{"综述与进展":[{"abstractInfo":"含氟的有机化合物被广泛地应用于制药、农业化学品、材料科学等多个领域.三氟甲基、二氟甲基、全氟烷基等是应用非常广泛的含氟官能团，因此发展普适高效的引入氟烷基的新方法具有重大意义.氟烷基自由基反应近年来已经发展成为引入氟烷基的有效方法.另一方面，氟烷基取代的手性有机分子的合成也受到了人们的重点关注.然而由于氟烷基自由基的高反应活性，其反应的选择性较难控制，特别是关于对映选择性控制的报道不多，更缺乏相关综述予以总结.综述了近二十年来基于氟烷基自由基过程的不对称合成方法的研究进展，对各反应的选择性、普适性、反应机理等方面进行着重介绍.本综述根据反应机理分为三部分：（1）经由氟烷基自由基的烯醇/烯胺中间体不对称氟烷基化；（2）经由氟烷基自由基的烯烃不对称双官能团化；（3）经由氟烷基自由基的烯基硼酸酯酸根型复合物立体选择性1，2-迁移.","abstractInfoCn":"含氟的有机化合物被广泛地应用于制药、农业化学品、材料科学等多个领域.三氟甲基、二氟甲基、全氟烷基等是应用非常广泛的含氟官能团，因此发展普适高效的引入氟烷基的新方法具有重大意义.氟烷基自由基反应近年来已经发展成为引入氟烷基的有效方法.另一方面，氟烷基取代的手性有机分子的合成也受到了人们的重点关注.然而由于氟烷基自由基的高反应活性，其反应的选择性较难控制，特别是关于对映选择性控制的报道不多，更缺乏相关综述予以总结.综述了近二十年来基于氟烷基自由基过程的不对称合成方法的研究进展，对各反应的选择性、普适性、反应机理等方面进行着重介绍.本综述根据反应机理分为三部分：（1）经由氟烷基自由基的烯醇/烯胺中间体不对称氟烷基化；（2）经由氟烷基自由基的烯烃不对称双官能团化；（3）经由氟烷基自由基的烯基硼酸酯酸根型复合物立体选择性1，2-迁移.","abstractInfoEn":"Fluorine-containing organic compounds have been widely applied in various fields, such as pharmacy, agrochemicals, materials science, <i>etc<\/i>. Trifluoromethyl, difluoromethyl and perfluoroalkyl groups represent the typical fluorine-containing functional groups. Hence, the development of highly efficient methods for introducing fluoroalkyl groups is of primary importance. In recent years, the reactions based on fluoroalkyl radicals have been developed into competent methods for introducing fluoroalkyl groups. On the other hand, the synthesis of the chiral molecules containing fluoroalkyl groups has attracted considerable attentions. However, attributed to the high reactivity of the fluoroalkyl radicals, the control of the reaction selectivity is difficult. Particularly, so far there have been only limited reports on the enantiocontrol of the reaction in this regard and the corresponding review of the field still lacks. This review summarizes the research on the asymmetric synthesis based on fluoroalkyl radical reactions developed over the past 20 years. The review introduces the selectivities, scope and mechanism of various reactions. It is divided into three different parts according to the type of the reaction: (1) asymmetric fluoroalkylation of enol/enamine intermediate through fluoroalkyl radical, (2) asymmetric difunctionalization of olefin through fluoroalkyl radical, (3) stereoselective 1, 2-shift of vinylboronate complexes through fluoroalkyl radical.","articleNo":"","authorCnList":["黄航"," 王兮"," 王剑波"],"authorEnList":["Huang Hang"," Wang Xi"," Wang Jianbo"],"authorList":["黄航"," 王兮"," 王剑波"],"authors":"黄航, 王兮, 王剑波","authorsCn":"黄航, 王兮, 王剑波","authorsEn":"Huang Hang, Wang Xi, Wang Jianbo","categoryName":"综述与进展","categoryNameCn":"综述与进展","categoryNameEn":"REVIEW","citation":"黄航, 王兮, 王剑波. 基于氟烷基自由基过程构建手性中心的研究进展. 有机化学, 2019, 39(1): 1-14. doi: 10.6023/cjoc201808030.","citationCn":"黄航, 王兮, 王剑波. 基于氟烷基自由基过程构建手性中心的研究进展. 有机化学, 2019, 39(1): 1-14. doi: 10.6023/cjoc201808030.","citationEn":"黄航, 王兮, 王剑波. Research Developments of the Construction of Chiral Center Based on Fluoroalkyl Radical Reactions. Chinese Journal of Organic Chemistry, 2019, 39(1): 1-14. doi: 10.6023/cjoc201808030.","doi":"10.6023/cjoc201808030","figContent":"yjhx-39-1-1-1.jpg$$yjhx-39-1-1-2.jpg$$yjhx-39-1-1-S1.jpg$$yjhx-39-1-1-S2.jpg$$yjhx-39-1-1-S3.jpg$$yjhx-39-1-1-S4.jpg$$yjhx-39-1-1-S5.jpg$$yjhx-39-1-1-S6.jpg$$yjhx-39-1-1-S7.jpg$$yjhx-39-1-1-S8.jpg$$yjhx-39-1-1-S9.jpg$$yjhx-39-1-1-S10.jpg$$yjhx-39-1-1-S11.jpg$$yjhx-39-1-1-S12.jpg$$yjhx-39-1-1-S13.jpg$$yjhx-39-1-1-S14.jpg$$yjhx-39-1-1-S15.jpg$$yjhx-39-1-1-S16.jpg","figList":["yjhx-39-1-1-1.jpg","yjhx-39-1-1-2.jpg","yjhx-39-1-1-S1.jpg","yjhx-39-1-1-S2.jpg","yjhx-39-1-1-S3.jpg","yjhx-39-1-1-S4.jpg","yjhx-39-1-1-S5.jpg","yjhx-39-1-1-S6.jpg","yjhx-39-1-1-S7.jpg","yjhx-39-1-1-S8.jpg","yjhx-39-1-1-S9.jpg","yjhx-39-1-1-S10.jpg","yjhx-39-1-1-S11.jpg","yjhx-39-1-1-S12.jpg","yjhx-39-1-1-S13.jpg","yjhx-39-1-1-S14.jpg","yjhx-39-1-1-S15.jpg","yjhx-39-1-1-S16.jpg"],"firstFig":"yjhx-39-1-1-1.jpg","fpage":"1","highCitedState":"","htmlCount":495,"htmlFile":"","id":"3fa5ba73-d7a6-47b5-a1f2-b566696395b0","issnPpub":"0253-2786","issue":"1","journalPublishId":"yjhx","journalReferenceCodeType":0,"journalTitleCn":"有机化学","journalTitleEn":"Chinese Journal of Organic Chemistry","keyword":"氟烷基化, 自由基, 不对称合成, 催化","keywordCn":"氟烷基化, 自由基, 不对称合成, 催化","keywordCnList":["氟烷基化"," 自由基"," 不对称合成"," 催化"],"keywordEn":"fluoroalkylation, radicals, asymmetric synthesis, catalysis References","keywordEnList":["fluoroalkylation"," radicals"," asymmetric synthesis"," catalysis References"],"keywordList":["氟烷基化"," 自由基"," 不对称合成"," 催化"],"language":"zh","latestInfo":"","latestState":"","latestStateEn":"","lpage":"14","oldUrl":"http://sioc-journal.cn/Jwk_yjhx/CN/volumn/home.shtml","pdfDownCount":51,"pdfSize":688.92,"pubDate":"2019-01-25","recommendState":"","releaseState":"1","secCount":0,"title":"基于氟烷基自由基过程构建手性中心的研究进展","titleCn":"基于氟烷基自由基过程构建手性中心的研究进展","titleEn":"Research Developments of the Construction of Chiral Center Based on Fluoroalkyl Radical Reactions","viewCount":2153,"volume":"39","year":2019},{"abstractInfo":"过渡金属催化的烯丙基取代反应是构建碳-碳键、碳-杂原子键的重要手段.由于镍价廉易得，适用性广，赢得了化学家们的广泛青睐.在过去50年里，关于镍催化的烯丙基取代反应的报道不断涌现.根据成键类型及亲核试剂的种类进行划分，总结近年来镍催化的烯丙基取代反应的进展及其在有机合成中的应用.","abstractInfoCn":"过渡金属催化的烯丙基取代反应是构建碳-碳键、碳-杂原子键的重要手段.由于镍价廉易得，适用性广，赢得了化学家们的广泛青睐.在过去50年里，关于镍催化的烯丙基取代反应的报道不断涌现.根据成键类型及亲核试剂的种类进行划分，总结近年来镍催化的烯丙基取代反应的进展及其在有机合成中的应用.","abstractInfoEn":"Transition-metal catalyzed allylic substitution reaction is an important approach for constructing carbon-carbon bond and carbon-heteroatom bond. Due to its cheapness, easy access, and wide applicability in organic synthesis, nickel has attracted intense attention. Over the past 50 years, nickel-catalyzed allylic substitution reactions have been extensively studied. The progresses on nickel-catalyzed allylic substitution reactions and their applications in organic synthesis are summarized according to bond formation and nucleophilic reagent.","articleNo":"","authorCnList":["张慧君"," 顾庆"," 游书力"],"authorEnList":["Zhang Huijun"," Gu Qing"," You Shuli"],"authorList":["张慧君"," 顾庆"," 游书力"],"authors":"张慧君, 顾庆, 游书力","authorsCn":"张慧君, 顾庆, 游书力","authorsEn":"Zhang Huijun, Gu Qing, You Shuli","categoryName":"综述与进展","categoryNameCn":"综述与进展","categoryNameEn":"REVIEW","citation":"张慧君, 顾庆, 游书力. 镍催化的烯丙基取代反应研究进展. 有机化学, 2019, 39(1): 15-27. doi: 10.6023/cjoc201809037.","citationCn":"张慧君, 顾庆, 游书力. 镍催化的烯丙基取代反应研究进展. 有机化学, 2019, 39(1): 15-27. doi: 10.6023/cjoc201809037.","citationEn":"张慧君, 顾庆, 游书力. Recent Advances in Ni-Catalyzed Allylic Substitution Reactions. Chinese Journal of Organic Chemistry, 2019, 39(1): 15-27. doi: 10.6023/cjoc201809037.","doi":"10.6023/cjoc201809037","figContent":"yjhx-39-1-15-S1.jpg$$yjhx-39-1-15-S2.jpg$$yjhx-39-1-15-S3.jpg$$yjhx-39-1-15-S4.jpg$$yjhx-39-1-15-S5.jpg$$yjhx-39-1-15-S6.jpg$$yjhx-39-1-15-S7.jpg$$yjhx-39-1-15-S8.jpg$$yjhx-39-1-15-S9.jpg$$yjhx-39-1-15-S10.jpg$$yjhx-39-1-15-S11.jpg$$yjhx-39-1-15-S12.jpg$$yjhx-39-1-15-S13.jpg","figList":["yjhx-39-1-15-S1.jpg","yjhx-39-1-15-S2.jpg","yjhx-39-1-15-S3.jpg","yjhx-39-1-15-S4.jpg","yjhx-39-1-15-S5.jpg","yjhx-39-1-15-S6.jpg","yjhx-39-1-15-S7.jpg","yjhx-39-1-15-S8.jpg","yjhx-39-1-15-S9.jpg","yjhx-39-1-15-S10.jpg","yjhx-39-1-15-S11.jpg","yjhx-39-1-15-S12.jpg","yjhx-39-1-15-S13.jpg"],"firstFig":"yjhx-39-1-15-S1.jpg","fpage":"15","highCitedState":"","htmlCount":641,"htmlFile":"","id":"b6a4dac9-0251-4fa2-8f44-23c7e9207d4c","issnPpub":"0253-2786","issue":"1","journalPublishId":"yjhx","journalReferenceCodeType":0,"journalTitleCn":"有机化学","journalTitleEn":"Chinese Journal of Organic Chemistry","keyword":"烯丙基取代, 不对称催化, 镍, 过渡金属","keywordCn":"烯丙基取代, 不对称催化, 镍, 过渡金属","keywordCnList":["烯丙基取代"," 不对称催化"," 镍"," 过渡金属"],"keywordEn":"allylic substitution, asymmetric catalysis, nickel, transition metal","keywordEnList":["allylic substitution"," asymmetric catalysis"," nickel"," transition metal"],"keywordList":["烯丙基取代"," 不对称催化"," 镍"," 过渡金属"],"language":"zh","latestInfo":"","latestState":"","latestStateEn":"","lpage":"27","oldUrl":"http://sioc-journal.cn/Jwk_yjhx/CN/volumn/home.shtml","pdfDownCount":114,"pdfSize":808.77,"pubDate":"2019-01-25","recommendState":"","releaseState":"1","secCount":0,"title":"镍催化的烯丙基取代反应研究进展","titleCn":"镍催化的烯丙基取代反应研究进展","titleEn":"Recent Advances in Ni-Catalyzed Allylic Substitution Reactions","viewCount":2802,"volume":"39","year":2019},{"abstractInfo":"综述了中国学者在有机碘代和溴代氟化物的卤键研究方面的进展.从1987至1993年，陈庆云等发现全氟碘代烷作为Lewis酸可以和胺、醚和六甲基磷酰胺等Lewis碱形成供体-受体相互作用，代表了早期研究现在被称为卤键的非共价键作用力的重要进展.2001年以来，多个研究组利用卤键开展晶体工程研究.朱士正等首次证实，全氟-<i>α<\/i>，<i>ϖ<\/i>-二碘烷烃可以和胺、醚和六甲基磷酰胺等通过卤键形成一维扩展阵列结构，晋卫军等研究了卤键驱动的全氟碘代芳烃与氮杂芳环的共晶结构，张丹维和黎占亭等利用卤键诱导产生了双螺旋及四螺旋超分子聚合物.晋卫军等研究了C—I…π卤键在晶体工程中的应用.利用卤键诱导，王栋和万立骏等在表面实现了三角型芳香分子共组装形成二维蜂窝型阵列结构，王力彦等从两个聚合物或有机分子构筑了单层膜结构和实现了层-层自组装控制.赵新和黎占亭等合成了并入三个二氟碘甲基的三臂分子，基于氢键诱导的折叠型受体，建立了溶液相多位点卤键结合的识别模式.胡文平、龚和贵、廖良生等利用卤键提高了若干共轭有机分子的不同的材料性能.多个研究组利用卤键成功控制或提高不同类型的有机反应的选择性.","abstractInfoCn":"综述了中国学者在有机碘代和溴代氟化物的卤键研究方面的进展.从1987至1993年，陈庆云等发现全氟碘代烷作为Lewis酸可以和胺、醚和六甲基磷酰胺等Lewis碱形成供体-受体相互作用，代表了早期研究现在被称为卤键的非共价键作用力的重要进展.2001年以来，多个研究组利用卤键开展晶体工程研究.朱士正等首次证实，全氟-<i>α<\/i>，<i>ϖ<\/i>-二碘烷烃可以和胺、醚和六甲基磷酰胺等通过卤键形成一维扩展阵列结构，晋卫军等研究了卤键驱动的全氟碘代芳烃与氮杂芳环的共晶结构，张丹维和黎占亭等利用卤键诱导产生了双螺旋及四螺旋超分子聚合物.晋卫军等研究了C—I…π卤键在晶体工程中的应用.利用卤键诱导，王栋和万立骏等在表面实现了三角型芳香分子共组装形成二维蜂窝型阵列结构，王力彦等从两个聚合物或有机分子构筑了单层膜结构和实现了层-层自组装控制.赵新和黎占亭等合成了并入三个二氟碘甲基的三臂分子，基于氢键诱导的折叠型受体，建立了溶液相多位点卤键结合的识别模式.胡文平、龚和贵、廖良生等利用卤键提高了若干共轭有机分子的不同的材料性能.多个研究组利用卤键成功控制或提高不同类型的有机反应的选择性.","abstractInfoEn":"This review summarizes studies on halogen bonding of fluorine-containing alkyl and aryl iodides in China. From 1987 to 1993, Chen <i>et al<\/i>. found that there existed donor-acceptor interaction between fluorinated organic (di)iodides, as Lewis acids, and organic Lewis bases such as amines and ethers, which represented early important advances for the research on the non-covalent force currently called as halogen bonding. From 2001 to now, several groups have used halogen bonding as driving force to conduct researches on crystal engineering. In this catogery, Zhu <i>et al<\/i>. investigated the one-dimensional self-assembly between perfluoro-<i>α<\/i>, <i>ϖ<\/i>-diioodalkanes and amines, ethers, and hexamethylphosphamide. Jin <i>et al<\/i>. studied the complexation between fluorinated aryl iodides and various <i>N<\/i>-heterocycles, whereas Zhang and Li <i>et al<\/i>. constructed supramolecular double and quadruple helices from one or two molecular components. Jin <i>et al<\/i>. conducted extensive studies on C—I…π halogen bonding and its applications in crystal engineering. Wang and Wan <i>et al<\/i>. utilized halogen bonding to induce trianglular aromatic molecules to co-assemble into two-dimensional honeycomb arrays on surface, whereas Wang <i>et al<\/i>. utilized halogen bond to induce mono-layer and layer-by-layer self-assembly of two polymers or organic molecules. Zhao and Li <i>et al<\/i>. developed the applications of halogen bonding in solution-phase multi-site molecular recognition of foldamer receptors for ICF<sub>2<\/sub>-incorporated tri-armed guests. Hu, Gong, Liao <i>et al<\/i>. utilized halogen bonding to improve the material properties of a variety of organic aromatic molecules. Several groups have also used halogen bonding to increase the selectivity of a number of organic reactions. Representative examples are described, which highlight the utility of halogen bonding.","articleNo":"","authorCnList":["刘传志"," 王辉"," 张丹维"," 赵新"," 黎占亭"],"authorEnList":["Liu Chuan-Zhi"," Wang Hui"," Zhang Dan-Wei"," Zhao Xin"," Li Zhan-Ting"],"authorList":["刘传志"," 王辉"," 张丹维"," 赵新"," 黎占亭"],"authors":"刘传志, 王辉, 张丹维, 赵新, 黎占亭","authorsCn":"刘传志, 王辉, 张丹维, 赵新, 黎占亭","authorsEn":"Liu Chuan-Zhi, Wang Hui, Zhang Dan-Wei, Zhao Xin, Li Zhan-Ting","categoryName":"综述与进展","categoryNameCn":"综述与进展","categoryNameEn":"REVIEW","citation":"刘传志, 王辉, 张丹维, 赵新, 黎占亭. 中国有机氟化合物卤键研究. 有机化学, 2019, 39(1): 28-37. doi: 10.6023/cjoc201812026.","citationCn":"刘传志, 王辉, 张丹维, 赵新, 黎占亭. 中国有机氟化合物卤键研究. 有机化学, 2019, 39(1): 28-37. doi: 10.6023/cjoc201812026.","citationEn":"刘传志, 王辉, 张丹维, 赵新, 黎占亭. Study on Halogen Bonding of Organofluorine Compounds in China. Chinese Journal of Organic Chemistry, 2019, 39(1): 28-37. doi: 10.6023/cjoc201812026.","doi":"10.6023/cjoc201812026","figContent":"yjhx-39-1-28-1.jpg$$yjhx-39-1-28-2.jpg$$yjhx-39-1-28-3.jpg$$yjhx-39-1-28-4.jpg$$yjhx-39-1-28-5.jpg$$yjhx-39-1-28-6.jpg$$yjhx-39-1-28-7.jpg$$yjhx-39-1-28-8.jpg$$yjhx-39-1-28-9.jpg$$yjhx-39-1-28-10.jpg$$yjhx-39-1-28-11.jpg$$yjhx-39-1-28-12.jpg$$yjhx-39-1-28-13.jpg$$yjhx-39-1-28-14.jpg$$yjhx-39-1-28-15.jpg$$yjhx-39-1-28-16.jpg$$yjhx-39-1-28-17.jpg$$yjhx-39-1-28-18.jpg","figList":["yjhx-39-1-28-1.jpg","yjhx-39-1-28-2.jpg","yjhx-39-1-28-3.jpg","yjhx-39-1-28-4.jpg","yjhx-39-1-28-5.jpg","yjhx-39-1-28-6.jpg","yjhx-39-1-28-7.jpg","yjhx-39-1-28-8.jpg","yjhx-39-1-28-9.jpg","yjhx-39-1-28-10.jpg","yjhx-39-1-28-11.jpg","yjhx-39-1-28-12.jpg","yjhx-39-1-28-13.jpg","yjhx-39-1-28-14.jpg","yjhx-39-1-28-15.jpg","yjhx-39-1-28-16.jpg","yjhx-39-1-28-17.jpg","yjhx-39-1-28-18.jpg"],"firstFig":"yjhx-39-1-28-1.jpg","fpage":"28","highCitedState":"","htmlCount":361,"htmlFile":"","id":"625d5d09-b70a-426e-acd0-49e9eb6abfaf","issnPpub":"0253-2786","issue":"1","journalPublishId":"yjhx","journalReferenceCodeType":0,"journalTitleCn":"有机化学","journalTitleEn":"Chinese Journal of Organic Chemistry","keyword":"卤键, 有机氟化合物, 晶体工程, 分子识别, 自组装, 螺旋体, 人工折叠体, 电子转移反应","keywordCn":"卤键, 有机氟化合物, 晶体工程, 分子识别, 自组装, 螺旋体, 人工折叠体, 电子转移反应","keywordCnList":["卤键"," 有机氟化合物"," 晶体工程"," 分子识别"," 自组装"," 螺旋体"," 人工折叠体"," 电子转移反应"],"keywordEn":"halogen bond, organofluorine compounds, crystal engineering, molecular recognition, self-assembly, helix, foldamer, electron-transfer reaction","keywordEnList":["halogen bond"," organofluorine compounds"," crystal engineering"," molecular recognition"," self-assembly"," helix"," foldamer"," electron-transfer reaction"],"keywordList":["卤键"," 有机氟化合物"," 晶体工程"," 分子识别"," 自组装"," 螺旋体"," 人工折叠体"," 电子转移反应"],"language":"zh","latestInfo":"","latestState":"","latestStateEn":"","lpage":"37","oldUrl":"http://sioc-journal.cn/Jwk_yjhx/CN/volumn/home.shtml","pdfDownCount":38,"pdfSize":3281.99,"pubDate":"2019-01-25","recommendState":"","releaseState":"1","secCount":0,"title":"中国有机氟化合物卤键研究","titleCn":"中国有机氟化合物卤键研究","titleEn":"Study on Halogen Bonding of Organofluorine Compounds in China","viewCount":2037,"volume":"39","year":2019},{"abstractInfo":"有机氟化学凭借其独特的内涵在材料科学、催化化学、医学、精细化工以及生物化学领域引起了越来越多的重视，其核心在于碳-氟键的构建和切断.过渡金属的引入为活化碳-氟键提供了新的可能，也逐渐成为合成很多复杂有机物的一种替代途径.总结了以往对过渡金属促进碳-氟键活化和切断的理论研究进展，并系统性提出了碳-氟键活化的相关模式，包括碳-氟键对金属的氧化加成、过渡金属活化的芳香亲核取代、碳（sp<sup>3<\/sup>）-氟键双分子亲核取代（S<sub>N<\/sub>2）以及<i>β<\/i>-氟消除等.理论计算表明，当使用还原性较强的零价镍催化剂时，反应可按照氧化加成模式启动.而如果使用零价铂催化剂，则需要对氟原子进行额外活化才能发生氧化加成.当使用氢化金属物种还原多氟代芳烃时，氢负离子可以与多氟代芳烃发生芳香亲核取代实现碳-氟键活化.对于碳（sp<sup>3<\/sup>）-氟键来说，如果使用“硬”的Lewis碱，例如锂盐或镁盐，则可按照双分子亲核取代（S<sub>N<\/sub>2）方式活化碳（sp<sup>3<\/sup>）-氟键.此外，<i>β<\/i>-氟消除也是一种可能的替代机理.","abstractInfoCn":"有机氟化学凭借其独特的内涵在材料科学、催化化学、医学、精细化工以及生物化学领域引起了越来越多的重视，其核心在于碳-氟键的构建和切断.过渡金属的引入为活化碳-氟键提供了新的可能，也逐渐成为合成很多复杂有机物的一种替代途径.总结了以往对过渡金属促进碳-氟键活化和切断的理论研究进展，并系统性提出了碳-氟键活化的相关模式，包括碳-氟键对金属的氧化加成、过渡金属活化的芳香亲核取代、碳（sp<sup>3<\/sup>）-氟键双分子亲核取代（S<sub>N<\/sub>2）以及<i>β<\/i>-氟消除等.理论计算表明，当使用还原性较强的零价镍催化剂时，反应可按照氧化加成模式启动.而如果使用零价铂催化剂，则需要对氟原子进行额外活化才能发生氧化加成.当使用氢化金属物种还原多氟代芳烃时，氢负离子可以与多氟代芳烃发生芳香亲核取代实现碳-氟键活化.对于碳（sp<sup>3<\/sup>）-氟键来说，如果使用“硬”的Lewis碱，例如锂盐或镁盐，则可按照双分子亲核取代（S<sub>N<\/sub>2）方式活化碳（sp<sup>3<\/sup>）-氟键.