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Citation: HOU Xiao-Na, WANG Zhao-Yang, LUO Yu-Fen, YE Rui-Rong. Synthesis of Poly(lactic acid-co-valine) via Direct Melt Copolycondensation[J]. Chinese Journal of Applied Chemistry, ;2009, 26(3): 273-276. shu

Synthesis of Poly(lactic acid-co-valine) via Direct Melt Copolycondensation

1.
Department of Chemistry, South China Normal University, Guangzhou 510006

Corresponding author: WANG Zhao-Yang,
Received Date: 4 February 2008
Available Online: 8 May 2008
Fund Project: 国家自然科学基金(20772035) (20772035)广东省自然科学基金博士科研启动基金(5300082)资助项目 (5300082)

With cheap D,L-Lactic acid(D,L-LA) and valine(Val) as the stanting materials,and SnO as the catalyst,a novel biomaterial,poly(lactic acid-co-valine)[P(LAco-Val),was directly synthesized via melt copolycondensation.The copolymer was characterized with viscosity measurements,FTIR,¹H NMR,DSC,XRD and GPC.The effects of feed molar ratio were discussed.When the feed molar ratio n(LA):n(Val) was 95:5,the weight-average molecular mass(M_w) was 7 300,the number-average molecular mass(M_n) was 5 400,which were all the highest.Its crystallinity(13.5%) was lower than that of homopolymer poly(D,L-lactic acid)(PDLLA).With the increase of the feed molar ratio of Val,M_w of the copolymer P(LA-co-Val) gradually became smaller,and the crystallinity gradually disappeared.But the lowest M_w of 1 800 and the glass-transition temperature(T_g) and the melting temperature(T_m) of the copolymer were similar to that of PDLLA,which could meet the requests for the application in drug delivery of this biodegradable material.
- D,L-lactic acid,
- Valine,
- poly(lactic acid-co-valine),
- biomaterial,
- direct synthesis,
- characterization
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