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Citation: XIE Yu, SHANG Xiao-Xian, YAN Liu-Shui. Preparation of Hydroxypropyl-chitosan Nanospheres and Their Controlled Release in vitro[J]. Chinese Journal of Applied Chemistry, ;2009, 26(2): 193-197. shu

Preparation of Hydroxypropyl-chitosan Nanospheres and Their Controlled Release in vitro

1.
Department of Material Chemistry of Nanchang Hangkong University, Nanchang 330063

Corresponding author: XIE Yu,
Received Date: 21 January 2008
Available Online: 19 May 2008
Fund Project: 江西省自然科学基金(0620071)资助项目 (0620071)江西省教育厅科技项目(赣教技字[2007]168号) (赣教技字[2007]168号)航空高校科研基金(EA200502138)资助项目 (EA200502138)

Hydroxypropyl-chitsoan(HCS) with a substitution degree of 0.46 was prepared.Hydroxypropyl-chitosan nanospheres with the particle size of 100~300 nm were formed when hydroxypropyl-chitosan water solution reacts with sodium polyphosphate based on ion gel method.TEM micrograph reveals that the morpho-logy of hydroxypropyl-chitosan nanospheres was regular.Bovine Serum Albumin(BSA) was taken as the typical drug to determine the controlled release in vitro.The result suggests that the highest encapsulation efficiency and load of BSA reached to 86% and 46% respectively.The HCS nanospheres released 28% of BSA in average within 2 h,and it continuously release the entrapped protein,but with a slower rate.
- chitosan,
- hydroxypropyl,
- nanosphere,
- Bovine Serum Albumin,
- controlled release
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