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Citation: LI Ya, WANG Xiao-Mei, HAN Shi-Tian, LIU Yan-Qin, CAO Xiu-Lian. Synthesis and Antitumor Activity of New Metalloporphyrin 5-Fluorouracil Compounds[J]. Chinese Journal of Applied Chemistry, ;2009, 26(3): 316-320. shu

Synthesis and Antitumor Activity of New Metalloporphyrin 5-Fluorouracil Compounds

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a College of Chemistry and Materials Science, Hebei Normal University, Shijiazhuang 050016;
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b Department of Chemistry, Handan College, Handan;
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c Physics and Chemistry Group, Ordnance Engineering College, Shijiazhuang

Corresponding author: HAN Shi-Tian,
Received Date: 6 February 2008
Available Online: 11 April 2008
Fund Project: 河北省自然科学基金(203147) (203147)河北省教育厅科学研究基金(2001120)资助项目 (2001120)

Four new porphyrin-5-fluorouracil compounds were designed and synthesized with yields of 27.1%~58.3% and mp300 ℃.The reaction conditions were optimized,and the separation method of the target products was explored.The compositions and structures of these compounds were confirmed by IR,UV-Vis,¹H NMR,and MS.The antitumor activity experimental results showed that D1,C2,D2 compounds inhibited distinctly the growth of cancer S₁₈₀ in the mice.
- metalloporphyrin,
- fluorouacil synthesis,
- antitumor activity,
- tumor-bearing mice,
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