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Citation: Fang Yue'e, Lü Xiaobin, Wang Yongming, Zhou Tao, Feng Jianping, Chen Bojun, Li Lisheng, Wang Yong jie, Wang Shaogen. Study of in vitro Drug Release from Chitosan Composite Membranes Containing Antibiotic Drugs[J]. Chinese Journal of Applied Chemistry, ;1997, 14(5): 67-70. shu

Study of in vitro Drug Release from Chitosan Composite Membranes Containing Antibiotic Drugs

1.
1. Department of Applied Chemistry, University of Science and Technology of China, Hefei 230026;
2.
2. First Af f iliated Hospital of Anhui Medical University, Hefei 230026
3.

Received Date: 31 December 1996
Available Online: 10 July 1997
Fund Project:

A novel composite membrane based on chitosan/starch/polyvinyl alcohol was prepared by solvent-casting technique and its mechanical properties were measured. The drug release and its mechanism in static state from the composite membranes containing ciprofloxacin and protocatechuic acid have been investigated. The release rate was found to be controlled by the starch content in membrane matrices as well as by crosslinking state.
- chitosan composite membrane,
- protocatechuic acid,
- ciprofloxacin,
- drug release
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