此外，<i>β<\/i>-氟消除也是一种可能的替代机理.","abstractInfoEn":"Organic fluorine chemistry has attracted considerable attention due to its unique character in the field of materials science, catalytic chemistry, medicine, fine chemicals and biochemistry, which majorly focus on the construction and cleavage of carbon-fluorine bonds. The transition metals are introduced to allow new possibilities for activating carbon-fluorine bonds and are gradually becoming an alternative way to synthesize numerous complex organics containing fluorine. In this review, the recent works on the theoretical mechanistic study for transition metals mediated carbon-fluorine bonds activation and cleavage are summarized. Meanwhile, the general modes of carbon-fluorine bonds activation have been concluded systematically, including the oxidative addition of carbon-fluorine bonds to transition metals, transition-metal-activated nucleophilic substitution, S<sub>N<\/sub>2 type activation of carbon(sp<sup>3<\/sup>)-fluorine bonds and <i>β<\/i>-fluorine elimination, <i>etc<\/i>. The theoretical calculation shows that the reaction could be proceed by an oxidation addition mode, when the zero-valent nickel catalyst with strong reducibility is employed. However, if a zero-valent platinum catalyst is used, oxidation addition only occurs at extra activated carbon-fluorine bonds. In the reduction of polyfluorinated aromatic hydrocarbons by hydrogenated metal species, aromatic nucleophilic substitution between hydride and polyfluorinated aromatic hydrocarbons could occur to realize the activation of carbon-fluoride bonds. For carbon(sp<sup>3<\/sup>)-fluorine bonds, if \"hard\" Lewis base such as lithium or magnesium salt is employed, the carbon(sp<sup>3<\/sup>)-fluorine bonds can be activated via bimolecular nucleophilic substitution (S<sub>N<\/sub>2). In addition, <i>β<\/i>-fluoride elimination is also frequently proposed in transition metal-catalyzed C—F functionalizations.","articleNo":"","authorCnList":["李园园"," 王元鉴"," 朱磊"," 屈凌波"," 蓝宇"],"authorEnList":["Li Yuanyuan"," Wang Yuanjian"," Zhu Lei"," Qu Lingbo"," Lan Yu"],"authorList":["李园园"," 王元鉴"," 朱磊"," 屈凌波"," 蓝宇"],"authors":"李园园, 王元鉴, 朱磊, 屈凌波, 蓝宇","authorsCn":"李园园, 王元鉴, 朱磊, 屈凌波, 蓝宇","authorsEn":"Li Yuanyuan, Wang Yuanjian, Zhu Lei, Qu Lingbo, Lan Yu","categoryName":"综述与进展","categoryNameCn":"综述与进展","categoryNameEn":"REVIEW","citation":"李园园, 王元鉴, 朱磊, 屈凌波, 蓝宇. 过渡金属参与的C—F键官能团化反应机理研究进展. 有机化学, 2019, 39(1): 38-46. doi: 10.6023/cjoc201810020.","citationCn":"李园园, 王元鉴, 朱磊, 屈凌波, 蓝宇. 过渡金属参与的C—F键官能团化反应机理研究进展. 有机化学, 2019, 39(1): 38-46. doi: 10.6023/cjoc201810020.","citationEn":"李园园, 王元鉴, 朱磊, 屈凌波, 蓝宇. Theoretical Advances on the Mechanism of Transition Metal-Catalyzed C—F Functionalization. Chinese Journal of Organic Chemistry, 2019, 39(1): 38-46. doi: 10.6023/cjoc201810020.","doi":"10.6023/cjoc201810020","figContent":"yjhx-39-1-38-S1.jpg$$yjhx-39-1-38-S2.jpg$$yjhx-39-1-38-1.jpg$$yjhx-39-1-38-S3.jpg$$yjhx-39-1-38-2.jpg$$yjhx-39-1-38-3.jpg$$yjhx-39-1-38-S4.jpg$$yjhx-39-1-38-4.jpg$$yjhx-39-1-38-5.jpg$$yjhx-39-1-38-6.jpg$$yjhx-39-1-38-7.jpg$$yjhx-39-1-38-8.jpg","figList":["yjhx-39-1-38-S1.jpg","yjhx-39-1-38-S2.jpg","yjhx-39-1-38-1.jpg","yjhx-39-1-38-S3.jpg","yjhx-39-1-38-2.jpg","yjhx-39-1-38-3.jpg","yjhx-39-1-38-S4.jpg","yjhx-39-1-38-4.jpg","yjhx-39-1-38-5.jpg","yjhx-39-1-38-6.jpg","yjhx-39-1-38-7.jpg","yjhx-39-1-38-8.jpg"],"firstFig":"yjhx-39-1-38-S1.jpg","fpage":"38","highCitedState":"","htmlCount":566,"htmlFile":"","id":"5364e140-b0ea-4d53-bd8f-e0d3a6d54d54","issnPpub":"0253-2786","issue":"1","journalPublishId":"yjhx","journalReferenceCodeType":0,"journalTitleCn":"有机化学","journalTitleEn":"Chinese Journal of Organic Chemistry","keyword":"过渡金属, C-F键官能团化, 反应机理, 氟化学","keywordCn":"过渡金属, C-F键官能团化, 反应机理, 氟化学","keywordCnList":["过渡金属"," C-F键官能团化"," 反应机理"," 氟化学"],"keywordEn":"transition metal, C—F functionalization, reaction mechanism, fluorine chemistry","keywordEnList":["transition metal"," C—F functionalization"," reaction mechanism"," fluorine chemistry"],"keywordList":["过渡金属"," C-F键官能团化"," 反应机理"," 氟化学"],"language":"zh","latestInfo":"","latestState":"","latestStateEn":"","lpage":"46","oldUrl":"http://sioc-journal.cn/Jwk_yjhx/CN/volumn/home.shtml","pdfDownCount":52,"pdfSize":852.8,"pubDate":"2019-01-25","recommendState":"","releaseState":"1","secCount":0,"title":"过渡金属参与的C—F键官能团化反应机理研究进展","titleCn":"过渡金属参与的C—F键官能团化反应机理研究进展","titleEn":"Theoretical Advances on the Mechanism of Transition Metal-Catalyzed C—F Functionalization","viewCount":2442,"volume":"39","year":2019},{"abstractInfo":"（-）-Peduncularine是从塔斯玛尼亚灌木<i>Aristoteliapeduncularis<\/i>中分离得到的生物碱，含吲哚结构单元且含有高张力的6-氮杂双环[3.2.1]辛烷核心骨架.由于其独特的结构，受到合成化学家的极大关注.目前，已有多个课题组对其展开了全合成研究.本文将介绍近年来不同研究小组所发展peduncularine的合成策略，对于药物合成研究中类似特殊环系的构建提供借鉴.","abstractInfoCn":"（-）-Peduncularine是从塔斯玛尼亚灌木<i>Aristotelia peduncularis<\/i>中分离得到的生物碱，含吲哚结构单元且含有高张力的6-氮杂双环[3.2.1]辛烷核心骨架.由于其独特的结构，受到合成化学家的极大关注.目前，已有多个课题组对其展开了全合成研究.本文将介绍近年来不同研究小组所发展peduncularine的合成策略，对于药物合成研究中类似特殊环系的构建提供借鉴.","abstractInfoEn":"(-)-Peduncularine is the principal alkaloid isolated from Tasmanian shrub <i>Aristotelia peduncularis<\/i>. Due to its unusual 6-azabicyclo[3.2.1]octane core, the indole alkaloid was received numerous attention from the synthetic community and several innovative synthetic strategies have been developed. In this minireview, the synthetic efforts of peduncularine are summarized as inspiration for future development of medicinally interesting derivatives.","articleNo":"","authorCnList":["章玉平"," 田学超"," 张岩"," 洪然"," 黄莎华"],"authorEnList":["Zhang Yuping"," Tian Xuechao"," Zhang Yan"," Hong Ran"," Huang Shahua"],"authorList":["章玉平"," 田学超"," 张岩"," 洪然"," 黄莎华"],"authors":"章玉平, 田学超, 张岩, 洪然, 黄莎华","authorsCn":"章玉平, 田学超, 张岩, 洪然, 黄莎华","authorsEn":"Zhang Yuping, Tian Xuechao, Zhang Yan, Hong Ran, Huang Shahua","categoryName":"综述与进展","categoryNameCn":"综述与进展","categoryNameEn":"REVIEW","citation":"章玉平, 田学超, 张岩, 洪然, 黄莎华. 生物碱Peduncularine的合成策略和方法. 有机化学, 2019, 39(1): 47-58. doi: 10.6023/cjoc201810008.","citationCn":"章玉平, 田学超, 张岩, 洪然, 黄莎华. 生物碱Peduncularine的合成策略和方法. 有机化学, 2019, 39(1): 47-58. doi: 10.6023/cjoc201810008.","citationEn":"章玉平, 田学超, 张岩, 洪然, 黄莎华. Methods and Strategies for the Synthesis of Peduncularine. Chinese Journal of Organic Chemistry, 2019, 39(1): 47-58. doi: 10.6023/cjoc201810008.","doi":"10.6023/cjoc201810008","figContent":"yjhx-39-1-47-1.jpg$$yjhx-39-1-47-2.jpg$$yjhx-39-1-47-S1.jpg$$yjhx-39-1-47-S2.jpg$$yjhx-39-1-47-S3.jpg$$yjhx-39-1-47-S4.jpg$$yjhx-39-1-47-S5.jpg$$yjhx-39-1-47-S6.jpg$$yjhx-39-1-47-S7.jpg$$yjhx-39-1-47-S8.jpg$$yjhx-39-1-47-S9.jpg$$yjhx-39-1-47-S10.jpg$$yjhx-39-1-47-S11.jpg$$yjhx-39-1-47-S12.jpg$$yjhx-39-1-47-S13.jpg$$yjhx-39-1-47-3.jpg","figList":["yjhx-39-1-47-1.jpg","yjhx-39-1-47-2.jpg","yjhx-39-1-47-S1.jpg","yjhx-39-1-47-S2.jpg","yjhx-39-1-47-S3.jpg","yjhx-39-1-47-S4.jpg","yjhx-39-1-47-S5.jpg","yjhx-39-1-47-S6.jpg","yjhx-39-1-47-S7.jpg","yjhx-39-1-47-S8.jpg","yjhx-39-1-47-S9.jpg","yjhx-39-1-47-S10.jpg","yjhx-39-1-47-S11.jpg","yjhx-39-1-47-S12.jpg","yjhx-39-1-47-S13.jpg","yjhx-39-1-47-3.jpg"],"firstFig":"yjhx-39-1-47-1.jpg","fpage":"47","highCitedState":"","htmlCount":365,"htmlFile":"","id":"96ec3f42-6246-459d-bc3b-db0c2c600f8c","issnPpub":"0253-2786","issue":"1","journalPublishId":"yjhx","journalReferenceCodeType":0,"journalTitleCn":"有机化学","journalTitleEn":"Chinese Journal of Organic Chemistry","keyword":"6-氮杂双环[3.2.1]辛烷, 成环反应, 吲哚生物碱, peduncularine, 全合成","keywordCn":"6-氮杂双环[3.2.1]辛烷, 成环反应, 吲哚生物碱, peduncularine, 全合成","keywordCnList":["6-氮杂双环[3.2.1]辛烷"," 成环反应"," 吲哚生物碱"," peduncularine"," 全合成"],"keywordEn":"6-azabicyclo[3.2.1]octane, cyclization, indole alkaloids, peduncularine, total synthesis","keywordEnList":["6-azabicyclo[3.2.1]octane"," cyclization"," indole alkaloids"," peduncularine"," total synthesis"],"keywordList":["6-氮杂双环[3.2.1]辛烷"," 成环反应"," 吲哚生物碱"," peduncularine"," 全合成"],"language":"zh","latestInfo":"","latestState":"","latestStateEn":"","lpage":"58","oldUrl":"http://sioc-journal.cn/Jwk_yjhx/CN/volumn/home.shtml","pdfDownCount":40,"pdfSize":759.63,"pubDate":"2019-01-25","recommendState":"","releaseState":"1","secCount":0,"title":"生物碱Peduncularine的合成策略和方法","titleCn":"生物碱Peduncularine的合成策略和方法","titleEn":"Methods and Strategies for the Synthesis of Peduncularine","viewCount":2011,"volume":"39","year":2019},{"abstractInfo":"芳基三氟甲基酮是一类非常重要的有机合成中间体.由于其具有潜在的生物活性，越来越引起研究者的广泛关注.综述了近年来芳基三氟甲基酮类化合物的合成，主要包括<i>α<\/i>-三氟甲基醇的氧化，羧酸衍生物的三氟甲基化，金属有机试剂、富电子芳烃，芳基卤化物、芳基重氮盐等的三氟乙酰化反应，以及其机理的探讨.","abstractInfoCn":"芳基三氟甲基酮是一类非常重要的有机合成中间体.由于其具有潜在的生物活性，越来越引起研究者的广泛关注.综述了近年来芳基三氟甲基酮类化合物的合成，主要包括<i>α<\/i>-三氟甲基醇的氧化，羧酸衍生物的三氟甲基化，金属有机试剂、富电子芳烃，芳基卤化物、芳基重氮盐等的三氟乙酰化反应，以及其机理的探讨.","abstractInfoEn":"Aryl trifluoromethyl ketone is a very important intermediate in the organic synthesis. Much attention has been attracted from researchers, due to its potential bioactivity. In this paper, the recent progress in the synthesis of aryl trifluoromethyl ketone is reviewed, including the oxidant of <i>α<\/i>-trifluoromethyl alcohols, trifluoromethylation of carboxylic acid derivatives, trifluoroacetylation of organometallic reagents, electron-rich aromatics, aryl halides and aryl diazonium salts, and the reaction mechanisms are also discussed.","articleNo":"","authorCnList":["张洁雨"," 柯求敏"," 陈家英"," 何平"," 严国兵"],"authorEnList":["Zhang Jieyu"," Ke Qiumin"," Chen Jiaying"," He Ping"," Yan Guobing"],"authorList":["张洁雨"," 柯求敏"," 陈家英"," 何平"," 严国兵"],"authors":"张洁雨, 柯求敏, 陈家英, 何平, 严国兵","authorsCn":"张洁雨, 柯求敏, 陈家英, 何平, 严国兵","authorsEn":"Zhang Jieyu, Ke Qiumin, Chen Jiaying, He Ping, Yan Guobing","categoryName":"综述与进展","categoryNameCn":"综述与进展","categoryNameEn":"REVIEWS","citation":"张洁雨, 柯求敏, 陈家英, 何平, 严国兵. 芳基三氟甲基酮类化合物的合成进展. 有机化学, 2019, 39(1): 74-83. doi: 10.6023/cjoc201808046.","citationCn":"张洁雨, 柯求敏, 陈家英, 何平, 严国兵. 芳基三氟甲基酮类化合物的合成进展. 有机化学, 2019, 39(1): 74-83. doi: 10.6023/cjoc201808046.","citationEn":"张洁雨, 柯求敏, 陈家英, 何平, 严国兵. Recent Progress in the Synthesis of Aryl Trifluoromethyl Ketones. Chinese Journal of Organic Chemistry, 2019, 39(1): 74-83. doi: 10.6023/cjoc201808046.","doi":"10.6023/cjoc201808046","figContent":"yjhx-39-1-74-S1.jpg$$yjhx-39-1-74-S2.jpg$$yjhx-39-1-74-S3.jpg$$yjhx-39-1-74-S4.jpg$$yjhx-39-1-74-S5.jpg$$yjhx-39-1-74-S6.jpg$$yjhx-39-1-74-S7.jpg$$yjhx-39-1-74-S8.jpg$$yjhx-39-1-74-S9.jpg$$yjhx-39-1-74-S10.jpg$$yjhx-39-1-74-S11.jpg$$yjhx-39-1-74-S12.jpg$$yjhx-39-1-74-S13.jpg$$yjhx-39-1-74-S14.jpg$$yjhx-39-1-74-S15.jpg$$yjhx-39-1-74-S16.jpg$$yjhx-39-1-74-S17.jpg","figList":["yjhx-39-1-74-S1.jpg","yjhx-39-1-74-S2.jpg","yjhx-39-1-74-S3.jpg","yjhx-39-1-74-S4.jpg","yjhx-39-1-74-S5.jpg","yjhx-39-1-74-S6.jpg","yjhx-39-1-74-S7.jpg","yjhx-39-1-74-S8.jpg","yjhx-39-1-74-S9.jpg","yjhx-39-1-74-S10.jpg","yjhx-39-1-74-S11.jpg","yjhx-39-1-74-S12.jpg","yjhx-39-1-74-S13.jpg","yjhx-39-1-74-S14.jpg","yjhx-39-1-74-S15.jpg","yjhx-39-1-74-S16.jpg","yjhx-39-1-74-S17.jpg"],"firstFig":"yjhx-39-1-74-S1.jpg","fpage":"74","highCitedState":"","htmlCount":550,"htmlFile":"","id":"7c84a19a-3727-4b15-93c2-cde3da1c9bcb","issnPpub":"0253-2786","issue":"1","journalPublishId":"yjhx","journalReferenceCodeType":0,"journalTitleCn":"有机化学","journalTitleEn":"Chinese Journal of Organic Chemistry","keyword":"芳基三氟甲基酮, 三氟乙酰化, 偶联反应, 反应机理","keywordCn":"芳基三氟甲基酮, 三氟乙酰化, 偶联反应, 反应机理","keywordCnList":["芳基三氟甲基酮"," 三氟乙酰化"," 偶联反应"," 反应机理"],"keywordEn":"aryl trifluoromethyl ketones, trifluoroacetylation, coupling reaction, reaction mechanism","keywordEnList":["aryl trifluoromethyl ketones"," trifluoroacetylation"," coupling reaction"," reaction mechanism"],"keywordList":["芳基三氟甲基酮"," 三氟乙酰化"," 偶联反应"," 反应机理"],"language":"zh","latestInfo":"","latestState":"","latestStateEn":"","lpage":"83","oldUrl":"http://sioc-journal.cn/Jwk_yjhx/CN/volumn/home.shtml","pdfDownCount":43,"pdfSize":594.94,"pubDate":"2019-01-25","recommendState":"","releaseState":"1","secCount":0,"title":"芳基三氟甲基酮类化合物的合成进展","titleCn":"芳基三氟甲基酮类化合物的合成进展","titleEn":"Recent Progress in the Synthesis of Aryl Trifluoromethyl Ketones","viewCount":2302,"volume":"39","year":2019},{"abstractInfo":"传统合成热力学不稳定的<i>Z<\/i>-式烯烃的方法往往都需要使用高能量的试剂，通过动力学来进行控制，反应条件较为苛刻，操作复杂，原子经济性低下.在分离的过程中，也极易造成<i>Z<\/i>-式烯烃向热力学更加稳定的<i>E<\/i>-式烯烃的异构化.随着有机光化学和光催化技术的不断发展，越来越多的具有挑战性的有机合成反应可以通过有机光化学手段来解决.总结了可见光促进的烯烃的异构化反应，并对其进行了展望.","abstractInfoCn":"传统合成热力学不稳定的<i>Z<\/i>-式烯烃的方法往往都需要使用高能量的试剂，通过动力学来进行控制，反应条件较为苛刻，操作复杂，原子经济性低下.在分离的过程中，也极易造成<i>Z<\/i>-式烯烃向热力学更加稳定的<i>E<\/i>-式烯烃的异构化.随着有机光化学和光催化技术的不断发展，越来越多的具有挑战性的有机合成反应可以通过有机光化学手段来解决.总结了可见光促进的烯烃的异构化反应，并对其进行了展望.","abstractInfoEn":"The traditional methods for synthesizing <i>Z<\/i>-olefins generally require the use of high-energy reagents. These methods are usually controlled by kinetics. The reaction conditions are harsh and low atom economic. During the process of separation, <i>Z<\/i>-olefins are easy to convert to the thermodynamically more stable <i>E<\/i>-olefins. With the continuous development of organic photochemistry and photocatalysis technology, more and more synthetic challenges have been solved by photocatalysis. Herein, various types of visible light-promoted photocatalytic isomerization of olefins are reviewed.","articleNo":"","authorCnList":["张昊"," 俞寿云"],"authorEnList":["Zhang Hao"," Yu Shouyun"],"authorList":["张昊"," 俞寿云"],"authors":"张昊, 俞寿云","authorsCn":"张昊, 俞寿云","authorsEn":"Zhang Hao, Yu Shouyun","categoryName":"综述与进展","categoryNameCn":"综述与进展","categoryNameEn":"REVIEWS","citation":"张昊, 俞寿云. 可见光促进的烯烃异构化反应. 有机化学, 2019, 39(1): 95-108. doi: 10.6023/cjoc201809010.","citationCn":"张昊, 俞寿云. 可见光促进的烯烃异构化反应. 有机化学, 2019, 39(1): 95-108. doi: 10.6023/cjoc201809010.","citationEn":"张昊, 俞寿云. Visible Light-Promoted Isomerization of Alkenes. Chinese Journal of Organic Chemistry, 2019, 39(1): 95-108. doi: 10.6023/cjoc201809010.","doi":"10.6023/cjoc201809010","figContent":"yjhx-39-1-95-S1.jpg$$yjhx-39-1-95-S2.jpg$$yjhx-39-1-95-S3.jpg$$yjhx-39-1-95-S4.jpg$$yjhx-39-1-95-S5.jpg$$yjhx-39-1-95-S6.jpg$$yjhx-39-1-95-S7.jpg$$yjhx-39-1-95-S8.jpg$$yjhx-39-1-95-S9.jpg$$yjhx-39-1-95-S10.jpg$$yjhx-39-1-95-S11.jpg$$yjhx-39-1-95-S12.jpg$$yjhx-39-1-95-S13.jpg$$yjhx-39-1-95-S14.jpg$$yjhx-39-1-95-S15.jpg$$yjhx-39-1-95-S16.jpg$$yjhx-39-1-95-S17.jpg$$yjhx-39-1-95-S18.jpg$$yjhx-39-1-95-S19.jpg$$yjhx-39-1-95-S20.jpg$$yjhx-39-1-95-S21.jpg$$yjhx-39-1-95-S22.jpg$$yjhx-39-1-95-S23.jpg$$yjhx-39-1-95-S24.jpg$$yjhx-39-1-95-S25.jpg","figList":["yjhx-39-1-95-S1.jpg","yjhx-39-1-95-S2.jpg","yjhx-39-1-95-S3.jpg","yjhx-39-1-95-S4.jpg","yjhx-39-1-95-S5.jpg","yjhx-39-1-95-S6.jpg","yjhx-39-1-95-S7.jpg","yjhx-39-1-95-S8.jpg","yjhx-39-1-95-S9.jpg","yjhx-39-1-95-S10.jpg","yjhx-39-1-95-S11.jpg","yjhx-39-1-95-S12.jpg","yjhx-39-1-95-S13.jpg","yjhx-39-1-95-S14.jpg","yjhx-39-1-95-S15.jpg","yjhx-39-1-95-S16.jpg","yjhx-39-1-95-S17.jpg","yjhx-39-1-95-S18.jpg","yjhx-39-1-95-S19.jpg","yjhx-39-1-95-S20.jpg","yjhx-39-1-95-S21.jpg","yjhx-39-1-95-S22.jpg","yjhx-39-1-95-S23.jpg","yjhx-39-1-95-S24.jpg","yjhx-39-1-95-S25.jpg"],"firstFig":"yjhx-39-1-95-S1.jpg","fpage":"95","highCitedState":"","htmlCount":1185,"htmlFile":"","id":"99b4c9d0-7d56-4d27-9a07-e5f12664b5ce","issnPpub":"0253-2786","issue":"1","journalPublishId":"yjhx","journalReferenceCodeType":0,"journalTitleCn":"有机化学","journalTitleEn":"Chinese Journal of Organic Chemistry","keyword":"光化学, 烯烃, 异构化, 能量转移","keywordCn":"光化学, 烯烃, 异构化, 能量转移","keywordCnList":["光化学"," 烯烃"," 异构化"," 能量转移"],"keywordEn":"photochemistry, olefins, isomerization, energy transfer","keywordEnList":["photochemistry"," olefins"," isomerization"," energy transfer"],"keywordList":["光化学"," 烯烃"," 异构化"," 能量转移"],"language":"zh","latestInfo":"","latestState":"","latestStateEn":"","lpage":"108","oldUrl":"http://sioc-journal.cn/Jwk_yjhx/CN/volumn/home.shtml","pdfDownCount":133,"pdfSize":1149.3,"pubDate":"2019-01-25","recommendState":"","releaseState":"1","secCount":0,"title":"可见光促进的烯烃异构化反应","titleCn":"可见光促进的烯烃异构化反应","titleEn":"Visible Light-Promoted Isomerization of Alkenes","viewCount":3815,"volume":"39","year":2019},{"abstractInfo":"三氟甲基取代的三氮唑及四氮唑化合物在药物、农药、催化及材料等领域发挥着越来越重要的作用，其合成方法也日益受到重视.对近10年来三氟甲基三氮唑及四氮唑化合物的合成方法研究进展进行了分类归纳总结，着重展示了三氟甲基炔烃、三氟乙酰基衍生物、三氟甲基吡喃酮及三氟重氮乙烷等含氟砌块在这两类杂环合成中的应用.","abstractInfoCn":"三氟甲基取代的三氮唑及四氮唑化合物在药物、农药、催化及材料等领域发挥着越来越重要的作用，其合成方法也日益受到重视.对近10年来三氟甲基三氮唑及四氮唑化合物的合成方法研究进展进行了分类归纳总结，着重展示了三氟甲基炔烃、三氟乙酰基衍生物、三氟甲基吡喃酮及三氟重氮乙烷等含氟砌块在这两类杂环合成中的应用.","abstractInfoEn":"Trifluoromethylated triazoles and tetrazoles have emerged as increasingly important heterocycles in pharmaceuticals, agrochemicals, catalysis, and materials. As a consequence, great attention has been paid to the efficient synthesis of these valuable CF<sub>3<\/sub>-containing molecules. Herein, the advances in the past decade towards the synthesis of CF<sub>3<\/sub>-substituted triazoles and tetrazoles are summarized. The remarkable progress in the utilization of versatile CF<sub>3<\/sub>-functionalized building blocks including CF<sub>3<\/sub>-containing alkynes, CF<sub>3<\/sub>-containing carbonyl compounds, CF<sub>3<\/sub>-containing pyrones and trifluorodiazoethane (CF<sub>3<\/sub>CHN<sub>2<\/sub>) is demonstrated accordingly.","articleNo":"","authorCnList":["张发光"," 彭星"," 马军安"],"authorEnList":["Zhang Faguang"," Peng Xing"," Ma Jun'an"],"authorList":["张发光"," 彭星"," 马军安"],"authors":"张发光, 彭星, 马军安","authorsCn":"张发光, 彭星, 马军安","authorsEn":"Zhang Faguang, Peng Xing, Ma Jun'an","categoryName":"综述与进展","categoryNameCn":"综述与进展","categoryNameEn":"REVIEWS","citation":"张发光, 彭星, 马军安. 