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Citation: Yue Guoren, Wang Jianhua, Zhang Zheng. Knoevenagel Condensation Catalyzed by N,N-Dimethyl-1,3-Propanediamine[J]. Chinese Journal of Applied Chemistry, ;1996, 13(1): 14-17. shu

Knoevenagel Condensation Catalyzed by N,N-Dimethyl-1,3-Propanediamine

1.
Department of Chemistry, Nanjing University, Nanjing 210008

Received Date: 27 April 1995
Available Online: 12 October 1995
Fund Project:

3-N,N-Dimethyl-1,3-propanediamine(DPA) is a useful catalyst for Knoevenagel reaction.2-(4-Nitrophenyl sulfonyl)-cinnamonitriles(3a~k) were obtained by condensation of 4-nitrophenylsulfonylacetonitrile(1) with aromatic aldehydes(2a~k) in the presence of DPA.The yields ranged from 83%~98%.However,the condensation between 2-hydroxybenzaldehyde and 4-nitrophenylsulfonyl-acetonitril gave a six-memberod lactone(31).The structure of compounds 3a~1 was confirmed by elemental analysis,IR,¹H NMR and MS.
- dimethylpropanediamine(DPA),
- catalysis,
- nitrophenylsulfonylacetonitrile,
- Knoevenagel reaction
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