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Citation: Qi Guorong, Yang Yunsong, Yang Shilin, Zhang Guolin, Zhang Qingdi. Study on the Niclosamide Transdermal Therapeutic System[J]. Chinese Journal of Applied Chemistry, ;1997, 14(4): 25-28. shu

Study on the Niclosamide Transdermal Therapeutic System

1.
1. Department of Polymer Science and Engineering, Zhejiang University, Hangzhou 310027;
2.
2. Department of Pharmacy, Zhejiang Medical University, Hangzhou 310027

Received Date: 20 October 1996
Available Online: 26 May 1997
Fund Project:

The efficiency of penetration enhancers for niclosamide has been studied using double-cell skin permeation system. It was found that oleic acid was a good enhancer for niclosamide and was more efficient than azone. Azone showed a synergism with oleic acid or propylene glycol. It was also demonstrated that niclosamide could be used as a long-lasting liniment. The mechanism of the effect of azone and oleic acid has been investigated by IR and DSC techniques.
- niclosamide,
- transdermal therapeutic system,
- azone,
- oleic acid
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