三氟甲基三氮唑及四氮唑化合物的合成研究进展. 有机化学, 2019, 39(1): 109-116. doi: 10.6023/cjoc201808007.","citationCn":"张发光, 彭星, 马军安. 三氟甲基三氮唑及四氮唑化合物的合成研究进展. 有机化学, 2019, 39(1): 109-116. doi: 10.6023/cjoc201808007.","citationEn":"张发光, 彭星, 马军安. Recent Advances in the Synthesis of CF<sub>3<\/sub>-Substituted Triazoles and Tetrazoles. Chinese Journal of Organic Chemistry, 2019, 39(1): 109-116. doi: 10.6023/cjoc201808007.","doi":"10.6023/cjoc201808007","figContent":"yjhx-39-1-109-1.jpg$$yjhx-39-1-109-S1.jpg$$yjhx-39-1-109-S2.jpg$$yjhx-39-1-109-S3.jpg$$yjhx-39-1-109-S4.jpg$$yjhx-39-1-109-S5.jpg$$yjhx-39-1-109-S6.jpg$$yjhx-39-1-109-S7.jpg$$yjhx-39-1-109-S8.jpg","figList":["yjhx-39-1-109-1.jpg","yjhx-39-1-109-S1.jpg","yjhx-39-1-109-S2.jpg","yjhx-39-1-109-S3.jpg","yjhx-39-1-109-S4.jpg","yjhx-39-1-109-S5.jpg","yjhx-39-1-109-S6.jpg","yjhx-39-1-109-S7.jpg","yjhx-39-1-109-S8.jpg"],"firstFig":"yjhx-39-1-109-1.jpg","fpage":"109","highCitedState":"","htmlCount":507,"htmlFile":"","id":"50222c2f-7814-460f-b764-450f0873457d","issnPpub":"0253-2786","issue":"1","journalPublishId":"yjhx","journalReferenceCodeType":0,"journalTitleCn":"有机化学","journalTitleEn":"Chinese Journal of Organic Chemistry","keyword":"三氟甲基, 三氮唑, 四氮唑, 含氟杂环, 环加成反应","keywordCn":"三氟甲基, 三氮唑, 四氮唑, 含氟杂环, 环加成反应","keywordCnList":["三氟甲基"," 三氮唑"," 四氮唑"," 含氟杂环"," 环加成反应"],"keywordEn":"trifluoromethyl group, triazole, tetrazole, fluorine-containing heterocycle, cycloaddition","keywordEnList":["trifluoromethyl group"," triazole"," tetrazole"," fluorine-containing heterocycle"," cycloaddition"],"keywordList":["三氟甲基"," 三氮唑"," 四氮唑"," 含氟杂环"," 环加成反应"],"language":"zh","latestInfo":"","latestState":"","latestStateEn":"","lpage":"116","oldUrl":"http://sioc-journal.cn/Jwk_yjhx/CN/volumn/home.shtml","pdfDownCount":30,"pdfSize":585.67,"pubDate":"2019-01-25","recommendState":"","releaseState":"1","secCount":0,"title":"三氟甲基三氮唑及四氮唑化合物的合成研究进展","titleCn":"三氟甲基三氮唑及四氮唑化合物的合成研究进展","titleEn":"Recent Advances in the Synthesis of CF<sub>3<\/sub>-Substituted Triazoles and Tetrazoles","viewCount":2118,"volume":"39","year":2019}],"REVIEWS":[{"abstractInfo":"Recentyearsthegreatprogressintransitionmetal-catalyzeddirectaromaticC—Hoxidationhasbeenwitnessed,whichhasbeenutilizedinthepreparationofvariousphenoliccompounds.Thesetransformationsemployinteraliapalladium,copper,ruthenium,iridium,<i>etc<\/i>.asthetransitionmetalcatalysts,andhypervalentiodine,persulfate,oroxygenastheoxidants.TherehavebeenseveralreviewsinwhichtheC—Hoxidationswithspecifictransitionmetaloroxidantwasdiscussed.Thisreviewfocusesspecificallyontransitionmetal-catalyzedaromaticC—Hoxidationswith<i>ortho<\/i>-,<i>meta<\/i>-,or<i>para<\/i>-selectivity,andrationalizesthepossiblegenerationmechanismofregio-selectivities,whichmightbecontrolledbythedirectinggroupviachelation-assistance,theligand,orintrinsicpropertiesofthesubstrate.Thediscussionsectionindicatedtheexistingproblemsoftransitionmetal-catalyzedaromaticC—Hoxidations,aswellasthepossiblelimitingfactorsforthedevelopmentandapplicationofthisstrategy.","abstractInfoCn":"近年来过渡金属催化的芳烃直接C—H氧化反应取得了重要进展，该策略被用于多种酚类化合物的制备.反应体系使用的过渡金属催化剂包括钯、铜、钌、铱等；氧化剂包括高价碘化合物、过硫酸盐、氧气等.此前已有多篇综述就特定的过渡金属或氧化剂参与的C—H氧化反应进行了详尽的讨论.本综述着重探讨过渡金属催化的邻、间、对位选择性的芳烃C—H氧化反应，并试图阐释上述区域选择性的产生机制，其中包括导向基团的螯合辅助作用、配体控制、底物自身因素等.在讨论部分提出了过渡金属催化的芳烃C—H氧化反应中存在的问题以及影响该策略发展应用的可能限制因素.","abstractInfoEn":"Recent years the great progress in transition metal-catalyzed direct aromatic C—H oxidation has been witnessed, which has been utilized in the preparation of various phenolic compounds. These transformations employ inter alia palladium, copper, ruthenium, iridium, <i>etc<\/i>. as the transition metal catalysts, and hypervalent iodine, persulfate, or oxygen as the oxidants. There have been several reviews in which the C—H oxidations with specific transition metal or oxidant was discussed. This review focuses specifically on transition metal-catalyzed aromatic C—H oxidations with <i>ortho<\/i>-, <i>meta<\/i>-, or <i>para<\/i>-selectivity, and rationalizes the possible generation mechanism of regio-selectivities, which might be controlled by the directing group via chelation-assistance, the ligand, or intrinsic properties of the substrate. The discussion section indicated the existing problems of transition metal-catalyzed aromatic C—H oxidations, as well as the possible limiting factors for the development and application of this strategy.","articleNo":"","authorCnList":["杨帆致"," 张晗"," 刘旭日"," 王博"," AckermannLutz"],"authorEnList":["Yang Fanzhi"," Zhang Han"," Liu Xuri"," Wang Bo"," Ackermann Lutz"],"authorList":["Yang Fanzhi"," Zhang Han"," Liu Xuri"," Wang Bo"," Ackermann Lutz"],"authors":"Yang Fanzhi, Zhang Han, Liu Xuri, Wang Bo, Ackermann Lutz","authorsCn":"杨帆致, 张晗, 刘旭日, 王博, AckermannLutz","authorsEn":"Yang Fanzhi, Zhang Han, Liu Xuri, Wang Bo, Ackermann Lutz","categoryName":"REVIEWS","categoryNameCn":"综述与进展","categoryNameEn":"REVIEWS","citation":"Yang Fanzhi, Zhang Han, Liu Xuri, Wang Bo, Ackermann Lutz. Transition Metal-Catalyzed Regio-selective Aromatic C—H Bond Oxidation for C—O Bond Formation. Chinese Journal of Organic Chemistry, 2019, 39(1): 59-73. doi: 10.6023/cjoc201808017.","citationCn":"Yang Fanzhi, Zhang Han, Liu Xuri, Wang Bo, Ackermann Lutz. 过渡金属催化的区域选择性芳烃C—H键氧化生成C—O键. 有机化学, 2019, 39(1): 59-73. doi: 10.6023/cjoc201808017.","citationEn":"Yang Fanzhi, Zhang Han, Liu Xuri, Wang Bo, Ackermann Lutz. Transition Metal-Catalyzed Regio-selective Aromatic C—H Bond Oxidation for C—O Bond Formation. Chinese Journal of Organic Chemistry, 2019, 39(1): 59-73. doi: 10.6023/cjoc201808017.","doi":"10.6023/cjoc201808017","figContent":"yjhx-39-1-59-S1.jpg$$yjhx-39-1-59-S2.jpg$$yjhx-39-1-59-S3.jpg$$yjhx-39-1-59-S4.jpg$$yjhx-39-1-59-S5.jpg$$yjhx-39-1-59-S6.jpg$$yjhx-39-1-59-S7.jpg$$yjhx-39-1-59-S8.jpg$$yjhx-39-1-59-S9.jpg$$yjhx-39-1-59-S10.jpg$$yjhx-39-1-59-S11.jpg$$yjhx-39-1-59-S12.jpg$$yjhx-39-1-59-S13.jpg$$yjhx-39-1-59-S14.jpg$$yjhx-39-1-59-S15.jpg$$yjhx-39-1-59-S16.jpg$$yjhx-39-1-59-S17.jpg$$yjhx-39-1-59-S18.jpg$$yjhx-39-1-59-S19.jpg$$yjhx-39-1-59-1.jpg$$yjhx-39-1-59-S20.jpg$$yjhx-39-1-59-S21.jpg$$yjhx-39-1-59-S22.jpg$$yjhx-39-1-59-S23.jpg$$yjhx-39-1-59-S24.jpg$$yjhx-39-1-59-S25.jpg$$yjhx-39-1-59-S26.jpg$$yjhx-39-1-59-S27.jpg$$yjhx-39-1-59-S28.jpg$$yjhx-39-1-59-S29.jpg$$yjhx-39-1-59-S30.jpg","figList":["yjhx-39-1-59-S1.jpg","yjhx-39-1-59-S2.jpg","yjhx-39-1-59-S3.jpg","yjhx-39-1-59-S4.jpg","yjhx-39-1-59-S5.jpg","yjhx-39-1-59-S6.jpg","yjhx-39-1-59-S7.jpg","yjhx-39-1-59-S8.jpg","yjhx-39-1-59-S9.jpg","yjhx-39-1-59-S10.jpg","yjhx-39-1-59-S11.jpg","yjhx-39-1-59-S12.jpg","yjhx-39-1-59-S13.jpg","yjhx-39-1-59-S14.jpg","yjhx-39-1-59-S15.jpg","yjhx-39-1-59-S16.jpg","yjhx-39-1-59-S17.jpg","yjhx-39-1-59-S18.jpg","yjhx-39-1-59-S19.jpg","yjhx-39-1-59-1.jpg","yjhx-39-1-59-S20.jpg","yjhx-39-1-59-S21.jpg","yjhx-39-1-59-S22.jpg","yjhx-39-1-59-S23.jpg","yjhx-39-1-59-S24.jpg","yjhx-39-1-59-S25.jpg","yjhx-39-1-59-S26.jpg","yjhx-39-1-59-S27.jpg","yjhx-39-1-59-S28.jpg","yjhx-39-1-59-S29.jpg","yjhx-39-1-59-S30.jpg"],"firstFig":"yjhx-39-1-59-S1.jpg","fpage":"59","highCitedState":"","htmlCount":298,"htmlFile":"","id":"8b321e80-9f7b-4e10-8b37-1e6471a46b2c","issnPpub":"0253-2786","issue":"1","journalPublishId":"yjhx","journalReferenceCodeType":0,"journalTitleCn":"有机化学","journalTitleEn":"Chinese Journal of Organic Chemistry","keyword":"transition metal, arene, C—H oxidation, regio-selectivity, directing group","keywordCn":"过渡金属, 芳烃, C-H氧化, 区域选择性, 导向基团","keywordCnList":["过渡金属"," 芳烃"," C-H氧化"," 区域选择性"," 导向基团"],"keywordEn":"transition metal, arene, C—H oxidation, regio-selectivity, directing group","keywordEnList":["transition metal"," arene"," C—H oxidation"," regio-selectivity"," directing group"],"keywordList":["transition metal"," arene"," C—H oxidation"," regio-selectivity"," directing group"],"language":"en","latestInfo":"","latestState":"","latestStateEn":"","lpage":"73","oldUrl":"http://sioc-journal.cn/Jwk_yjhx/CN/volumn/home.shtml","pdfDownCount":28,"pdfSize":823.35,"pubDate":"2019-01-25","recommendState":"","releaseState":"1","secCount":0,"title":"Transition Metal-Catalyzed Regio-selective Aromatic C—H Bond Oxidation for C—O Bond Formation","titleCn":"过渡金属催化的区域选择性芳烃C—H键氧化生成C—O键","titleEn":"Transition Metal-Catalyzed Regio-selective Aromatic C—H Bond Oxidation for C—O Bond Formation","viewCount":1471,"volume":"39","year":2019},{"abstractInfo":"Transitionmetal-freeandmetal-catalyzedreactionsusingaryl(trifluoroethyl)iodoniumsaltsasthetrifluoroethylationreagentsaresummarizedinthisreview.AlargenumberofdifferenttypesofN-,O-,S-,andC-nucleophileswerereadilytrifluoroethylatedinthesereactionsundermildconditions.Theresultsrevealedthataryl(trifluoroethyl)iodoniumsaltspossessmuchhigherelectrophilicreactivitythantheotherCH<sub>2<\/sub>CF<sub>3<\/sub>sources.Especially,aryl(trifluoroethyl)iodoniumbis(trifluoromethanesulfonyl)amidesarestableandslightlysolubleinwater,whichweresuccessfullyappliedintheaqueoustrifluoroethylationofaminoacidderivativesandpeptides.Theutilizationofaryl(trifluoroethyl)iodoniumsaltsforaromatictrifluoroethylationhaspromisinglysolvedtheproblemsthatarisefromtheotherreagents.Theseachievementshavealsodemonstratedthesyntheticpossibilitiesofdirecttrifluoroethylationusingaryl(trifluoroethyl)iodoniumsaltsundertransition-metalcatalysis.","abstractInfoCn":"综述了过渡金属催化和无过渡金属催化的、以芳基（三氟乙基）三价碘盐为三氟乙基化试剂的三氟乙基化反应的研究进展.在这些反应中，大量不同类型的N-，O-，S-以及C-亲核性底物在温和的条件下被三氟乙基化.相比于其他三氟乙基化试剂，芳基（三氟乙基）三价碘盐具有更高的亲电反应活性.特别值得一提的是，双（三氟甲磺酰）亚胺芳基（三氟乙基）三价碘盐微溶于水、在水中稳定存在，并且可以在水溶液中对氨基酸衍生物和肽类化合物进行直接的三氟乙基化反应.将芳基（三氟乙基）三价碘盐用于芳烃的三氟乙基化反应时，它能够很好地克服反应使用其他试剂时带来的不足.这些研究成果也证明了过渡金属催化芳基（三氟乙基）三价碘盐进行直接的三氟乙基化反应的可能性.","abstractInfoEn":"Transition metal-free and metal-catalyzed reactions using aryl(trifluoroethyl)iodonium salts as the trifluoroethylation reagents are summarized in this review. A large number of different types of N-, O-, S-, and C-nucleophiles were readily trifluoroethylated in these reactions under mild conditions. The results revealed that aryl(trifluoroethyl)iodonium salts possess much higher electrophilic reactivity than the other CH<sub>2<\/sub>CF<sub>3<\/sub> sources. Especially, aryl(trifluoroethyl)iodonium bis(trifluoromethanesulfonyl)amides are stable and slightly soluble in water, which were successfully applied in the aqueous trifluoroethylation of amino acid derivatives and peptides. The utilization of aryl(trifluoroethyl)iodonium salts for aromatic trifluoroethylation has promisingly solved the problems that arise from the other reagents. These achievements have also demonstrated the synthetic possibilities of direct trifluoroethylation using aryl(trifluoroethyl)iodonium salts under transition-metal catalysis.","articleNo":"","authorCnList":["韩秋燕"," 赵成龙"," 张成潘"],"authorEnList":["Han Qiuyan"," Zhao Chenglong"," Zhang Chengpan"],"authorList":["Han Qiuyan"," Zhao Chenglong"," Zhang Chengpan"],"authors":"Han Qiuyan, Zhao Chenglong, Zhang Chengpan","authorsCn":"韩秋燕, 赵成龙, 张成潘","authorsEn":"Han Qiuyan, Zhao Chenglong, Zhang Chengpan","categoryName":"REVIEWS","categoryNameCn":"综述与进展","categoryNameEn":"REVIEWS","citation":"Han Qiuyan, Zhao Chenglong, Zhang Chengpan. Progress on Trifluoroethylation Reactions Using Aryl(trifluoroethyl)iodonium Salts. Chinese Journal of Organic Chemistry, 2019, 39(1): 84-94. doi: 10.6023/cjoc201808029.","citationCn":"Han Qiuyan, Zhao Chenglong, Zhang Chengpan. 基于芳基(三氟乙基)三价碘盐的三氟乙基化反应研究进展. 有机化学, 2019, 39(1): 84-94. doi: 10.6023/cjoc201808029.","citationEn":"Han Qiuyan, Zhao Chenglong, Zhang Chengpan. Progress on Trifluoroethylation Reactions Using Aryl(trifluoroethyl)iodonium Salts. Chinese Journal of Organic Chemistry, 2019, 39(1): 84-94. doi: 10.6023/cjoc201808029.","doi":"10.6023/cjoc201808029","figContent":"yjhx-39-1-84-1.jpg$$yjhx-39-1-84-S1.jpg$$yjhx-39-1-84-S2.jpg$$yjhx-39-1-84-S3.jpg$$yjhx-39-1-84-S4.jpg$$yjhx-39-1-84-S5.jpg$$yjhx-39-1-84-S6.jpg$$yjhx-39-1-84-S7.jpg$$yjhx-39-1-84-S8.jpg$$yjhx-39-1-84-S9.jpg$$yjhx-39-1-84-S10.jpg$$yjhx-39-1-84-S11.jpg$$yjhx-39-1-84-S12.jpg$$yjhx-39-1-84-S13.jpg$$yjhx-39-1-84-S14.jpg$$yjhx-39-1-84-S15.jpg$$yjhx-39-1-84-S16.jpg$$yjhx-39-1-84-S17.jpg$$yjhx-39-1-84-S18.jpg$$yjhx-39-1-84-S19.jpg$$yjhx-39-1-84-S20.jpg$$yjhx-39-1-84-S21.jpg$$yjhx-39-1-84-S22.jpg$$yjhx-39-1-84-S23.jpg$$yjhx-39-1-84-S24.jpg$$yjhx-39-1-84-S25.jpg","figList":["yjhx-39-1-84-1.jpg","yjhx-39-1-84-S1.jpg","yjhx-39-1-84-S2.jpg","yjhx-39-1-84-S3.jpg","yjhx-39-1-84-S4.jpg","yjhx-39-1-84-S5.jpg","yjhx-39-1-84-S6.jpg","yjhx-39-1-84-S7.jpg","yjhx-39-1-84-S8.jpg","yjhx-39-1-84-S9.jpg","yjhx-39-1-84-S10.jpg","yjhx-39-1-84-S11.jpg","yjhx-39-1-84-S12.jpg","yjhx-39-1-84-S13.jpg","yjhx-39-1-84-S14.jpg","yjhx-39-1-84-S15.jpg","yjhx-39-1-84-S16.jpg","yjhx-39-1-84-S17.jpg","yjhx-39-1-84-S18.jpg","yjhx-39-1-84-S19.jpg","yjhx-39-1-84-S20.jpg","yjhx-39-1-84-S21.jpg","yjhx-39-1-84-S22.jpg","yjhx-39-1-84-S23.jpg","yjhx-39-1-84-S24.jpg","yjhx-39-1-84-S25.jpg"],"firstFig":"yjhx-39-1-84-1.jpg","fpage":"84","highCitedState":"","htmlCount":191,"htmlFile":"","id":"389a51c3-1578-4f0a-a544-1a4b1c999cb9","issnPpub":"0253-2786","issue":"1","journalPublishId":"yjhx","journalReferenceCodeType":0,"journalTitleCn":"有机化学","journalTitleEn":"Chinese Journal of Organic Chemistry","keyword":"trifluoroethylation, transition metal-free, transition metal-catalyzed, electrophilic, aryl (trifluoroethyl)iodonium salts","keywordCn":"三氟乙基化, 无过渡金属催化, 过渡金属催化, 亲电, 芳基(三氟乙基)三价碘盐","keywordCnList":["三氟乙基化"," 无过渡金属催化"," 过渡金属催化"," 亲电"," 芳基(三氟乙基)三价碘盐"],"keywordEn":"trifluoroethylation, transition metal-free, transition metal-catalyzed, electrophilic, aryl (trifluoroethyl)iodonium salts","keywordEnList":["trifluoroethylation"," transition metal-free"," transition metal-catalyzed"," electrophilic"," aryl (trifluoroethyl)iodonium salts"],"keywordList":["trifluoroethylation"," transition metal-free"," transition metal-catalyzed"," electrophilic"," aryl (trifluoroethyl)iodonium salts"],"language":"en","latestInfo":"","latestState":"","latestStateEn":"","lpage":"94","oldUrl":"http://sioc-journal.cn/Jwk_yjhx/CN/volumn/home.shtml","pdfDownCount":13,"pdfSize":592.92,"pubDate":"2019-01-25","recommendState":"","releaseState":"1","secCount":0,"title":"Progress on Trifluoroethylation Reactions Using Aryl(trifluoroethyl)iodonium Salts","titleCn":"基于芳基(三氟乙基)三价碘盐的三氟乙基化反应研究进展","titleEn":"Progress on Trifluoroethylation Reactions Using Aryl(trifluoroethyl)iodonium Salts","viewCount":1248,"volume":"39","year":2019}],"研究论文":[{"abstractInfo":"手性1，2-二醇骨架是天然产物或生物活性分子构建过程中的重要骨架，而<i>α<\/i>-羟基酮参与的不对称Aldol缩合反应是实现手性1，2-二醇骨架的重要手段.设计并合成了含三氟甲基的咪唑啉型化合物，并将其应用于羟基丙酮和醛的不对称Aodol缩合反应.研究结果表明，当采用含氟咪唑啉（2<i>R<\/i>，4<i>S<\/i>）-4-苄基-1，2-二甲基-2-三氟甲基咪唑啉（<b>1a<\/b>）作为不对称Aldol反应的催化剂时，能够以产率高达96%、最高<i>ee<\/i>值达到99%及<i>dr<\/i>值达到15:1的效率高效构建一系列顺式1，2-二醇产物.同时，我们也初步探讨了氟-氢键在不对称催化反应中的作用.","abstractInfoCn":"手性1，2-二醇骨架是天然产物或生物活性分子构建过程中的重要骨架，而<i>α<\/i>-羟基酮参与的不对称Aldol缩合反应是实现手性1，2-二醇骨架的重要手段.设计并合成了含三氟甲基的咪唑啉型化合物，并将其应用于羟基丙酮和醛的不对称Aodol缩合反应.研究结果表明，当采用含氟咪唑啉（2<i>R<\/i>，4<i>S<\/i>）-4-苄基-1，2-二甲基-2-三氟甲基咪唑啉（<b>1a<\/b>）作为不对称Aldol反应的催化剂时，能够以产率高达96%、最高<i>ee<\/i>值达到99%及<i>dr<\/i>值达到15:1的效率高效构建一系列顺式1，2-二醇产物.