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Citation: HUANG Qiong-Yu, ZHANG Ming-Xia, LIU Fang, XIAO Xiu-Feng, LIU Rong-Fang. Preparation and Performance of Chitosan-Polyvinyl Alcohol-Sodium Tripolyphosphate Complex Microparticles[J]. Chinese Journal of Applied Chemistry, ;2010, 27(1): 21-26. shu

Preparation and Performance of Chitosan-Polyvinyl Alcohol-Sodium Tripolyphosphate Complex Microparticles

1.
College of Chemistry and Materials Science, Key Laboratory of Polymer Science, Fujian Normal University, Fuzhou 350007

Received Date: 23 December 2008
Available Online: 25 July 2009
Fund Project: 福建省科技厅重点资助项目(2006I0015) (2006I0015)

Chitosan/polyvinyl alcohol/sodium tripolyphosphate complex microparticles were prepared from chitosan(CS),polyvinyl alcohol(PVA) and sodium tripolyphosphate(TPP).The effects of CS content on complex microparticles and different ions,pH on the degree of equilibrium swelling were investigated.The component,structure and morphology of the complex microparticles were characterized by means of X-ray diffraction(XRD),Fourier transform infrared spectroscopy(FTIR),scanning electron microscopy(SEM).The results indicate that the CS-PVA is a compatible system;the crystallization of PVA declines with the increase of CS content;the particle size is about 400~950 μm with rough surfaces.The equilibrium swelling tests show that with the increase of CS content,the equilibrium swelling ratio increases firstly then decreases.The CS/PVA/TPP complex microparticles show highest equilibrium swelling ratio in a pH 3~8 solution and tend to decrease with the increase of ion content in the same aqueous solution.The microparticles have swelling-shrinking reversibility,implying that CS/PVA/TPP complex microparticles are pH/ion-sensitive and could provide experimental and theoretical basis for drug delivery system.
- chitosan,
- polyvinyl alcohol,
- compatibility,
- degree of equilibrium swelling,
- drug carriers
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