Citation: JIN Ru-Yi, SUN Xiao-Hong, LIU Yuan-Fa, CHEN Bang, SHEN Sheng-Qiang, MA Hai-Xia. Synthesis, Structure and Biological Activity of 5-Benzyl-4-amino-1,2,4-triazole-3-thione Schiff Base[J]. Chinese Journal of Structural Chemistry, ;2014, 33(2): 253-257. shu

Synthesis, Structure and Biological Activity of 5-Benzyl-4-amino-1,2,4-triazole-3-thione Schiff Base

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a School of Chemical Engineering, Northwest University, Xi'an 710069, China;
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b Chemical Research Institute, Northwest University, Xi'an 710069, China;
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c College of Chemistry & Materials Science, Northwest University, Xi'an 710069, China

Received Date: 9 July 2013
Available Online: 16 September 2013
Fund Project: This project was supported by the National Natural Science Foundation of China (No.21073141) (No.21073141)the Shaanxi Provincial Education Department Foundation (No.2013JK0666) (No.2013JK0666)

A novel Schiff base was synthesized via 5-benzyl-4-amino-1,2,4-triazole-3-thione with 3-phenoxy-benzaldehyde under refluxing. The structure was characterized by elemental analysis, IR, ¹H NMR, ESI-MS and single-crystal X-ray diffraction. This compound crystallizes in monoclinic, space group P2₁/c with a=16.0289(16), b=5.8022(6), c=20.542(2) Å, β=95.667(2)°, C₂₂H₁₈N₄OS, M_r=386.46, V=1901.1(3) Å³, Z=4, D_c=1.347 g/cm³, F(000)=804, μ=0.191 mm^-1, the final R=0.0453 and wR=0.1307 for 2456 observed reflections with I>2σ(I). The crystal packing of the compound is stabilized by classical intermolecular N-H…S hydrogen bonds. Furthermore, the biological activity to four vegetable pathogens has been tested. The title compound exhibited good fungicidal activities to Gibberlla nicotiancola.
- Schiff base,
- structure,
- 1,2,4-triazole,
- biological activity
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