同时，我们也初步探讨了氟-氢键在不对称催化反应中的作用.","abstractInfoEn":"Aldol reaction of hydroxyacetone is an all-purpose route to construct the 1, 2-diol building blocks for the synthesis of multifarious natural products and biological active molecules. In this work, a new series of trifluoromethylated-imidazoline organocatalysts have been designed and synthesized. It is found that the trifluoromethylated chiral organocatalyst (2<i>R<\/i>, 4<i>S<\/i>)-4-benzyl-1, 2-dimethyl-2-(trifluoromethyl) imidazolidine (<b>1a<\/b>) has proved to be very efficient for the direct asymmetric aldol reaction of <i>α<\/i>-hydroxyketones with aldehydes to build the <i>syn<\/i>-1, 2-diol building blocks. Among the synthesized <i>syn<\/i>-aldol products, a good yield (up to 96%) and high stereoselectivity (up to <i>dr<\/i>＝15:1, 99% <i>ee<\/i>) could be obtained. The F—H bonding derived from trifluoromethyl group was proposed to play an important role in the stabilization of the transition state.","articleNo":"","authorCnList":["解晓娟"," 张忠"," 赵华欣"," 万文"," 郝健"],"authorEnList":["Xie Xiaojuan"," Zhang Zhong"," Zhao Huaxin"," Wan Wen"," Hao Jian"],"authorList":["解晓娟"," 张忠"," 赵华欣"," 万文"," 郝健"],"authors":"解晓娟, 张忠, 赵华欣, 万文, 郝健","authorsCn":"解晓娟, 张忠, 赵华欣, 万文, 郝健","authorsEn":"Xie Xiaojuan, Zhang Zhong, Zhao Huaxin, Wan Wen, Hao Jian","categoryName":"研究论文","categoryNameCn":"研究论文","categoryNameEn":"ARTICLES","citation":"解晓娟, 张忠, 赵华欣, 万文, 郝健. 含氟咪唑啉型有机催化剂在不对称Aldol反应中的研究. 有机化学, 2019, 39(1): 117-121. doi: 10.6023/cjoc201809026.","citationCn":"解晓娟, 张忠, 赵华欣, 万文, 郝健. 含氟咪唑啉型有机催化剂在不对称Aldol反应中的研究. 有机化学, 2019, 39(1): 117-121. doi: 10.6023/cjoc201809026.","citationEn":"解晓娟, 张忠, 赵华欣, 万文, 郝健. Trifluoromethylated-Imidazolines as Efficient Organocatalyst for Asymmetric Aldol Reaction of Hydroxyacetone with Aldehydes. Chinese Journal of Organic Chemistry, 2019, 39(1): 117-121. doi: 10.6023/cjoc201809026.","doi":"10.6023/cjoc201809026","figContent":"yjhx-39-1-117-1.jpg$$yjhx-39-1-117-2.jpg","figList":["yjhx-39-1-117-1.jpg","yjhx-39-1-117-2.jpg"],"firstFig":"yjhx-39-1-117-1.jpg","fpage":"117","highCitedState":"","htmlCount":204,"htmlFile":"","id":"3eea88d9-de93-4eea-aa58-1314f8902424","issnPpub":"0253-2786","issue":"1","journalPublishId":"yjhx","journalReferenceCodeType":0,"journalTitleCn":"有机化学","journalTitleEn":"Chinese Journal of Organic Chemistry","keyword":"不对称Aldol反应, 有机催化, 咪唑啉, 三氟甲基, 合成","keywordCn":"不对称Aldol反应, 有机催化, 咪唑啉, 三氟甲基, 合成","keywordCnList":["不对称Aldol反应"," 有机催化"," 咪唑啉"," 三氟甲基"," 合成"],"keywordEn":"asymmetric aldol reaction, organocatalysis, imidazoline, trifluoromethyl, synthesis","keywordEnList":["asymmetric aldol reaction"," organocatalysis"," imidazoline"," trifluoromethyl"," synthesis"],"keywordList":["不对称Aldol反应"," 有机催化"," 咪唑啉"," 三氟甲基"," 合成"],"language":"zh","latestInfo":"","latestState":"","latestStateEn":"","lpage":"121","oldUrl":"http://sioc-journal.cn/Jwk_yjhx/CN/volumn/home.shtml","pdfDownCount":12,"pdfSize":500.36,"pubDate":"2019-01-25","recommendState":"","releaseState":"1","secCount":0,"title":"含氟咪唑啉型有机催化剂在不对称Aldol反应中的研究","titleCn":"含氟咪唑啉型有机催化剂在不对称Aldol反应中的研究","titleEn":"Trifluoromethylated-Imidazolines as Efficient Organocatalyst for Asymmetric Aldol Reaction of Hydroxyacetone with Aldehydes","viewCount":1194,"volume":"39","year":2019},{"abstractInfo":"报道了一种构建含氟的<i>β<\/i>-酮酸酯及<i>β<\/i>-酮酰胺的亲核氟化反应.该反应采用PhI（OAc）<sub>2<\/sub>为氧化剂、3HF·Et<sub>3<\/sub>N为氟化试剂，在室温下反应30min高效构建一系列含有季碳中心的含氟化合物.与传统的亲电氟化反应相比，该方法具有无金属参与、反应时间短、反应条件简单、反应收率高等优点.","abstractInfoCn":"报道了一种构建含氟的<i>β<\/i>-酮酸酯及<i>β<\/i>-酮酰胺的亲核氟化反应.该反应采用PhI（OAc）<sub>2<\/sub>为氧化剂、3HF·Et<sub>3<\/sub>N为氟化试剂，在室温下反应30 min高效构建一系列含有季碳中心的含氟化合物.与传统的亲电氟化反应相比，该方法具有无金属参与、反应时间短、反应条件简单、反应收率高等优点.","abstractInfoEn":"Herein, a nucleophilic fluorination reaction to construct fluorine-containing <i>β<\/i>-ketoesters and <i>β<\/i>-ketoamides is reported. The reaction uses PhI(OAc)<sub>2<\/sub> as oxidant and 3HF·Et<sub>3<\/sub>N as fluorinating reagent. It can effectively build a series of fluorochemical compounds containing quaternary carbon center under room temperature reaction conditions for 30 min. Compared with the traditional electrophilic fluorination reaction, this method has the advantages of no metal participation, short reaction time, simple reaction conditions and high reaction yield.","articleNo":"","authorCnList":["吴文胜"," 袁航"," 黄高魁"," 蒋春辉"," 陆鸿飞"],"authorEnList":["Wu Wensheng"," Yuan Hang"," Huang Gaokui"," Jiang Chunhui"," Lu Hongfei"],"authorList":["吴文胜"," 袁航"," 黄高魁"," 蒋春辉"," 陆鸿飞"],"authors":"吴文胜, 袁航, 黄高魁, 蒋春辉, 陆鸿飞","authorsCn":"吴文胜, 袁航, 黄高魁, 蒋春辉, 陆鸿飞","authorsEn":"Wu Wensheng, Yuan Hang, Huang Gaokui, Jiang Chunhui, Lu Hongfei","categoryName":"研究论文","categoryNameCn":"研究论文","categoryNameEn":"ARTICLE","citation":"吴文胜, 袁航, 黄高魁, 蒋春辉, 陆鸿飞. PhI(OAc)<sub>2<\/sub>参与的<i>β<\/i>-酮酸酯及<i>β<\/i>-酮酰胺亲核氟化反应. 有机化学, 2019, 39(1): 137-143. doi: 10.6023/cjoc201808047.","citationCn":"吴文胜, 袁航, 黄高魁, 蒋春辉, 陆鸿飞. PhI(OAc)<sub>2<\/sub>参与的<i>β<\/i>-酮酸酯及<i>β<\/i>-酮酰胺亲核氟化反应. 有机化学, 2019, 39(1): 137-143. doi: 10.6023/cjoc201808047.","citationEn":"吴文胜, 袁航, 黄高魁, 蒋春辉, 陆鸿飞. Fluorination of <i>β<\/i>-Ketoesters and <i>β<\/i>-Ketoamides Based on PhI(OAc)<sub>2<\/sub>. Chinese Journal of Organic Chemistry, 2019, 39(1): 137-143. doi: 10.6023/cjoc201808047.","doi":"10.6023/cjoc201808047","figContent":"yjhx-39-1-137-S1.jpg$$yjhx-39-1-137-S2.jpg","figList":["yjhx-39-1-137-S1.jpg","yjhx-39-1-137-S2.jpg"],"firstFig":"yjhx-39-1-137-S1.jpg","fpage":"137","highCitedState":"","htmlCount":638,"htmlFile":"","id":"8a4e56ae-7829-45e8-a8ba-ece94968a539","issnPpub":"0253-2786","issue":"1","journalPublishId":"yjhx","journalReferenceCodeType":0,"journalTitleCn":"有机化学","journalTitleEn":"Chinese Journal of Organic Chemistry","keyword":"高价碘, <i>β<\/i>-酮酸酯, <i>β<\/i>-酮酰胺, 亲核氟化反应","keywordCn":"高价碘, <i>β<\/i>-酮酸酯, <i>β<\/i>-酮酰胺, 亲核氟化反应","keywordCnList":["高价碘"," <i>β<\/i>-酮酸酯"," <i>β<\/i>-酮酰胺"," 亲核氟化反应"],"keywordEn":"hypervalent iodine, <i>β<\/i>-ketoesters, <i>β<\/i>-ketoamides, nucleophilic fluorination reaction","keywordEnList":["hypervalent iodine"," <i>β<\/i>-ketoesters"," <i>β<\/i>-ketoamides"," nucleophilic fluorination reaction"],"keywordList":["高价碘"," <i>β<\/i>-酮酸酯"," <i>β<\/i>-酮酰胺"," 亲核氟化反应"],"language":"zh","latestInfo":"","latestState":"","latestStateEn":"","lpage":"143","oldUrl":"http://sioc-journal.cn/Jwk_yjhx/CN/volumn/home.shtml","pdfDownCount":14,"pdfSize":500.24,"pubDate":"2019-01-25","recommendState":"","releaseState":"1","secCount":0,"title":"PhI(OAc)<sub>2<\/sub>参与的<i>β<\/i>-酮酸酯及<i>β<\/i>-酮酰胺亲核氟化反应","titleCn":"PhI(OAc)<sub>2<\/sub>参与的<i>β<\/i>-酮酸酯及<i>β<\/i>-酮酰胺亲核氟化反应","titleEn":"Fluorination of <i>β<\/i>-Ketoesters and <i>β<\/i>-Ketoamides Based on PhI(OAc)<sub>2<\/sub>","viewCount":2176,"volume":"39","year":2019},{"abstractInfo":"脱卤亚磺化反应是引入氟烷基基团的一种常用方法.探索了<i>α<\/i>-三氟甲基苄溴在脱卤亚磺化条件下的反应，发现产物并不是亚磺酸盐[ArCH（CF<sub>3<\/sub>）SO<sub>2<\/sub>Na]，而是烷基硫酸盐[ArCH（CF<sub>3<\/sub>）OSO<sub>3<\/sub>Na].即使在烯烃的存在的条件下，<i>α<\/i>-三氟甲基苄溴在脱卤亚磺化条件下产生了自由基，也不与烯烃发生加成反应，而是直接生成亚磺酸盐，亚磺酸盐被空气氧化成烷基硫酸盐.","abstractInfoCn":"脱卤亚磺化反应是引入氟烷基基团的一种常用方法.探索了<i>α<\/i>-三氟甲基苄溴在脱卤亚磺化条件下的反应，发现产物并不是亚磺酸盐[ArCH（CF<sub>3<\/sub>）SO<sub>2<\/sub>Na]，而是烷基硫酸盐[ArCH（CF<sub>3<\/sub>）OSO<sub>3<\/sub>Na].即使在烯烃的存在的条件下，<i>α<\/i>-三氟甲基苄溴在脱卤亚磺化条件下产生了自由基，也不与烯烃发生加成反应，而是直接生成亚磺酸盐，亚磺酸盐被空气氧化成烷基硫酸盐.","abstractInfoEn":"The sulfinatodehalogenation reaction is a common method of introducing a fluoroalkyl group. In this paper, the reaction of <i>α<\/i>-trifluoromethylbenzyl bromide under sulfinatodehalogenation conditions was investigated. It was found that the product was an sodium alkyl sulfate (ArCH(CF<sub>3<\/sub>)OSO<sub>3<\/sub>Na) instead of an sodium alkyl sulfinate (ArCH(CF<sub>3<\/sub>)SO<sub>2<\/sub>Na) which was normal produced. <i>α<\/i>-Trifluoromethylbenzyl bromide did not react with the olefin after its generation of a radical intermediate under sulfinatodehalogenation conditions even though an olefin was presented. Instead, the reaction directly gave an alkyl sulfinate, and then oxidized by air to provide a product as an alkyl sulfate.","articleNo":"","authorCnList":["付晓林"," 孙岩"," 赵志刚"," 郭勇"," 陈庆云"," 念保义"],"authorEnList":["Fu Xiaolin"," Sun Yan"," Zhao Zhigang"," Guo Yong"," Chen Qingyun"," Nian Baoyi"],"authorList":["付晓林"," 孙岩"," 赵志刚"," 郭勇"," 陈庆云"," 念保义"],"authors":"付晓林, 孙岩, 赵志刚, 郭勇, 陈庆云, 念保义","authorsCn":"付晓林, 孙岩, 赵志刚, 郭勇, 陈庆云, 念保义","authorsEn":"Fu Xiaolin, Sun Yan, Zhao Zhigang, Guo Yong, Chen Qingyun, Nian Baoyi","categoryName":"研究论文","categoryNameCn":"研究论文","categoryNameEn":"ARTICLE","citation":"付晓林, 孙岩, 赵志刚, 郭勇, 陈庆云, 念保义. 从<i>α<\/i>-三氟甲基苄溴合成烷基硫酸盐——脱卤亚磺化反应的延伸. 有机化学, 2019, 39(1): 144-150. doi: 10.6023/cjoc201810022.","citationCn":"付晓林, 孙岩, 赵志刚, 郭勇, 陈庆云, 念保义. 从<i>α<\/i>-三氟甲基苄溴合成烷基硫酸盐——脱卤亚磺化反应的延伸. 有机化学, 2019, 39(1): 144-150. doi: 10.6023/cjoc201810022.","citationEn":"付晓林, 孙岩, 赵志刚, 郭勇, 陈庆云, 念保义. Synthesis of Alkyl Sulfate from <i>α<\/i>-Trifluoromethylbenzylbromide—An Extension of Sulfinatodehalogenation. Chinese Journal of Organic Chemistry, 2019, 39(1): 144-150. doi: 10.6023/cjoc201810022.","doi":"10.6023/cjoc201810022","figContent":"yjhx-39-1-144-S1.jpg$$yjhx-39-1-144-S2.jpg$$yjhx-39-1-144-S3.jpg","figList":["yjhx-39-1-144-S1.jpg","yjhx-39-1-144-S2.jpg","yjhx-39-1-144-S3.jpg"],"firstFig":"yjhx-39-1-144-S1.jpg","fpage":"144","highCitedState":"","htmlCount":183,"htmlFile":"","id":"51b57c54-f8c5-4435-b9e1-d78e2add5d12","issnPpub":"0253-2786","issue":"1","journalPublishId":"yjhx","journalReferenceCodeType":0,"journalTitleCn":"有机化学","journalTitleEn":"Chinese Journal of Organic Chemistry","keyword":"三氟甲基, 自由基, 脱卤亚磺化, 烷基硫酸盐","keywordCn":"三氟甲基, 自由基, 脱卤亚磺化, 烷基硫酸盐","keywordCnList":["三氟甲基"," 自由基"," 脱卤亚磺化"," 烷基硫酸盐"],"keywordEn":"Trifiluoromethyl, free radical, sulfinatodehalogenation, alkyl sulfate","keywordEnList":["Trifiluoromethyl"," free radical"," sulfinatodehalogenation"," alkyl sulfate"],"keywordList":["三氟甲基"," 自由基"," 脱卤亚磺化"," 烷基硫酸盐"],"language":"zh","latestInfo":"","latestState":"","latestStateEn":"","lpage":"150","oldUrl":"http://sioc-journal.cn/Jwk_yjhx/CN/volumn/home.shtml","pdfDownCount":14,"pdfSize":519.11,"pubDate":"2019-01-25","recommendState":"","releaseState":"1","secCount":0,"title":"从<i>α<\/i>-三氟甲基苄溴合成烷基硫酸盐——脱卤亚磺化反应的延伸","titleCn":"从<i>α<\/i>-三氟甲基苄溴合成烷基硫酸盐——脱卤亚磺化反应的延伸","titleEn":"Synthesis of Alkyl Sulfate from <i>α<\/i>-Trifluoromethylbenzylbromide—An Extension of Sulfinatodehalogenation","viewCount":1289,"volume":"39","year":2019},{"abstractInfo":"氨基粘土（Aminoclay，AC）是一种具有片层结构的硅酸盐材料，由于其在水中具有高分散性的特点，因此被广泛应用于构筑智能杂化水凝胶.利用静电相互作用，将带负电的7-[6-脱氧-6-（2-乙磺酸）]-<i>β<\/i>-环糊精（磺化环糊精，SCD）与氨基粘土非共价结合，构筑了一种新型的杂化水凝胶，并利用X射线衍射（XRD）、扫描式电子显微镜（SEM）、傅里叶变换红外光谱（FT-IR）、Zeta电势、流变测试等对所构筑的凝胶进行了结构表征.进而发现SCD-AC凝胶在水相中展现出对I<sub>3<\/sub><sup>-<\/sup>离子的高效吸附特性，并且在有机相中能够吸附I<sub>2<\/sub>分子.","abstractInfoCn":"氨基粘土（Aminoclay，AC）是一种具有片层结构的硅酸盐材料，由于其在水中具有高分散性的特点，因此被广泛应用于构筑智能杂化水凝胶.利用静电相互作用，将带负电的7-[6-脱氧-6-（2-乙磺酸）]-<i>β<\/i>-环糊精（磺化环糊精，SCD）与氨基粘土非共价结合，构筑了一种新型的杂化水凝胶，并利用X射线衍射（XRD）、扫描式电子显微镜（SEM）、傅里叶变换红外光谱（FT-IR）、Zeta电势、流变测试等对所构筑的凝胶进行了结构表征.进而发现SCD-AC凝胶在水相中展现出对I<sub>3<\/sub><sup>-<\/sup>离子的高效吸附特性，并且在有机相中能够吸附I<sub>2<\/sub>分子.","abstractInfoEn":"Aminoclay (AC), as a kind of layered silicates with positive charges, shows high dispersity in water and has been widely applied in the fabrication of intelligent hybrid hydrogel. Herein, heptakis-[6-deoxy-6-(2-sulfanylethanesulfonic acid)]-<i>β<\/i>-cyclodextrin (SCD), a kind of negatively charged cyclodextrin, was employed to construct the supramolecular hydrogel with aminoclay through the static electronic interactions, and the resultant SCD-AC hydrogel was fully characterized by means of X-ray powder diffraction (XRD), scanning electronic microscopy (SEM), fourier transform infrared spectroscopy (FT-IR), zeta potential, rheological test, <i>etc<\/i>. Significantly, the SCD-AC hydrogel can efficiently absorb not only I<sub>3<\/sub><sup>-<\/sup> ion in aqueous solution but also I<sub>2<\/sub> molecule in organic solvent, giving a high adsorption capacity up to 90% with 10 min.","articleNo":"","authorCnList":["牛杰"," 陈湧"," 刘育"],"authorEnList":["Niu Jie"," Chen Yong"," Liu Yu"],"authorList":["牛杰"," 陈湧"," 刘育"],"authors":"牛杰, 陈湧, 刘育","authorsCn":"牛杰, 陈湧, 刘育","authorsEn":"Niu Jie, Chen Yong, Liu Yu","categoryName":"研究论文","categoryNameCn":"研究论文","categoryNameEn":"ARTICLE","citation":"牛杰, 陈湧, 刘育. 环糊精/氨基粘土超分子水凝胶的构筑及其I<sub>3<\/sub><sup>-<\/sup>/I<sub>2<\/sub>吸附性能. 有机化学, 2019, 39(1): 151-156. doi: 10.6023/cjoc201807054.","citationCn":"牛杰, 陈湧, 刘育. 环糊精/氨基粘土超分子水凝胶的构筑及其I<sub>3<\/sub><sup>-<\/sup>/I<sub>2<\/sub>吸附性能. 有机化学, 2019, 39(1): 151-156. doi: 10.6023/cjoc201807054.","citationEn":"牛杰, 陈湧, 刘育. Construction of Cyclodextrin/Aminoclay-Based Supramolecular Hydrogel and Its I<sub>3<\/sub><sup>-<\/sup>/I<sub>2<\/sub> Adsorption Property. Chinese Journal of Organic Chemistry, 2019, 39(1): 151-156. doi: 10.6023/cjoc201807054.","doi":"10.6023/cjoc201807054","figContent":"yjhx-39-1-151-1.jpg$$yjhx-39-1-151-2.jpg$$yjhx-39-1-151-3.jpg$$yjhx-39-1-151-4.jpg","figList":["yjhx-39-1-151-1.jpg","yjhx-39-1-151-2.jpg","yjhx-39-1-151-3.jpg","yjhx-39-1-151-4.jpg"],"firstFig":"yjhx-39-1-151-1.jpg","fpage":"151","highCitedState":"","htmlCount":290,"htmlFile":"","id":"5af11987-a30b-4bec-9ee1-b0294399615d","issnPpub":"0253-2786","issue":"1","journalPublishId":"yjhx","journalReferenceCodeType":0,"journalTitleCn":"有机化学","journalTitleEn":"Chinese Journal of Organic Chemistry","keyword":"超分子水凝胶, 环糊精, 氨基粘土, 碘, 吸附","keywordCn":"超分子水凝胶, 环糊精, 氨基粘土, 碘, 吸附","keywordCnList":["超分子水凝胶"," 环糊精"," 氨基粘土"," 碘"," 吸附"],"keywordEn":"supramolecular hydrogel, cyclodextrin, aminoclay, iodine, adsorption","keywordEnList":["supramolecular hydrogel"," cyclodextrin"," aminoclay"," iodine"," adsorption"],"keywordList":["超分子水凝胶"," 环糊精"," 氨基粘土"," 碘"," 吸附"],"language":"zh","latestInfo":"","latestState":"","latestStateEn":"","lpage":"156","oldUrl":"http://sioc-journal.cn/Jwk_yjhx/CN/volumn/home.shtml","pdfDownCount":6,"pdfSize":2276.58,"pubDate":"2019-01-25","recommendState":"","releaseState":"1","secCount":0,"title":"环糊精/氨基粘土超分子水凝胶的构筑及其I<sub>3<\/sub><sup>-<\/sup>/I<sub>2<\/sub>吸附性能","titleCn":"环糊精/氨基粘土超分子水凝胶的构筑及其I<sub>3<\/sub><sup>-<\/sup>/I<sub>2<\/sub>吸附性能","titleEn":"Construction of Cyclodextrin/Aminoclay-Based Supramolecular Hydrogel and Its I<sub>3<\/sub><sup>-<\/sup>/I<sub>2<\/sub> Adsorption Property","viewCount":1463,"volume":"39","year":2019},{"abstractInfo":"在其组成的共轭基元上进行氟取代是有机光电材料功能修饰的常见策略之一.在前期苯并二噻吩/苯并噻二唑ADA型小分子光电化合物基础上，在两个苯并噻二唑基元上引入不同个数的氟取代基，考察氟修饰位置和个数对其基本性质、场效应晶体管和光伏性能的影响.研究表明，随着氟原子数目的增加，化合物的溶解性能降低，热稳定性提高，最高占有轨道和最低空轨道能级降低，但光谱吸收范围变化不大.有机场效应晶体管器件测试表明，当苯并噻二唑单氟代且位于外侧位点时，化合物的空穴迁移率有所降低；当苯并噻二唑双氟代时，迁移率得到了明显提高，达到0.27cm<sup>2<\/sup>·V<sup>-1<\/sup>·s<sup>-1<\/sup>.光伏器件研究发现，氟原子的引入提高了器件的开路电压，但活性层形貌变差，最终导致短路电流密度和电池效率下降.","abstractInfoCn":"在其组成的共轭基元上进行氟取代是有机光电材料功能修饰的常见策略之一.在前期苯并二噻吩/苯并噻二唑ADA型小分子光电化合物基础上，在两个苯并噻二唑基元上引入不同个数的氟取代基，考察氟修饰位置和个数对其基本性质、场效应晶体管和光伏性能的影响.研究表明，随着氟原子数目的增加，化合物的溶解性能降低，热稳定性提高，最高占有轨道和最低空轨道能级降低，但光谱吸收范围变化不大.有机场效应晶体管器件测试表明，当苯并噻二唑单氟代且位于外侧位点时，化合物的空穴迁移率有所降低；当苯并噻二唑双氟代时，迁移率得到了明显提高，达到0.27 cm<sup>2<\/sup>·V<sup>-1<\/sup>·s<sup>-1<\/sup>.光伏器件研究发现，氟原子的引入提高了器件的开路电压，但活性层形貌变差，最终导致短路电流密度和电池效率下降.","abstractInfoEn":"Fluorination on conjugated components is one of popular strategies to modify organic optoelectronic materials. Following the research of a benzodithiophene/benzothiadiazole ADA-type optoelectronic molecule, two benzothiadiazole (BT) units were fluorinated with different numbers and positions, and the change in basic properties and performances for field-effect transistors and organic solar cells was investigated. It was found that when the F-substitution number increases, the molecule enhances thermal stability, decreases solubility, lowers HOMO and LUMO energy levels, but almost does not alter light absorption range. Furthermore, investigations on organic field-effect transistors found the molecular hole mobility reduces with only one F-substituent at outer position of BT units, while increases up to 0.27 cm<sup>2<\/sup>·V<sup>-1<\/sup>·s<sup>-1<\/sup> with two F substituents on BT units. However, when these materials are applied in organic solar cells, the fluorinated ones enhance open-circuit voltage, but deteriorate active layer morphology, finally leading to decrease in short-circuit current and device efficiency.","articleNo":"","authorCnList":["梁龙"," 刘丽娜"," 陈学强"," 项宣"," 凌君"," 鲁郑全"," 李靖靖"," 李维实"],"authorEnList":["Liang Long"," Liu Li-Na"," Chen Xue-Qiang"," Xiang Xuan"," Ling Jun"," Lu Zheng-Quan"," Li Jing-Jing"," Li Wei-Shi"],"authorList":["梁龙"," 刘丽娜"," 陈学强"," 项宣"," 凌君"," 鲁郑全"," 李靖靖"," 李维实"],"authors":"梁龙, 刘丽娜, 陈学强, 项宣, 凌君, 鲁郑全, 李靖靖, 李维实","authorsCn":"梁龙, 刘丽娜, 陈学强, 项宣, 凌君, 鲁郑全, 李靖靖, 李维实","authorsEn":"Liang Long, Liu Li-Na, Chen Xue-Qiang, Xiang Xuan, Ling Jun, Lu Zheng-Quan, Li Jing-Jing, Li Wei-Shi","categoryName":"研究论文","categoryNameCn":"研究论文","categoryNameEn":"ARTICLE","citation":"梁龙, 刘丽娜, 陈学强, 项宣, 凌君, 鲁郑全, 李靖靖, 李维实. 