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Citation: ZHOU Shuang-Sheng, ZHANG Qun-Ying, LU Chuan-Hua, BI Jian-Hong. Synthesis and Biological Activities of Triazacyclodecane and Its Derivatives[J]. Chinese Journal of Applied Chemistry, ;2009, 26(6): 671-675. shu

Synthesis and Biological Activities of Triazacyclodecane and Its Derivatives

1.
a School of Pharmacy, Anhui College of Traditional Chinese Medicine, Hefei 230031;
2.
b Department of Chemistry, Hefei Normal College, Hefei 230061

Corresponding author: ZHOU Shuang-Sheng,
Received Date: 22 May 2008
Available Online: 20 July 2008
Fund Project: 国家自然科学基金(20071001)资助项目、安徽省教育厅自然科学基金项目(KJ2007B209) (20071001)资助项目、安徽省教育厅自然科学基金项目(KJ2007B209)

A novel 1,4,7-triazacyclodecane and its 4 derivatives were synthesized.These compounds were characterized by elemental analysis,IR,¹H NMR and MS techniques.The biological activities of these compounds were investigated against human cancer cells Hela and HCT26.The results showed that all the compounds possess,to some extent,antitumor activities which change in dose dependent manner.After treatment with compound 4,the degeneration and necrosis of HCT26 cells occurred,showing that compound 4 has significant apoptotic effect on HCT26 cells.
- azamacrocycle,
- derivative,
- synthesis,
- biological activity
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