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Citation: ZHANG Wan-Quan, LI Yan-Ping, LIU Chen-Jiang, WANG Ji-De, ZAO Xin-Min. Synthesis of 1-(2-Trifluoromethylbenzimidazol-1-acetyl)-4-Aroylthiosemicarbazide under Microwave Irradiation[J]. Chinese Journal of Applied Chemistry, ;2009, 26(1): 59-62. shu

Synthesis of 1-(2-Trifluoromethylbenzimidazol-1-acetyl)-4-Aroylthiosemicarbazide under Microwave Irradiation

1.
MOE Key Laboratory of Oil and Gas Fine Chemicals, School of Chemistry and Chemical Engineering, Xinjiang University, Urumqi 830046

Corresponding author: LIU Chen-Jiang,
Received Date: 28 November 2007
Available Online: 21 February 2008
Fund Project: 国家自然科学基金(20662009) (20662009)教育部博士点专项基金(20050755003)资助项目 (20050755003)

A series of novel 1-(2-trifluoromethylbenzimidazol-1-acetyl)-4-aroylthios-emicarbazides(2a~2k) was synthesized by the reaction of 1-hydrazinocarbonylmethyl-2-trifluoromethylbenzimidazole with each of aroylisothiocyanates(1a~1k) under microwave irradiation and classical heating conditions.Compared to classical heating method,microwave irradiation has many advantages in the organic synthesis process,such as simple operation,short reaction time,high yields,less side reactions and easy purification of products.The structures of these compounds were confirmed by elemental analysis,IR,and 1H NMR.The preliminary biological activities of the target compounds were tested,and the result showed that only compound 2a had low anti-HIV-1 reverse transcriptase activity.
- microwave irradiation,
- benzimidazole,
- aroylthiosemicarbazide,
- synthesis
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