苯并二噻吩/苯并噻二唑ADA型光电化合物:氟取代的影响. 有机化学, 2019, 39(1): 157-169. doi: 10.6023/cjoc201808034.","citationCn":"梁龙, 刘丽娜, 陈学强, 项宣, 凌君, 鲁郑全, 李靖靖, 李维实. 苯并二噻吩/苯并噻二唑ADA型光电化合物:氟取代的影响. 有机化学, 2019, 39(1): 157-169. doi: 10.6023/cjoc201808034.","citationEn":"梁龙, 刘丽娜, 陈学强, 项宣, 凌君, 鲁郑全, 李靖靖, 李维实. Benzodithiophene/Benzothiadiazole-Based ADA-Type Optoelectronic Molecules: Influence of Fluorine Substitution. Chinese Journal of Organic Chemistry, 2019, 39(1): 157-169. doi: 10.6023/cjoc201808034.","doi":"10.6023/cjoc201808034","figContent":"yjhx-39-1-157-1.jpg$$yjhx-39-1-157-S1.jpg$$yjhx-39-1-157-2.jpg$$yjhx-39-1-157-3.jpg$$yjhx-39-1-157-4.jpg$$yjhx-39-1-157-5.jpg$$yjhx-39-1-157-6.jpg$$yjhx-39-1-157-7.jpg$$yjhx-39-1-157-8.jpg$$yjhx-39-1-157-9.jpg$$yjhx-39-1-157-10.jpg","figList":["yjhx-39-1-157-1.jpg","yjhx-39-1-157-S1.jpg","yjhx-39-1-157-2.jpg","yjhx-39-1-157-3.jpg","yjhx-39-1-157-4.jpg","yjhx-39-1-157-5.jpg","yjhx-39-1-157-6.jpg","yjhx-39-1-157-7.jpg","yjhx-39-1-157-8.jpg","yjhx-39-1-157-9.jpg","yjhx-39-1-157-10.jpg"],"firstFig":"yjhx-39-1-157-1.jpg","fpage":"157","highCitedState":"","htmlCount":302,"htmlFile":"","id":"04f3a842-a02d-475c-bedb-59ab1da8b5ef","issnPpub":"0253-2786","issue":"1","journalPublishId":"yjhx","journalReferenceCodeType":0,"journalTitleCn":"有机化学","journalTitleEn":"Chinese Journal of Organic Chemistry","keyword":"有机光电材料, 氟化效应, 有机场效应晶体管, 有机太阳能电池","keywordCn":"有机光电材料, 氟化效应, 有机场效应晶体管, 有机太阳能电池","keywordCnList":["有机光电材料"," 氟化效应"," 有机场效应晶体管"," 有机太阳能电池"],"keywordEn":"organic optoelectronic materials, fluorination effect, organic field-effect transistors, organic solar cells","keywordEnList":["organic optoelectronic materials"," fluorination effect"," organic field-effect transistors"," organic solar cells"],"keywordList":["有机光电材料"," 氟化效应"," 有机场效应晶体管"," 有机太阳能电池"],"language":"zh","latestInfo":"","latestState":"","latestStateEn":"","lpage":"169","oldUrl":"http://sioc-journal.cn/Jwk_yjhx/CN/volumn/home.shtml","pdfDownCount":10,"pdfSize":5961.52,"pubDate":"2019-01-25","recommendState":"","releaseState":"1","secCount":0,"title":"苯并二噻吩/苯并噻二唑ADA型光电化合物:氟取代的影响","titleCn":"苯并二噻吩/苯并噻二唑ADA型光电化合物:氟取代的影响","titleEn":"Benzodithiophene/Benzothiadiazole-Based ADA-Type Optoelectronic Molecules: Influence of Fluorine Substitution","viewCount":1968,"volume":"39","year":2019},{"abstractInfo":"研究了原位生成的全氟烷基次磺酸分别与炔烃和联烯的加成反应，成功合成了一系列全氟烷基烯基亚砜类化合物.结果显示芳基或烷基取代的炔烃与全氟烷基次磺酸在加热条件下可以直接得到符合马氏规则的加成产物，当炔烃上连有强吸电子取代基时，则生成类Michael加成产物.全氟烷基次磺酸与富电子联烯的加成反应选择性地发生在空间位阻较小的双键上，当联烯分子中含有吸电子基团时，则会优先选择与连接吸电子基团的双键进行反应.","abstractInfoCn":"研究了原位生成的全氟烷基次磺酸分别与炔烃和联烯的加成反应，成功合成了一系列全氟烷基烯基亚砜类化合物.结果显示芳基或烷基取代的炔烃与全氟烷基次磺酸在加热条件下可以直接得到符合马氏规则的加成产物，当炔烃上连有强吸电子取代基时，则生成类Michael加成产物.全氟烷基次磺酸与富电子联烯的加成反应选择性地发生在空间位阻较小的双键上，当联烯分子中含有吸电子基团时，则会优先选择与连接吸电子基团的双键进行反应.","abstractInfoEn":"The addition reaction of perfluoroalkanesulfenic acids, <i>in-situ<\/i> formed from imines, to alkynes and allenes were investigated. A series of perfluoroalkyl alkenyl sulfoxides were synthesized. Markovnikov adducts were obtained in good to excellent yields from the reactions of aryl or alkyl-substituted alkynes with perfluoroalkanesulfenic acids under mild conditions. However, the reaction of terminal alkynes containing an electron-withdrawing group afforded Michael-type adducts in good yields. The addition reaction of electron-rich allenes took place at the double bond with less steric hindrance, while the double bond connecting an electron-withdrawing group was the prior reaction site in the case of electron-deficient allenes.","articleNo":"","authorCnList":["李晓波"," 赵娟"," 刘倩"," 蒋敏"," 刘金涛"],"authorEnList":["Li Xiaobo"," Zhao Juan"," Liu Qian"," Jiang Min"," Liu Jintao"],"authorList":["李晓波"," 赵娟"," 刘倩"," 蒋敏"," 刘金涛"],"authors":"李晓波, 赵娟, 刘倩, 蒋敏, 刘金涛","authorsCn":"李晓波, 赵娟, 刘倩, 蒋敏, 刘金涛","authorsEn":"Li Xiaobo, Zhao Juan, Liu Qian, Jiang Min, Liu Jintao","categoryName":"研究论文","categoryNameCn":"研究论文","categoryNameEn":"ARTICLES","citation":"李晓波, 赵娟, 刘倩, 蒋敏, 刘金涛. 全氟烷基次磺酸与炔烃和联烯的加成反应. 有机化学, 2019, 39(1): 183-191. doi: 10.6023/cjoc201808036.","citationCn":"李晓波, 赵娟, 刘倩, 蒋敏, 刘金涛. 全氟烷基次磺酸与炔烃和联烯的加成反应. 有机化学, 2019, 39(1): 183-191. doi: 10.6023/cjoc201808036.","citationEn":"李晓波, 赵娟, 刘倩, 蒋敏, 刘金涛. Addition of Perfluoroalkanesulfenic Acids to Alkynes and Allenes. Chinese Journal of Organic Chemistry, 2019, 39(1): 183-191. doi: 10.6023/cjoc201808036.","doi":"10.6023/cjoc201808036","figContent":"yjhx-39-1-183-S1.jpg$$yjhx-39-1-183-S2.jpg$$yjhx-39-1-183-S3.jpg","figList":["yjhx-39-1-183-S1.jpg","yjhx-39-1-183-S2.jpg","yjhx-39-1-183-S3.jpg"],"firstFig":"yjhx-39-1-183-S1.jpg","fpage":"183","highCitedState":"","htmlCount":132,"htmlFile":"","id":"78291f2c-f102-4cad-bffc-d21656bfb52f","issnPpub":"0253-2786","issue":"1","journalPublishId":"yjhx","journalReferenceCodeType":0,"journalTitleCn":"有机化学","journalTitleEn":"Chinese Journal of Organic Chemistry","keyword":"全氟烷基次磺酸, 炔烃, 联烯, 全氟烷基烯基亚砜, 加成反应","keywordCn":"全氟烷基次磺酸, 炔烃, 联烯, 全氟烷基烯基亚砜, 加成反应","keywordCnList":["全氟烷基次磺酸"," 炔烃"," 联烯"," 全氟烷基烯基亚砜"," 加成反应"],"keywordEn":"perfluoroalkanesulfenic acid, alkyne, allene, perfluoroalkyl alkenyl sulfoxide, addition reaction","keywordEnList":["perfluoroalkanesulfenic acid"," alkyne"," allene"," perfluoroalkyl alkenyl sulfoxide"," addition reaction"],"keywordList":["全氟烷基次磺酸"," 炔烃"," 联烯"," 全氟烷基烯基亚砜"," 加成反应"],"language":"zh","latestInfo":"","latestState":"","latestStateEn":"","lpage":"191","oldUrl":"http://sioc-journal.cn/Jwk_yjhx/CN/volumn/home.shtml","pdfDownCount":10,"pdfSize":496.05,"pubDate":"2019-01-25","recommendState":"","releaseState":"1","secCount":0,"title":"全氟烷基次磺酸与炔烃和联烯的加成反应","titleCn":"全氟烷基次磺酸与炔烃和联烯的加成反应","titleEn":"Addition of Perfluoroalkanesulfenic Acids to Alkynes and Allenes","viewCount":1105,"volume":"39","year":2019},{"abstractInfo":"报道了一种以茚酮、丙二腈、全氟烷基炔膦酸二乙酯为原料合成全氟烷基取代的芴基炔膦酸二乙酯类化合物的新方法.采用一锅合成法，可将不同基团取代的茚酮直接转化为一系列相应的全氟烷基取代的芴基炔膦酸二乙酯衍生物.整个反应过程无需金属催化，具备反应条件温和、区域选择性好、产率较高、操作简便等优点.","abstractInfoCn":"报道了一种以茚酮、丙二腈、全氟烷基炔膦酸二乙酯为原料合成全氟烷基取代的芴基炔膦酸二乙酯类化合物的新方法.采用一锅合成法，可将不同基团取代的茚酮直接转化为一系列相应的全氟烷基取代的芴基炔膦酸二乙酯衍生物.整个反应过程无需金属催化，具备反应条件温和、区域选择性好、产率较高、操作简便等优点.","abstractInfoEn":"A simple and versatile metal-free protocol for the synthesis of perfluoroalkyated fluorene derivatives bearing phosphonate group is achieved. The reactions proceeded via one-pot three-component condensation of indenones, fluorinated alkynylphosphonates and malononitrile under mild conditions. This protocol is highly regioselective, operationally facile and applicable to a variety of indenones in good to excellent yields.","articleNo":"","authorCnList":["孙小莉"," 孙振华"," 韩敏敏"," 韩靖"," 何伟民"," 陈杰"," 邓红梅"," 邵敏"," 张慧"," 曹卫国"],"authorEnList":["Sun Xiaoli"," Sun Zhenhua"," Han Minmin"," Han Jing"," He Weimin"," Chen Jie"," Deng Hongmei"," Shao Min"," Zhang Hui"," Cao Weiguo"],"authorList":["孙小莉"," 孙振华"," 韩敏敏"," 韩靖"," 何伟民"," 陈杰"," 邓红梅"," 邵敏"," 张慧"," 曹卫国"],"authors":"孙小莉, 孙振华, 韩敏敏, 韩靖, 何伟民, 陈杰, 邓红梅, 邵敏, 张慧, 曹卫国","authorsCn":"孙小莉, 孙振华, 韩敏敏, 韩靖, 何伟民, 陈杰, 邓红梅, 邵敏, 张慧, 曹卫国","authorsEn":"Sun Xiaoli, Sun Zhenhua, Han Minmin, Han Jing, He Weimin, Chen Jie, Deng Hongmei, Shao Min, Zhang Hui, Cao Weiguo","categoryName":"研究论文","categoryNameCn":"研究论文","categoryNameEn":"ARTICLES","citation":"孙小莉, 孙振华, 韩敏敏, 韩靖, 何伟民, 陈杰, 邓红梅, 邵敏, 张慧, 曹卫国. 全氟烷基取代的芴基炔膦酸二乙酯化合物的一锅法合成. 有机化学, 2019, 39(1): 192-199. doi: 10.6023/cjoc201808028.","citationCn":"孙小莉, 孙振华, 韩敏敏, 韩靖, 何伟民, 陈杰, 邓红梅, 邵敏, 张慧, 曹卫国. 全氟烷基取代的芴基炔膦酸二乙酯化合物的一锅法合成. 有机化学, 2019, 39(1): 192-199. doi: 10.6023/cjoc201808028.","citationEn":"孙小莉, 孙振华, 韩敏敏, 韩靖, 何伟民, 陈杰, 邓红梅, 邵敏, 张慧, 曹卫国. Synthesis of Perfluoroalkylated Fluorenes with Phosphonate Group via One-Pot Synthesis Process. Chinese Journal of Organic Chemistry, 2019, 39(1): 192-199. doi: 10.6023/cjoc201808028.","doi":"10.6023/cjoc201808028","figContent":"yjhx-39-1-192-1.jpg$$yjhx-39-1-192-2.jpg$$yjhx-39-1-192-S1.jpg","figList":["yjhx-39-1-192-1.jpg","yjhx-39-1-192-2.jpg","yjhx-39-1-192-S1.jpg"],"firstFig":"yjhx-39-1-192-1.jpg","fpage":"192","highCitedState":"","htmlCount":171,"htmlFile":"","id":"45356c5f-256b-4024-b712-62317b8937d5","issnPpub":"0253-2786","issue":"1","journalPublishId":"yjhx","journalReferenceCodeType":0,"journalTitleCn":"有机化学","journalTitleEn":"Chinese Journal of Organic Chemistry","keyword":"多组分反应, 一锅法合成, 全氟烷基炔膦酸二乙酯, 芴类衍生物","keywordCn":"多组分反应, 一锅法合成, 全氟烷基炔膦酸二乙酯, 芴类衍生物","keywordCnList":["多组分反应"," 一锅法合成"," 全氟烷基炔膦酸二乙酯"," 芴类衍生物"],"keywordEn":"multicomponent reactions (MCRs), one-pot synthesis, perfluoroalkynyl phosphonate, fluorene","keywordEnList":["multicomponent reactions (MCRs)"," one-pot synthesis"," perfluoroalkynyl phosphonate"," fluorene"],"keywordList":["多组分反应"," 一锅法合成"," 全氟烷基炔膦酸二乙酯"," 芴类衍生物"],"language":"zh","latestInfo":"","latestState":"","latestStateEn":"","lpage":"199","oldUrl":"http://sioc-journal.cn/Jwk_yjhx/CN/volumn/home.shtml","pdfDownCount":5,"pdfSize":723.92,"pubDate":"2019-01-25","recommendState":"","releaseState":"1","secCount":0,"title":"全氟烷基取代的芴基炔膦酸二乙酯化合物的一锅法合成","titleCn":"全氟烷基取代的芴基炔膦酸二乙酯化合物的一锅法合成","titleEn":"Synthesis of Perfluoroalkylated Fluorenes with Phosphonate Group via One-Pot Synthesis Process","viewCount":1080,"volume":"39","year":2019},{"abstractInfo":"发展了一类吡咯取代的手性亚磷酰胺配体，并将其成功地应用于铑催化的1，1-双取代烯烃的不对称氢甲酰化反应，以优秀的区域选择性、良好的化学选择性和对映选择性（71%~86%<i>ee<\/i>）得到相应的手性直链醛，反应的转化数（TurnoverNumber，TON）值最高达到8900.该类催化剂容易制备且具有广泛的官能团兼容性，通过不对称氢甲酰化反应为手性<i>α<\/i>-烷基-<i>β<\/i>-甲酰基丙酸酯类化合物的合成提供了一类新的方法.","abstractInfoCn":"发展了一类吡咯取代的手性亚磷酰胺配体，并将其成功地应用于铑催化的1，1-双取代烯烃的不对称氢甲酰化反应，以优秀的区域选择性、良好的化学选择性和对映选择性（71%~86%<i>ee<\/i>）得到相应的手性直链醛，反应的转化数（Turnover Number，TON）值最高达到8900.该类催化剂容易制备且具有广泛的官能团兼容性，通过不对称氢甲酰化反应为手性<i>α<\/i>-烷基-<i>β<\/i>-甲酰基丙酸酯类化合物的合成提供了一类新的方法.","abstractInfoEn":"A readily prepared chiral pyrrolylphosphinite has been found highly efficient for Rh(I) catalyzed asymmetric hydroformylation of 1, 1-disubstituted olefins. Chiral linear aldehydes have been synthesized with high productivity (turnover number (TON) up to 8900), excellent regioselectivity, and good to high chemo- and enantio-selectivites (71%~86% <i>ee<\/i>). The reaction features ready catalyst preparation and wide functional group tolerance, thus will be of practical value in the use of asymmetric hydroformylation (AHF) for the synthesis of chiral <i>α<\/i>-alkyl-<i>β<\/i>-formylpropanoate analogues.","articleNo":"","authorCnList":["贾肖飞"," 任新意"," 王正"," 夏春谷"," 丁奎岭"],"authorEnList":["Jia Xiaofei"," Ren Xinyi"," Wang Zheng"," Xia Chungu"," Ding Kuiling"],"authorList":["贾肖飞"," 任新意"," 王正"," 夏春谷"," 丁奎岭"],"authors":"贾肖飞, 任新意, 王正, 夏春谷, 丁奎岭","authorsCn":"贾肖飞, 任新意, 王正, 夏春谷, 丁奎岭","authorsEn":"Jia Xiaofei, Ren Xinyi, Wang Zheng, Xia Chungu, Ding Kuiling","categoryName":"研究论文","categoryNameCn":"研究论文","categoryNameEn":"ARTICLES","citation":"贾肖飞, 任新意, 王正, 夏春谷, 丁奎岭. 手性吡咯亚磷酰胺/Rh催化的1, 1-双取代烯烃的不对称氢甲酰化反应. 有机化学, 2019, 39(1): 207-214. doi: 10.6023/cjoc201809033.","citationCn":"贾肖飞, 任新意, 王正, 夏春谷, 丁奎岭. 手性吡咯亚磷酰胺/Rh催化的1, 1-双取代烯烃的不对称氢甲酰化反应. 有机化学, 2019, 39(1): 207-214. doi: 10.6023/cjoc201809033.","citationEn":"贾肖飞, 任新意, 王正, 夏春谷, 丁奎岭. Pyrrolyl-Based Phosphoramidite/Rh Catalyzed Asymmetric Hydroformylation of 1, 1-Disubstituted Olefins. Chinese Journal of Organic Chemistry, 2019, 39(1): 207-214. doi: 10.6023/cjoc201809033.","doi":"10.6023/cjoc201809033","figContent":"yjhx-39-1-207-1.jpg$$yjhx-39-1-207-2.jpg","figList":["yjhx-39-1-207-1.jpg","yjhx-39-1-207-2.jpg"],"firstFig":"yjhx-39-1-207-1.jpg","fpage":"207","highCitedState":"","htmlCount":115,"htmlFile":"","id":"b4026871-6978-4904-963f-e881f643c76a","issnPpub":"0253-2786","issue":"1","journalPublishId":"yjhx","journalReferenceCodeType":0,"journalTitleCn":"有机化学","journalTitleEn":"Chinese Journal of Organic Chemistry","keyword":"氢甲酰化, 烯烃, 铑, 不对称催化, 亚磷酰胺","keywordCn":"氢甲酰化, 烯烃, 铑, 不对称催化, 亚磷酰胺","keywordCnList":["氢甲酰化"," 烯烃"," 铑"," 不对称催化"," 亚磷酰胺"],"keywordEn":"hydroformylation, olefin, Rhodium, asymmetric catalysis, phosphoramidite","keywordEnList":["hydroformylation"," olefin"," Rhodium"," asymmetric catalysis"," phosphoramidite"],"keywordList":["氢甲酰化"," 烯烃"," 铑"," 不对称催化"," 亚磷酰胺"],"language":"zh","latestInfo":"","latestState":"","latestStateEn":"","lpage":"214","oldUrl":"http://sioc-journal.cn/Jwk_yjhx/CN/volumn/home.shtml","pdfDownCount":8,"pdfSize":0,"pubDate":"2019-01-25","recommendState":"","releaseState":"1","secCount":0,"title":"手性吡咯亚磷酰胺/Rh催化的1, 1-双取代烯烃的不对称氢甲酰化反应","titleCn":"手性吡咯亚磷酰胺/Rh催化的1, 1-双取代烯烃的不对称氢甲酰化反应","titleEn":"Pyrrolyl-Based Phosphoramidite/Rh Catalyzed Asymmetric Hydroformylation of 1, 1-Disubstituted Olefins","viewCount":1073,"volume":"39","year":2019},{"abstractInfo":"作为一类重要的碳环化合物，茚、螺环茚及其衍生物常见于各种天然产物骨架结构中，并作为合成中间体广泛地应用于材料、医药、有机不对称合成等领域.在路易斯酸TiCl<sub>4<\/sub>或AlCl<sub>3<\/sub>作用下，二苯甲醇或芳基取代环醇等苄醇通过生成碳正离子中间体，与炔烃进行环化反应高效合成多种茚及螺环茚.该反应仅需30min，反应过程中完成了2个新C—C键的构建，对具有各种取代基的炔烃均有较好的适用性.芳基取代的环丁醇、环己醇、环庚醇、环辛醇以及环十二醇都可以适用于该方法，多样性地构建多种有合成价值的螺环骨架.该方法具有操作简便、反应时间短、条件温和等优点.","abstractInfoCn":"作为一类重要的碳环化合物，茚、螺环茚及其衍生物常见于各种天然产物骨架结构中，并作为合成中间体广泛地应用于材料、医药、有机不对称合成等领域.在路易斯酸TiCl<sub>4<\/sub>或AlCl<sub>3<\/sub>作用下，二苯甲醇或芳基取代环醇等苄醇通过生成碳正离子中间体，与炔烃进行环化反应高效合成多种茚及螺环茚.该反应仅需30 min，反应过程中完成了2个新C—C键的构建，对具有各种取代基的炔烃均有较好的适用性.芳基取代的环丁醇、环己醇、环庚醇、环辛醇以及环十二醇都可以适用于该方法，多样性地构建多种有合成价值的螺环骨架.该方法具有操作简便、反应时间短、条件温和等优点.","abstractInfoEn":"As a type of important carbocyclic compounds, indenes and spiroindenes are not only widely found in natural products but extensively employed as synthetic building blocks in materials, pharmaceuticals, and asymmetric synthesis. An efficient and rapid synthesis of indenes and spiroindenes via the annulation of benzylic alcohols (or aryl-substituted cycloalkanols) with alkynes in the presence of TiCl<sub>4<\/sub> or AlCl<sub>3<\/sub> was desclosed. This reaction is normally completed within 30 min at room temperature and compatible with a variety of substituted alkynes. Two new C—C bonds are constructed during the reaction. Cycloalkanols such as cyclobutanol, cyclohexanol, cycloheptanol, cyclooctanol, and cyclododecanol are suitable substrates to afford a set of valuable spiroindenes. This method is featured with simple operation, short reaction time, and mild reaction conditions.","articleNo":"","authorCnList":["余佳佳"," 杨珊"," 吴镇"," 朱晨"],"authorEnList":["Yu Jiajia"," Yang Shan"," Wu Zhen"," Zhu Chen"],"authorList":["余佳佳"," 杨珊"," 吴镇"," 朱晨"],"authors":"余佳佳, 杨珊, 吴镇, 朱晨","authorsCn":"余佳佳, 杨珊, 吴镇, 朱晨","authorsEn":"Yu Jiajia, Yang Shan, Wu Zhen, Zhu Chen","categoryName":"研究论文","categoryNameCn":"研究论文","categoryNameEn":"ARTICLES","citation":"余佳佳, 杨珊, 吴镇, 朱晨. 通过苄醇与炔烃的环化反应快速高效构建茚及螺环茚. 有机化学, 2019, 39(1): 223-231. doi: 10.6023/cjoc201808009.","citationCn":"余佳佳, 杨珊, 吴镇, 朱晨. 通过苄醇与炔烃的环化反应快速高效构建茚及螺环茚. 有机化学, 2019, 39(1): 223-231. doi: 10.6023/cjoc201808009.","citationEn":"余佳佳, 杨珊, 吴镇, 朱晨. Annulation of Benzylic Alcohols with Alkynes for Rapid and Efficient Synthesis of Indenes and Spiroindenes. Chinese Journal of Organic Chemistry, 2019, 39(1): 223-231. doi: 10.6023/cjoc201808009.","doi":"10.6023/cjoc201808009","figContent":"yjhx-39-1-223-1.jpg$$yjhx-39-1-223-2.jpg","figList":["yjhx-39-1-223-1.jpg","yjhx-39-1-223-2.jpg"],"firstFig":"yjhx-39-1-223-1.jpg","fpage":"223","highCitedState":"","htmlCount":338,"htmlFile":"","id":"3d38e89a-ef52-4740-9452-b18bc830c468","issnPpub":"0253-2786","issue":"1","journalPublishId":"yjhx","journalReferenceCodeType":0,"journalTitleCn":"有机化学","journalTitleEn":"Chinese Journal of Organic Chemistry","keyword":"路易斯酸, 环化反应, 茚, 螺环茚","keywordCn":"路易斯酸, 环化反应, 茚, 螺环茚","keywordCnList":["路易斯酸"," 环化反应"," 茚"," 螺环茚"],"keywordEn":"Lewis acid, cyclization, indene, spiroindene","keywordEnList":["Lewis acid"," cyclization"," indene"," spiroindene"],"keywordList":["路易斯酸"," 环化反应"," 茚"," 螺环茚"],"language":"zh","latestInfo":"","latestState":"","latestStateEn":"","lpage":"231","oldUrl":"http://sioc-journal.cn/Jwk_yjhx/CN/volumn/home.shtml","pdfDownCount":26,"pdfSize":533.91,"pubDate":"2019-01-25","recommendState":"","releaseState":"1","secCount":0,"title":"通过苄醇与炔烃的环化反应快速高效构建茚及螺环茚","titleCn":"通过苄醇与炔烃的环化反应快速高效构建茚及螺环茚","titleEn":"Annulation of Benzylic Alcohols with Alkynes for Rapid and Efficient Synthesis of Indenes and Spiroindenes","viewCount":1786,"volume":"39","year":2019},{"abstractInfo":"使用稳定易得的三氟甲硫基银作为“三氟甲硫基”源，通过苯乙烯的三氟甲硫基化/氧化反应，合成了一系列多取代<i>α<\/i>-三氟甲硫基苯乙酮.