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Citation: TAN Ni, SHAO Chang-Lun, TAO Li-Ming, HE Li-Xian, SHE Zhi-Gang, LIN Yong-Cheng. Identification and Bioassay of Three Anthraquinone Secondary Metabolites of Mangrove Endophytic Fungus #2240 from South China Sea[J]. Chinese Journal of Applied Chemistry, ;2009, 26(3): 277-281. shu

Identification and Bioassay of Three Anthraquinone Secondary Metabolites of Mangrove Endophytic Fungus #2240 from South China Sea

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a School of Chemistry and Chemical Engineering, South China University, Hengyang;
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b School of Chemistry and Chemical Engineering, Sun Yat-sen University, Guangzhou 510275;
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c School of Medicine and Pharmacy, Ocean University of China, Qingdao;
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d Department of Chemistry and Life Science, Xiangnan College, Chenzhou

Corresponding author: LIN Yong-Cheng,
Received Date: 3 April 2008
Available Online: 9 September 2008
Fund Project: 国家“八六三”科技攻关计划(2006AA09Z422) (2006AA09Z422)国家自然科学基金(20072058) (20072058)广东省自然科学基金重点(021732) (021732)南华大学博士启动基金(5-2007-XQD-002)资助项目 (5-2007-XQD-002)

Three anthraquinone secondary metabolites,(+)-3,3',7,7',8,8'-hexahydroxy-5,5'-dimethyl-bianthraquinone(compound 1),1,4,5-thihydroxy-7-methylanthraquinone(compound 2),and 1,6,8-thihydroxy-3-methylanthraquinone(compound 3),were isolated from the culture media of mangrove endo-phytic fungus #2240 collected from a mangrove Castaniopsic Fissa from South China Sea coast through chromatographic separation.Compound 1 was found for the first time.Their structures were elucidated based on related literature and spectral analyses including ¹H/¹³C NMR,DEPT,HMQC,HMBC,HREIMS,IR,and UV-Vis.The DNA hTopo I isomerase inhibition test showed that compound 1 possessed strong activity,and the lowest inhibiting concentration(2.35×10^-4 mol/L) was much less than that of the positive control camptothecin(1.00×10^-3 mol/L).
- mangrove endophytic fungus,
- anthraquinone,
- secondary metabolites,
- DNA hTopo I isomerase,
- inhibition activity
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