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Citation: Wu Daocheng, Xu Liang, Zhang Xueyong. Synthesis of Liposomes of Oleoyl Mitomycin C and Its Antitumor Activity[J]. Chinese Journal of Applied Chemistry, ;1994, 44(5): 98-100. shu

Synthesis of Liposomes of Oleoyl Mitomycin C and Its Antitumor Activity

1.
1. Department of Chemistry, The Fourth Military Medical Universily, Xi'an 710032;
2.
2. Center of Gastroenterology, Xijing Hospital, The Fourth Military Medical University, Xi'an

Received Date: 3 January 1994
Available Online: 4 May 1994

The oleoyl mitomycin C was synthesized by reacting mitomycin C with oleic acid.Its structure was determined by elementary analysis,¹H NMR spectra and IR spectra。The liposome of oleoyl mitomycin was prepared by a modified reverse-phase evaporation method.The antitumor assay on mice indicated that this liposome showed 2.2 times more powerful cytotoxicity to human gastric cancer cell line than MMC and very low cytotoxicity to normal human embryonic lung cell line.
- oleoyl mitomycin C,
- liposome,
- antitumor activity
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