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Citation: CHEN Chang-Bao, WU Chun-Hui, ZHOU Jie. Synthesis,Spectroscopic Properties and Biochemical Evaluation of 6-Chloro-2-aminopurine Nucleoside Triphosphate[J]. Chinese Journal of Applied Chemistry, ;2009, 26(10): 1200-1205. shu

Synthesis,Spectroscopic Properties and Biochemical Evaluation of 6-Chloro-2-aminopurine Nucleoside Triphosphate

1.
College of Chemistry and Materials Science, Shandong Agricultural University, Tai'an 271018

Corresponding author: ZHOU Jie,
Received Date: 16 October 2008
Available Online: 20 December 2008
Fund Project: 山东省中青年奖励基金(02BS019)资助项目 (02BS019)

A purine nucleotide derivative,6-chloro-2-aminopurine nucleoside triphosphate,was synthesized in four steps and characterized with ¹H NMR,³¹P NMR,¹³C NMR,EA and IR. Its ultraviolet properties at various pH values were studied. The pK_a value of the compound was determined by the curves of UV abso-rption dependency on pH,which was 1.44. Hydrolysis of the nucleotide derivative under the catalysis of potato apyrase was studied. The competion of the ATP analogue with ATP for potato apyrase' active site was proved to be mixed prohibition mechanism.
- chloro-aminopurine nucleoside triphosphate,
- synthesis,
- spectroscopic property,
- biochemical evaluation
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