Citation: Heping Wang, Tianzhe Chu, Xiaona Li, Jing Wang, Chensi Wu, Dandan Geng, Ligang Zhao. Syntheses and Enhancing Effect Evaluation of the Stereoisomeric Monoterpene Alcohol Oleates[J]. Chemistry, ;2021, 84(6): 578-584, 590. shu

Syntheses and Enhancing Effect Evaluation of the Stereoisomeric Monoterpene Alcohol Oleates

Heping Wang ¹ ,
Tianzhe Chu ² ,
Xiaona Li ¹ ,
Jing Wang ¹ ,
Chensi Wu ¹ ,
Dandan Geng ¹ ,
Ligang Zhao ^{1, 3,,}

1.
School of Pharmacy, North China University of Science and Technology, Tangshan, 063210
2.
School of Pharmacy, Chengdu University of TCM, Chengdu, 611137
3.
Tangshan important laboratory of novel preparations and drug release technology, Tangshan, 063210

Corresponding author: Ligang Zhao, tsyxzlg@163.com
Received Date: 4 November 2020
Accepted Date: 1 December 2020

Figures(6)

In the present research, (E)-3, 7-dimethyl-2, 6-octadien-1-yl-octadec-9-enoate (GER-dC18) and (Z)-3, 7-dimethyl-2, 6-octadien-1-yl-octadec-9-enoate (NER-dC18) were synthesized by geraniol (GER)/nerol (NER) and oleic acid using acyl chloride esterification method. The percutaneous absorption of Donepezil (DNP) was evaluated using GER, NER, GER-dC18, NER-dC18 as the enhancer, respectively. In addition, the promoting mechanism was explored by in vitro release experiment, ATR-FTIR and molecular simulation technology. It was found that the selected penetration enhancers not only could promote the release of DNP from pressure-sensitive adhesive, but also could act on the lipid and keratin of the stratum corneum and promote hydration of skin to reduce the barrier function of stratum corneum, thus increasing the transdermal penetration of DNP. GER-dC18 had the optimal penetration promotion effect on DNP, which was expected to provide the important excipient for the development of transdermal drug delivery system.
- Donepezil,
- (E/Z)-3, 7-Dimethyl-2, 6-octadien-1-yl-octadec-9-enoate,
- Transdermal drug delivery system,
- Enhancing mechanism
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沈阳化工大学材料科学与工程学院沈阳 110142