以二甲基亚砜和氯仿的为溶剂，过硫酸钾为氧化剂，通过自由基历程进行双官能化反应，在温和条件下，以中等到良好的收率实现了一系列不同取代的苯乙烯的氧化三氟甲硫基化的高效转化，为<i>α<\/i>-三氟甲硫基苯乙酮的合成提供了一种简单、步骤经济的有效合成方法.","abstractInfoCn":"使用稳定易得的三氟甲硫基银作为“三氟甲硫基”源，通过苯乙烯的三氟甲硫基化/氧化反应，合成了一系列多取代<i>α<\/i>-三氟甲硫基苯乙酮.以二甲基亚砜和氯仿的为溶剂，过硫酸钾为氧化剂，通过自由基历程进行双官能化反应，在温和条件下，以中等到良好的收率实现了一系列不同取代的苯乙烯的氧化三氟甲硫基化的高效转化，为<i>α<\/i>-三氟甲硫基苯乙酮的合成提供了一种简单、步骤经济的有效合成方法.","abstractInfoEn":"Trifluoromethylthiolation/oxidation of styrenes with easiy-handling AgSCF<sub>3<\/sub> used as the trifluoromethylthiolating reagent has been described, which furnished a series of <i>α<\/i>-trifluoromethylthio acetophenons. A variety of substituted styrene could be bifunctionalized via radical process in a mixed solvent of dimethyl sulfoxide (DMSO) and CHCl<sub>3<\/sub>, with potassium persulfate used as the oxidant under mild conditions. A simple and efficent method for the facile construction of various <i>α<\/i>-trifluoromethylthio acetophenons is thus demonstrated.","articleNo":"","authorCnList":["王建勇"," 马岚"," 李彦"," 王细胜"],"authorEnList":["Wang Jian-Yong"," Ma Lan"," Li Yan"," Wang Xi-Sheng"],"authorList":["王建勇"," 马岚"," 李彦"," 王细胜"],"authors":"王建勇, 马岚, 李彦, 王细胜","authorsCn":"王建勇, 马岚, 李彦, 王细胜","authorsEn":"Wang Jian-Yong, Ma Lan, Li Yan, Wang Xi-Sheng","categoryName":"研究论文","categoryNameCn":"研究论文","categoryNameEn":"ARTICLES","citation":"王建勇, 马岚, 李彦, 王细胜. 苯乙烯的氧化三氟甲硫基化反应. 有机化学, 2019, 39(1): 232-237. doi: 10.6023/cjoc201807052.","citationCn":"王建勇, 马岚, 李彦, 王细胜. 苯乙烯的氧化三氟甲硫基化反应. 有机化学, 2019, 39(1): 232-237. doi: 10.6023/cjoc201807052.","citationEn":"王建勇, 马岚, 李彦, 王细胜. Trifluoromethylthiolation/Oxidation of Styrenes for Facile Synthesis of <i>α<\/i>-Trifluoromethylthio Acetophenons. Chinese Journal of Organic Chemistry, 2019, 39(1): 232-237. doi: 10.6023/cjoc201807052.","doi":"10.6023/cjoc201807052","figContent":"yjhx-39-1-232-S1.jpg","figList":["yjhx-39-1-232-S1.jpg"],"firstFig":"yjhx-39-1-232-S1.jpg","fpage":"232","highCitedState":"","htmlCount":151,"htmlFile":"","id":"c761d72e-5182-4b94-8874-dffb5dfc9456","issnPpub":"0253-2786","issue":"1","journalPublishId":"yjhx","journalReferenceCodeType":0,"journalTitleCn":"有机化学","journalTitleEn":"Chinese Journal of Organic Chemistry","keyword":"苯乙烯, 三氟甲硫基化, 自由基","keywordCn":"苯乙烯, 三氟甲硫基化, 自由基","keywordCnList":["苯乙烯"," 三氟甲硫基化"," 自由基"],"keywordEn":"styrene, trifluoromethylthiolation, radical","keywordEnList":["styrene"," trifluoromethylthiolation"," radical"],"keywordList":["苯乙烯"," 三氟甲硫基化"," 自由基"],"language":"zh","latestInfo":"","latestState":"","latestStateEn":"","lpage":"237","oldUrl":"http://sioc-journal.cn/Jwk_yjhx/CN/volumn/home.shtml","pdfDownCount":14,"pdfSize":512.24,"pubDate":"2019-01-25","recommendState":"","releaseState":"1","secCount":0,"title":"苯乙烯的氧化三氟甲硫基化反应","titleCn":"苯乙烯的氧化三氟甲硫基化反应","titleEn":"Trifluoromethylthiolation/Oxidation of Styrenes for Facile Synthesis of <i>α<\/i>-Trifluoromethylthio Acetophenons","viewCount":1055,"volume":"39","year":2019},{"abstractInfo":"立体位阻拥挤C—C键，尤其是包含全碳季碳中心C—C键的构建一直是现代有机合成化学的挑战.利用硝酸铈铵（CAN）诱导的双烯醇硅醚化合物分子内交叉氧化偶联反应来非对映选择性地构建连续全碳季碳中心以及叔碳中心.该方法在相对温和的反应条件下，以CAN作为单电子氧化剂，高产率、高非对映选择性地构建立体位阻拥挤的C—C键.本研究提供了一种通过分子内交叉氧化偶联反应来实现两个不同片段高效连接的有效手段，可以应用到复杂天然产物的全合成研究中去.","abstractInfoCn":"立体位阻拥挤C—C键，尤其是包含全碳季碳中心C—C键的构建一直是现代有机合成化学的挑战.利用硝酸铈铵（CAN）诱导的双烯醇硅醚化合物分子内交叉氧化偶联反应来非对映选择性地构建连续全碳季碳中心以及叔碳中心.该方法在相对温和的反应条件下，以CAN作为单电子氧化剂，高产率、高非对映选择性地构建立体位阻拥挤的C—C键.本研究提供了一种通过分子内交叉氧化偶联反应来实现两个不同片段高效连接的有效手段，可以应用到复杂天然产物的全合成研究中去.","abstractInfoEn":"The formation of sterically hindered C—C bond represents a great challenge in modern synthetic organic chemistry. A particularly challenging issue is the construction of all-carbon quaternary stereocenters. Herein, a ceric ammonium nitrate (CAN)-mediated intramolecular oxidative cross-coupling of silyl ethers for direct construction of valuable polycyclic scaffolds is described. The reaction enables sterically congested vicinal all-carbon quaternary and tertiary stereocenters to be installed diastereoselectively. The developed method provides a concise and efficient approach for ligation of two different segments through a compact C—C bond formation, which has potential applications in the synthesis of complex molecules as well as sterically congested natural products.","articleNo":"","authorCnList":["陈伟"," 郭人予"," 龚建贤"," 杨震"],"authorEnList":["Chen Wei"," Guo Renyu"," Gong Jianxian"," Yang Zhen"],"authorList":["陈伟"," 郭人予"," 龚建贤"," 杨震"],"authors":"陈伟, 郭人予, 龚建贤, 杨震","authorsCn":"陈伟, 郭人予, 龚建贤, 杨震","authorsEn":"Chen Wei, Guo Renyu, Gong Jianxian, Yang Zhen","categoryName":"研究论文","categoryNameCn":"研究论文","categoryNameEn":"ARTICLES","citation":"陈伟, 郭人予, 龚建贤, 杨震. 基于分子内交叉氧化偶联反应来非对映选择性构建全碳季碳中心. 有机化学, 2019, 39(1): 238-248. doi: 10.6023/cjoc201805023.","citationCn":"陈伟, 郭人予, 龚建贤, 杨震. 基于分子内交叉氧化偶联反应来非对映选择性构建全碳季碳中心. 有机化学, 2019, 39(1): 238-248. doi: 10.6023/cjoc201805023.","citationEn":"陈伟, 郭人予, 龚建贤, 杨震. Diastereoselective Construction of All-Carbon Quaternary Stereocenters via Intramolecular Oxidative Cross-Coupling Reaction. Chinese Journal of Organic Chemistry, 2019, 39(1): 238-248. doi: 10.6023/cjoc201805023.","doi":"10.6023/cjoc201805023","figContent":"yjhx-39-1-238-S1.jpg$$yjhx-39-1-238-1.jpg$$yjhx-39-1-238-S2.jpg$$yjhx-39-1-238-S3.jpg$$yjhx-39-1-238-S4.jpg$$yjhx-39-1-238-S5.jpg$$yjhx-39-1-238-S6.jpg","figList":["yjhx-39-1-238-S1.jpg","yjhx-39-1-238-1.jpg","yjhx-39-1-238-S2.jpg","yjhx-39-1-238-S3.jpg","yjhx-39-1-238-S4.jpg","yjhx-39-1-238-S5.jpg","yjhx-39-1-238-S6.jpg"],"firstFig":"yjhx-39-1-238-S1.jpg","fpage":"238","highCitedState":"","htmlCount":393,"htmlFile":"","id":"f9c5ed66-5146-46d0-a8cc-2e16727a06ae","issnPpub":"0253-2786","issue":"1","journalPublishId":"yjhx","journalReferenceCodeType":0,"journalTitleCn":"有机化学","journalTitleEn":"Chinese Journal of Organic Chemistry","keyword":"氧化偶联反应, 季碳中心, 叔碳中心, 方法学","keywordCn":"氧化偶联反应, 季碳中心, 叔碳中心, 方法学","keywordCnList":["氧化偶联反应"," 季碳中心"," 叔碳中心"," 方法学"],"keywordEn":"oxidative coupling reaction, quaternary stereocenter, tertiary stereocenter, methodology","keywordEnList":["oxidative coupling reaction"," quaternary stereocenter"," tertiary stereocenter"," methodology"],"keywordList":["氧化偶联反应"," 季碳中心"," 叔碳中心"," 方法学"],"language":"zh","latestInfo":"","latestState":"","latestStateEn":"","lpage":"248","oldUrl":"http://sioc-journal.cn/Jwk_yjhx/CN/volumn/home.shtml","pdfDownCount":26,"pdfSize":1150.55,"pubDate":"2019-01-25","recommendState":"","releaseState":"1","secCount":0,"title":"基于分子内交叉氧化偶联反应来非对映选择性构建全碳季碳中心","titleCn":"基于分子内交叉氧化偶联反应来非对映选择性构建全碳季碳中心","titleEn":"Diastereoselective Construction of All-Carbon Quaternary Stereocenters via Intramolecular Oxidative Cross-Coupling Reaction","viewCount":1935,"volume":"39","year":2019},{"abstractInfo":"报道了在NiCl<sub>2<\/sub>（dppp）催化和氯化锂促进下，室温下将偕二氟芳基乙烯与有机锌试剂进行交叉偶联反应，合成一系列（<i>Z<\/i>）-单氟烯烃的方法.该方法具有反应条件温和、操作简单、官能团兼容性较好、立体选择性出色等优点.","abstractInfoCn":"报道了在NiCl<sub>2<\/sub>（dppp）催化和氯化锂促进下，室温下将偕二氟芳基乙烯与有机锌试剂进行交叉偶联反应，合成一系列（<i>Z<\/i>）-单氟烯烃的方法.该方法具有反应条件温和、操作简单、官能团兼容性较好、立体选择性出色等优点.","abstractInfoEn":"An efficient method for the synthesis of various <i>Z<\/i>-fluorostyrene derivatives via nickel-catalyzed cross-coupling of <i>gem<\/i>-difluorostyrenes with organozinc reagents with the assistance of LiCl was developed. The reaction proceeds efficiently under mild condition, affording monofluoroalkenes in moderate to good yields. This novel method exhibits good functional group compatibility and excellent stereoselectivity.","articleNo":"","authorCnList":["张娟"," 王碧云"," 刘熠森"," 曹松"],"authorEnList":["Zhang Juan"," Wang Biyun"," Liu Yisen"," Cao Song"],"authorList":["张娟"," 王碧云"," 刘熠森"," 曹松"],"authors":"张娟, 王碧云, 刘熠森, 曹松","authorsCn":"张娟, 王碧云, 刘熠森, 曹松","authorsEn":"Zhang Juan, Wang Biyun, Liu Yisen, Cao Song","categoryName":"研究论文","categoryNameCn":"研究论文","categoryNameEn":"ARTICLES","citation":"张娟, 王碧云, 刘熠森, 曹松. 镍催化的偕二氟芳基乙烯与有机锌交叉偶联反应立体选择性合成(<i>Z<\/i>)-单氟烯烃. 有机化学, 2019, 39(1): 249-256. doi: 10.6023/cjoc201807013.","citationCn":"张娟, 王碧云, 刘熠森, 曹松. 镍催化的偕二氟芳基乙烯与有机锌交叉偶联反应立体选择性合成(<i>Z<\/i>)-单氟烯烃. 有机化学, 2019, 39(1): 249-256. doi: 10.6023/cjoc201807013.","citationEn":"张娟, 王碧云, 刘熠森, 曹松. Stereoselective Synthesis of <i>Z<\/i>-Fluorostyrene Derivatives via Nickel-Catalyzed Cross-Coupling of <i>gem<\/i>-Difluorostyrenes with Organozinc Reagents. Chinese Journal of Organic Chemistry, 2019, 39(1): 249-256. doi: 10.6023/cjoc201807013.","doi":"10.6023/cjoc201807013","figContent":"yjhx-39-1-249-1.jpg$$yjhx-39-1-249-S1.jpg$$yjhx-39-1-249-S2.jpg","figList":["yjhx-39-1-249-1.jpg","yjhx-39-1-249-S1.jpg","yjhx-39-1-249-S2.jpg"],"firstFig":"yjhx-39-1-249-1.jpg","fpage":"249","highCitedState":"","htmlCount":147,"htmlFile":"","id":"fe706443-7489-4082-b08e-ed74c9e2d473","issnPpub":"0253-2786","issue":"1","journalPublishId":"yjhx","journalReferenceCodeType":0,"journalTitleCn":"有机化学","journalTitleEn":"Chinese Journal of Organic Chemistry","keyword":"偕二氟芳基乙烯, 镍催化, 有机锌, 单氟烯烃","keywordCn":"偕二氟芳基乙烯, 镍催化, 有机锌, 单氟烯烃","keywordCnList":["偕二氟芳基乙烯"," 镍催化"," 有机锌"," 单氟烯烃"],"keywordEn":"<i>gem<\/i>-difluorostyrenes, nickel-catalyzed, organozinc reagents, monofluoroalkenes","keywordEnList":["<i>gem<\/i>-difluorostyrenes"," nickel-catalyzed"," organozinc reagents"," monofluoroalkenes"],"keywordList":["偕二氟芳基乙烯"," 镍催化"," 有机锌"," 单氟烯烃"],"language":"zh","latestInfo":"","latestState":"","latestStateEn":"","lpage":"256","oldUrl":"http://sioc-journal.cn/Jwk_yjhx/CN/volumn/home.shtml","pdfDownCount":16,"pdfSize":547.16,"pubDate":"2019-01-25","recommendState":"","releaseState":"1","secCount":0,"title":"镍催化的偕二氟芳基乙烯与有机锌交叉偶联反应立体选择性合成(<i>Z<\/i>)-单氟烯烃","titleCn":"镍催化的偕二氟芳基乙烯与有机锌交叉偶联反应立体选择性合成(<i>Z<\/i>)-单氟烯烃","titleEn":"Stereoselective Synthesis of <i>Z<\/i>-Fluorostyrene Derivatives via Nickel-Catalyzed Cross-Coupling of <i>gem<\/i>-Difluorostyrenes with Organozinc Reagents","viewCount":1201,"volume":"39","year":2019}],"ARTICLE":[{"abstractInfo":"Anovelpalladium-catalyzedintramolecularfluoroarylationofalkeneshasbeendeveloped,inwhichArIF<sub>2<\/sub>wasemployedasfluorinesourceaswellasⅠ(Ⅲ)reagenttoactivateolefin,todeliverthefluoroarylationproductsfrom4-aryl-1-olefinsinmoderatetogoodyields.Thecurrenttransformationpresentsaconvenientmethodtoprovidefluorotetralinsandfluorochromanesundermildconditionsfromalkenestetheredarenes.","abstractInfoCn":"发展了一种钯催化的烯烃分子内氟芳基化反应，以ArIF<sub>2<\/sub>作为氟源和亲电试剂来活化烯烃，实现了4-芳基-1-丁烯的氟化关环反应，以中等到良好的收率得到氟芳基化产物.这类反应为从烯基芳烃出发合成氟代四氢萘和氟代色满提供了高效方法.","abstractInfoEn":"A novel palladium-catalyzed intramolecular fluoroarylation of alkenes has been developed, in which ArIF<sub>2<\/sub> was employed as fluorine source as well as Ⅰ(Ⅲ) reagent to activate olefin, to deliver the fluoroarylation products from 4-aryl- 1-olefins in moderate to good yields. The current transformation presents a convenient method to provide fluorotetralins and fluorochromanes under mild conditions from alkenes tethered arenes.","articleNo":"","authorCnList":["杨文铖"," 亓晓旭"," 陈品红"," 刘国生"],"authorEnList":["Yang Wencheng"," Qi Xiaoxu"," Chen Pinhong"," Liu Guosheng"],"authorList":["Yang Wencheng"," Qi Xiaoxu"," Chen Pinhong"," Liu Guosheng"],"authors":"Yang Wencheng, Qi Xiaoxu, Chen Pinhong, Liu Guosheng","authorsCn":"杨文铖, 亓晓旭, 陈品红, 刘国生","authorsEn":"Yang Wencheng, Qi Xiaoxu, Chen Pinhong, Liu Guosheng","categoryName":"ARTICLE","categoryNameCn":"研究论文","categoryNameEn":"ARTICLE","citation":"Yang Wencheng, Qi Xiaoxu, Chen Pinhong, Liu Guosheng. Palladium-Catalyzed Intramolecular Fluoroarylation of Alkenes. Chinese Journal of Organic Chemistry, 2019, 39(1): 122-128. doi: 10.6023/cjoc201810026.","citationCn":"Yang Wencheng, Qi Xiaoxu, Chen Pinhong, Liu Guosheng. 钯催化烯烃的分子内氟芳基化反应. 有机化学, 2019, 39(1): 122-128. doi: 10.6023/cjoc201810026.","citationEn":"Yang Wencheng, Qi Xiaoxu, Chen Pinhong, Liu Guosheng. Palladium-Catalyzed Intramolecular Fluoroarylation of Alkenes. Chinese Journal of Organic Chemistry, 2019, 39(1): 122-128. doi: 10.6023/cjoc201810026.","doi":"10.6023/cjoc201810026","figContent":"yjhx-39-1-122-S1.jpg$$yjhx-39-1-122-S2.jpg$$yjhx-39-1-122-S3.jpg","figList":["yjhx-39-1-122-S1.jpg","yjhx-39-1-122-S2.jpg","yjhx-39-1-122-S3.jpg"],"firstFig":"yjhx-39-1-122-S1.jpg","fpage":"122","highCitedState":"","htmlCount":132,"htmlFile":"","id":"35dc4f59-246e-4525-b103-73390856de9a","issnPpub":"0253-2786","issue":"1","journalPublishId":"yjhx","journalReferenceCodeType":0,"journalTitleCn":"有机化学","journalTitleEn":"Chinese Journal of Organic Chemistry","keyword":"palladium-catalyzed, alkenes, fluoroarylation, tetralin","keywordCn":"钯催化, 烯烃, 氟芳基化, 四氢萘","keywordCnList":["钯催化"," 烯烃"," 氟芳基化"," 四氢萘"],"keywordEn":"palladium-catalyzed, alkenes, fluoroarylation, tetralin","keywordEnList":["palladium-catalyzed"," alkenes"," fluoroarylation"," tetralin"],"keywordList":["palladium-catalyzed"," alkenes"," fluoroarylation"," tetralin"],"language":"en","latestInfo":"","latestState":"","latestStateEn":"","lpage":"128","oldUrl":"http://sioc-journal.cn/Jwk_yjhx/CN/volumn/home.shtml","pdfDownCount":11,"pdfSize":488.67,"pubDate":"2019-01-25","recommendState":"","releaseState":"1","secCount":0,"title":"Palladium-Catalyzed Intramolecular Fluoroarylation of Alkenes","titleCn":"钯催化烯烃的分子内氟芳基化反应","titleEn":"Palladium-Catalyzed Intramolecular Fluoroarylation of Alkenes","viewCount":1141,"volume":"39","year":2019},{"abstractInfo":"Aniron(Ⅲ)-porphyrin-catalyzedcyclizationofketoneswithdimethylsulfoxide(DMSO)andammoniumacetateforthesynthesisofunsymmetricalandsymmetricalpyridinesbyemployingDMSOasC<sub>4<\/sub>orC<sub>6<\/sub>sourcehasbeendeveloped.VariousarylketonederivativesreactreadilywithDMSO,producingthepyridinesinyieldsof30%~85%.Thismethodusesnon-noblemetalsandproceedsundermildreactionconditionswithoperationalsimplicity,whichthusallowstheexpedientassemblyofpyridinesfromreadilyavailableketones.Basedonthepreliminaryexperiments,aplausiblemechanismofthistransformationisdisclosed.","abstractInfoCn":"发展了一种在铁卟啉催化下酮和二甲亚砜（DMSO）以及醋酸铵的环化反应，该反应利用DMSO作为碳源来合成不对称和对称的吡啶化合物，多种酮能够很好地和DMSO反应产生吡啶化合物，产率在30%到85%之间.该方法利用非贵金属和简单酮类化合物来合成吡啶，条件温和，操作简单.在初步的控制实验基础上，提出了该反应可能的机理.","abstractInfoEn":"An iron(Ⅲ)-porphyrin-catalyzed cyclization of ketones with dimethyl sulfoxide (DMSO) and ammonium acetate for the synthesis of unsymmetrical and symmetrical pyridines by employing DMSO as C<sub>4<\/sub> or C<sub>6<\/sub> source has been developed. Various aryl ketone derivatives react readily with DMSO, producing the pyridines in yields of 30%~85%. This method uses non-noble metals and proceeds under mild reaction conditions with operational simplicity, which thus allows the expedient assembly of pyridines from readily available ketones. Based on the preliminary experiments, a plausible mechanism of this transformation is disclosed.","articleNo":"","authorCnList":["刘玉峰"," 曹重仲"," 苏淼东"," 李慧"," 符美强"," 刘强"," 罗伟平"," 郭灿城"],"authorEnList":["Liu Yufeng"," Cao Zhongzhong"," Su Miaodong"," Li Hui"," Fu Meiqiang"," Liu Qiang"," Luo Weiping"," Guo Cancheng"],"authorList":["Liu Yufeng"," Cao Zhongzhong"," Su Miaodong"," Li Hui"," Fu Meiqiang"," Liu Qiang"," Luo Weiping"," Guo Cancheng"],"authors":"Liu Yufeng, Cao Zhongzhong, Su Miaodong, Li Hui, Fu Meiqiang, Liu Qiang, Luo Weiping, Guo Cancheng","authorsCn":"刘玉峰, 曹重仲, 苏淼东, 李慧, 符美强, 刘强, 罗伟平, 郭灿城","authorsEn":"Liu Yufeng, Cao Zhongzhong, Su Miaodong, Li Hui, Fu Meiqiang, Liu Qiang, Luo Weiping, Guo Cancheng","categoryName":"ARTICLE","categoryNameCn":"研究论文","categoryNameEn":"ARTICLE","citation":"Liu Yufeng, Cao Zhongzhong, Su Miaodong, Li Hui, Fu Meiqiang, Liu Qiang, Luo Weiping, Guo Cancheng. Iron(Ⅲ) Porphyrin Catalyzed Cyclization of Ketones with Dimethyl Sulfoxide and Ammonium Acetate: One-Pot Synthesis of Pyridines. Chinese Journal of Organic Chemistry, 2019, 39(1): 129-136. doi: 10.6023/cjoc201809014.","citationCn":"Liu Yufeng, Cao Zhongzhong, Su Miaodong, Li Hui, Fu Meiqiang, Liu Qiang, Luo Weiping, Guo Cancheng. 铁卟啉催化酮和二甲亚砜以及醋酸铵的环化反应:吡啶的一步合成. 