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Citation: Zhuo Renxi, Yin Chao, Wu Yinnan, Zhu Lei, Zhen Shuiqing. Synthesis and Degradation Behavior of Poly (DL-Lactide) for Ophthalmic Application[J]. Chinese Journal of Applied Chemistry, ;1997, 14(2): 102-104. shu

Synthesis and Degradation Behavior of Poly (DL-Lactide) for Ophthalmic Application

1.
1. Department of Chemistry, Wuhan University, Wuhan 430072;
2.
2. Xiehe Hospital, Tongji Medical University, Wuhan 430072

Received Date: 18 August 1996
Available Online: 17 January 1997
Fund Project:

The application of poly(DL-lactide)(PLA) as a biodegradable ophthalmic implant has been studied. The PLA was synthesized from DL-lactide by bulk ring-opening polymerization initiated by stannous 2-ethylhexanoate. Both the pressure of polymerization system and the mole ratio of monomer to initiator showed a marked influence on the relative molecular weights of PLA. The in vitro and in vivo degradation of PLA has been investigated in 0.2 mol/L Na₂HPO₄-NaH₂PO₄ solution in rabbit's eyes.
- polylactide,
- synthesis,
- biodegradation,
- ophthalmic implant
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