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Citation: MENG Xiang-Yu, PI Zi-Feng, SONG Feng-Rui, LIU Zhi-Qiang, LIU Shu-Ying. Changes in the Effective Compounds and the Anti-inflammatory Activity before and after the Decoction of Ephedra and Liquorite[J]. Chinese Journal of Applied Chemistry, ;2009, 26(7): 801-806. shu

Changes in the Effective Compounds and the Anti-inflammatory Activity before and after the Decoction of Ephedra and Liquorite

1.
a Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022;
2.
b Graduate School of Chinese Academy of Sciences, Beijing

Corresponding author: SONG Feng-Rui,
Received Date: 3 July 2008
Available Online: 16 September 2008
Fund Project: 国家自然科学基金(30472134,30672600) (30472134,30672600)吉林省科技重点项目(20060902)资助项目 (20060902)

The major chemical constituents of glycyrrhiza(glycyrrhizic acid,liquiritin) and ephedra(ephedrine and methephedrine) in the decoction of ephedra-glycyrrhiza were analyzed by high performance liquid chromatography(HPLC) and gas chromatography(GC),respectively.The influences of different parts of ephedra-glycyrrhiza on the auricular swelling of mice caused by dimethylbenzene were studied.This method can sensitively detect the difference between the single decoction of glycyrrhiza,ephedra and combined decoction of ephedra-glycyrrhiza.Compared to that of single decoction,the abundances of glycyrrhizic acid,liquiritin,ephedrine and methephedrine in the combined decoction of ephedra-glycyrrhiza were increased by 13.50%,-19.38%,14.52% and 64.0%,respectively.The anti-inflammatory ability of the combined decoction of ephedra-glycyrrhiza was higher than that of the single decoctions.
- ephedra,
- glycyrrhiza,
- preparation combination,
- HPLC-MS/MS,
- GC-MS
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