有机化学, 2019, 39(1): 129-136. doi: 10.6023/cjoc201809014.","citationEn":"Liu Yufeng, Cao Zhongzhong, Su Miaodong, Li Hui, Fu Meiqiang, Liu Qiang, Luo Weiping, Guo Cancheng. Iron(Ⅲ) Porphyrin Catalyzed Cyclization of Ketones with Dimethyl Sulfoxide and Ammonium Acetate: One-Pot Synthesis of Pyridines. Chinese Journal of Organic Chemistry, 2019, 39(1): 129-136. doi: 10.6023/cjoc201809014.","doi":"10.6023/cjoc201809014","figContent":"yjhx-39-1-129-S1.jpg$$yjhx-39-1-129-1.jpg","figList":["yjhx-39-1-129-S1.jpg","yjhx-39-1-129-1.jpg"],"firstFig":"yjhx-39-1-129-S1.jpg","fpage":"129","highCitedState":"","htmlCount":134,"htmlFile":"","id":"74098fb2-d270-4875-944d-f9bd388126c2","issnPpub":"0253-2786","issue":"1","journalPublishId":"yjhx","journalReferenceCodeType":0,"journalTitleCn":"有机化学","journalTitleEn":"Chinese Journal of Organic Chemistry","keyword":"pyridine, iron(Ⅲ) porphyrin, dimethyl sulfoxide, ketone","keywordCn":"吡啶, 铁卟啉, 二甲亚砜, 酮","keywordCnList":["吡啶"," 铁卟啉"," 二甲亚砜"," 酮"],"keywordEn":"pyridine, iron(Ⅲ) porphyrin, dimethyl sulfoxide, ketone","keywordEnList":["pyridine"," iron(Ⅲ) porphyrin"," dimethyl sulfoxide"," ketone"],"keywordList":["pyridine"," iron(Ⅲ) porphyrin"," dimethyl sulfoxide"," ketone"],"language":"en","latestInfo":"","latestState":"","latestStateEn":"","lpage":"136","oldUrl":"http://sioc-journal.cn/Jwk_yjhx/CN/volumn/home.shtml","pdfDownCount":2,"pdfSize":486.39,"pubDate":"2019-01-25","recommendState":"","releaseState":"1","secCount":0,"title":"Iron(Ⅲ) Porphyrin Catalyzed Cyclization of Ketones with Dimethyl Sulfoxide and Ammonium Acetate: One-Pot Synthesis of Pyridines","titleCn":"铁卟啉催化酮和二甲亚砜以及醋酸铵的环化反应:吡啶的一步合成","titleEn":"Iron(Ⅲ) Porphyrin Catalyzed Cyclization of Ketones with Dimethyl Sulfoxide and Ammonium Acetate: One-Pot Synthesis of Pyridines","viewCount":961,"volume":"39","year":2019},{"abstractInfo":"3,3-Bis(difluoroamino)-1,5-dinitratopentanewasusedasenergeticplasticizerwithimprovingenergypropertiesandlowglasstransitiontemperature.Toobtainmorenewdifluoroaminoenergeticcompoundswithsimilarsturctures,aseriesof3,3-bis(difluoroamino)-1,5-substituted-pentanederivativesweredesignedascandidatesofnovelenergeticplasticizers.Theheatsofformation(HOFs),electronicstructure,energypropertyandthermalstabilitywerestudiedusingdensityfunctionaltheory(DFT)method.Thedifluoroaminogroupscanincreaseenergygapsofelectronicstructure,densityanddetonationpropertiesamongthetitlecompounds.Especially,1,3,3,5-tetra(difluoroamino)pentane(<b>S<\/b><sub><b>3<\/b><\/sub>)hasgivenoutstandingvaluesofpotentialenergeticplasticizer.Itscrystaldensity(1.91g/cm<sup>3<\/sup>),detonationvelocity(9.01km/s),detonationpressure(37.31GPa)andimpactsensitivity(<i>h<\/i><sub>50<\/sub>29.83cm)areveryclosetothoseofcyclotetramethylenetetranitramine(HMX).Furthermore,<b>S<\/b><sub><b>3<\/b><\/sub>canbesynthesizedviasomematureprocessesinfivesteps.","abstractInfoCn":"3，3-二（二氟氨基）-1，5-二硝酸酯基戊烷是一种高能低玻璃化转变温度的含能增塑剂.为了获得更多此类结构的新型二氟氨基含能化合物，设计了一系列3，3-二（二氟氨基）-1，5-取代戊烷衍生物作为新型含能增塑剂的候选品种.采用泛函密度理论（DFT）法研究了生成热、电子结构、能量特性和热稳定性.二氟氨基基团能增加标题化合物之间电子结构、密度和爆轰性质的能隙.特别是1，3，3，5-四（二氟氨基）戊烷（<b>S<\/b><sub><b>3<\/b><\/sub>）具有作为潜在含能增塑剂的显著价值.其晶体密度（1.91 g/cm<sup>3<\/sup>）、爆速（9.01 km/s）、爆压（37.31 GPa）和冲击灵敏度（<i>h<\/i><sub>50<\/sub> 29.83 cm）均与奥克托今（HMX）非常接近.此外，<b>S<\/b><sub><b>3<\/b><\/sub>可以通过一些成熟的过程5步合成得到.","abstractInfoEn":"3, 3-Bis(difluoroamino)-1, 5-dinitratopentane was used as energetic plasticizer with improving energy properties and low glass transition temperature. To obtain more new difluoroamino energetic compounds with similar sturctures, a series of 3, 3-bis(difluoroamino)-1, 5-substituted-pentane derivatives were designed as candidates of novel energetic plasticizers. The heats of formation (HOFs), electronic structure, energy property and thermal stability were studied using density functional theory (DFT) method. The difluoroamino groups can increase energy gaps of electronic structure, density and detonation properties among the title compounds. Especially, 1, 3, 3, 5-tetra(difluoroamino)pentane (<b>S<\/b><sub><b>3<\/b><\/sub>) has given outstanding values of potential energetic plasticizer. Its crystal density (1.91 g/cm<sup>3<\/sup>), detonation velocity (9.01 km/s), detonation pressure (37.31 GPa) and impact sensitivity (<i>h<\/i><sub>50<\/sub> 29.83 cm) are very close to those of cyclotetramethylenetetranitramine (HMX). Furthermore, <b>S<\/b><sub><b>3<\/b><\/sub> can be synthesized via some mature processes in five steps.","articleNo":"","authorCnList":["王万军"," 李欢"," 潘仁明"," 朱卫华"],"authorEnList":["Wang Wanjun"," Li Huan"," Pan Renming"," Zhu Weihua"],"authorList":["Wang Wanjun"," Li Huan"," Pan Renming"," Zhu Weihua"],"authors":"Wang Wanjun, Li Huan, Pan Renming, Zhu Weihua","authorsCn":"王万军, 李欢, 潘仁明, 朱卫华","authorsEn":"Wang Wanjun, Li Huan, Pan Renming, Zhu Weihua","categoryName":"ARTICLE","categoryNameCn":"研究论文","categoryNameEn":"ARTICLE","citation":"Wang Wanjun, Li Huan, Pan Renming, Zhu Weihua. Molecular Design and Property Prediction for a Series of 3, 3-Bis(difluoroamino)-1, 5-substituted-pentane Derivatized as Energetic Plasticizers. Chinese Journal of Organic Chemistry, 2019, 39(1): 170-176. doi: 10.6023/cjoc201808024.","citationCn":"Wang Wanjun, Li Huan, Pan Renming, Zhu Weihua. 含能增塑剂用系列3, 3-二(二氟氨基)-1, 5-取代戊烷衍生物的分子设计和性能预测. 有机化学, 2019, 39(1): 170-176. doi: 10.6023/cjoc201808024.","citationEn":"Wang Wanjun, Li Huan, Pan Renming, Zhu Weihua. Molecular Design and Property Prediction for a Series of 3, 3-Bis(difluoroamino)-1, 5-substituted-pentane Derivatized as Energetic Plasticizers. Chinese Journal of Organic Chemistry, 2019, 39(1): 170-176. doi: 10.6023/cjoc201808024.","doi":"10.6023/cjoc201808024","figContent":"yjhx-39-1-170-1.jpg$$yjhx-39-1-170-2.jpg$$yjhx-39-1-170-3.jpg$$yjhx-39-1-170-4.jpg$$yjhx-39-1-170-5.jpg$$yjhx-39-1-170-6.jpg$$yjhx-39-1-170-7.jpg","figList":["yjhx-39-1-170-1.jpg","yjhx-39-1-170-2.jpg","yjhx-39-1-170-3.jpg","yjhx-39-1-170-4.jpg","yjhx-39-1-170-5.jpg","yjhx-39-1-170-6.jpg","yjhx-39-1-170-7.jpg"],"firstFig":"yjhx-39-1-170-1.jpg","fpage":"170","highCitedState":"","htmlCount":93,"htmlFile":"","id":"52823deb-8dd1-40a6-89dd-c4a961574ba8","issnPpub":"0253-2786","issue":"1","journalPublishId":"yjhx","journalReferenceCodeType":0,"journalTitleCn":"有机化学","journalTitleEn":"Chinese Journal of Organic Chemistry","keyword":"difluoroamino pentane, density functional theory, heats of formation, detonation properties, bond","keywordCn":"二氟氨基戊烷, 密度泛函理论, 生成热, 爆轰性质, 键","keywordCnList":["二氟氨基戊烷"," 密度泛函理论"," 生成热"," 爆轰性质"," 键"],"keywordEn":"difluoroamino pentane, density functional theory, heats of formation, detonation properties, bond","keywordEnList":["difluoroamino pentane"," density functional theory"," heats of formation"," detonation properties"," bond"],"keywordList":["difluoroamino pentane"," density functional theory"," heats of formation"," detonation properties"," bond"],"language":"en","latestInfo":"","latestState":"","latestStateEn":"","lpage":"176","oldUrl":"http://sioc-journal.cn/Jwk_yjhx/CN/volumn/home.shtml","pdfDownCount":3,"pdfSize":802.25,"pubDate":"2019-01-25","recommendState":"","releaseState":"1","secCount":0,"title":"Molecular Design and Property Prediction for a Series of 3, 3-Bis(difluoroamino)-1, 5-substituted-pentane Derivatized as Energetic Plasticizers","titleCn":"含能增塑剂用系列3, 3-二(二氟氨基)-1, 5-取代戊烷衍生物的分子设计和性能预测","titleEn":"Molecular Design and Property Prediction for a Series of 3, 3-Bis(difluoroamino)-1, 5-substituted-pentane Derivatized as Energetic Plasticizers","viewCount":949,"volume":"39","year":2019}],"ARTICLES":[{"abstractInfo":"Recently,thepreparationoffluorinatedcompoundsthroughdifunctionalizationstrategieshasbecomeahotresearchareainfluorinechemistry.Inthiswork,acopper-catalyzedhydroxytrifluoromethylthiolationofarylpropynonesforthesynthesisofthecorrespondingtrifluoromethylthiolatedenolswasdeveloped.Thecoppersaltandsolventarecrucialtotheyieldsofthisreaction.Underoptimizedreactionconditions,aseriesoftrifluoromethylthiolatedenolswereobtainedinmoderatetogoodyields.","abstractInfoCn":"近年来通过双官能团化的策略来制备含氟化合物已经成为氟化学研究的热点.报道了一例铜催化的芳基炔酮的羟化-三氟甲硫基化反应来合成相应的含三氟甲硫基的烯醇.铜盐和溶剂对于该反应产率的影响非常关键.在最优条件下，一系列含三氟甲硫基的烯醇以中等到良好的产率被制备出来，并且各种官能团能够在该反应中很好地兼容.","abstractInfoEn":"Recently, the preparation of fluorinated compounds through difunctionalization strategies has become a hot research area in fluorine chemistry. In this work, a copper-catalyzed hydroxytrifluoromethylthiolation of arylpropynones for the synthesis of the corresponding trifluoromethylthiolated enols was developed. The copper salt and solvent are crucial to the yields of this reaction. Under optimized reaction conditions, a series of trifluoromethylthiolated enols were obtained in moderate to good yields.","articleNo":"","authorCnList":["胡娟娟"," 黄焰根"," 徐修华"," 卿凤翎"],"authorEnList":["Hu Juanjuan"," Huang Yangen"," Xu Xiuhua"," Qing Fengling"],"authorList":["Hu Juanjuan"," Huang Yangen"," Xu Xiuhua"," Qing Fengling"],"authors":"Hu Juanjuan, Huang Yangen, Xu Xiuhua, Qing Fengling","authorsCn":"胡娟娟, 黄焰根, 徐修华, 卿凤翎","authorsEn":"Hu Juanjuan, Huang Yangen, Xu Xiuhua, Qing Fengling","categoryName":"ARTICLES","categoryNameCn":"研究论文","categoryNameEn":"ARTICLES","citation":"Hu Juanjuan, Huang Yangen, Xu Xiuhua, Qing Fengling. Copper-Catalyzed Hydroxytrifluoromethylthiolation of Arylpropynones. Chinese Journal of Organic Chemistry, 2019, 39(1): 177-182. doi: 10.6023/cjoc201808041.","citationCn":"Hu Juanjuan, Huang Yangen, Xu Xiuhua, Qing Fengling. 铜催化的芳基炔酮的羟化三氟甲硫基化反应. 有机化学, 2019, 39(1): 177-182. doi: 10.6023/cjoc201808041.","citationEn":"Hu Juanjuan, Huang Yangen, Xu Xiuhua, Qing Fengling. Copper-Catalyzed Hydroxytrifluoromethylthiolation of Arylpropynones. Chinese Journal of Organic Chemistry, 2019, 39(1): 177-182. doi: 10.6023/cjoc201808041.","doi":"10.6023/cjoc201808041","figContent":"yjhx-39-1-177-S1.jpg$$yjhx-39-1-177-S2.jpg","figList":["yjhx-39-1-177-S1.jpg","yjhx-39-1-177-S2.jpg"],"firstFig":"yjhx-39-1-177-S1.jpg","fpage":"177","highCitedState":"","htmlCount":118,"htmlFile":"","id":"b475bbb6-247b-4385-9692-e460ad23846b","issnPpub":"0253-2786","issue":"1","journalPublishId":"yjhx","journalReferenceCodeType":0,"journalTitleCn":"有机化学","journalTitleEn":"Chinese Journal of Organic Chemistry","keyword":"copper, trifluoromethylthiolation, hydroxylation, propynone, radical","keywordCn":"铜, 三氟甲硫基化, 羟化, 炔酮, 自由基","keywordCnList":["铜"," 三氟甲硫基化"," 羟化"," 炔酮"," 自由基"],"keywordEn":"copper, trifluoromethylthiolation, hydroxylation, propynone, radical","keywordEnList":["copper"," trifluoromethylthiolation"," hydroxylation"," propynone"," radical"],"keywordList":["copper"," trifluoromethylthiolation"," hydroxylation"," propynone"," radical"],"language":"en","latestInfo":"","latestState":"","latestStateEn":"","lpage":"182","oldUrl":"http://sioc-journal.cn/Jwk_yjhx/CN/volumn/home.shtml","pdfDownCount":7,"pdfSize":451.81,"pubDate":"2019-01-25","recommendState":"","releaseState":"1","secCount":0,"title":"Copper-Catalyzed Hydroxytrifluoromethylthiolation of Arylpropynones","titleCn":"铜催化的芳基炔酮的羟化三氟甲硫基化反应","titleEn":"Copper-Catalyzed Hydroxytrifluoromethylthiolation of Arylpropynones","viewCount":1060,"volume":"39","year":2019},{"abstractInfo":"Anefficientprotocolforfacileaccesstotrifluoromethylatedtetrahydrofuranandtetrahydropyranhasbeendevelopedundervisiblelightirradiationconditionsviaradical1,2-alkoxyl-trifluoromethylationofunactivatedalkene.Itfeaturestheuseofreadilycommerciallyavailableandoperativelysimpletrifluoromethanesulfonylchlorideasatrifluoro-methylradicalsource,thusmakingtheprotocolpotentiallyappealingforpracticalpreparation.","abstractInfoCn":"利用相对廉价易得、操控简便的三氟甲基磺酰氯为三氟甲基自由基前体，在可见光催化下通过非活化烯烃的自由基1，2-烷氧基-三氟甲基化反应实现了一系列三氟甲基化的四氢呋喃和四氢吡喃化合物的高效合成.","abstractInfoEn":"An efficient protocol for facile access to trifluoromethylated tetrahydrofuran and tetrahydropyran has been developed under visible light irradiation conditions via radical 1, 2-alkoxyl-trifluoromethylation of unactivated alkene. It features the use of readily commercially available and operatively simple trifluoromethanesulfonyl chloride as a trifluoro- methyl radical source, thus making the protocol potentially appealing for practical preparation.","articleNo":"","authorCnList":["王娜"," 顾强帅"," 程永峰"," 李磊"," 李忠良"," 郭臻"," 刘心元"],"authorEnList":["Wang Na"," Gu Qiang-Shuai"," Cheng Yong-Feng"," Li Lei"," Li Zhong-Liang"," Guo Zhen"," Liu Xin-Yuan"],"authorList":["Wang Na"," Gu Qiang-Shuai"," Cheng Yong-Feng"," Li Lei"," Li Zhong-Liang"," Guo Zhen"," Liu Xin-Yuan"],"authors":"Wang Na, Gu Qiang-Shuai, Cheng Yong-Feng, Li Lei, Li Zhong-Liang, Guo Zhen, Liu Xin-Yuan","authorsCn":"王娜, 顾强帅, 程永峰, 李磊, 李忠良, 郭臻, 刘心元","authorsEn":"Wang Na, Gu Qiang-Shuai, Cheng Yong-Feng, Li Lei, Li Zhong-Liang, Guo Zhen, Liu Xin-Yuan","categoryName":"ARTICLES","categoryNameCn":"研究论文","categoryNameEn":"ARTICLES","citation":"Wang Na, Gu Qiang-Shuai, Cheng Yong-Feng, Li Lei, Li Zhong-Liang, Guo Zhen, Liu Xin-Yuan. Visible-Light Promoted Preparation of Trifluoromethylated Tetrahydrofuran and Tetrahydropyran. Chinese Journal of Organic Chemistry, 2019, 39(1): 200-206. doi: 10.6023/cjoc201808048.","citationCn":"Wang Na, Gu Qiang-Shuai, Cheng Yong-Feng, Li Lei, Li Zhong-Liang, Guo Zhen, Liu Xin-Yuan. 可见光促进合成三氟甲基取代的四氢呋喃和四氢吡喃. 有机化学, 2019, 39(1): 200-206. doi: 10.6023/cjoc201808048.","citationEn":"Wang Na, Gu Qiang-Shuai, Cheng Yong-Feng, Li Lei, Li Zhong-Liang, Guo Zhen, Liu Xin-Yuan. Visible-Light Promoted Preparation of Trifluoromethylated Tetrahydrofuran and Tetrahydropyran. Chinese Journal of Organic Chemistry, 2019, 39(1): 200-206. doi: 10.6023/cjoc201808048.","doi":"10.6023/cjoc201808048","figContent":"yjhx-39-1-200-S1.jpg$$yjhx-39-1-200-S2.jpg","figList":["yjhx-39-1-200-S1.jpg","yjhx-39-1-200-S2.jpg"],"firstFig":"yjhx-39-1-200-S1.jpg","fpage":"200","highCitedState":"","htmlCount":97,"htmlFile":"","id":"cadd90d8-b823-4526-9eb6-0abe2427435f","issnPpub":"0253-2786","issue":"1","journalPublishId":"yjhx","journalReferenceCodeType":0,"journalTitleCn":"有机化学","journalTitleEn":"Chinese Journal of Organic Chemistry","keyword":"trifluoromethanesulfonyl chloride, tetrahydrofuran, tetrahydropyran, visible light, alkoxyl-trifluoromethylation","keywordCn":"三氟甲基磺酰氯, 四氢呋喃, 四氢吡喃, 可见光, 烷氧-三氟甲基化","keywordCnList":["三氟甲基磺酰氯"," 四氢呋喃"," 四氢吡喃"," 可见光"," 烷氧-三氟甲基化"],"keywordEn":"trifluoromethanesulfonyl chloride, tetrahydrofuran, tetrahydropyran, visible light, alkoxyl-trifluoromethylation","keywordEnList":["trifluoromethanesulfonyl chloride"," tetrahydrofuran"," tetrahydropyran"," visible light"," alkoxyl-trifluoromethylation"],"keywordList":["trifluoromethanesulfonyl chloride"," tetrahydrofuran"," tetrahydropyran"," visible light"," alkoxyl-trifluoromethylation"],"language":"en","latestInfo":"","latestState":"","latestStateEn":"","lpage":"206","oldUrl":"http://sioc-journal.cn/Jwk_yjhx/CN/volumn/home.shtml","pdfDownCount":7,"pdfSize":474.82,"pubDate":"2019-01-25","recommendState":"","releaseState":"1","secCount":0,"title":"Visible-Light Promoted Preparation of Trifluoromethylated Tetrahydrofuran and Tetrahydropyran","titleCn":"可见光促进合成三氟甲基取代的四氢呋喃和四氢吡喃","titleEn":"Visible-Light Promoted Preparation of Trifluoromethylated Tetrahydrofuran and Tetrahydropyran","viewCount":815,"volume":"39","year":2019},{"abstractInfo":"Anickel-catalyzeddirectdifluoromethylationof(hetero)arylbromideswithbromodifluoromethane(BrCF<sub>2<\/sub>H)isdescribed.Thisreactionfeatureshighefficiency,broadsubstratescopeandhighfunctionalgrouptolerance,providingacost-efficientandstraightforwardrouteforapplicationsinmedicinalchemistry.Preliminarymechanisticstudiesrevealthatanickel-based,reductivecross-couplingcatalyticcycleisinvolvedinthereaction.","abstractInfoCn":"二氟甲基取代的（杂）芳烃化合物由于二氟甲基的独特性质越来越受到了化学家和药物学家的广泛关注.在过去的几年中，大量合成该类化合物的方法不断被发展，但这些方法中大多使用了价格昂贵的需要多步合成的二氟甲基化试剂，从而制约了其广泛应用.因此，发展以廉价易得的二氟甲基化试剂为氟源制备二氟甲基（杂）芳烃化合物的方法是十分必要的.以廉价易得的溴二氟甲烷（BrCF<sub>2<\/sub>H）为二氟甲基化试剂，发展了镍催化下（杂）芳基溴代物与BrCF<sub>2<\/sub>H的偶联反应.该反应高效温和，底物普适性好，官能团兼容性优秀，并且可以克量级合成，为合成二氟甲基（杂）芳烃化合物提供了一种高效简洁、廉价的方法.