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Citation: Tao Zhifu, Qian Xuhong, Tang Jun, Chen Fuheng. Synthesis, Spectra and DNA Intercalation of 2H-4, 9-Dimethylfuro[2', 3': 5, 6] naphtho[1, 2-b] pyron-2-one[J]. Chinese Journal of Applied Chemistry, ;1996, 13(4): 34-37. shu

Synthesis, Spectra and DNA Intercalation of 2H-4, 9-Dimethylfuro[2', 3': 5, 6] naphtho[1, 2-b] pyron-2-one

1.
1. Institute of Pesticides and Pharmaceuticals, East China University of Science and Technology, Shanghai 200237;
2.
2. Department of Applied Chemistry, Beijing Agricultural University, Beijing

Received Date: 17 October 1995
Available Online: 18 December 1995
Fund Project:

The title compound was synthesized by three methods from naphthopyrone. The structures of this compound and its precursors were fully characterized by ¹H NMR, MS, IR and elemental analysis.Its DNA-intercalative activity was investigated in DMSO-Tris HCl system by fluorescence quenching technique and the apparent Scatchard binding constant was estimated. Results showed that it efficiently intercalated into DNA.The spectral properties and DNA-intercalative activity have been compared with those of its analogues.
- naphthopyrones,
- DNA intercalation activity,
- synthesis,
- spectrum
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