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Citation: ZHOU Jie, WANG Yan-Zhi, ZHANG Zhen-Zhong. Separation of Five Medicines on a New β-cyclodextrin Derivative Bonded Chiral Stationary Phase[J]. Chinese Journal of Applied Chemistry, ;2009, 26(3): 355-357. shu

Separation of Five Medicines on a New β-cyclodextrin Derivative Bonded Chiral Stationary Phase

1.
The School of Pharmacy, Zhengzhou University, Zhengzhou 450001

Corresponding author: ZHOU Jie,
Received Date: 16 March 2008
Available Online: 27 August 2008
Fund Project: 教育部高等学校博士学科点专项科研基金(20040335045)资助项目 (20040335045)

Several chiral medicines were separated on a new home-made β-cyclodextrins chiral stationary phase.The perphenylcarbamoylated β-cyclodextrin bonded silica CSP was prepared step by step,from synthesized and purified mono-6-p-toluenesulfonyl-β-cyclodextrin,mono-6-N-allylamino-β-cyclodextrin and mono-6-Nβ-cyclodextrin.By this CSP,baseline separation of five racemic medicines(fluoxetine,paroxetine,naproxen,propranolol and alprenolol) was realized.The optimal conditions were determined.The mobile phase was methanol-0.15%TEAA(35:65,V/V,pH=4.0) for paroxetine and naproxen,methanol-0.15%TEAA(30:70,V/V,pH=4.0) for fluoxetine,and methanol-0.15%TEAA(40:60,V/V,pH=5.0) for propranolol and alprenolol,respectively;the flowrate was 0.5 mL/min,the temperature 20 ℃,and UV-detector was used(254 nm).
- β-cyclodextrin derivative,
- chiral stationary phase,
- enantiomer,
- separation,
- HPLC
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