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Citation: ZHANG Qi-Ping, WANG Nan-Ping, ZHOU Li-Fang, GE Cun-Wang. Electrochemical Quantitative Detection of Daunorubicin with Gold Electrode Modified with SAM-β-CD[J]. Chinese Journal of Applied Chemistry, ;2009, 26(5): 602-606. shu

Electrochemical Quantitative Detection of Daunorubicin with Gold Electrode Modified with SAM-β-CD

1.
School of Chemistry and Chemical Engineering, Nantong University, Nantong 226007

Corresponding author: WANG Nan-Ping,
Received Date: 14 April 2008
Available Online: 30 June 2008
Fund Project: 国家自然科学基金(20675042,60571055)资助项目 (20675042,60571055)

Daunorubicin(DNR) is a potent anti-leukemia agent.However,it also has cardiac,genic and genital toxicities.Thus,the study on the dosage of DNR and determination methods of DNR is very important to its clinical application.This paper is focused on the electrochemical performance of DNR at the β-cyclodextrin(β-CD) modified electrode.It was found that DNR can be complexed with β-CD on the electrode.The complexing constant was 6.1×10⁴ L/mol.Furthermore,only the DNR complexed with β-CD can undergo irreversible electrochemical reaction.Its rate constant was 28.03/s.The cathodic peak current of DNR was proportional to the concentration of DNR in the 3~30 μmol/L concentration range.Therefore,the β-CD modified electrode can be applied to the quantitative determination of DNR.When the pH of the electrolyte was 7.0 and the temperature was close to 40 ℃,the electrochemical activity of DNR at the β-CD modified electrode was the best.Under these conditions,the detection limit of DNR at the β-CD modified electrode was low.
- Daunorubicin,
- β-cyclodextrin,
- modified electrode,
- complex
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