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Citation: Shi Lei, Zhang Lingli, Lu Zehua, Liu Qingfeng, Zhang Guisheng. Syntheses and Antitumor Activities of 3,4-Di(indole-3-yl)-2,5-diketone-1-pyrrole Imine Thiourea Compounds[J]. Chemistry, ;2016, 79(12): 1150-1155. shu

Syntheses and Antitumor Activities of 3,4-Di(indole-3-yl)-2,5-diketone-1-pyrrole Imine Thiourea Compounds

Shi Lei ^1,2,, ,
Zhang Lingli ¹ ,
Lu Zehua ¹ ,
Liu Qingfeng ^1,2 ,
Zhang Guisheng ^1,2,,

1.
1. School of Chemistry and Chemical Engineering, Henan Normal University;
2.
2. Key Laboratory of Green Chemical Media and Reactions, Ministry of Education, Xinxiang 453007

Corresponding author: Shi Lei, Zhang Guisheng,
Received Date: 1 June 2016
Available Online: 15 August 2016
Fund Project:

Considering a variety of biological activities of bisindolyl maleimide and thiourea compounds, seventeen 3,4-bis(indole-3-yl)-2,5-diketone-1-pyrrole imine thiourea compounds were synthesized through the reaction of 1-amino-3,4-di(indole-3-yl)-3-pyrroline-2,5-diketone with isothiocyanate. Their structures were confirmed by ¹H NMR, ¹³C NMR and HRMS (ESI). The preliminary antitumor activities tests of the prepared compounds were performed. The results showed that most of the compounds have good inhibitory activity (above 96%) against cell division cycle 25B (CDC 25B), so they may have potential application in antitumor drug discovery.
- Bisindolylmaleimide,
- 1-Amino-3,4-bi(3-indole)-3-pyrroline-2,5-diketone,
- Thiourea compounds,
- Antitumor activity
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