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Citation: LI Meng-Long, CHENG Jian, CAO Shao-Ting, LIU Zu-Liang. Improved Process for Synthesizing 2-Mercapto-5-methoxyimidazo[4,5-b] pyridine[J]. Chinese Journal of Applied Chemistry, ;2010, 27(1): 122-124. shu

Improved Process for Synthesizing 2-Mercapto-5-methoxyimidazo[4,5-b] pyridine

1.
Chemical Engineering School, Nanjing University of Science & Technology, Nanjing 210094

Received Date: 7 January 2009
Available Online: 20 May 2009

2-Mercapto-5-methoxyimidazo[4,5-b]pyridine was obtained with 2,6-dichloropyridine as the starting material in five steps,including methoxylation,nitration,amination,reduction and cyclization.The overall yield of 2-mercapto-5-methoxyimidazo[4,5-b]pyridine was up to 45.7%.The differences between reaction conditions and yields of nitration of 2-chloro-6-methoxypyridine and 2,6-dichloropyridine were discussed,the effects of the amounts of hydrazine hydrate and the amounts of sodium hydroxide on the yield of the target product were also discussed.The structure of the target product was identified by ¹H NMR,MS and IR.
- mercaptomethoxyimidazo[4,5-b]pyridine,
- aminonitromethoxylpyridine,
- nitration,
- reduction
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