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Citation: XU Hong-Tao, SHEN Xiao-Xia, CAO Dan, CHEN Chang-Shui. Synthesis and Bacteriostatic Activity of N-nitro-N,N'-diphenyl Urea Derivatives[J]. Chinese Journal of Applied Chemistry, ;2009, 26(5): 507-510. shu

Synthesis and Bacteriostatic Activity of N-nitro-N,N'-diphenyl Urea Derivatives

1.
Department of Chemistey, Huazhong Agricultural University, Wuhan 430070

Corresponding author: CHEN Chang-Shui,
Received Date: 30 April 2008
Available Online: 16 June 2008
Fund Project: 国家自然科学基金资助项目(39770845) (39770845)

Nine compounds of N-nitro urea were prepared by one pot method.The yields of products were in a range of 50.2%~76.8%.The structures of the compounds were identified by ¹H NMR,IR and elemental analysis.Preliminary bacteriostatic activity tests show that all the compounds exhibited varying degrees of antibacterial activity on tested strains when the concentration was 50 mg/L;especially,the inhibitory rates of compounds 3d and 3e on Rhizoctonia Solani were over 50%.Quantum chemistry calculation results indicate that the urea-bridge in the compounds was the chemical active site for such bacteriostatic activity.
- N-nitro urea,
- synthesis,
- fungicidal activities,
- quantum chemistry calculation
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