初步机理研究表明，该反应经历了一种镍催化的还原偶联历程.","abstractInfoEn":"A nickel-catalyzed direct difluoromethylation of (hetero)aryl bromides with bromodifluoromethane (BrCF<sub>2<\/sub>H) is described. This reaction features high efficiency, broad substrate scope and high functional group tolerance, providing a cost-efficient and straightforward route for applications in medicinal chemistry. Preliminary mechanistic studies reveal that a nickel-based, reductive cross-coupling catalytic cycle is involved in the reaction.","articleNo":"","authorCnList":["高兴"," 何旭"," 张新刚"],"authorEnList":["Gao Xing"," He Xu"," Zhang Xingang"],"authorList":["Gao Xing"," He Xu"," Zhang Xingang"],"authors":"Gao Xing, He Xu, Zhang Xingang","authorsCn":"高兴, 何旭, 张新刚","authorsEn":"Gao Xing, He Xu, Zhang Xingang","categoryName":"ARTICLES","categoryNameCn":"研究论文","categoryNameEn":"ARTICLES","citation":"Gao Xing, He Xu, Zhang Xingang. Nickel-Catalyzed Difluoromethylation of (Hetero)aryl Bromides with BrCF<sub>2<\/sub>H. Chinese Journal of Organic Chemistry, 2019, 39(1): 215-222. doi: 10.6023/cjoc201808014.","citationCn":"Gao Xing, He Xu, Zhang Xingang. 镍催化下一溴二氟甲烷对(杂)芳基溴代物的二氟甲基化反应. 有机化学, 2019, 39(1): 215-222. doi: 10.6023/cjoc201808014.","citationEn":"Gao Xing, He Xu, Zhang Xingang. Nickel-Catalyzed Difluoromethylation of (Hetero)aryl Bromides with BrCF<sub>2<\/sub>H. Chinese Journal of Organic Chemistry, 2019, 39(1): 215-222. doi: 10.6023/cjoc201808014.","doi":"10.6023/cjoc201808014","figContent":"yjhx-39-1-215-S1.jpg$$yjhx-39-1-215-S2.jpg","figList":["yjhx-39-1-215-S1.jpg","yjhx-39-1-215-S2.jpg"],"firstFig":"yjhx-39-1-215-S1.jpg","fpage":"215","highCitedState":"","htmlCount":124,"htmlFile":"","id":"b73f1f15-9139-430c-b9ed-3cece64dbc36","issnPpub":"0253-2786","issue":"1","journalPublishId":"yjhx","journalReferenceCodeType":0,"journalTitleCn":"有机化学","journalTitleEn":"Chinese Journal of Organic Chemistry","keyword":"aryl bromide, bromodifluoromethane, difluoromethylation, nickel, reductive cross-coupling","keywordCn":"芳基溴代物, 一溴二氟甲烷, 二氟甲基化, 镍, 还原偶联","keywordCnList":["芳基溴代物"," 一溴二氟甲烷"," 二氟甲基化"," 镍"," 还原偶联"],"keywordEn":"aryl bromide, bromodifluoromethane, difluoromethylation, nickel, reductive cross-coupling","keywordEnList":["aryl bromide"," bromodifluoromethane"," difluoromethylation"," nickel"," reductive cross-coupling"],"keywordList":["aryl bromide"," bromodifluoromethane"," difluoromethylation"," nickel"," reductive cross-coupling"],"language":"en","latestInfo":"","latestState":"","latestStateEn":"","lpage":"222","oldUrl":"http://sioc-journal.cn/Jwk_yjhx/CN/volumn/home.shtml","pdfDownCount":15,"pdfSize":489.91,"pubDate":"2019-01-25","recommendState":"","releaseState":"1","secCount":0,"title":"Nickel-Catalyzed Difluoromethylation of (Hetero)aryl Bromides with BrCF<sub>2<\/sub>H","titleCn":"镍催化下一溴二氟甲烷对(杂)芳基溴代物的二氟甲基化反应","titleEn":"Nickel-Catalyzed Difluoromethylation of (Hetero)aryl Bromides with BrCF<sub>2<\/sub>H","viewCount":1306,"volume":"39","year":2019},{"abstractInfo":"Twoelectrophilicpentafluoroethylatingreagentsofpentafluoroethyl(<i>p<\/i>-methylphenyl)sulfoniumbis(carbometh-oxy)methylide(<b>4a<\/b>)andpentafluoroethyl(4-nitrophenyl)sulfoniumbis(carbomethoxy)methylide(<b>4b<\/b>),andtheirreactionsundermildconditionswith<i>β<\/i>-ketoesters,aryliodidesandheteroaromaticsaredescribed.","abstractInfoCn":"发展了两个基于硫叶立德骨架的亲电五氟乙基化试剂，其合成高效简洁、固体状态下稳定而溶液中反应活性高.在温和条件下，该试剂可以与<i>β<\/i>-酮酸酯、芳基/杂芳基碘化物以及富电子芳烃反应高产率地得到相应的五氟乙基化产物.","abstractInfoEn":"Two electrophilic pentafluoroethylating reagents of pentafluoroethyl(<i>p<\/i>-methylphenyl)sulfonium bis(carbometh- oxy)methylide (<b>4a<\/b>) and pentafluoroethyl(4-nitrophenyl)sulfonium bis(carbomethoxy)methylide (<b>4b<\/b>), and their reactions under mild conditions with <i>β<\/i>-ketoesters, aryl iodides and heteroaromatics are described.","articleNo":"","authorCnList":["刘亚飞"," 葛航铭"," 吕龙"," 沈其龙"],"authorEnList":["Liu Yafei"," Ge Hangming"," Lu Long"," Shen Qilong"],"authorList":["Liu Yafei"," Ge Hangming"," Lu Long"," Shen Qilong"],"authors":"Liu Yafei, Ge Hangming, Lu Long, Shen Qilong","authorsCn":"刘亚飞, 葛航铭, 吕龙, 沈其龙","authorsEn":"Liu Yafei, Ge Hangming, Lu Long, Shen Qilong","categoryName":"ARTICLES","categoryNameCn":"研究论文","categoryNameEn":"ARTICLES","citation":"Liu Yafei, Ge Hangming, Lu Long, Shen Qilong. Pentafluoroethyl-Substituted Sulfonium Ylides: New Electrophilic Pentafluoroethylating Reagents. Chinese Journal of Organic Chemistry, 2019, 39(1): 257-264. doi: 10.6023/cjoc201807018.","citationCn":"Liu Yafei, Ge Hangming, Lu Long, Shen Qilong. 五氟乙基硫叶立德:一类新的亲电五氟乙基化试剂. 有机化学, 2019, 39(1): 257-264. doi: 10.6023/cjoc201807018.","citationEn":"Liu Yafei, Ge Hangming, Lu Long, Shen Qilong. Pentafluoroethyl-Substituted Sulfonium Ylides: New Electrophilic Pentafluoroethylating Reagents. Chinese Journal of Organic Chemistry, 2019, 39(1): 257-264. doi: 10.6023/cjoc201807018.","doi":"10.6023/cjoc201807018","figContent":"yjhx-39-1-257-1.jpg$$yjhx-39-1-257-2.jpg$$yjhx-39-1-257-3.jpg","figList":["yjhx-39-1-257-1.jpg","yjhx-39-1-257-2.jpg","yjhx-39-1-257-3.jpg"],"firstFig":"yjhx-39-1-257-1.jpg","fpage":"257","highCitedState":"","htmlCount":118,"htmlFile":"","id":"c7b1de97-6022-4502-9dec-f55a147d2af5","issnPpub":"0253-2786","issue":"1","journalPublishId":"yjhx","journalReferenceCodeType":0,"journalTitleCn":"有机化学","journalTitleEn":"Chinese Journal of Organic Chemistry","keyword":"fluorine, pentafluoroethyl, sulfonium ylide, electrophilic","keywordCn":"氟, 五氟乙基, 硫叶立德, 亲电","keywordCnList":["氟"," 五氟乙基"," 硫叶立德"," 亲电"],"keywordEn":"fluorine, pentafluoroethyl, sulfonium ylide, electrophilic","keywordEnList":["fluorine"," pentafluoroethyl"," sulfonium ylide"," electrophilic"],"keywordList":["fluorine"," pentafluoroethyl"," sulfonium ylide"," electrophilic"],"language":"en","latestInfo":"","latestState":"","latestStateEn":"","lpage":"264","oldUrl":"http://sioc-journal.cn/Jwk_yjhx/CN/volumn/home.shtml","pdfDownCount":11,"pdfSize":460.36,"pubDate":"2019-01-25","recommendState":"","releaseState":"1","secCount":0,"title":"Pentafluoroethyl-Substituted Sulfonium Ylides: New Electrophilic Pentafluoroethylating Reagents","titleCn":"五氟乙基硫叶立德:一类新的亲电五氟乙基化试剂","titleEn":"Pentafluoroethyl-Substituted Sulfonium Ylides: New Electrophilic Pentafluoroethylating Reagents","viewCount":1540,"volume":"39","year":2019},{"abstractInfo":"Wittig<i>gem<\/i>-difluoroolefinationofaldehydeswithdifluoromethylphosphoniumsalt(Ph<sub>3<\/sub>P<sup>+<\/sup>CF<sub>2<\/sub>H·Br<sup>-<\/sup>)byusingzincoxideasabaseisdescribed.AlthoughtheprotonintheCF<sub>2<\/sub>Hgroupisacidicandabasecouldeasilyleadtoitsdeprotonationtoformylide(Ph<sub>3<\/sub>P<sup>+<\/sup>CF<sub>2<\/sub><sup>-<\/sup>),theattackofthebaseatthepositivephosphorusatommayalsotakeplacetoproduceanucleophilic[HCF<sub>2<\/sub><sup>-<\/sup>]equivalent,andthennucleophilicdifluoromethylationinsteadofWittigreactionwouldoccur.TheuseofZnOasthebasefavoredtheWittigreactionandthenucleophilicdifluoromethylationwasnotobserved.Furthermore,theexcessiveZnOandZn<sup>Ⅱ<\/sup>saltsproducedfromZnOcouldbeeasilyremovedbyfiltration,whichmaybeconvenientforthepurificationprocess.","abstractInfoCn":"以氧化锌为碱实现了醛与二氟甲基鏻盐[Ph<sub>3<\/sub>P<sup>+<\/sup>CF<sub>2<\/sub>H·Br<sup>-<\/sup>]的Wittig偕二氟烯基化反应.虽然鏻盐中二氟甲基上的氢原子具有一定酸性，但是碱不一定就会与其发生中和反应而使鏻盐转化为叶立德.碱也有可能进攻磷原子而产生具有亲核性的二氟甲基物种，从而发生亲核二氟甲基化.以氧化锌为碱可抑制二氟甲基化，有利于Wittig反应；此外，氧化锌及其产生的锌盐都可经简单过滤而除去，方便产物纯化.","abstractInfoEn":"Wittig <i>gem<\/i>-difluoroolefination of aldehydes with difluoromethyl phosphonium salt (Ph<sub>3<\/sub>P<sup>+<\/sup>CF<sub>2<\/sub>H·Br<sup>-<\/sup>) by using zinc oxide as a base is described. Although the proton in the CF<sub>2<\/sub>H group is acidic and a base could easily lead to its deprotonation to form ylide (Ph<sub>3<\/sub>P<sup>+<\/sup>CF<sub>2<\/sub><sup>-<\/sup>), the attack of the base at the positive phosphorus atom may also take place to produce a nucleophilic [HCF<sub>2<\/sub><sup>-<\/sup>] equivalent, and then nucleophilic difluoromethylation instead of Wittig reaction would occur. The use of ZnO as the base favored the Wittig reaction and the nucleophilic difluoromethylation was not observed. Furthermore, the excessive ZnO and Zn<sup>Ⅱ<\/sup> salts produced from ZnO could be easily removed by filtration, which may be convenient for the purification process.","articleNo":"","authorCnList":["于蛟"," 林锦鸿"," 肖吉昌"],"authorEnList":["Yu Jiao"," Lin Jinhong"," Xiao Jichang"],"authorList":["Yu Jiao"," Lin Jinhong"," Xiao Jichang"],"authors":"Yu Jiao, Lin Jinhong, Xiao Jichang","authorsCn":"于蛟, 林锦鸿, 肖吉昌","authorsEn":"Yu Jiao, Lin Jinhong, Xiao Jichang","categoryName":"ARTICLES","categoryNameCn":"研究论文","categoryNameEn":"ARTICLES","citation":"Yu Jiao, Lin Jinhong, Xiao Jichang. ZnO-Promoted Wittig <i>gem<\/i>-Difluoroolefination of Aldehydes with [Ph<sub>3<\/sub>P<sup>+<\/sup>CF<sub>2<\/sub>H·Br<sup>-<\/sup>]. Chinese Journal of Organic Chemistry, 2019, 39(1): 265-269. doi: 10.6023/cjoc201806024.","citationCn":"Yu Jiao, Lin Jinhong, Xiao Jichang. 氧化锌促进的醛与[Ph<sub>3<\/sub>P<sup>+<\/sup>CF<sub>2<\/sub>H·Br<sup>-<\/sup>]的Wittig偕二氟烯基化反应. 有机化学, 2019, 39(1): 265-269. doi: 10.6023/cjoc201806024.","citationEn":"Yu Jiao, Lin Jinhong, Xiao Jichang. ZnO-Promoted Wittig <i>gem<\/i>-Difluoroolefination of Aldehydes with [Ph<sub>3<\/sub>P<sup>+<\/sup>CF<sub>2<\/sub>H·Br<sup>-<\/sup>]. Chinese Journal of Organic Chemistry, 2019, 39(1): 265-269. doi: 10.6023/cjoc201806024.","doi":"10.6023/cjoc201806024","figContent":"yjhx-39-1-265-S1.jpg","figList":["yjhx-39-1-265-S1.jpg"],"firstFig":"yjhx-39-1-265-S1.jpg","fpage":"265","highCitedState":"","htmlCount":113,"htmlFile":"","id":"2370fcd5-a661-47ba-857d-2b6f1d020f09","issnPpub":"0253-2786","issue":"1","journalPublishId":"yjhx","journalReferenceCodeType":0,"journalTitleCn":"有机化学","journalTitleEn":"Chinese Journal of Organic Chemistry","keyword":"Wittig, <i>gem<\/i>-difluoroolefination, aldehydes, difluoromethyl phosphonium salt, zinc oxide","keywordCn":"Wittig, 偕二氟烯基化, 醛, 二氟甲基鏻盐, 氧化锌","keywordCnList":["Wittig"," 偕二氟烯基化"," 醛"," 二氟甲基鏻盐"," 氧化锌"],"keywordEn":"Wittig, <i>gem<\/i>-difluoroolefination, aldehydes, difluoromethyl phosphonium salt, zinc oxide","keywordEnList":["Wittig"," <i>gem<\/i>-difluoroolefination"," aldehydes"," difluoromethyl phosphonium salt"," zinc oxide"],"keywordList":["Wittig"," <i>gem<\/i>-difluoroolefination"," aldehydes"," difluoromethyl phosphonium salt"," zinc oxide"],"language":"en","latestInfo":"","latestState":"","latestStateEn":"","lpage":"269","oldUrl":"http://sioc-journal.cn/Jwk_yjhx/CN/volumn/home.shtml","pdfDownCount":12,"pdfSize":638.05,"pubDate":"2019-01-25","recommendState":"","releaseState":"1","secCount":0,"title":"ZnO-Promoted Wittig <i>gem<\/i>-Difluoroolefination of Aldehydes with [Ph<sub>3<\/sub>P<sup>+<\/sup>CF<sub>2<\/sub>H·Br<sup>-<\/sup>]","titleCn":"氧化锌促进的醛与[Ph<sub>3<\/sub>P<sup>+<\/sup>CF<sub>2<\/sub>H·Br<sup>-<\/sup>]的Wittig偕二氟烯基化反应","titleEn":"ZnO-Promoted Wittig <i>gem<\/i>-Difluoroolefination of Aldehydes with [Ph<sub>3<\/sub>P<sup>+<\/sup>CF<sub>2<\/sub>H·Br<sup>-<\/sup>]","viewCount":1006,"volume":"39","year":2019}],"研究简报":[{"abstractInfo":"二芳基碘盐具有潜在的生物活性.合成了13种邻位三氟甲磺酸酯基取代的线性二芳基碘盐，利用核磁共振谱和质谱表征了它们的结构.通过微量肉汤稀释法测试该系列化合物的最低抑菌浓度（MIC），结果表明含氟基团取代的二芳基碘盐对于大肠杆菌（<i>E.coli<\/i>）、金黄色葡萄球菌（<i>S.aureus<\/i>）和枯草芽孢杆菌（<i>B.subtilis<\/i>）具有良好的抑菌性.其中，化合物（3-氟苯基）（2-（（（三氟甲基）磺酰基）氧基）苯基）三氟甲磺酸碘盐（<b>1<\/b>）对大肠杆菌、金黄色葡萄球菌和枯草芽孢杆菌的MIC值分别为16，4，4μg·mL<sup>-1<\/sup>，明显低于市售抗菌剂卡松（异噻唑啉酮）.此外，扫描电子显微镜（SEM）结果显示，该二芳基碘盐能够明显诱导细菌死亡；细胞试验结果显示在体外条件下，化合物<b>1<\/b>与市售卡松对Hela细胞的生长影响相当，是一种低毒性的抗菌剂.","abstractInfoCn":"二芳基碘盐具有潜在的生物活性.合成了13种邻位三氟甲磺酸酯基取代的线性二芳基碘盐，利用核磁共振谱和质谱表征了它们的结构.通过微量肉汤稀释法测试该系列化合物的最低抑菌浓度（MIC），结果表明含氟基团取代的二芳基碘盐对于大肠杆菌（<i>E.coli<\/i>）、金黄色葡萄球菌（<i>S.aureus<\/i>）和枯草芽孢杆菌（<i>B.subtilis<\/i>）具有良好的抑菌性.其中，化合物（3-氟苯基）（2-（（（三氟甲基）磺酰基）氧基）苯基）三氟甲磺酸碘盐（<b>1<\/b>）对大肠杆菌、金黄色葡萄球菌和枯草芽孢杆菌的MIC值分别为16，4，4 μg·mL<sup>-1<\/sup>，明显低于市售抗菌剂卡松（异噻唑啉酮）.此外，扫描电子显微镜（SEM）结果显示，该二芳基碘盐能够明显诱导细菌死亡；细胞试验结果显示在体外条件下，化合物<b>1<\/b>与市售卡松对Hela细胞的生长影响相当，是一种低毒性的抗菌剂.","abstractInfoEn":"Diaryliodonium salts with fluorines have potential bioactivity. Vicinal trifluoromethanesulfonate substituted diaryliodonium salts were synthesized for the purpose of studying their anti-bacterial properties aganist <i>Escherichia coli<\/i> (<i>E. coli<\/i>), <i>Staphylococcus aureus<\/i> (<i>S. aureus<\/i>) and <i>Bacillus subtilis<\/i> (<i>B. subtilis<\/i>). Firstly, their chemical structures were characterized by <sup>1<\/sup>H NMR, <sup>13<\/sup>C NMR, <sup>19<\/sup>F NMR and mass spectra. The minimum inhibitory concentration (MIC) of these compounds was tested by the micro-broth dilution method. The most active 2-((3-fluorophenyl)(((trifluoromethyl)sulfonyl)oxy)-l3-iodanyl)- phenyl trifluoromethanesulfonate (<b>1<\/b>) containing fluorine group gave the promising results for <i>Escherichia coli<\/i> (<i>E. coli<\/i>), <i>Staphylococcus aureus<\/i> (<i>S. aureus<\/i>) and <i>Bacillus subtilis<\/i> (<i>B. subtilis<\/i>) (MIC values of 16, 4 and 4 μg·mL<sup>-1<\/sup>), which is significantly lower than the commercial antibacterial agent of isothiazolinones. Scanning electron microscope (SEM) analysis sugggested that the compound led to the death of bacteria. Cytotoxicity tests showed that the compound <b>1<\/b> as well as isothiazolinones had a slight effect on the growth of Hela cells <i>in vitro<\/i> conditions.","articleNo":"","authorCnList":["崔丽媛"," 陈煌冠"," 马静怡"," 韩建伟"," 王利民"],"authorEnList":["Cui Liyuan"," Chen Huangguan"," Ma Jingyi"," Han Jianwei"," Wang Limin"],"authorList":["崔丽媛"," 陈煌冠"," 马静怡"," 韩建伟"," 王利民"],"authors":"崔丽媛, 陈煌冠, 马静怡, 韩建伟, 王利民","authorsCn":"崔丽媛, 陈煌冠, 马静怡, 韩建伟, 王利民","authorsEn":"Cui Liyuan, Chen Huangguan, Ma Jingyi, Han Jianwei, Wang Limin","categoryName":"研究简报","categoryNameCn":"研究简报","categoryNameEn":"NOTES","citation":"崔丽媛, 陈煌冠, 马静怡, 韩建伟, 王利民. 邻三氟甲磺酸酯基取代二芳基碘盐的合成及其抑菌活性研究. 有机化学, 2019, 39(1): 270-276. doi: 10.6023/cjoc201808043.","citationCn":"崔丽媛, 陈煌冠, 马静怡, 韩建伟, 王利民. 邻三氟甲磺酸酯基取代二芳基碘盐的合成及其抑菌活性研究. 有机化学, 2019, 39(1): 270-276. doi: 10.6023/cjoc201808043.","citationEn":"崔丽媛, 陈煌冠, 马静怡, 韩建伟, 王利民. Synthesis of Vicinal Trifluoromethanesulfonate Substituted Diaryliodonium Salts and Their Anti-bacterial Properties. Chinese Journal of Organic Chemistry, 2019, 39(1): 270-276. doi: 10.6023/cjoc201808043.","doi":"10.6023/cjoc201808043","figContent":"yjhx-39-1-270-S1.jpg$$yjhx-39-1-270-1.jpg$$yjhx-39-1-270-2.jpg$$yjhx-39-1-270-3.jpg$$yjhx-39-1-270-4.jpg$$yjhx-39-1-270-5.jpg","figList":["yjhx-39-1-270-S1.jpg","yjhx-39-1-270-1.jpg","yjhx-39-1-270-2.jpg","yjhx-39-1-270-3.jpg","yjhx-39-1-270-4.jpg","yjhx-39-1-270-5.jpg"],"firstFig":"yjhx-39-1-270-S1.jpg","fpage":"270","highCitedState":"","htmlCount":183,"htmlFile":"","id":"21f852fb-6413-4d7e-aafd-3cc88271fbb3","issnPpub":"0253-2786","issue":"1","journalPublishId":"yjhx","journalReferenceCodeType":0,"journalTitleCn":"有机化学","journalTitleEn":"Chinese Journal of Organic Chemistry","keyword":"二芳基碘盐, 抗菌剂, 卡松, 含氟化合物, 三氟甲磺酸酯","keywordCn":"二芳基碘盐, 抗菌剂, 卡松, 含氟化合物, 三氟甲磺酸酯","keywordCnList":["二芳基碘盐"," 抗菌剂"," 卡松"," 含氟化合物"," 三氟甲磺酸酯"],"keywordEn":"diaryliodonium salts, anti-bacterial, Kathon, fluorine, trifluoromethanesulfonate","keywordEnList":["diaryliodonium salts"," anti-bacterial"," Kathon"," fluorine"," trifluoromethanesulfonate"],"keywordList":["二芳基碘盐"," 抗菌剂"," 卡松"," 含氟化合物"," 三氟甲磺酸酯"],"language":"zh","latestInfo":"","latestState":"","latestStateEn":"","lpage":"276","oldUrl":"http://sioc-journal.cn/Jwk_yjhx/CN/volumn/home.shtml","pdfDownCount":4,"pdfSize":1795.96,"pubDate":"2019-01-25","recommendState":"","releaseState":"1","secCount":0,"title":"邻三氟甲磺酸酯基取代二芳基碘盐的合成及其抑菌活性研究","titleCn":"邻三氟甲磺酸酯基取代二芳基碘盐的合成及其抑菌活性研究","titleEn":"Synthesis of Vicinal Trifluoromethanesulfonate Substituted Diaryliodonium Salts and Their Anti-bacterial Properties","viewCount":1250,"volume":"39","year":2019}],"亮点介绍":[{"abstractInfo":"","abstractInfoCn":"","abstractInfoEn":"","articleNo":"","authorCnList":[],"authorEnList":[],"authorList":[],"authors":"","authorsCn":"","authorsEn":"","categoryName":"亮点介绍","categoryNameCn":"亮点介绍","categoryNameEn":"HIGHLIGHTS","citation":". 亮点介绍(8)篇. 有机化学, 2019, 39(1): 277-280.","citationCn":". 亮点介绍(8)篇. 有机化学, 2019, 39(1): 277-280.","citationEn":". . 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