐炭团菌FS521的次级代谢产物研究. 有机化学, 2020, 40(5): 1367-1371. doi: 10.6023/cjoc201912012.","citationEn":"Zhang Jie, Chen Yuchan, Liu Zhaoming, Guo Bohong, Gao Xiaoxia, Liu Hongxin, Zhang Weimin. Cytotoxic Secondary Metabolites from a Sea-Derived Fungal Strain of Hypoxylon rubiginosum<\/i> FS521. 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