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Citation: HE Yun-Hua, CHEN Zhi-Hong. Flow Injection-Post Chemiluminescence Method for the Determination of Isoniazid[J]. Chinese Journal of Applied Chemistry, ;2009, 26(7): 869-871. shu

Flow Injection-Post Chemiluminescence Method for the Determination of Isoniazid

HE Yun-Hua ^, ,
CHEN Zhi-Hong

1.
School of Environmental Science and Engineering, Chang'an University, Xi'an 710054

Corresponding author: HE Yun-Hua,
Received Date: 14 July 2008
Available Online: 5 September 2008

A post chemiluminescence(PCL) reaction was observed when isoniazid was injected into the reaction mixture of potassium ferricyanide-calcein chemiluminescence(CL) reaction system.The experimental conditions of the CL reactions were optimized.A new chemiluminesence method coupled with flow injection technique for the determination of isoniazid was developed.The detection limit was 6×10^-8 g/mL,and the relative standard deviation was 1.8%(2.0×10^-6 g/mL isoniazid,n=11),and the liner range was 2.0×10^-7~1.0×10^-5 g/mL.The method has been successfully applied to the determination of isoniazid in the isoniazid tablets and the results were consistent with that determined by means of the method in the Chinese pharmacopoeia.
- post-chemiluminescence reaction,
- potassium ferricyanide,
- calcein,
- isoniazid
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